Recent progress of electrospun nanofibers as burning dressings

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14374 - 14391

Published: Jan. 1, 2024

Burns are a global public health problem, which brings great challenges to and the economy.

Language: Английский

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Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3849 - 3849

Published: March 29, 2024

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients

Language: Английский

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On‐Demand Silk Protein‐Based Spray for Acute Burn Wound Management

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract There is a critical unmet need to improve the treatment of battlefield burns. Rapid and efficient wound protection closure are essential prevent infections, reduce pain, minimize scarring. This study introduces portable, field‐applicable spray system designed instantly apply protective hydrogel coating with therapeutic agents wounds varying sizes shapes for emergency treatments. By mimicking natural silk‐spinning processes, current spray‐on optimized create self‐standing, spider‐web‐like interwoven structure that supports tissue adhesion, cell viability, vascular regeneration. In vivo testing in porcine burn model demonstrates these silk‐based coatings, especially when combined antibiotics, significantly accelerated healing deep partial‐thickness burns compared standard rapid effective performance medical use, offering an advancement functional biomaterials.

Language: Английский

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Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 251 - 264

Published: July 22, 2023

Excessive reactive oxygen species (ROS) at severe burn injury sites may promote metabolic reprogramming of macrophages to induce a deteriorative and uncontrolled inflammation cycle, leading delayed wound healing regeneration. Here, novel bioactive, anti-fouling, flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate (EGCG)-copper (Cu) capsules (termed as [email protected]gel) is engineered for management, which dedicated synergistically exerting ROS-scavenging, immune regulation pro-angiogenic effects. protected]gel can scavenge ROS normalize intracellular redox homeostasis, effectively relieving oxidative damages blocking proinflammatory signal transduction. Importantly, EGCG-Cu inhibit the activity hexokinase phosphofructokinase, alleviate accumulation pyruvate convert it acetyl coenzyme A (CoA), whereby inhibits glycolysis normalizes tricarboxylic acid (TCA) cycle. Additionally, by downregulates M1-type polarization expression cytokines both in vitro vivo. Meanwhile, copper ions (Cu2+) released from facilitate angiogenesis. significantly accelerates via promoting closure, weakening tissue-damaging inflammatory responses enhancing remodeling pathological structure. Overall, this study demonstrates great potential bioactive dressing treating wounds without unnecessary secondary damage newly formed skin, highlights importance immunometabolism modulation tissue repair

Language: Английский

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Damage-mediated macrophage polarization in sterile inflammation

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 3, 2023

Most of the leading causes death, such as cardiovascular diseases, cancer, dementia, neurodegenerative and many more, are associated with sterile inflammation, either a cause or consequence these conditions. The ability to control progression inflammation toward tissue resolution before it becomes chronic holds significant clinical potential. During initiation occurs through damage-associated molecular patterns (DAMPs) in absence pathogen-associated molecules. Macrophages, which primarily localized tissue, play pivotal role sensing DAMPs. Furthermore, macrophages can also detect respond resolution-associated (RAMPs) specific pro-resolving mediators (SPMs) during inflammation. being highly adaptable cells, particularly influenced by changes microenvironment. In response environment, monocytes, pro-inflammatory macrophages, pro-resolution modulate their differentiation state. Ultimately, DAMP RAMP-primed depending on predominant subpopulation, regulate balance between inflammatory resolving processes. While injury pathogen-induced reactions may have distinct effects most studies focused macrophage responses induced pathogens. this review, emphasizes available human data, we illustrate how sense examining expression receptors for DAMPs, RAMPs, SPMs. We delve into signaling pathways SPMs, contribute regulation from phenotype. Understanding regulatory mechanisms behind transition subtypes offer insights manipulating diseases.

