Identification and Validation of a m5c-related lncrna signature predict prognosis and immune response of clear cell renal cell carcinoma DOI Creative Commons

Shan Ao,

Leqi Liang,

Riwei Yang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: June 29, 2023

Abstract Objective M5C-related LncRNAs (Long non-coding RNAs) were related to the occurrence and development of tumors. In this study, we investigated whether m5C-related could predict prognosis clear cell renal carcinoma (ccRCC) patients. Methods Co-expression analysis Cox regression used construct prognostic features, then a series model validation was performed evaluate value model. Gene Ontology (GO), Kyoto Encyclopedia Genome Enrichment (KEGG), immune-related function tumor mutation burden (TMB) analyses also performed. Finally, potential sensitivity drugs ccRCC predicted. Results A total 9 obtained established. Our has independent is closely immune characteristics escape, which can be including Entinostat, SB216763, Sapitinib. in vitro experiments showed that GNG12-AS1 inhibited proliferation migration lines. Conclusions summary, accurately patients, may provide new ideas for clinical application immunotherapy promising biomarker predicting survival outcome ccRCC.

Language: Английский

Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells DOI
Na Young Kim, Chakrabhavi Dhananjaya Mohan, Gautam Sethi

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 125(4)

Published: Feb. 15, 2024

Abstract Mitogen‐activated protein kinase (MAPK) activation by natural compounds is known to be involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a bioactive compound found Cannabis sativa , endowed with many pharmacological activities. We investigated cytotoxic effect CBD panel colorectal cancer (CRC) cells (HT‐29, SW480, HCT‐116, HCT‐15). induced significant cytotoxicity as evidenced results MTT assay, live‐dead flow cytometric analysis. Since displayed against CRC cells, we examined on decreased expression antiapoptotic proteins increased Annexin‐V‐positive well TUNEL‐positive suggesting that induces apoptosis. ATF4 (activating transcription factor 4) CHOP (CCAAT/enhancer‐binding homologous protein), elevated endoplasmic reticulum stress, enhanced reactive oxygen species levels indicating also promotes paraptosis. Atg7, phospho‐Beclin‐1, LC3 accelerates Since, MAPK pathway common cascade regulation autophagy, JNK, p38, ERK pathways. activated all forms inhibition these reverted observed effects. Our findings implied could induce cell death activating autophagy through pathway.

Language: Английский

Citations

20
Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer DOI Creative Commons
Giovanni Tossetta, Sonia Fantone, Daniela Marzioni

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(7)

Published: July 21, 2023

Prostate cancer is the second most common malignancy in men worldwide. can be treated by surgery, radiotherapy and hormone therapy. The latter, form of androgen-deprivation therapy needed to reduce prostate progression at an advanced stage. Several studies demonstrated that oxidative stress involved occurrence, development Nuclear factor erythroid 2-related 2 (NRF2)/Kelch Like ECH Associated Protein 1 (KEAP1) pathway affected reactive oxygen species (ROS). Furthermore, NRF2/KEAP1 signaling has been investigated several related anti-androgen therapy, biochemical recurrence radiotherapy. In this review we analysed current literature regarding indirect modulators regulation their role as possible therapeutic targets cells.

Language: Английский

Citations

38
Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review DOI Open Access

Bethsebie Lalduhsaki Sailo,

Le Liu,

Suravi Chauhan

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 244 - 244

Published: Jan. 5, 2024

Recent advances in oncological research have highlighted the potential of naturally derived compounds cancer prevention and treatment. Notably, sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli cabbage, has exhibited potent chemosensitizing capabilities across diverse types bone, brain, breast, lung, skin, etc. Chemosensitization refers to enhancement cell sensitivity chemotherapy agents, counteracting chemoresistance often developed by tumor cells. Mechanistically, SFN orchestrates this sensitization modulating array cellular signaling pathways (e.g., Akt/mTOR, NF-κB, Wnt/β-catenin), regulating expression activity pivotal genes, proteins, enzymes p53, p21, survivin, Bcl-2, caspases). When combined with conventional chemotherapeutic synergistically inhibits proliferation, invasion, migration, metastasis while potentiating drug-induced apoptosis. This positions as a adjunct therapy augment efficacy standard treatments. Ongoing preclinical clinical investigations aim further delineate therapeutic oncology. review illuminates multifaceted role phytochemical, emphasizing its enhance anti-cancer suggesting prospective contributions chemosensitization management.

Language: Английский

Citations

13
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

Citations

9
A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy DOI Creative Commons
Ying‐Ying Wu,

Shaojie Cheng,

Ting Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 3, 2025

Progression to castration resistance is the leading cause of death in prostate cancer patients. Long non-coding RNAs (lncRNAs) have recently become a focal point regulation development. However, few lncRNAs associated with castration-resistant (CRPC) been reported. Firstly, we explore CRPC by RNA sequencing and validated using quantitative polymerase chain reaction (qRT-PCR) fluorescence situ hybridization (RNA-FISH). The clinical significance FLJ was evaluated collected cohort. Functional loss assays were performed assess effects on cells both vitro vivo. regulatory mechanism investigated immunohistochemistry (IHC), qRT-PCR, dual-luciferase reporter assays, chromatin immunoprecipitation (ChIP) assays. highly expressed higher stages Gleason scores cancer. strongly positively correlated androgen receptor (AR), which acts as transcription factor directly binds promoter region enhance its transcription. Knockdown inhibits cell proliferation increases sensitivity enzalutamide (ENZA) vitro. Mechanistically, promotes inhibiting AR nuclear import cytoplasmic protein degradation, thereby activating androgen-independent signaling pathway. Importantly, vivo experiments showed that knockdown inhibited tumor growth enhanced therapeutic effect ENZA. This study identifies novel lncRNA progression. Sustained activation upregulate expression. circumvents traditional androgen-dependent survival entry Targeting FLJ-AR axis may represent strategy for patients

