Inflammation balance in skeletal muscle damage and repair

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 26, 2023

Responding to tissue injury, skeletal muscles undergo the destruction and reconstruction accompanied with inflammation. The immune system recognizes molecules released from or exposed on damaged tissue. In local minor damage, tissue-resident macrophages sequester pro-inflammatory debris prevent initiation of most cases muscle however, a cascade inflammation will be initiated through activation mast cells recruitment blood circulation injured site by recongnization damage-associated molecular patterns (DAMPs) activated complement system. During inflammation, neutrophils scavenge release inflammatory cytokines latter stimulates myoblast fusion vascularization promote repair. On other hand, an abundance chemokines causes profound hyper-inflammation mobilization trigger vicious cycle lead cytokine storm. storm results in elevation cytolytic cytotoxic reactive oxygen species (ROS) aggravates including healthy bystander Severe can rhabdomyolysis cause sepsis-like systemic response syndrome (SIRS) remote organ damage. Therefore, understanding more details involvement factors damage repair provide new precise therapeutic strategies, attenuation promotion

Language: Английский

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An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

Medicine & Science in Sports & Exercise, Journal Year: 2022, Volume and Issue: 54(9), P. 1546 - 1559

Published: April 6, 2022

Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is highly adaptable tissue that responds to resistance exercise (RE; loading) by hypertrophying, or during disuse, RE mitigates loss. Resistance training (RET)-induced skeletal hypertrophy product of external (e.g., programming, diet, some supplements) internal variables mechanotransduction, ribosomes, gene expression, satellite cells activity). undeniably the most potent nonpharmacological variable stimulate activation/suppression linked muscular countering disuse-induced Here, we posit despite considerable research on impact RET hypertrophy, (i.e., inherent biology) are dominant regulating extent response stimuli. Thus, identifying key muscle-derived mediate translation will be pivotal determining effective strategies for healthy persons. Such work aid enhancing clinical populations, slowing functional decline, promoting mobility. We provide up-to-date, evidence-based perspectives mechanisms RET-induced hypertrophy.

Language: Английский

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Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

Molecular and Cellular Endocrinology, Journal Year: 2022, Volume and Issue: 552, P. 111676 - 111676

Published: May 13, 2022

Language: Английский

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Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 3, 2023

Spinal cord injury leads to loss of innervation skeletal muscle, decreased motor function, and significantly reduced load on resulting in atrophy. Factors such as braking, hormone level fluctuation, inflammation, oxidative stress damage accelerate muscle The atrophy process can result cell apoptosis, protein degradation, fat deposition, other pathophysiological changes. Skeletal not only hinders the recovery function but is also closely related many systemic dysfunctions, affecting prognosis patients with spinal injury. Extensive research mechanism intervention at molecular has shown that inflammation are main mechanisms after multiple pathways involved. These may become targets future clinical intervention. However, most experimental studies still basic stage have some limitations application, treatments focused rehabilitation training, so how develop more efficient interventions treatment needs be further explored. Therefore, this review focuses mainly summarizes cytokines signaling associated recent studies, hoping provide new therapeutic ideas for work.

Language: Английский

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Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Jan. 12, 2024

Abstract Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed promising antimycotic activity. This aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) control skin fungal ailments since nanosponges augment retention tested agents skin. Box-Behnken design used produce optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), particle size (PS) were assigned as dependent parameters, while independent process parameters polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, speed. The carbopol 940 then created by incorporating nanosponges. fit Higuchi’s kinetic release model best, according vitro drug release. Stability photodegradation studies revealed that NS-HG remained stable under conditions. formulation also higher antifungal activity against Candida albicans compared fluconazole. In vivo ODHP-NS-HG increased survival rates, wound contraction, healing gap inhibited inflammation other groups. histopathological examinations Masson’s trichrome staining improved records collagen deposition. Moreover, permeability through rats’ 1.5-folds isoconazole 1%. Therefore, based on these results, is potential carrier for enhanced topical delivery ODHP. Our pioneering research development produced naturally bacteria. Key points • successfully formulated statistically . new formula exhibited good stability, release, C. fluconazole Ex permeability, analysis high evidenced measurement various biochemical examination

Language: Английский

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Emerging Targets and Treatments for Sarcopenia: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3271 - 3271

Published: Sept. 27, 2024

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.

