International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 640, P. 123020 - 123020
Published: May 4, 2023
Language: Английский
Ceramics International, Journal Year: 2022, Volume and Issue: 48(16), P. 22647 - 22663
Published: May 13, 2022
Language: Английский
Citations
47
Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3222 - 3222
Published: Aug. 8, 2022
Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety surgical techniques, current clinical strategies defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient volume, graft resorption, rejection. Bone tissue engineering (BTE) has emerged as novel approach to guided regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors bioactive scaffolds using bioreactors. The successful translation requires overcoming number challenges. Currently, vascularization is critical limitation viability tissue-engineered construct. Furthermore, efficacy safety cell-seeding exogenous administration are still controversial. vivo bioreactor principle (IVB) an exceptionally promising concept regeneration predictable patient-specific manner. This based self-regenerative capacity human body, combines flap prefabrication axial strategies. Multiple experimental studies presented this review approach. Routine application future direction BTE; however, it further investigation some limitations.
Language: Английский
Citations
45
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(19)
Published: Feb. 15, 2023
Abstract Injectable hydrogels are valuable tools in tissue engineering and regenerative medicine due to their unique advantages of injectability with minimal invasiveness usability for irregularly shaped sites. However, it remains challenging achieve scalable manufacturing together matching physicochemical properties on‐demand drug release a high level control over biophysical biomedical cues direct endogenous cells. Here, the use an injectable fibro‐gel is demonstrated, water‐filled network entangled hydrogel microfibers, whose profiles can be tailored overcome these shortcomings. This exhibits favorable vitro biocompatibility capability aid vascularization. The potential advancing regeneration explored mice excision skin model. Preliminary vivo tests indicate that promotes wound healing new healthy at faster rate than commercial gel. Moreover, demonstrated distinct drugs different rates further accelerate higher efficiency, by using two‐layer combination tailorable this offers promising approach fields such as therapeutic delivery, medical dressings, 3D scaffolds engineering.
Language: Английский
Citations
38
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: June 28, 2023
Biomedicine and tissue regeneration have made significant advancements recently, positively affecting the whole healthcare spectrum. This opened way for them to develop their applications revitalizing damaged tissues. Thus, functionality will be restored. Cardiac engineering (CTE) using curative procedures that combine biomolecules, biomimetic scaffolds, cells plays a critical part in this path. Stimuli-responsive hydrogels (SRHs) are excellent three-dimensional (3D) biomaterials (TE) various biomedical applications. They can mimic intrinsic tissues’ physicochemical, mechanical, biological characteristics variety of ways. also provide 3D setup, adequate aqueous conditions, mechanical consistency required cell development. Furthermore, they function as competent delivery platforms biomolecules. Many natural synthetic polymers were used fabricate these intelligent with innovative enhanced features specialized capabilities appropriate CTE In present review, different strategies employed outlined. The light was shed on limitations use conventional CTE. Moreover, diverse types SRHs, characteristics, assembly exploitation discussed. To summarize, recent development construction SRHs increases potential operate intelligent, sophisticated systems reconstruction degenerated cardiac
Language: Английский
Citations
29
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 383 - 383
Published: Jan. 22, 2023
Sodium alginate (SA)-based hydrogels are often employed as bioink for three-dimensional (3D) scaffold bioprinting. They offer a suitable environment cell proliferation and differentiation during tissue regeneration also control the release of growth factors mesenchymal stem secretome, which is useful biointegration. However, such show poor mechanical properties, fast-release kinetics, low biological performance, hampering their successful clinical application. In this work, silk fibroin (SF), protein with excellent biomechanical properties frequently used controlled drug release, was blended SA to obtain improved properties. Firstly, we produced printable solution containing SF capable conformational change from Silk I (random coil) II (β-sheet): transition fundamental condition improve scaffold's Then, SA-SF blends' printability shape fidelity were demonstrated, characterization printed performed: significantly increased compressive elastic modulus, while no influence on tensile response detected. Finally, profile Lyosecretome-a freeze-dried formulation MSC-secretome extracellular vesicles (EV)-from scaffolds determined: not only dramatically slowed EV rate, but modified kinetics mechanism respect baseline hydrogel. Overall, these results lay foundation development bioinks modulable EV-release application in 3D printing.
Language: Английский
Citations
26
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2356 - 2356
Published: Feb. 16, 2024
Adipose tissue (AT) is a large and important energy storage organ as well an endocrine with critical role in many processes. Additionally, AT enormous easily accessible source of multipotent cell types used our day for all regeneration. The ability adipose-derived stem cells (ADSCs) to differentiate into other cells, such endothelial (ECs), vascular smooth muscle or cardiomyocytes, engineering order promote/stimulate the process angiogenesis. Being key future successful clinical applications, functional networks engineered are targeted by numerous vivo ex studies. article reviews angiogenic potential ADSCs explores their capacity field (TE).
Language: Английский
Citations
16
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 15, 2024
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 148933 - 148933
Published: Jan. 23, 2024
In bone tissue engineering studies, establishing vascular networks plays a crucial role in enhancing graft repair strategies. While most engineered bones rely on host invasion after implantation, this process is often slow. Therefore, exploring highly vascularized strategies may be beneficial to improving the success of repair. This study aimed construct scaffolds with biomimetic using dual-model composite printing promote angiogenic integration and enhance osteogenic First, polycaprolactone nano-tricalcium phosphate scaffold provided good mechanical properties porosity reserved space for bionic network. Meanwhile, researchers used concentrated growth-factorized gelatin methacryloyl hydrogel-loaded endothelial cells three-dimensional interoperable cavity structure, multi-level connectivity into network diffusing throughout scaffold. The slow release biological signals from hydrogel enhanced functions acetogenesis osteogenesis. results vivo vitro experiments showed that angiogenesis, promoted vessels, synergized osteogenesis induction, facilitating defect regeneration. strategy was versatile valuable basis positive insight constructing large-scale grafts.
Language: Английский
Citations
10
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 243 - 252
Published: Feb. 15, 2024
Language: Английский
Citations
10
Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2050 - 2050
Published: April 29, 2024
Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response promote angiogenesis. Blood vessels play crucial role in sustaining vital life facilitating the delivery immune cells, oxygen, nutrients, as well eliminating waste products generated during cellular metabolism. Dysfunction blood may contribute significantly development life-threatening diseases. Anti-angiogenesis therapy pro-angiogenesis/angiogenesis strategies been frequently recommended various Herein, we describe mechanism which promotes angiogenesis summarize its application chronic wounds, bone repair, respiratory system. Furthermore, discuss drug system treating diseases, providing constructive ideas inspiration new treatment strategies.
Language: Английский
Citations
9