The Protective Effects of Annexin A1 in Acute Lung Injury Mediated by Nrf2 DOI Creative Commons
Hui Huang, Yuqin Shi, Yuequan Zhou

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Acute lung injury (ALI), one of the most severe respiratory system diseases, is prevalent worldwide. Annexin A1 (AnxA1) an important member annexin superfamily, known for its wide range physiological functions. However, potential protective effect against lipopolysaccharide (LPS)-induced ALI remains unclear. Mice were divided into four groups: Sham, LPS + vehicle, 0.1 μg AnxA1, and 0.5 AnxA1. Lung was assessed through histopathology, pulmonary wet-to-dry (W/D) ratio, cell counting bronchoalveolar lavage fluid (BALF), oxidative stress analysis, noninvasive function testing. Gene protein expression levels measured using RT-PCR, ELISA, western blot analysis. AnxA1 alleviated LPS-induced by protecting tissue from damage, reducing wet/dry weight improving impaired function. Interestingly, administration found to repress infiltration inflammatory cells decreasing total count, neutrophils, concentrations in (BALF). mitigated response lowering IL-1β, IL-6, TNF-α BALF mice. Additionally, attenuated tissues mice restoring activity catalase (CAT), SOD, glutathione (GSH) but malondialdehyde (MDA). We also that suppressed activation NLRP3 signaling pathway. Mechanistically, activated Nrf2/HO-1 pathway while preventing NF-κB. Collectively, these findings suggest alleviates might be a promising novel therapeutic agent ALI.

Language: Английский

Transdermal fluocinolone acetonide loaded decorated hyalurosomes cellulose acetate/polycaprolactone nanofibers mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats DOI Creative Commons
Sammar Fathy Elhabal, Mohamed A. El-Nabarawi, Soha Osama Hassanin

et al.

Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Purpose This study aimed to develop a transdermal delivery system for fluocinolone acetonide (FLA), corticosteroid used in treating inflammatory conditions like rheumatoid arthritis (RA), overcome the limitations of oral administration, such as poor solubility and bioavailability. Methods FLA-loaded PEG decorated hyalurosomes (FLA-PHs) were fabricated using ethanol injection, incorporating various Brij® surfactants different amounts hyaluronic acid (HA) based on full factorial design. The impact independent variables, HA amount (mg) (X 1 ) Brij type 2 inspected entrapment efficiency (EE%), particle size (PS), zeta potential (ZP). optimum FLA-PHs then incorporated into ε-polycaprolactone (PCL) cellulose acetate (CA) nanofibers enhance sustained (FLA-NFs). Results exhibited EE% 83.58 ± 0.69%, PS 169.00 1.41 nm, ZP -22.90 0.14 mV. Morphological assessment FLA-NFs showed promising results terms surface roughness. In Freund-induced rat model adjuvant-induced arthritis, treatment with significantly improved joint histopathological analyses. Furthermore, it suppressed markers mTORC1, TNF-α, NF-κB while upregulating TRIM24 anti-inflammatory IL-10. Conclusion present strategy enhancing FLA managing RA, offering improvements efficacy reduced systemic side effects compared conventional administration.

Language: Английский

Citations

6
SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction DOI Creative Commons
Ying Nie,

Lumin Mou,

Qizhou Long

et al.

Virus Research, Journal Year: 2023, Volume and Issue: 328, P. 199086 - 199086

Published: March 13, 2023

Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-2 infection. Patients with severe COVID-19 exhibit robust induction of proinflammatory cytokines, which are closely associated the development acute respiratory distress syndrome. However, underlying mechanisms NF-κB activation mediated infection remain poorly understood. Here, we screened genes and found that ORF3a induces cytokines activating pathway. Moreover, interacts IKKβ NEMO enhances interaction IKKβ-NEMO, thereby positively regulating activity. Together, these results suggest may play pivotal roles in pathogenesis provide novel insights into between host immune responses

Language: Английский

Citations

14
Endothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsis: a narrative review DOI Creative Commons
Rachael Cusack, Lieuwe D. J. Bos, Pedro Póvoa

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Acute respiratory distress syndrome (ARDS) is a severe organ failure occurring mainly in critically ill patients as result of different types insults such sepsis, trauma or aspiration. Sepsis the main cause ARDS, and it contributes to high mortality resources consumption both hospital setting community. ARDS develops an acute with often refractory hypoxemia. also has long term implications sequelae. Endothelial damage plays important role pathogenesis ARDS. Understanding mechanisms presents opportunities for novel diagnostic therapeutic targets. Biochemical signals can be used concert identify classify into phenotypes allowing earlier effective treatment personalised therapies. This narrative review where we aimed flesh out pathogenetic heterogeneity We examine links between endothelium its contribution failure. have investigated future strategies special emphasis endothelial damage.

