The potential role of ferroptosis in the physiopathology of deep tissue injuries DOI Creative Commons
Lin Han, Juhong Pei, Hongxia Tao

et al.

International Wound Journal, Journal Year: 2023, Volume and Issue: 21(2)

Published: Oct. 31, 2023

Abstract Deep tissue injuries (DTIs) are a serious type of pressure that mainly occur at the bony prominences and can develop rapidly, making prevention treatment more difficult. Although consistent research efforts have been made over years, cellular molecular mechanisms contributing to development DTIs remain unclear. More recently, ferroptosis, novel regulatory cell death (RCD) type, has identified is morphological, biochemical genetic criteria distinct from apoptosis, autophagy other known pathways. Ferroptosis characterized by iron overload, iron‐dependent lipid peroxidation shrunken mitochondria. We also note some pathological features DTI be key ferroptosis pathway. Numerous studies confirmed may involved in chronic wounds, including DTIs. Here, we elaborate on basic ferroptosis. present evidence pathology highlight future perspective this emerging field, desiring provide possibilities for

Language: Английский

Mechanisms controlling cellular and systemic iron homeostasis DOI
Bruno Galy, Marcus Conrad, Martina U. Muckenthaler

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(2), P. 133 - 155

Published: Oct. 2, 2023

Language: Английский

Citations

290
The mechanism of ferroptosis and its related diseases DOI Creative Commons
Shijian Feng, Dan Tang, Yichang Wang

et al.

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

Citations

64
Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future DOI Creative Commons

Wenxi Fang,

Saiyang Xie, Wei Deng

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: March 21, 2024

Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved

Language: Английский

Citations

22
Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3/SLC7A11-mediated ferroptosis DOI

Xuerong Zhao,

Zhuoya Wang, Guanlin Wu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 182 - 193

Published: Jan. 2, 2024

Language: Английский

Citations

16
In defence of ferroptosis DOI Creative Commons
Francesca M. Alves, Darius J.R. Lane,

Triet Phu Minh Nguyen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 2, 2025

Abstract Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained cellular defences. Ferroptosis increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation conceived to occur not an endogenous executioner, but withdrawal guardians that otherwise constantly oppose induction. Here, we profile key ferroptotic defence strategies including regulation, modulation enzymes metabolite systems: glutathione reductase (GR), suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase (NQO1), Dihydrofolate (DHFR), retinal reductases dehydrogenases (RDH) thioredoxin (TR). A common thread uniting all metabolites combat lipid during dependence on reductant, nicotinamide adenine dinucleotide phosphate (NADPH). We will outline how cells control central carbon metabolism produce NADPH necessary precursors defend against ferroptosis. Subsequently discuss evidence for dysregulation different disease contexts glucose-6-phosphate dehydrogenase deficiency, cancer neurodegeneration. Finally, several anti-ferroptosis therapeutic spanning use radical trapping agents, dependent redox support highlight current landscape clinical trials focusing

Language: Английский

Citations

2
The Lactate‐Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM‐Dependent Mitochondrial Fatty Acid Synthesis DOI Creative Commons
Jingsheng Yuan, Mingyang Yang,

Zhenru Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether exacerbates hepatic ischemia‐reperfusion injury (IRI) after donor implantation remains unclear. Here, the role of in IRI is explored. In this work, found to exacerbate ferroptosis IRI. Lactate‐primed lysine acetyltransferase 8 (KAT8) determined directly lactylate mitochondrial phosphoenolpyruvate carboxykinase 2 (PCK2) at Lys100 and augments PCK2 kinase activity. By using gene‐edited mice, evidence indicating that generated. Mechanistically, acts as a critical inducer by competitively inhibiting Parkin‐mediated polyubiquitination 3‐oxoacyl‐ACP synthase (OXSM), thereby leading metabolic remodeling fatty acid synthesis (mtFAS) potentiation oxidative phosphorylation tricarboxylic cycle. More importantly, targeting demonstrated markedly ameliorate hyperlactatemia‐mediated Collectively, findings support use therapeutics suppress patients with LT.

Language: Английский

Citations

2
Ferroptosis Regulated by Hypoxia in Cells DOI Creative Commons
Xiangnan Zheng,

Yuqiong Liang,

Cen Zhang

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(7), P. 1050 - 1050

Published: March 30, 2023

Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which associated many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, immunologically distinct from other forms. by iron metabolism, anti-oxidant defense systems, as well various signal pathways. Hypoxia, found in a group of conditions, can affect multiple cellular functions activation the hypoxia-inducible factor (HIF) signaling mechanisms. Emerging evidence demonstrated hypoxia regulates ferroptosis certain types conditions. In this review, we summarize basic mechanisms regulations hypoxia, regulation may contribute to numerous diseases therapies.

Language: Английский

Citations

33
New Insights into the Role of Ferroptosis in Cardiovascular Diseases DOI Creative Commons
Anna Maria Fratta Pasini,

Chiara Stranieri,

Fabiana Busti

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(6), P. 867 - 867

Published: March 10, 2023

Cardiovascular diseases (CVDs) are the principal cause of disease burden and death worldwide. Ferroptosis is a new form regulated cell mainly characterized by altered iron metabolism, increased polyunsaturated fatty acid peroxidation reactive oxygen species, depletion glutathione inactivation peroxidase 4. Recently, series studies have indicated that ferroptosis involved in cardiac vascular cells has key impact on mechanisms leading to CVDs such as ischemic heart disease, ischemia/reperfusion injury, cardiomyopathies, failure. In this article, we reviewed molecular mechanism current understanding pathophysiological role some cardiomyopathies. Moreover, comprehension machinery governing cardiomyocytes may provide insights into preventive therapeutic strategies CVDs.

Language: Английский

Citations

32
Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies DOI

Xiaoyu Luan,

Peng Chen, Longyu Miao

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 31, 2024

Language: Английский

Citations

11
The Regulation of Ferroptosis by Noncoding RNAs DOI Open Access
Xiangnan Zheng, Cen Zhang

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13336 - 13336

Published: Aug. 28, 2023

As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which different from other death forms morphologically, biochemically, immunologically. Ferroptosis metabolism, antioxidant defense systems as well various transcription factors related signal pathways. Emerging evidence has highlighted that associated with many physiological pathological processes, including cancer, neurodegeneration diseases, cardiovascular ischemia/reperfusion injury. Noncoding RNAs are group functional RNA molecules not translated into proteins, can regulate gene expression in manners. An increasing number studies have shown noncoding RNAs, especially miRNAs, lncRNAs, circRNAs, interfere the progression modulating ferroptosis-related genes or proteins directly indirectly. In this review, we summarize basic mechanisms regulations focus on recent mechanism for types ncRNAs to conditions, will deepen our understanding regulation provide new insights employing ferroptosis-associated therapeutic strategies.

Language: Английский

Citations

15