Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Coatings, Journal Year: 2023, Volume and Issue: 13(10), P. 1772 - 1772

Published: Oct. 15, 2023

In recent years, significant progress has been made in the surface functionalization of magnetic nanoparticles (MNPs), revolutionizing their utility multimodal imaging, drug delivery, and catalysis. This progression, spanning over last decade, unfolded discernible phases, each marked by distinct advancements paradigm shifts. nascent stage, emphasis was placed on foundational techniques, such as ligand exchange organic coatings, establishing groundwork for subsequent innovations. review navigates through cutting-edge developments tailoring MNP surfaces, illuminating pivotal role advancing these diverse applications. The exploration encompasses an array innovative strategies inorganic encapsulation, engineering, self-assembly, bioconjugation, elucidating how approach impacts or augments performance. Notably, surface-functionalized MNPs exhibit increased efficacy demonstrating improved MRI contrast targeted imaging. current underscores transformative impact modifications delivery systems, enabling controlled release, therapy, enhanced biocompatibility. With a comprehensive analysis characterization techniques future prospects, this surveys dynamic landscape past three years (2021–2023). By dissecting underlying principles applications, provides not only retrospective but also forward-looking perspective potential surface-engineered shaping science, technology, medicine.

Language: Английский

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Recent Advances in pH and Redox Responsive Polymer Nanocomposites for Cancer Therapy

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(1), P. 28 - 28

Published: Jan. 11, 2024

Cancer therapy currently focuses on personalized targeted treatments. A promising approach uses stimuli-responsive biomaterials for site-specific drug release, such as pH- and redox-triggered polymer nanocomposites. These materials respond to the tumor microenvironment, enhance efficacy, reduce off-target effects. cells with anomalous properties acidic cytosolic pH elevated redox potential are by these biomaterials. An imbalance in ions biological thiols cytoplasm contributes growth. Functionalized nanocomposites large surface areas specific targeting outperform conventional small-molecule materials. To overcome problems low bioavailability, uncontrolled poor cell penetration, multifunctional nanomaterials make it easier drugs enter certain cellular or subcellular systems. High therapeutic efficacy is achieved through functionalization, targeting, use of components. In particular, dual-stimuli-based polymeric cancer therapeutics have scarcely been reported. This article provides recent progress redox-responsive delivery therapy. It explores design principles, fabrication methods, mechanisms action, prospects dual-stimuli-responsive

Language: Английский

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Nanoscale strides: exploring innovative therapies for breast cancer treatment

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14017 - 14040

Published: Jan. 1, 2024

Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential superiority over conventional methods, transforming management.

Language: Английский

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Development and Characterization of Genistein-Loaded Silver Nanoparticles for the Induction of Apoptosis on Human Hepatocellular Carcinoma Cell Lines

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 8, 2025

Language: Английский

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pH-Responsible Doxorubicin-Loaded Fe3O4@CaCO3 Nanocomposites for Cancer Treatment

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 771 - 771

Published: Feb. 26, 2023

A magnetic nanocomposite (MNC) is an integrated nanoplatform that combines a set of functions two types materials. successful combination can give rise to completely new material with unique physical, chemical, and biological properties. The core MNC provides the possibility resonance or particle imaging, field-influenced targeted delivery, hyperthermia, other outstanding applications. Recently, gained attention for external field-guided specific delivery cancer tissue. Further, drug loading enhancement, construction stability, biocompatibility improvement may lead high progress in area. Herein, novel method nanoscale Fe3O4@CaCO3 composites synthesis was proposed. For procedure, oleic acid-modified Fe3O4 nanoparticles were coated porous CaCO3 using ion coprecipitation technique. PEG-2000, Tween 20, DMEM cell media successfully used as stabilization agent template synthesis. Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS) data MNC's characterization. To improve properties, concentration varied, yielding optimal size, polydispersity, aggregation ability. resulting had size 135 nm narrow distributions, which suitable biomedical stability experiment various pH, media, fetal bovine serum also evaluated. showed low cytotoxicity biocompatibility. An excellent anticancer doxorubicin (DOX) up 1900 µg/mg (DOX/MNC) demonstrated. Fe3O4@CaCO3/DOX displayed at neutral pH efficient acid-responsive release. series DOX-loaded MNCs indicated effective inhibition Hela MCF-7 lines, IC 50 values calculated. Moreover, 1.5 μg sufficient inhibit 50% cells, shows prospect treatment. experiments human albumin solution release due formation protein corona. presented "pitfalls" nanocomposites provided step-by-step guidance on efficient, smart, nanoconstruction fabrication. Thus, exhibits good performance treatment

Language: Английский

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Superparamagnetic Iron-Oxide Nanoparticles Synthesized via Green Chemistry for the Potential Treatment of Breast Cancer

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2343 - 2343

Published: March 3, 2023

In the emerging field of nanomedicine, nanoparticles have been widely considered as drug carriers and are now used in various clinically approved products. Therefore, this study, we synthesized superparamagnetic iron-oxide (SPIONs) via green chemistry, SPIONs were further coated with tamoxifen-conjugated bovine serum albumin (BSA-SPIONs-TMX). The BSA-SPIONs-TMX within nanometric hydrodynamic size (117 ± 4 nm), a small poly dispersity index (0.28 0.02) zeta potential -30.2 0.09 mV. FTIR, DSC, X-RD, elemental analysis confirmed that successfully prepared. saturation magnetization (Ms) was found to be ~8.31 emu/g, indicating possess properties for theragnostic applications. addition, efficiently internalized into breast cancer cell lines (MCF-7 T47D) effective reducing proliferation cells, IC50 values 4.97 0.42 μM 6.29 0.21 MCF-7 T47D respectively. Furthermore, an acute toxicity study on rats these safe use delivery systems. conclusion, may also diagnostic

