Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 31, 2024
Magnetic nanoparticles (MNPs) are of great interest for their wide applications in biomedical applications, such as bioimaging, antitumoral therapies, regenerative medicine, and drug delivery. The work aimed to obtain biocompatible magnetite coated with amino acids the general formula Fe
Language: Английский
Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 971 - 971
Published: Feb. 16, 2023
Iron oxide nanoparticles are one of the nanocarriers that suitable for novel drug delivery systems due to low toxicity, biocompatibility, loading capacity, and controlled cancer cells. The purpose present study is synthesis coated iron sorafenib (SFB) its effects on In this study, Fe3O4 were synthesized by co-precipitation method, then was loaded onto PEG@Fe3O4 nanoparticles. FTIR used ensure polyethylene glycol (PEG) binding nanoshells. A comparison mean size crystalline structure performed TEM, DLS, X-ray diffraction patterns. Then, cell viability obtained MTT assay 3T3 HepG2 lines. According FT-IR results, presence O-H C-H bands at 3427 cm-1 1420 peak correlate with PEG XRD pattern showed cubic spinel trapped magnetite carrying medium. magnetic properties examined a vibrating-sample magnetometer (VSM). IC50 values 72 h treatment carriers Fe3O4@PEG nanoparticle line 15.78 μg/mL (p < 0.05). This using them in process could be beneficial increasing effect
Language: Английский
Citations
18
Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown
Published: May 13, 2024
Language: Английский
Citations
8
ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 760 - 772
Published: Jan. 2, 2024
Magnetite nanoparticles (MNPs), with their distinct properties and controllability by using magnetic fields, have secured a central position in various industrial applications. Nevertheless, the surging demand for MNPs necessitates meticulous examination of sustainability production processes. This study embarks on comprehensive evaluation four case studies associated large-scale MNPs, specifically focused environmental, economic, exergy aspects. Our environmental assessment, employing life cycle revealed that microfluidic devices (Case Study 4) showcased promising footprint. With lowest electricity impact constituting only 8% overall impact, it substantiates efficacy mitigating ecological repercussions. Economic analysis further reinforced Case 4. They exhibited superior financial viability, boasting net present value US$ 28,033,346, modified internal rate return 19.73%, benefit–cost ratio 2.07. These figures underscore economic robustness this methodology, suggesting an enticing prospect MNP manufacturers. Finally, our exergetic demonstrated 4 least total destruction, thereby displaying thermodynamic efficiency. In summary, indicates adoption significantly enhances performance, feasibility, energy utilization. findings offer vital insights those seeking to balance demands objectives.
Language: Английский
Citations
7
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 167, P. 112679 - 112679
Published: June 4, 2024
Language: Английский
Citations
7
Magnetochemistry, Journal Year: 2023, Volume and Issue: 9(4), P. 106 - 106
Published: April 12, 2023
Nanoplatforms used for the loading of anticancer drugs constitute a promising approach to cancer treatment and reducing side effects these drugs. Among cutting-edge systems in this area are magnetic nanocomposites (MNCs) nanocapsules (NCs). MNCs considered smart tool magnetic-field-guided targeted drug delivery, resonance imaging, hyperthermia therapy. Nanocapsules offer great potential due their ability control drug-loading capacity, release efficiency, stability, ease with which surfaces can be modified. This study proposes method development nylon-6-coated nylon-6 polymeric membrane NCs. A biocompatible polymer was first NC synthesis. Oleic-acid-modified non-modified Fe3O4 nanoparticles were synthesized production nylon-coated MNCs. Dynamic light scattering (DLS), transmission electron microscopy (TEM), ζ-potential measurements perform size, morphology, charge analyses. The above-mentioned two types templates manufacture nylon nanocapsules, leading NCs different charges structures. developed oleic-acid-coated showed excellent values chemotherapy doxorubicin (DOX) up 732 943 µg/mg (DOX/MNC or NC), respectively. On contrary, capacity nano-construction that not modified oleic acid did exceed 140 µg/mg. DOX-loaded nanosystems displayed pH-sensitive properties, highest efficiency observed at an acidic pH. series inhibited A549 HEK 293FT cell lines, lowest IC50 value 0.31 µM is 1.5-fold lower concentration than free DOX. Therefore, presented nanoscale treatment.