Language: Английский

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Role of exercise in nursing care for burn wound patients: A narrative review from a nursing perspective

Journal of Nursing Reports in Clinical Practice, Journal Year: 2024, Volume and Issue: 0(0), P. 0 - 0

Published: Jan. 7, 2024

Burn injuries are a global health issue with extensive physical and psychological ramifications. Nursing care plays an instrumental role in the recovery of individuals burn wounds. There is growing interest incorporating exercise programs as supplementary approach alongside conventional wound care. This review meticulously assesses influence interventions integrated into nursing for patients. By amalgamating current empirical evidence, it seeks to provide valuable insights potential advantages, obstacles, optimal strategies. encompass spectrum noteworthy physical, psychological, socioeconomic repercussions. Exercise confers several benefits, including enhanced circulation, prevention muscle wasting, expedited healing, effective pain management, anxiety alleviation, bolstered self-esteem. Nurses occupy indispensable position promoting not only but also during rehabilitation, addressing mental concerns, facilitating education. Ultimately, emerges substantial contributor holistic patient care, thereby warranting further exploration development comprehensive guidelines.

Language: Английский

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Pathophysiology of Severe Burn Injuries: New Therapeutic Opportunities From a Systems Perspective

Journal of Burn Care & Research, Journal Year: 2024, Volume and Issue: 45(4), P. 1041 - 1050

Published: March 22, 2024

Severe burn injury elicits a profound stress response with the potential for high morbidity and mortality. If polytrauma is present, patient outcomes appear to be worse. Sex-based comparisons indicate females have worse than males. There are few effective drug therapies treat shock secondary progression. The lack of drugs appears arise from current treat-as-you-go approach rather more integrated systems approach. In this review, we present brief history burns research discuss its pathophysiology systems' perspective. severe phenotype develop rapid relentless barrage damage-associated molecular patterns, pathogen-associated neural afferent signals, which leads state hyperinflammation, immune dysfunction, coagulopathy, hypermetabolism, intense pain. We propose that if central nervous system control cardiovascular function endothelial-glycocalyx-mitochondrial coupling can restored early, these processes may minimized. therapeutic goal switch healing by reducing fluid leak maintaining tissue O2 perfusion. Currently, no systems-based exist burns. been developing small-volume therapy comprising adenosine, lidocaine, magnesium (ALM) hemorrhagic shock, traumatic brain injury, sepsis. Our early studies ALM holds some promise in supporting pulmonary functions following Future will investigate ability sex disparities, translation humans.

Language: Английский

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Association between platelet-to-lymphocyte ratio at admission and short-term mortality in severe burn patients: a meta-analysis

Burns, Journal Year: 2025, Volume and Issue: unknown, P. 107444 - 107444

Published: Feb. 1, 2025

Language: Английский

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Acute kidney injury in patients with burns

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 20(3), P. 188 - 200

Published: Sept. 27, 2023

Language: Английский

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Rosmarinic Acid-Grafted Dextran/Gelatin Hydrogel as a Wound Dressing with Improved Properties: Strong Tissue Adhesion, Antibacterial, Antioxidant and Anti-Inflammatory

Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 4034 - 4034

Published: May 11, 2023

Designing a strong tissue adhesive and multifunctional hydrogel dressing for various skin injuries is still significant challenge. Based on the bioactive activities of rosmarinic acid (RA) its catechol structure being similar to dopamine, RA-grafted dextran/gelatin (ODex-AG-RA) was designed systemically characterized in this study. The ODex-AG-RA exhibited excellent physicochemical properties, including fast gelation time (61.6 ± 2.8 s), strength (27.30 2.02 kPa) enhanced mechanical properties (1.31 × 104 Pa G'). examination hemolysis co-culturing with L929 cells showed vitro biocompatibility hydrogels. hydrogels 100% mortality rate against S. aureus at least 89.7% E. coli vitro. In vivo evaluation efficacy wound healing carried out rat model full-thickness skindefect. amount collagen deposition CD31 wounds two ODex-AG-RA-1 groups day 14 4.3 times 2.3 that control group, respectively. Furthermore, mechanism promoting proved be related anti-inflammatory by adjusting expression inflammatory cytokines (TNF-α CD163) reducing level oxidative stress (MDA H2O2). Overall, study demonstrated wound-healing first time. hydrogel, due adhesive, anti-inflammatory, antibacterial antioxidative activities, promising candidate as dressing.

Language: Английский

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