Language: Английский

Citations

14
Urolithin A exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating HMGB1-mediated MAPK and NF-κB signaling pathways DOI
Pengfei Jiao, Yingrui Wang, Gaofei Ren

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(8), P. 5765 - 5777

Published: Feb. 6, 2024

Language: Английский

Citations

6
Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome DOI Creative Commons
Po‐Jen Chen, Shun‐Hua Chen, Yu‐Li Chen

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 62, P. 229 - 243

Published: March 27, 2024

Overwhelming neutrophil activation and oxidative stress significantly contribute to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of repurposing ribociclib, a cyclin-dependent kinase 4 6 (CDK4/6) inhibitor used clinically in cancer treatment, for treating neutrophilic ARDS remains uncertain. This study illustrated ability underlying mechanism ribociclib inflammation.

Language: Английский

Citations

6
Tetrastigma hemsleyanum polysaccharide ameliorates cytokine storm syndrome via the IFN-γ-JAK2/STAT pathway DOI

Siyu Fu,

Xiaodan Bao,

Zian Mao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133427 - 133427

Published: June 25, 2024

Language: Английский

Citations

6
Both partial inactivation as well as activation of NF-κB signaling lead to hypertension and chronic kidney disease DOI Creative Commons
Xiaotan Zhang, Guang Wang, Ming Li

et al.

Nephrology Dialysis Transplantation, Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

Activation of NF-κB-signalling is key in the pathogenesis chronic kidney diseases (CKD). However, a certain level NF-κB activity necessary to enable tissue repair.

Language: Английский

Citations

5
Particulate matter-induced oxidative stress – mechanistic insights and antioxidant approaches reported in in vitro studies DOI Creative Commons
Vânia Vilas‐Boas, Nivedita Chatterjee,

Andreia Carvalho

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 110, P. 104529 - 104529

Published: Aug. 9, 2024

Inhaled particulate matter (PM) is a key factor in millions of yearly air pollution-related deaths worldwide. The oxidative potential PM indicates its ability to promote an environment. Excessive reactive oxygen species (ROS) can cause cell damage via stress, leading inflammation, endoplasmic reticulum airway remodeling, and various death modes (apoptosis, ferroptosis, pyroptosis). ROS also interact with macromolecules, inducing DNA epigenetic modifications, disrupting homeostasis. These effects have been studied extensively vitro confirmed vivo. This review explores the airborne particles PM-induced ROS-mediated cellular observed vitro, highlighting link between described latest literature. analyzes on damage, repair, carcinogenicity, epigenetics. Additionally, developments antioxidants prevent ROS's harmful are described, providing future perspectives topic.

Language: Английский

Citations

5
Lactobacillus reuteri Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the Gut Microbiota in Mice DOI Open Access
Jian Shen, Shuting Wang, Yong Huang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4256 - 4256

Published: Oct. 4, 2023

Acute lung injury (ALI) causes inflammation and edema as well resulting in gut microbiota disorder. Probiotics, however, can improve the composition modulate its immune response, playing an important role ALI pathogenesis. Therefore, our study aims to investigate effect of Lactobacillus reuteri on Lipopolysaccharide (LPS)-induced mice probe mechanism synergistic modulatory lungs intestines. We assessed therapeutic effects L. mouse model by histopathology, alveolar lavage fluid serum inflammatory factor analysis explored microbiome transcriptome alterations. intervention effectively attenuated tissue significantly reduced LPS-induced response macrophage neutrophil infiltration. Additionally, improved intestinal barrier function remodeled disordered microbiota. In conclusion, showed that ameliorated pulmonary edema, repaired barrier, mice. This provides new perspectives clinical treatment ALI.

Language: Английский

Citations

13
Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review DOI
Zhuqing Li, Yanyong Yang, Fu Gao

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(4), P. 2203 - 2217

Published: May 9, 2024

Language: Английский

Citations

4