Language: Английский

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The Roles of IL-22 and Its Receptor in the Regulation of Inflammatory Responses in the Brain

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 757 - 757

Published: Jan. 11, 2022

Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that expression restricted to non-hematopoietic cells in skin, pancreas, intestine, liver, lung, kidney. Although involved development responses, there been no reports its role brain inflammation. Here, we used RT-PCR, Western blotting, flow cytometry, immunohistochemical, microarray analyses examine brain, using microglial cell line, hippocampal neuronal inflamed mouse tissue. Treatment BV2 HT22 with recombinant increased levels pro-inflammatory cytokines IL-6 TNF-α, as well cyclooxygenase (COX)-2 prostaglandin E2. We also found JNK STAT3 signaling pathways play an important IL-22-mediated increases mediators. Microarray revealed upregulated inflammation-related genes IL-22-treated cells. Finally, spontaneously expressed brain. Overall, our results demonstrate interaction plays responses

Language: Английский

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The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review

Foods, Journal Year: 2023, Volume and Issue: 12(5), P. 916 - 916

Published: Feb. 21, 2023

Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, such as antioxidant anti-inflammatory action. The primary food sources the are fruits, vegetables, wines, teas, seasonings, spices, there still no daily recommendations for their intake. Depending intensity volume, physical exercise can stimulate oxidative stress muscle inflammation to generate recovery. However, little is known about role that polyphenols may have in process injury, inflammation, regeneration. This review aimed relate supplementation mentation some post-exercise inflammatory markers. consulted papers suggest 74 900 mg cocoa, 250 1000 green tea extract around 4 weeks, 90 up 5 days curcumin attenuate cell damage markers during after exercise. regarding anthocyanins, quercetins, resveratrol, results conflicting. Based these findings, new reflection was made possible impact associating several FBCs simultaneously. Finally, benefits discussed here do not consider existing divergences literature. Some contradictions inherent few studies carried out so far. Methodological limitations, time, doses used, forms supplementation, protocols, collection times, create barriers knowledge consolidation must be overcome.

Language: Английский

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Ghost messages: cell death signals spread

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 9, 2023

Abstract Cell death is a mystery in various forms. Whichever type of cell death, this always accompanied by active or passive molecules release. The recent years marked the renaissance study these showing they can signal to and communicate with recipient cells regulate physio- pathological events. This review summarizes defined forms messages could spread while dying, effects signals on target tissue/cells, how types communications processes. By doing so, hopes identify major unresolved questions field, formulate new hypothesis worthy further investigation, when possible, provide references for search novel diagnostic/therapeutics agents.

Language: Английский

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Effect of Phytobiotic Composition on Production Parameters, Oxidative Stress Markers and Myokine Levels in Blood and Pectoral Muscle of Broiler Chickens

Animals, Journal Year: 2022, Volume and Issue: 12(19), P. 2625 - 2625

Published: Sept. 30, 2022

The aim of this study was to evaluate the effect dietary level a phytobiotic composition (PBC) on production parameters, oxidative stress markers and cytokine levels in blood breast muscle broiler chickens. experiment performed 48 one-day-old female Ross 308 chickens divided into three groups (n = 16) fed control diet (without PBC), supplemented with 60 or 100 mg/kg PBC. After 35 days feeding, samples were collected for analyses. There no final body weight feed intake but PBC addition (100 mg/kg) improved efficiency as compared control. Also, contributed an increase interlukin-6 content reduction tumor necrosis factor-α concentrations pectoral comparison group. In conclusion, parameters beneficially influenced regeneration protection against pathophysiological processes that may occur during intensive rearing.

Language: Английский

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