Journal of Biomaterials Applications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
The
Diels-Alder
reaction,
a
classical
(4+2)
cycloaddition
process,
holds
significant
standing
within
the
realms
of
organic
synthesis
and
polymer
chemistry,
frequently
employed
in
areas
such
as
pharmaceutical
production
material
science.
Recently,
hydrogels
constructed
via
reactions
have
garnered
considerable
attention
from
researchers.
This
review
aims
to
summarize
advancements
utilizing
reaction
for
hydrogel
synthesis,
exploring
its
impact
on
structural
design,
functionalization,
application
domains.
Initially,
fundamental
principles
are
introduced
alongside
an
examination
benefits
characteristics
fabrication.
Subsequently,
applications
Diels-Alder-generated
biomedicine,
smart
responsive
materials,
drug
delivery
systems,
among
other
fields,
comprehensively
reviewed.
Challenges
limitations
encountered
during
using
this
also
discussed.
Finally,
prospective
research
directions
future
prospects
contemplated.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1172 - 1172
Published: March 6, 2024
Implant-associated
infections
(IAIs)
represent
a
major
health
burden
due
to
the
complex
structural
features
of
biofilms
and
their
inherent
tolerance
antimicrobial
agents
immune
system.
Thus,
viable
options
eradicate
embedded
on
medical
implants
are
surgical
operations
long-term
repeated
antibiotic
courses.
Recent
years
have
witnessed
growing
interest
in
development
robust
reliable
strategies
for
prevention
treatment
IAIs.
In
particular,
it
seems
promising
develop
materials
with
anti-biofouling
antibacterial
properties
combating
IAIs
implants.
this
contribution,
we
exclusively
focus
recent
advances
modified
functionalized
implant
surfaces
inhibiting
bacterial
attachment
eventually
biofilm
formation
orthopedic
Further,
highlight
progress
coatings
(including
self-assembled
nanocoatings)
preventing
Among
recently
introduced
approaches
efficient
durable
coatings,
use
safe
biocompatible
excellent
activities
local
delivery
combinatorial
treating
overcoming
resistance.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3849 - 3849
Published: March 29, 2024
This
state-of-the-art
review
explores
the
emerging
field
of
regenerative
hydrogels
and
their
profound
impact
on
treatment
skin
wounds.
Regenerative
hydrogels,
composed
mainly
water-absorbing
polymers,
have
garnered
attention
in
wound
healing,
particularly
for
Their
unique
properties
make
them
well
suited
tissue
regeneration.
Notable
benefits
include
excellent
water
retention,
creating
a
crucially
moist
environment
optimal
facilitating
cell
migration,
proliferation.
Biocompatibility
is
key
feature,
minimizing
adverse
reactions
promoting
natural
healing
process.
Acting
as
supportive
scaffold
growth,
mimic
extracellular
matrix,
aiding
attachment
proliferation
cells
like
fibroblasts
keratinocytes.
Engineered
controlled
drug
release,
enhance
by
angiogenesis,
reducing
inflammation,
preventing
infection.
The
demonstrated
acceleration
process,
beneficial
chronic
or
impaired
wounds,
adds
to
appeal.
Easy
application
conformity
various
shapes
practical,
including
irregular
challenging
areas.
Scar
minimization
through
regeneration
crucial,
especially
cosmetic
functional
regions.
Hydrogels
contribute
pain
management
protective
barrier,
friction,
fostering
soothing
environment.
Some
with
inherent
antimicrobial
properties,
aid
infection
prevention,
which
crucial
aspect
successful
healing.
flexibility
ability
conform
contours
ensure
contact,
enhancing
overall
effectiveness.
In
summary,
present
promising
approach
improving
outcomes
across
diverse
clinical
scenarios.
provides
comprehensive
analysis
benefits,
mechanisms,
challenges
associated
use
this
review,
authors
likely
delve
into
rational
design
principles
efficacy
performance
Through
an
exploration
methodologies
approaches,
paper
poised
highlight
how
these
been
instrumental
refining
potentially
revolutionizing
therapeutic
potential
addressing
By
synthesizing
current
knowledge
highlighting
avenues
future
research,
aims
advancement
medicine
ultimately
improve
patients
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13135 - 13135
Published: Aug. 24, 2023
The
inflammatory-associated
corrosion
of
metallic
dental
and
orthopedic
implants
causes
significant
complications,
which
may
result
in
the
implant's
failure.
resistance
can
be
improved
with
coatings
surface
treatments,
but
at
same
time,
it
might
affect
ability
to
undergo
proper
osteointegration.
In
this
work,
alginate
hydrogels
without
octacalcium
phosphate
(OCP)
were
made
on
3D-printed
(patterned)
titanium
alloys
(Ti
Group
2
Ti-Al-V
23)
enhance
their
anticorrosion
properties
simulated
normal,
inflammatory,
severe
inflammatory
conditions
vitro.
