Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer DOI Open Access
Rafał Watrowski,

Eva Schuster,

Toon Van Gorp

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10272 - 10272

Published: Sept. 24, 2024

Single nucleotide polymorphisms (SNPs) of the IL-16 gene have been reported to influence risk several cancers, but their role in ovarian cancer (OC) has not studied. Using restriction fragment length polymorphism (PCR-RFLP) method, we examined four SNPs: rs11556218 (T > G), rs4778889 C), rs4072111 (C T), and rs1131445 C) blood samples from 413 women Central European descent, including 200 OC patients 213 healthy controls. Among patients, 62% were postmenopausal, 84.5% diagnosed late stages (FIGO IIb-IV), 73.5% had high-grade serous (HGSOC). Minor allele frequencies controls 9.2% for (G allele), 13.7% 10.4% 32.3% allele). We found significant associations vs. T allele: OR 2.76, 95% CI 1.84–4.14, p < 0.0001) with elevated whole cohort (p 0.001) both premenopausal postmenopausal = subgroups. These remained across heterozygote 0.001), dominant overdominant models. was associated predominantly 0.0001 almost all models). In cohort, C (OR 1.54, 1.06–2.23, 0.024), association 0.019), 0.033), 0.027) Furthermore, linked HGSOC 0.036) endometriosis-related subtypes 0.002). No or 0.81 0.47, respectively). conclusion, SNPs are risk, especially women.

Language: Английский

Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress DOI Open Access
Abdelhakim Bouyahya, Saad Bakrim, Sara Aboulaghras

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116432 - 116432

Published: March 22, 2024

Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing crucial role the early and sustained phases of DNA damage genomic epigenetic instability, both which are intricately linked to development tumors. The molecular pathways contributing carcinogenesis this context, particularly those related double-strand single-strand breaks DNA, serve as indicators due cancer cases, well factors instability through ectopic expressions. has been considered therapeutic target for many years, an increasing number studies have highlighted promising effectiveness natural products treatment. In regard, we present significant research on targeting oxidative using molecules underscore essential cancer. consequences stress, especially also offer prospects. use epi-drugs capable modulating reorganizing network is beginning emerge remarkably. review, emphasize close connections between tumor transformation, while highlighting substances antioxidants anti-tumoral context.

Language: Английский

Citations

17
Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis DOI Creative Commons
Giovanni Tossetta, Sonia Fantone, Lucrezia Togni

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1270 - 1270

Published: Oct. 18, 2024

Periodontitis affects up to 40% of adults over 60 years old and is a consequence gingivitis. characterized by chronic inflammation, periodontal damage, alveolar bone resorption. The nuclear factor erythroid 2-related 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays key role in periodontitis modulating redox balance inflammation the periodontium. However, NRF2 expression decreased gingival tissues patients with while oxidative stress significantly increased this pathology. Oxidative lipopolysaccharide (LPS) produced gram-negative bacteria favor production inflammatory causing favoring bone. In review, we analyzed current literature regarding natural synthetic compounds NRF2/KEAP1 vitro vivo models order evaluate new potential treatments that can improve outcome disease.

Language: Английский

Citations

16
Clearance of apoptotic cells by neutrophils in inflammation and cancer DOI Creative Commons
Cristiano Ramos, Rudolf Oehler

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 13, 2024

When a cell dies of apoptosis, it is eliminated either by neighbouring cells or attracted professional phagocytes. Although was generally believed that neutrophils also have the ability to perform efferocytosis, their contribution clearance apoptotic considered less important compared with macrophages. Therefore, this remained unexplored for long time. Over past decade, has been shown during inflammation, contribute significantly accumulate in large numbers at site tissue damage. This "neutrophil cannibalism" accompanied inhibition pro-inflammatory activities these cells, such as respiratory burst and formation neutrophil extracellular traps (NETs). Furthermore, efferocytosing secrete anti-inflammatory mediators mitogens including hepatocyte growth factor (HGF), fibroblast 2 (FGF2), vascular endothelial factors (VEGF), transforming beta (TGFβ). Thus, efferocytosis involved resolution inflammation. Recent research indicates plays role cancer. Many different solid tumours contain aggregates dead tumour undergone spontaneous apoptosis. Their extent correlates poor clinical outcome most cancer types. These clusters are strongly infiltrated tumour-associated (TANs) acquired an pro-resolving polarization state. review summarizes potential consequences discussed current literature. picture inflammation becoming clearer, many questions still unexplored.