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4041 - 4041
Published: April 5, 2024
In cancer diagnostics, magnetic resonance imaging (MRI) uses contrast agents to enhance the distinction between target tissue and background. Several promising approaches have been developed increase MRI sensitivity, one of which is Overhauser dynamic nuclear polarization (ODNP)-enhanced (OMRI). this study, a macromolecular construct based on human serum albumin nitroxyl radicals (HSA-NIT) was using new synthesis method that significantly increased modification 21 nitroxide residues per protein. This confirmed by electron paramagnetic (EPR) spectroscopy matrix-assisted laser desorption/ionization time-of-flight (MALDI ToF) mass spectrometry. Gel electrophoresis circular dichroism showed no significant changes in structure HSA-NITs, oligomers were formed during modification. The cytotoxicity HSA-NITs comparable native albumin. evaluated as potential "metal-free" organic radical relaxation-based for 1H-MRI hyperpolarizing OMRI. Relaxivities (longitudinal transversal relaxation rates r1 r2) measured at different field strengths (1.88, 3, 7, 14 T). Phantoms used demonstrate use HSA-NIT T1- T2-weighted agent 3 T T. efficacy 1H (ODNP) liquids an ultralow (ULF, B0 = 92 ± 0.8 μT) investigated conjugates. themselves did not show ODNP enhancement; however, under proteolysis conditions simulating tissue, conjugates cleaved into lower-molecular-weight (MW) protein fragments activate capabilities, resulting maximum achievable enhancement |Emax| 40-50 radiofrequency power required achieve half Emax, P1/2, 21-27 W. with higher degree released number spin probes upon biodegradation, enhanced effect. Thus, may represent class well novel cleavable (HCAs)
Language: Английский
Citations
5
International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22
Published: July 8, 2024
Language: Английский
Citations
5
Magnetochemistry, Journal Year: 2022, Volume and Issue: 9(1), P. 12 - 12
Published: Dec. 30, 2022
Magnetic nanocomposites (MNCs) combine the features of magnetic nanoparticles and a second material, which provide distinct physical, chemical, biological properties. The core for nanocomposite synthesis is extensively used due to its high saturation magnetization, chemical stability, large surface area, easy functionalization. Moreover, (MNPs) have great potential resonance imaging (MRI), particle (MPI), hyperthermia, targeted drug gene delivery by an external field. Numerous composing units exist, leads outstanding application composites. This review focuses on nucleic acid-based bioapplications MNCs with polymeric, organic, inorganic, biomolecules, bioinspared coating. In addition, different forms, such as core–shell, doping, multilayer, yolk–shell, Janus-shaped hybrids, are discussed, their unique properties highlighted. types molecularly imprinted polymer (MMIP) presented. presents only using ready-made cores. These restrictions associated many materials, quantitative qualitative composition, procedures. aims discuss MNC information available researchers in this field guide them through some problems structure variation, functionalization possibilities. most recent advancements polymers therapy, diagnostics, theranostics, separation, biocatalytic, biosensing introduced.
Language: Английский
Citations
22
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 177 - 177
Published: Jan. 4, 2023
The iron oxide nanoparticles coated with different surface coatings were studied and characterized by multiple physicochemical biological methods. present paper aims at estimating the toxicity in vitro vivo of dextran aqueous magnetic fluids. studies conducted quantifying viability HeLa cells after their incubation samples (concentrations 62.5−125−250−500 μg/mL time intervals). estimation administering fluids (DIO-AMF) hydrodynamic diameter 25.73 ± 4 nm to Male Brown Norway rats has been made. Different concentrations (62.5−125−250−500 μg/mL) administered for 7 consecutive days. Hematology biochemistry assessment was performed various intervals (24−72 h 21−28 days) intra-peritoneal injection. results showed that high DIO-AMF (250 500 significantly increased white blood cells, red hemoglobin hematocrit compared values obtained control group (p < 0.05). Moreover, following administration DIO-AMF, levels alkaline phosphatase aspartate aminotransferase After administration, no significant difference observed alanine aminotransferase, gamma-glutamyl transpeptidase, urea creatinine study lower than 250 are reliable medical pharmaceutical applications.
Language: Английский
Citations
10
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125604 - 125604
Published: April 1, 2025
Language: Английский
Citations
0