Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: March 6, 2024

Abstract The quest for effective and reliable methods of delivering medications, with the aim improving delivery therapeutic agent to intended location, has presented a demanding yet captivating field in biomedical research. concept smart drug systems is an evolving approach, serving as model directing drugs specific targets or sites. These have been developed specifically target regulate administration substances diverse array chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel rheumatoid arthritis, different cancers. Nevertheless, numerous comprehensive clinical trials are still required ascertain both immediate enduring impacts such nanosystems on human subjects. This review delves into benefits vehicles, aiming enhance comprehension their applicability addressing present medical requirements. Additionally, it touches upon current applications these stimuli‐reactive biomedicine outlines future development prospects.

Language: Английский

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Connection between oral health and chronic diseases

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Chronic diseases have emerged as a paramount global health burden, accounting for 74% of mortality and causing substantial economic losses. The oral cavity serves critical indicator overall is inextricably linked to chronic disorders. Neglecting can exacerbate localized pathologies accelerate the progression conditions, whereas effective management has potential reduce their incidence mortality. Nevertheless, limited resources lack awareness often impede timely dental intervention, delaying optimal therapeutic measures. This review provides comprehensive analysis impact prevalent diseases-such diabetes mellitus, rheumatoid arthritis, cardiovascular disorders, respiratory diseases-on health, along with an exploration how changes in affect these conditions through both deterioration intervention mechanisms. Additionally, novel insights into underlying pathophysiological mechanisms governing relationships are presented. By synthesizing advancements, this aims illuminate complex interrelationship between while emphasizing urgent need greater collaboration practitioners general healthcare providers improve outcomes.

Language: Английский

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Estimation and Comparison of Salivary microRNA-21 Levels in Periodontitis among Type 2 Diabetes Mellitus and Nondiabetic Patients: A Comparative Study

World Journal of Dentistry, Journal Year: 2025, Volume and Issue: 15(12), P. 1050 - 1054

Published: Feb. 13, 2025

Language: Английский

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Oral hygiene practices and associated factors among rural communities in northwest Ethiopia

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 9, 2024

Abstract Background Poor oral hygiene affects the overall health and quality of life. However, practice in rural communities contributing factors are not well documented. Accordingly, this study was conducted to assess practices associated among northwest Ethiopia. Methods A cross-sectional 1190 households. Data were collected using a structured pretested questionnaire, prepared based on review relevant literature. The questionnaire comprises socio-demographic information, access messages, practices, water quality. We assessed with these criteria: mouth wash clean every morning, after eating, brushing teeth regularly, avoiding gum pricking. Gum pricking is defined as sticking needles or wires into gums make black for beauty. Multivariable logistic regression used identify practices. Significant associations declared basis adjusted odds ratio 95% confidence interval p -values < 0.05. Results showed that all family members usually washed their everyday morning eating 65.2% 49.6% households, respectively. Furthermore, 29.9% households reported regularly brushed toothbrush sticks one more 14.5% had Overall, 42.9% (95% CI: 39.9, 45.6%) good Health and/or education area (AOR: 1.66, 1.26, 2.21). Conclusion More than half poor cleaning toothpastes practiced area, where one-tenth local department needs provide community-level education/interventions, such washing at least twice day, indigenous methods modern toothpastes, promote health.

Language: Английский

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Clinical Efficacy of Extracellular Vesicle Therapy in Periodontitis: Reduced Inflammation and Enhanced Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5753 - 5753

Published: May 25, 2024

Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail restore lost periodontal structures. Emerging as novel approach in regenerative medicine, extracellular vesicle (EV) including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication modulating physiological pathological processes. This study is proof-of-concept type that evaluates clinical efficacy EV therapy non-surgical treatment stage I–III periodontitis, focusing its anti-inflammatory potential. The research involved seven patients undergoing healthy individuals. Clinical parameters, plaque index, bleeding probing, probing depth, attachment level, were assessed alongside cytokine levels gingival crevicular fluid. found improvements marked reduction pro-inflammatory cytokines post-treatment, matching subjects, underscoring therapy’s ability not only attenuate inflammation enhance tissue regeneration, but also highlighting potential restoring health. investigation illuminates promising role treatment, advocating shift towards therapies halt disease progression promote structural functional restoration tissues.