Alginate
(Alg)
OCP-laden
(Alg/OCP)
manufactured
Ti
substrates
characterized
wettability
analysis,
XRD,
FTIR.
electrochemical
characterization
samples
was
carried
out
open
circuit
potential,
potentiodynamic
polarization,
impedance
spectroscopy
(EIS).
It
observed
that
hydrophilicity
Alg/OCP
higher
than
pure
Alg
OCP
phase
crystallinity
increased
when
subjected
biological
media.
uncoated
coated
lower
environments
vs.
normal
media,
hydrogel
layers
moved
potential
towards
more
nobler
values,
reducing
current
density
all
solutions.
These
measurements
revealed
particles
matrix
noticeably
electrical
charge
transfer
substrate
coating
interface
alone.
Coatings,
Journal Year:
2024,
Volume and Issue:
14(3), P. 256 - 256
Published: Feb. 21, 2024
During
surgery
and
after,
pathogens
can
contaminate
indwelling
implanted
medical
devices,
resulting
in
serious
infections.
Microbial
colonization,
infection,
later
biofilm
formation
are
major
complications
associated
with
the
use
of
implants
represent
risk
factors
implant
failure.
Despite
fact
that
aseptic
antimicrobial
medications
lower
systemic
antibiotic
result
a
loss
efficacy,
increased
tissue
toxicity,
development
drug-resistant
diseases.
This
work
explores
advancements
coatings
for
head-related
implantable
addressing
critical
issue
infection
prevention.
It
emphasizes
significance
these
reducing
microbial
colonization
highlights
various
techniques
materials
used
creating
effective
surfaces.
Moreover,
this
article
presents
comprehensive
overview
current
strategies
future
directions
coating
research,
aiming
to
improve
patient
outcomes
by
preventing
implant-associated
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e36258 - e36258
Published: Aug. 1, 2024
Natural
bone
tissue
has
the
certain
function
of
self-regeneration
and
repair,
but
it
is
difficult
to
repair
large
damage.
Recently,
although
autologous
grafting
"gold
standard"
for
improving
high
cost,
few
donor
sources.
Besides,
allogeneic
causes
greater
immune
reactions,
which
hardly
meet
clinical
needs.
The
engineering
(BTE)
been
developed
promote
repair.
Gelatin,
due
its
biocompatibility,
receives
a
great
deal
attention
in
BTE
research
field.
However,
disadvantages
natural
gelatin
are
poor
mechanical
properties
single
structural
property.
With
development
BTE,
often
used
combination
with
range
natural,
synthetic
polymers,
inorganic
materials
achieve
synergistic
effects
complex
physiological
process
review
delves
into
fundamental
structure
unique
gelatin,
as
well
excellent
necessary
scaffold
materials.
Then
this
explores
application
modified
three-dimensional
(3D)
scaffolds
various
structures
including
3D
fiber
scaffolds,
hydrogels,
nanoparticles.
In
addition,
focuses
on
efficacy
composite
consisting
or
polymeric
materials,
bioactive
ceramics
metallic/non-metallic
defects.
these
gelatin-based
provides
new
ideas
design
good
biosafety.
Materials,
Journal Year:
2024,
Volume and Issue:
17(5), P. 1113 - 1113
Published: Feb. 28, 2024
Nanocomposites
based
on
silver
nanoparticles
and
chitosan
present
important
advantages
for
medical
applications,
showing
over
time
their
role
in
antibacterial
evaluation.
This
work
presents
the
comparative
study
of
two
chemical
synthesis
procedures
nanocomposites,
trisodium
citrate
dihydrate
sodium
hydroxide,
using
various
concentrations
a
complex
investigation.
The
nanocomposites
were
characterized
by
AFM
DLS
regarding
dimensions,
while
FT-IR
UV-VIS
spectrometry
used
optical
properties
to
reveal
binding
with
chitosan.
Their
effect
was
determined
disk
diffusion
method
bacteria
strains,
Materials,
Journal Year:
2024,
Volume and Issue:
17(23), P. 5770 - 5770
Published: Nov. 25, 2024
Chitosan,
a
natural
biopolymer
with
excellent
biocompatibility,
biodegradability,
and
modifiable
structure,
has
broad
applications
in
regenerative
medicine,
tissue
engineering,
food
packaging,
environmental
technology.
Its
abundance,
solubility
acidic
solutions,
capacity
for
chemical
modification
make
it
highly
adaptable
creating
specialized
derivatives
enhanced
properties.
Recent
advances
have
demonstrated
chitosan's
efficacy
composite
systems
regeneration,
drug
delivery,
antimicrobial
applications.
This
review
examines
unique
properties,
focus
on
its
antibacterial
activity
as
influenced
by
factors
like
pH,
concentration,
molecular
weight,
deacetylation
degree.
Additionally,
potential
sustainable,
non-toxic
material
eco-friendly
packaging
water
treatment
is
explored,
highlighting
the
growing
interest
chitosan
composites
other
polymers
metallic
nanoparticles
biomedical