Language: Английский

Citations

13
The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update DOI Creative Commons
Roberto Campagna, Laura Mazzanti, Veronica Pompei

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1469 - 1469

Published: Sept. 1, 2024

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known be longevity regulators, and exerts a key role in prevention of vascular aging. By aging, expression levels Sirt1 decline with severe impact on function, such as rise endothelial dysfunction, which turn promotes development cardiovascular diseases. In this context, activity preventing senescence is particularly important. Given counteracting senescence, great efforts have been made deepen knowledge about intricate cross-talks interactions other molecules, order set up possible strategies boost prevent or treat The aim review provide proper background regulation function endothelium discuss recent advances regarding therapeutic targeting counteract

Language: Английский

Citations

11
Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics DOI Open Access
Stefano Raffaele Giannubilo, Monia Cecati, Daniela Marzioni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1418 - 1418

Published: Jan. 24, 2024

In this review, we comprehensively present the literature on circulating microRNAs (miRNAs) associated with preeclampsia, a pregnancy-specific disease considered primary reason for maternal and fetal mortality morbidity. miRNAs are single-stranded non-coding RNAs, 20–24 nt long, which control mRNA expression. Changes in miRNA expression can induce variation relative level influence cellular homeostasis, strong presence of all body fluids has made them useful biomarkers several diseases. Preeclampsia is multifactorial disease, but etiopathogenesis remains unclear. The functions trophoblasts, including differentiation, proliferation, migration, invasion apoptosis, essential successful pregnancy. During early stages placental development, trophoblasts strictly regulated by molecular pathways; however, an imbalance these pathways lead to severe lesions pregnancy complications. We then discuss role trophoblast pathogenesis, diagnosis prediction preeclampsia. also potential from epigenetic perspective possible future therapeutic implications.

Language: Английский

Citations

9
The Impact of Metformin on Tumor-Infiltrated Immune Cells: Preclinical and Clinical Studies DOI Open Access
Mohamed Abdelmoneim,

Mona Alhussein Aboalela,

Yoshinori Naoe

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13353 - 13353

Published: Aug. 28, 2023

The tumor microenvironment (TME) plays a pivotal role in the fate of cancer cells, and tumor-infiltrating immune cells have emerged as key players shaping this complex milieu. Cancer is one leading causes death world. most common standard treatments for are surgery, radiation therapy, chemotherapeutic drugs. In last decade, immunotherapy has had potential effect on treatment patients with poor prognoses. One therapeutic targeted approaches that shows anticancer efficacy type 2 diabetes medication, metformin. Beyond its glycemic control properties, studies revealed intriguing immunomodulatory properties Meanwhile, several focus impact metformin various models. models, can modulate tumor-infiltrated effector CD8+, CD4+ T natural killer (NK) well suppressor regulatory tumor-associated macrophages (TAMs), myeloid-derived (MDSCs). review, we discuss modulating different preclinical models clinical trials. Both suggest holds promise adjunctive therapy by response within microenvironment. Nonetheless, both combined an specific targets TME. Further investigations warranted to elucidate precise mechanisms underlying effects optimize application patients.

Language: Английский

Citations

22
First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study DOI
Federica Piani, Giovanni Tossetta, Sonia Fantone

et al.

High Blood Pressure & Cardiovascular Prevention, Journal Year: 2023, Volume and Issue: 30(6), P. 591 - 594

Published: Nov. 27, 2023

Language: Английский

Citations

17
First Trimester Placental Biomarkers for Pregnancy Outcomes DOI Open Access

Martina Cristodoro,

M. Messa, Giovanni Tossetta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6136 - 6136

Published: June 2, 2024

The placenta plays a key role in several adverse obstetrical outcomes, such as preeclampsia, intrauterine growth restriction and gestational diabetes mellitus. early identification of at-risk pregnancies could significantly improve the management, therapy prognosis these pregnancies, especially if are identified first trimester. aim this review was to summarize possible biomarkers that can be used diagnose placental dysfunction and, consequently, pregnancies. We divided into proteins non-proteins. Among protein biomarkers, some already clinical practice, sFLT1/PLGF ratio or PAPP-A; others not yet validated, HTRA1, Gal-3 CD93. In literature, many studies analyzed but their results contrasting. On other hand, non-protein miR-125b, miR-518b miR-628-3p, seem linked an increased risk complicated pregnancy. Thus, trimester heterogeneous panel containing may more appropriate identify discriminate complications affect

Language: Английский

Citations

6
Targeting catalase in cancer DOI Creative Commons
Christophe Glorieux, Pedro Buc Calderón

Redox Biology, Journal Year: 2024, Volume and Issue: 77, P. 103404 - 103404

Published: Oct. 19, 2024

Language: Английский

Citations

6
Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction DOI
Dingyi Wang, Changyang Xing, Yuan Liang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 25, 2024

Vascular microenvironment is found to be closely related immunotherapy efficacy. Identification and ultrasound imaging of the unique vascular characteristics, able predict immune microenvironment, important for decision-making. Herein, it proved that high CD93 expression in tumor vessels poor response prostate cancer. For molecular CD93, CD93-targeted microbubbles (MBs) consist a gaseous core MMRN2 (Multimerin-2) containing cell membrane (CM) /lipid hybrid then synthesized. In vitro vivo assays demonstrate these MBs can recognize efficiently accumulate within regions highly expressing CD93. Contrast-enhanced (CEUS) with demonstrates targeted intensity negatively inflammatory (TIME) cytotoxic T infiltration. Together, endothelial predictor immunosuppressive have great potential evaluate status.

Language: Английский

Citations

5