Language: Английский

Citations

1
Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets DOI Open Access
Mateusz Kciuk, Esam Bashir Yahya,

Montaha Mohamed Ibrahim Mohamed

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(13), P. 3298 - 3298

Published: June 22, 2023

Accumulating evidence supports that both long non-coding and micro RNAs (lncRNAs miRNAs) are implicated in glioma tumorigenesis progression. Poor outcome of gliomas has been linked to late-stage diagnosis mostly ineffectiveness conventional treatment due low knowledge about the early stage gliomas, which not possible observe with diagnostic approaches. The past few years witnessed a revolutionary advance biotechnology neuroscience understanding tumor-related molecules, including involved angiogenesis progression cells thus used as prognostic biomarkers well novel therapeutic targets. emerging research on lncRNAs miRNAs highlights their crucial role progression, offering new insights into disease. These hold significant potential targets, paving way for innovative approaches against glioma. This review encompasses comprehensive discussion gene regulation is responsible promotion or inhibition collects existing links between these key cancer-related molecules.

Language: Английский

Citations

19
Long Non-Coding RNAs in Ovarian Cancer: Mechanistic Insights and Clinical Applications DOI Open Access

Sneha Basu,

Revathy Nadhan, Danny N. Dhanasekaran

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 472 - 472

Published: Jan. 30, 2025

Background/Objectives: Ovarian cancer is a leading cause of gynecological mortality worldwide, often diagnosed at advanced stages due to vague symptoms and the lack effective early detection methods. Long non-coding RNAs (lncRNAs) have emerged as key regulators in biology, influencing cellular processes such proliferation, apoptosis, chemoresistance. This review explores multifaceted roles lncRNAs ovarian pathogenesis their potential biomarkers therapeutic targets. Methods: A comprehensive literature was conducted analyze structural functional characteristics contributions biology. includes regulatory mechanisms, interactions with signaling pathways, implications for resistance. Advanced bioinformatics omics approaches were also evaluated lncRNA research. Results: The highlights dual role oncogenes tumor suppressors, modulating cell invasion, angiogenesis. Specific lncRNAs, HOTAIR GAS5, demonstrate significant diagnostic Emerging technologies, single-cell sequencing, provide valuable insights into microenvironment heterogeneity expression. Conclusions: LncRNAs hold transformative advancing diagnosis, prognosis, treatment. Targeting or associated pathways offers promising strategies overcome therapy resistance enhance personalized medicine. Continued research integrating will be essential unlock full clinical management.

Language: Английский

Citations

0
Identification and validation of an m5C-related lncRNA signature for predicting prognosis and immune response in clear cell renal cell carcinoma DOI Creative Commons

Shan Ao,

Leqi Liang,

Peng Lei

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 23, 2025

Language: Английский

Citations

0
The role and function of autophagy through signaling and pathogenetic pathways and lncRNAs in ovarian cancer DOI Open Access
Seyedsaber Mirabdali, Kimia Ghafouri,

Yalda Farahmand

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154899 - 154899

Published: Oct. 20, 2023

Language: Английский

Citations

10
A global bibliometric and visualized analysis of the links between the autophagy and acute myeloid leukemia DOI Creative Commons
Yao Gao,

Zhenhui Wu,

Yingfan Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 23, 2024

Background and objectives: Autophagy is a cellular process where damaged organelles or unwanted proteins are packaged into double-membrane structure transported to lysosomes for degradation. plays regulatory role in various hematologic malignancies, including acute myeloid leukemia (AML). However, there few bibliometric studies on the of autophagy AML. The purpose this study clarify through analysis. Methods: literature AML research from 2003 2023 was searched Web Science Core Collection, tools such as VOSviewer 1.6.18, Cite Space (6.1.R3), RStudio (R package bibliometrix), Scimago Graphica were used understand current status hotspots research. conducted an analysis dimensions quantity publications, countries, institutions, journals, authors, co-references, keywords, predict future development trends field by drawing relevant visualization maps. Results: A total 343 articles obtained, published 169 written 2,323 authors 295 institutions 43 countries. journals with most publications Blood Oncotarget. China had Chongqing Medical University Sun Yat-sen publications. author highest number Tschan, Mario P. main types included clinical research, vitro experiments, vivo public database information, reviews, forms therapeutic effects mainly focused genetic regulation, traditional Chinese medicine combination, inhibitors, drug targets. past 17 years have inhibition, targeted drugs. Chemotherapy resistance mitochondrial will be forefront Conclusion: gradual increase decline after 2022 could result focusing more type quality literature. autophagy-related In future, remain focus field, likely chemotherapy autophagy.

Language: Английский

Citations

3