Language: Английский

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Nylon-6-Coated Doxorubicin-Loaded Magnetic Nanoparticles and Nanocapsules for Cancer Treatment

Magnetochemistry, Journal Year: 2023, Volume and Issue: 9(4), P. 106 - 106

Published: April 12, 2023

Nanoplatforms used for the loading of anticancer drugs constitute a promising approach to cancer treatment and reducing side effects these drugs. Among cutting-edge systems in this area are magnetic nanocomposites (MNCs) nanocapsules (NCs). MNCs considered smart tool magnetic-field-guided targeted drug delivery, resonance imaging, hyperthermia therapy. Nanocapsules offer great potential due their ability control drug-loading capacity, release efficiency, stability, ease with which surfaces can be modified. This study proposes method development nylon-6-coated nylon-6 polymeric membrane NCs. A biocompatible polymer was first NC synthesis. Oleic-acid-modified non-modified Fe3O4 nanoparticles were synthesized production nylon-coated MNCs. Dynamic light scattering (DLS), transmission electron microscopy (TEM), ζ-potential measurements perform size, morphology, charge analyses. The above-mentioned two types templates manufacture nylon nanocapsules, leading NCs different charges structures. developed oleic-acid-coated showed excellent values chemotherapy doxorubicin (DOX) up 732 943 µg/mg (DOX/MNC or NC), respectively. On contrary, capacity nano-construction that not modified oleic acid did exceed 140 µg/mg. DOX-loaded nanosystems displayed pH-sensitive properties, highest efficiency observed at an acidic pH. series inhibited A549 HEK 293FT cell lines, lowest IC50 value 0.31 µM is 1.5-fold lower concentration than free DOX. Therefore, presented nanoscale treatment.

Language: Английский

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Contrast Agents Based on Human Serum Albumin and Nitroxides for 1H-MRI and Overhauser-Enhanced MRI

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4041 - 4041

Published: April 5, 2024

In cancer diagnostics, magnetic resonance imaging (MRI) uses contrast agents to enhance the distinction between target tissue and background. Several promising approaches have been developed increase MRI sensitivity, one of which is Overhauser dynamic nuclear polarization (ODNP)-enhanced (OMRI). this study, a macromolecular construct based on human serum albumin nitroxyl radicals (HSA-NIT) was using new synthesis method that significantly increased modification 21 nitroxide residues per protein. This confirmed by electron paramagnetic (EPR) spectroscopy matrix-assisted laser desorption/ionization time-of-flight (MALDI ToF) mass spectrometry. Gel electrophoresis circular dichroism showed no significant changes in structure HSA-NITs, oligomers were formed during modification. The cytotoxicity HSA-NITs comparable native albumin. evaluated as potential "metal-free" organic radical relaxation-based for 1H-MRI hyperpolarizing OMRI. Relaxivities (longitudinal transversal relaxation rates r1 r2) measured at different field strengths (1.88, 3, 7, 14 T). Phantoms used demonstrate use HSA-NIT T1- T2-weighted agent 3 T T. efficacy 1H (ODNP) liquids an ultralow (ULF, B0 = 92 ± 0.8 μT) investigated conjugates. themselves did not show ODNP enhancement; however, under proteolysis conditions simulating tissue, conjugates cleaved into lower-molecular-weight (MW) protein fragments activate capabilities, resulting maximum achievable enhancement |Emax| 40-50 radiofrequency power required achieve half Emax, P1/2, 21-27 W. with higher degree released number spin probes upon biodegradation, enhanced effect. Thus, may represent class well novel cleavable (HCAs)

Language: Английский

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Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment

Coatings, Journal Year: 2023, Volume and Issue: 13(2), P. 324 - 324

Published: Feb. 1, 2023

Silica nanoparticles (SiNPs) are a promising material for nanomedicine technology. SiNPs considered powerful tool drug delivery, functional coatings and films, biomolecule separation due to their stability, biocompatibility, accessible surface modification. Herein, the synthesis of nylon 6 (SiNPs-Nylon) coated nanocomposites was proposed. Transmission electron microscopy (TEM) dynamic light scattering (DLS) were used morphology, size, stability analysis. Anticancer doxorubicin (DOX) loading pH-dependent release experiments presented. DOX-loaded with high capacities up 258 μg/mg (DOX/SiNPs) 493 (DOX/SiNPs-Nylon) show effective inhibition A549 HEK 293FT cell lines. The IC50 values 0.08 ± 0.01 µM in terms DOX amount recalculated as 0.31 0.04 µg/mL concentration cells. Therefore, silica have potential cancer treatment.

Language: Английский

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Recent advances in composite materials integrating molecularly imprinted polymers for targeted drug delivery systems

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113825 - 113825

Published: Feb. 1, 2025

Language: Английский

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