Molecular Cancer Therapeutics,
Journal Year:
2024,
Volume and Issue:
23(5), P. 638 - 647
Published: Feb. 5, 2024
Abstract
Drug
resistance
is
the
major
determinant
for
metastatic
disease
and
fatalities,
across
all
cancers.
Depending
on
tissue
of
origin
therapeutic
course,
a
variety
biological
mechanisms
can
support
sustain
drug
resistance.
Although
genetic
mutations
gene
silencing
through
epigenetic
are
culprits
in
targeted
therapy,
efflux
polyploidization
more
global
that
prevail
broad
range
pathologies,
response
to
treatments.
There
an
unmet
need
identify
patients
at
risk
polyploidy,
understand
underlying
polyploidization,
develop
strategies
predict,
limit,
reverse
polyploidy
thus
enhancing
efficacy
standard-of-care
therapy
improve
better
outcomes.
This
literature
review
provides
overview
cancer
offers
perspective
patient
monitoring
actionable
therapy.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: July 12, 2023
Cell
cycle
arrest
(CCA)
is
seen
as
a
prime
candidate
for
effective
cancer
therapy.
This
mechanism
can
help
researchers
to
create
new
treatments
target
cells
at
particular
stages
of
the
cell
(CC).
The
CCA
characteristic
various
therapeutic
modalities,
including
radiation
(RT)
and
chemotherapy
(CT),
which
synchronizes
facilitates
standardization
radio-chemotherapy
protocols.
Although
it
was
discovered
that
photodynamic
treatment
(PDT)
had
biological
effect
on
in
cells,
remains
unclear.
Furthermore,
besides
conventional
forms
death
such
apoptosis,
autophagy,
necrosis,
unconventional
types
pyroptosis,
mitotic
catastrophe,
paraptosis,
ferroptosis,
necroptosis,
parthanatos
after
PDT
have
been
reported.
Thus,
variety
elements,
oxygen,
tumor’s
microenvironment,
characteristics
light,
photosensitizer
(PS),
influence
effectiveness
treatment,
not
yet
studied
clearly.
review
focuses
induced
by
PSs
agents
lines.
be
viewed
remarkable
instructive
management
protocol.
Regarding
relationship
between
quantity
reactive
oxygen
species
(ROS)
its
consequences,
we
proposed
two
mathematical
models
PDT.
Finally,
gathered
recent
vitro
vivo
studies
about
post-PDT
made
suggestions
how
standardize,
potentiate,
customize
methodology.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(4), P. 303 - 303
Published: March 23, 2024
The
understanding
that
tumor
cells
might
evade
immunity
through
various
mutations
and
the
potential
of
an
augmented
immune
system
to
eliminate
abnormal
led
idea
utilizing
platelet-rich
fibrin
(PRF),
a
blood
concentrate
containing
body’s
elements
as
adjunctive
therapy
for
localized
tumors.
This
study
is
first
evaluated
effect
PRF
generated
with
different
relative
centrifugal
forces
(RCFs)
on
osteoblastic
fibroblastic
cell
lines
MG63
HT1080
regard
viability,
cytokine
growth
factor
release,
gene
expression
factors
related
cycle
apoptosis.
Our
findings
could
demonstrate
decreased
proliferation
when
treated
indirectly
compared
cultures
without
PRF.
was
more
distinct
were
low-RCF
PRF,
where
higher
concentrations
cytokines
reduced
RCFs
can
be
found.
Similar
patterns
observed
assessing
regulation
apoptosis
in
both
Despite
variations,
there
consistent
trend
up-regulation
tumor-suppressive
genes
down-regulation
anti-apoptotic
types
following
treatment
high-
and,
particularly,
formulations.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
10
Published: Jan. 8, 2024
In
recent
years,
colon
cancer
has
become
one
of
the
most
common
malignant
tumors
worldwide,
posing
a
great
threat
to
human
health.
Studies
have
shown
that
natural
polysaccharides
rich
biological
activities
and
medicinal
value,
such
as
anti-inflammatory,
anti-cancer,
anti-oxidation,
immune-enhancing
effects,
especially
with
potential
anti-colon
mechanisms.
Natural
can
not
only
protect
enhance
homeostasis
intestinal
environment
but
also
exert
direct
inhibition
effect
on
cells,
making
it
promising
strategy
for
treating
cancer.
Preliminary
clinical
experiments
demonstrated
oral
administration
low
high
doses
citrus
pectin
reduce
tumor
volume
in
mice
by
38%
(
Cancer and Metastasis Reviews,
Journal Year:
2024,
Volume and Issue:
43(4), P. 1561 - 1571
Published: July 5, 2024
Anticancer
systemic
therapy
comprises
a
complex
and
growing
group
of
drugs.
Some
the
new
agents
with
novel
mechanisms
action
that
have
appeared
are
difficult
to
fit
in
groups
classical
chemotherapy,
hormones,
tyrosine-kinase
inhibitors,
monoclonal
antibodies.
We
propose
classification
based
on
two
levels
information:
site
mechanism
action.
Regarding
former,
drugs
can
exert
their
tumor
cell,
vasculature,
immune
system,
or
endocrine
system.
The
refers
molecular
target.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 5082 - 5082
Published: June 29, 2023
Ovarian
cancer
(OC)
is
one
of
the
most
common
types
in
women
with
a
high
mortality
rate,
and
treatment
OC
prone
to
recurrence
rates
side
effects.
Scutellaria
baicalensis
(SB)
herbal
medicine
good
anti-cancer
activity,
several
studies
have
shown
that
SB
its
flavonoids
some
anti-OC
properties.
This
paper
elucidated
pathogenesis
OC,
including
cell
proliferation
cycle
regulation,
invasion
metastasis,
apoptosis
autophagy,
drug
resistance
angiogenesis.
The
mechanisms
flavonoids,
wogonin,
baicalein,
baicalin,
Oroxylin
A,
scutellarein,
are
revealed,
such
as
wogonin
inhibits
proliferation,
induces
apoptosis,
increases
cytotoxicity
drug.
Baicalein
also
vascular
endothelial
growth
factor
(VEGF)
expression
etc.
Analyzing
their
advantages
disadvantages
treating
provides
new
perspective
on
role
treatment.
It
serves
resource
for
future
research
development.
