Journal of Invertebrate Pathology, Journal Year: 2024, Volume and Issue: 206, P. 108170 - 108170
Published: Aug. 22, 2024
Language: Английский
Cancer Letters, Journal Year: 2024, Volume and Issue: 596, P. 217004 - 217004
Published: June 4, 2024
Language: Английский
Citations
10
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 23, 2023
As one of the most abundant epigenetic modifications in RNA, N
Language: Английский
Citations
19
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: July 20, 2024
Abstract Recently, N6-methyladenosine (m 6 A) has aroused widespread discussion in the scientific community as a mode of RNA modification. m A comprises writers, erasers, and readers, which regulates production, nuclear export, translation is very important for human health. large number studies have found that regulation closely related to occurrence invasion tumors, while homeostasis function tumor microenvironment (TME) determine development tumors some extent. TME composed variety immune cells (T cells, B etc.) nonimmune (tumor-associated mesenchymal stem (TA-MSCs), cancer-associated fibroblasts (CAFs), etc.). Current suggest involved regulating various TME, thereby affecting progression. In this manuscript, we present composition relationship between methylation characteristic changes role potential therapeutic strategies provide new perspectives better treatment clinical work.
Language: Английский
Citations
8
Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)
Published: July 4, 2024
Metastasis is the leading cause of mortality in patients with colorectal cancer (CRC) and angiogenesis a crucial factor tumor invasion metastasis. Long noncoding RNAs (lncRNAs) play regulatory functions various biological processes cells, however, roles lncRNAs CRC-associated remain to be elucidated CRC, as do underlying mechanisms. We used bioinformatics screen differentially expressed from TCGA database. LOC101928222 expression was assessed by qRT-PCR. The impact CRC development both vitro vivo. mechanisms were investigated cellular fractionation, RNA-sequencing, mass spectrometric, RNA pull-down, immunoprecipitation, stability, gene-specific m6A assays. upregulated correlated worse outcome. Moreover, shown promote migration, invasion, CRC. Mechanistically, synergized IGF2BP1 stabilize HMGCS2 mRNA through an m6A-dependent pathway, increased cholesterol synthesis and, ultimately, promotion development. In summary, these findings demonstrate novel, LOC101928222-based mechanism involved regulation metastatic potential LOC101928222-HMGCS2-cholesterol pathway may effective target for diagnosing managing
Language: Английский
Citations
7
Fluids and Barriers of the CNS, Journal Year: 2023, Volume and Issue: 20(1)
Published: Feb. 28, 2023
Incomplete recovery of blood-brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after remains largely unknown. Emerging evidence suggests that epigenetic factors play a significant role in regulating post-stroke recovery. This study aimed evaluate and transcriptional profile cerebral microvessels thromboembolic (TE) define potential causes limited RNA-sequencing reduced representation bisulfite sequencing (RRBS) analyses were performed using isolated from young (6 months) old (18 mice seven days poststroke compared age-matched sham controls. DNA methylation profiling brain revealed 11,287 differentially methylated regions (DMR) 9818 DMR mice, corresponding annotated genes. These enriched genes encoding cell structural proteins (e.g., junction, polarity, actin cytoskeleton, extracellular matrix), transporters channels potassium transmembrane transporter, organic anion inorganic cation transporters, calcium ion transport), involved endothelial processes angiogenesis/vasculogenesis, signaling transcription regulation). Integrated analysis RNA identified changes junctions (occludin), remodeling (ezrin) as well pathways like Rho GTPase (RhoA Cdc42ep4). Aging hub aberrant affected by profound alterations (hypermethylation repression) protein expression claudin-5) activation set mesenchymal transformation Sox9, Snai1), repression angiogenesis regulation. findings plays an important repair stroke, through associated with restoration prevalently enhancing injury.
Language: Английский
Citations
16
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: April 21, 2023
N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A of plays a critical role occurrence progression tumors by regulating metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, lncRNA processing. Numerous studies have shown that involved development various cancers. This review aims to summarize significant proliferation tumorigenesis CRC, as well potential modulating for tumor treatment. These findings may offer new therapeutic strategies clinical implementation CRC near future.
Language: Английский
Citations
13
Cancer Management and Research, Journal Year: 2023, Volume and Issue: Volume 15, P. 547 - 561
Published: July 1, 2023
Abstract: Long non-coding RNAs (lncRNAs) are (ncRNAs) longer than 200nt. They have complex biological functions and take part in multiple fundamental processes, such as cell proliferation, differentiation, survival apoptosis. Recent studies suggest that lncRNAs modulate critical regulatory proteins involved cancer cycle, cyclin, cycle protein-dependent kinases (CDK) kinase inhibitors (CKI) through different mechanisms. To clarify the role of regulation will provide new ideas for design antitumor therapies which intervene with progression. In this paper, we review recent about controlling on related CDK CKI cancers. We further outline mechanisms describe emerging cycle-related diagnosis therapy. Keywords: cyclin-CDK, inhibitors, lncRNA
Language: Английский
Citations
13
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 220, P. 116016 - 116016
Published: Jan. 2, 2024
Language: Английский
Citations
5
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 7, 2024
Abstract Long noncoding RNAs (lncRNAs), which are more than 200 nucleotides in length and do not encode proteins, play crucial roles governing gene expression at both the transcriptional posttranscriptional levels. These molecules demonstrate specific patterns various tissues developmental stages, suggesting their involvement numerous processes diseases, notably cancer. Despite widespread acknowledgment growing enthusiasm surrounding potential as diagnostic prognostic biomarkers, precise mechanisms through lncRNAs function remain inadequately understood. A few have been studied depth, providing valuable insights into biological activities emerging functional themes mechanistic models. However, extent to mammalian genome is transcribed transcripts still a matter of debate. This review synthesizes our current understanding lncRNA biogenesis, genomic contexts, multifaceted tumorigenesis, highlighting cancer-targeted therapy. By exploring historical perspectives alongside recent breakthroughs, we aim illuminate diverse reflect on broader implications study for evolution function, well advancing clinical applications.
Language: Английский
Citations
5
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117907 - 117907
Published: Feb. 10, 2024
Language: Английский
Citations
4