Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
189, P. 106674 - 106674
Published: Jan. 23, 2023
Liver
cancer
is
one
of
the
most
common
malignancies,
with
severe
morbidity
and
mortality.
While
considerable
progress
has
been
made
in
liver
treatment,
5-year
overall
survival
(OS)
patients
not
improved
significantly.
Reasons
include
inadequate
capability
early
screening
diagnosis,
a
high
incidence
recurrence
metastasis,
degree
tumor
heterogeneity,
an
immunosuppressive
microenvironment.
Therefore,
identification
validation
specific
robust
biomarkers
are
major
importance
for
screening,
timely
accurate
prognosis,
prevention
progression.
In
this
review,
we
highlight
some
latest
research
potential
applications
biomarkers,
describing
hotspots
prospective
directions
biomarker
discovery.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 31, 2024
The
current
situation
of
hepatocellular
carcinoma
(HCC)
management
is
challenging
due
to
its
high
incidence,
mortality,
recurrence
and
metastasis.
Recent
advances
in
gene
genetic
expression
regulation
have
unveiled
the
significant
role
non-coding
RNA
(ncRNA)
various
cancers.
This
led
formulation
competing
endogenous
(ceRNA)
hypothesis,
which
posits
that
both
coding
ncRNA,
containing
miRNA
response
elements
(MRE),
can
share
same
sequence.
results
a
competitive
network
between
ncRNAs,
such
as
lncRNA
mRNA,
allowing
them
regulate
each
other.
Extensive
research
has
highlighted
crucial
ceRNA
HCC
development,
impacting
cellular
processes
including
proliferation,
metastasis,
cell
death,
angiogenesis,
tumor
microenvironment,
organismal
immunity,
chemotherapy
resistance.
Additionally,
network,
mediated
by
or
circRNA,
offers
potential
early
diagnosis
prevention
HCC.
Consequently,
ceRNAs
are
emerging
therapeutic
targets
for
complexity
these
networks
aligns
with
multi-target
approach
traditional
Chinese
medicine
(TCM),
presenting
novel
perspective
TCM
combating
Research
beginning
show
compounds
prescriptions
affect
progression
through
inhibiting
proliferation
inducing
apoptosis.
Currently,
lncRNAs
TUG1,
NEAT1,
CCAT1,
along
their
associated
networks,
among
most
promising
ncRNAs
research.
However,
this
field
still
infancy,
necessitating
advanced
technology
extensive
basic
fully
understand
mechanisms
treatment.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1582 - 1582
Published: April 20, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
form
of
liver
cancer,
accounting
for
~90%
neoplasms.
It
second
leading
cause
cancer-related
deaths
and
seventh
cancer
worldwide.
Although
there
have
been
rapid
developments
in
treatment
HCC
over
past
decade,
incidence
mortality
rates
remain
a
challenge.
With
widespread
use
hepatitis
B
vaccine
antiviral
therapy,
etiology
shifting
more
toward
metabolic-associated
steatohepatitis
(MASH).
Early-stage
can
be
treated
with
potentially
curative
strategies
such
as
surgical
resection,
transplantation,
radiofrequency
ablation,
improving
long-term
survival.
However,
patients,
when
diagnosed,
are
already
intermediate
or
advanced
stages.
Molecular
targeted
followed
by
immune
checkpoint
inhibitor
immunotherapy,
has
revolution
systemic
treatment.
Systemic
especially
patients
compromised
function
still
challenge
due
to
significant
resistance
blockade,
tumor
heterogeneity,
lack
oncogenic
addiction,
effective
predictive
therapeutic
biomarkers.
Immunity Inflammation and Disease,
Journal Year:
2024,
Volume and Issue:
12(2)
Published: Feb. 1, 2024
Abstract
Introduction
Tumor‐associated
macrophages,
a
major
component
of
the
tumor
microenvironment,
undergo
polarization
into
M2
macrophages
(M2),
and
thereby
exert
an
immunosuppressive
effect
to
induce
cancer
metastasis.
This
study
strives
uncover
molecular
mechanism
underlying
this
event
in
hepatocellular
carcinoma
(HCC).
Methods
Proteasome
subunit
alpha
5
(PSMA5)
expression
liver
(LIHC)
tissues
its
association
with
LIHC
patients
were
predicted
using
StarBase.
PSMA5
level
human
HCC
cells
was
manipulated
via
transfection.
Exosomes
isolated
from
cells,
internalized
which
cocultured
cells.
Exosome
internalization
observed
after
fluorescence
labeling.
cell
migration
invasion
evaluated
by
wound
healing
Transwell
assays.