Language: Английский

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Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus—A Comprehensive Review of Clinical Studies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7299 - 7299

Published: July 2, 2024

Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes (T1DM), focusing on cellular molecular mechanisms derived from interplay oral microbiota host immune response. A comprehensive search of studies published 2008 2023 was conducted elucidate association these two diseases. Preclinical clinical evidence suggests relationship, individuals T1DM exhibiting heightened susceptibility periodontitis, vice versa. The includes recent findings human studies, revealing variations in composition patients, including increases certain pathogenic species such as

Language: Английский

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Oral health’s role in diabetes risk: a cross-sectional study with sociodemographic and lifestyle insights

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 7, 2024

Diabetes, a key chronic non-communicable disease, poses substantial public health burden. The role of oral as determinant in the epidemiology diabetes mellitus, particularly Central Eastern European region, remains underexplored. This research aims to examine impact specific parameters, including gum bleeding, active dental caries, tooth mobility, and loss, on prevalence. Additionally, it seeks clarify moderating effects socio-demographic lifestyle variables this relationship.

Language: Английский

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Antimicrobial properties of alternative medicines used in the management of infections in diabetic patients: A comprehensive review

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 11, P. 100432 - 100432

Published: April 22, 2024

Diabetes mellitus poses major health risks due to increased vulnerability infections stemming from weakened immune systems and physiological complications. With antimicrobial resistance worsening prognosis, diabetic affecting multiple body present critical treatment challenges. This review examines the properties of alternative medicines used in management addresses apparent research gap this area. A comprehensive literature search was conducted on databases (PubMed, Scopus, ScienceDirect, Google Scholar) using specified keywords. Exclusion criteria removed non-relevant articles, resulting selection articles published between 2012 2023, focusing medicinal plants, polyherbal formulations, effects against pathogens causing infections. The study revealed a significant regarding use for infection treatment, as only 14 2023 were relevant review. Selected primarily addressed wound (39%), foot ulcers (28%), (17%), urinary tract (11%), skin (5%). Commonly plants include Curcuma longa, Azadirachta indica, Zingiber officinale, Glycyrrhiza glabra among others. demonstrated potential common microorganisms associated with infections, especially Gram-positive bacteria. shows efficacy attributed diverse secondary metabolites offering promising prospects novel agents. Given susceptibility patients microbial further investigation into is essential. Further also imperative validate standardize these therapies conduct clinical trials evaluate their safety management.

Language: Английский

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Toward Digital Periodontal Health: Recent Advances and Future Perspectives

Bioengineering, Journal Year: 2024, Volume and Issue: 11(9), P. 937 - 937

Published: Sept. 18, 2024

Periodontal diseases, ranging from gingivitis to periodontitis, are prevalent oral diseases affecting over 50% of the global population. These arise infections and inflammation gums supporting bones, significantly impacting health. The established link between periodontal systemic such as cardiovascular underscores their importance a public health concern. Consequently, early detection prevention have become critical objectives in healthcare, particularly through integration advanced artificial intelligence (AI) technologies. This paper aims bridge gap clinical practices cutting-edge technologies by providing comprehensive review current research. We examine identification causative factors, disease progression, role AI enhancing treatment. Our goal is underscore intervention improving patient outcomes stimulate further interest among researchers, bioengineers, specialists ongoing exploration applications diagnosis.

Language: Английский

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Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2453 - 2453

Published: Nov. 1, 2024

Type 2 diabetes mellitus is a complex metabolic disorder characterized by insulin resistance and, subsequently, decreased secretion. This condition closely linked to obesity, major risk factor that boosts the development of chronic systemic inflammation, which, in turn, recognized for its crucial role onset resistance. Under conditions adipose tissue, particularly visceral fat, becomes an active endocrine organ releases wide range pro-inflammatory mediators, including cytokines, chemokines, and adipokines. These along with cluster differentiation (CD) markers, contribute maintenance low-grade promote cellular signaling facilitate infiltration inflammatory cells into tissues. Emerging studies have indicated accumulation new cell population tissue these conditions, known as myeloid-derived suppressor (MDSCs). possess ability suppress immune system, impacting obesity-related inflammation. Given limited literature addressing MDSCs context type diabetes, this article aims explore interaction between MDSC activity. Identifying understanding immature essential not only improving management but also potential targeted therapeutic strategies aimed at both glycemic control reduction associated

Language: Английский

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