Xenograft
assay
performed
investigate
role
vitro
tumorigenesis.
assessed
enzyme‐linked
immunosorbent
assay,
quantitative
reverse
transcription
polymerase
chain
reaction,
immunohistochemistry.
exosomes
Janus
Kinase
2
(JAK2)/signal
transducer
activator
3
(STAT3)
activation
tumors
detected
Western
blot
analysis.
Results
High
associated
compromised
survival
patients.
knockdown
inhibited
invasion.
downregulated
these
cell‐isolated
successfully
facilitated
JAK2/STAT3
pathway
activation.
cell‐secreted
exosomal
exosome‐induced
on
attenuated
promotion
induced
exosome‐treated
migration/invasion
tumorigenesis
along
vivo
Conclusion
hinders
suppress
progression
restraining
signaling.
ACS Pharmacology & Translational Science,
Journal Year:
2024,
Volume and Issue:
7(3), P. 586 - 613
Published: Feb. 14, 2024
Cancer
is
one
of
the
leading
causes
death
worldwide.
Early
cancer
detection
critical
because
it
can
significantly
improve
treatment
outcomes,
thus
saving
lives,
reducing
suffering,
and
lessening
psychological
economic
burdens.
biomarkers
provide
varied
information
about
cancer,
from
early
malignancy
to
decisions
on
subsequent
monitoring.
A
large
variety
molecular,
histologic,
radiographic,
or
physiological
entities
features
are
among
common
types
biomarkers.
Sizeable
recent
methodological
progress
insights
have
promoted
significant
developments
in
field
Here
we
an
overview
advances
knowledge
related
biomolecules
cellular
used
for
detection.
We
examine
data
CAS
Content
Collection,
largest
human-curated
collection
published
scientific
information,
as
well
biomarker
datasets
at
Excelra,
analyze
publication
landscape
research.
also
discuss
evolution
key
concepts
development
pipelines,
with
a
particular
focus
pancreatic
liver
cancers,
which
known
be
remarkably
difficult
detect
particularly
high
morbidity
mortality.
The
objective
paper
broad
evolving
current
outline
challenges
evaluate
growth
opportunities,
order
further
efforts
solving
problems
that
remain.
merit
this
review
stems
extensive,
wide-ranging
coverage
most
up-to-date
allowing
unique,
unmatched
breadth
analysis
in-depth
insights.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(8), P. 3517 - 3524
Published: Feb. 15, 2024
The
digital
immunoassay
is
a
highly
sensitive
detection
technique
based
on
single-molecule
counting
and
widely
used
in
the
ultrasensitive
of
biomarkers.
Herein,
we
developed
fluorescent
microsphere-based
(FMDIA)
by
employing
microspheres
as
both
carriers
for
immunoreaction
reports
imaging.
In
this
approach,
target
protein
sample
was
captured
to
form
biotin-labeled
sandwich
immunocomplex,
then,
containing
molecules
were
adding
streptavidin-coated
magnetic
beads
(SA-MBs).
By
proportion
fluorescence-positive
beads,
concentration
can
be
precisely
quantified.
As
proof
concept,
α
fetoprotein
(AFP)
human
interleukin-6
(IL-6)
assess
analytical
performance
proposed
FMDIA,
limit
(LOD)
values
21
pg/mL
(0.30
pM)
0.19
(7.3
fM)
achieved,
respectively.
results
AFP
serum
samples
patients
healthy
people
consistent
with
reference
given
hospital.
Furthermore,
various
colors
encoding,
FMDIA
easily
realize
simultaneous
multiple
proteins
without
need
introduce
modified
beads.
This
multiplex
strategy,
which
reactions
are
first
carried
out
then
capture
reporters
molecules,
provides
new
idea
assays.
Cells,
Journal Year:
2024,
Volume and Issue:
13(15), P. 1245 - 1245
Published: July 24, 2024
Circular
RNAs
(circRNAs)
are
cardinal
players
in
numerous
physiological
and
pathological
processes.
CircRNAs
play
dual
roles
as
tumor
suppressors
oncogenes
different
oncological
contexts,
including
hepatocellular
carcinoma
(HCC).
Their
significantly
impact
the
disease
at
all
stages,
initiation,
development,
progression,
invasion,
metastasis,
addition
to
response
treatment.
In
this
review,
we
discuss
biogenesis
regulatory
functional
of
circRNAs,
well
circRNA-protein-mRNA
ternary
complex
formation,
elucidating
intricate
pathways
tuned
by
circRNAs
modulate
gene
expression
cellular
processes
through
a
comprehensive
literature
search,
silico
bioinformatics
analysis.
With
particular
focus
on
interplay
between
epigenetics,
HCC
pathology,
article
sets
stage
for
further
exploration
novel
investigational
theranostic
agents
dynamic
realm
HCC.
