Wiadomości Lekarskie,
Journal Year:
2022,
Volume and Issue:
75(11), P. 2839 - 2842
Published: Jan. 1, 2022
Acute
kidney
injury
(AKI),
formerly
called
acute
renal
failure
(ARF),
is
clinically
manifested
as
a
reversible
increase
in
nitrogen
waste
products,
measured
by
blood
urea
(BUN)
and
serum
creatinine
levels.
Contrast
induced
(CIAKI)
potentially
fatal
complication
of
angiographic
procedures
caused
the
use
contrast
media
(CM).
It
third
most
prevalent
cause
hospital
acquired
damage,
accounting
for
around
up
to
30%
cases.
nephropathy
(CIN)
defined
greater
than
25%
or
0.5
mg/dl
(44
μmol/l)
(Scr)
from
baseline
within
3
days.
More
sensitive
indicators
damage
are
sought,
hence
numerous
tubular
biomarkers
being
studied.
Multiple
risk
factors
may
lead
development
CIN;
these
classified
patient-related
procedure-related.
Treatment
CIN
Is
primarily
symptomatic
consist
firstly
careful
fluid
electrolyte
management,
although
dialysis
be
necessary
some
With
available
treatment
options,
prevention
cornerstone
management.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(10), P. 2038 - 2038
Published: May 12, 2022
Toxic
ingredients
in
food
can
lead
to
serious
food-related
diseases.
Such
compounds
are
bacterial
toxins
(Shiga-toxin,
listeriolysin,
Botulinum
toxin),
mycotoxins
(aflatoxin,
ochratoxin,
zearalenone,
fumonisin),
pesticides
of
different
classes
(organochlorine,
organophosphate,
synthetic
pyrethroids),
heavy
metals,
and
natural
antinutrients
such
as
phytates,
oxalates,
cyanide-generating
glycosides.
The
generally
regarded
safe
(GRAS)
status
long
history
lactic
acid
bacteria
(LAB)
essential
fermented
foods
probiotics
make
them
a
major
biological
tool
against
great
variety
toxins.
This
state-of-the-art
review
aims
summarize
discuss
the
data
revealing
involvement
LAB
detoxification
from
hazardous
agents
microbial
chemical
nature.
It
is
focused
on
specific
properties
that
allow
counteract
destroy
them,
well
mechanisms
antagonism
toward
toxigenic
producers.
Toxins
origin
either
adsorbed
or
degraded,
toxic
chemicals
hydrolyzed
then
used
carbon
source,
while
metals
bound
accumulated.
Based
these
comprehensive
data,
prospects
for
developing
new
combinations
probiotic
starters
considered.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(22), P. 9515 - 9524
Published: April 30, 2024
Deltamethrin
(DM)
is
a
widely
used
insecticide
that
has
demonstrated
developmental
toxicity
in
the
early
life
stages
of
fish.
To
better
characterize
underlying
mechanisms,
embryos
from
Tg(cmlc2:RFP),
Tg(apo14:GFP),
and
Tg(mpx:GFP)
transgenic
strains
zebrafish
were
exposed
to
nominal
DM
concentrations
0.1,
1,
10,
25,
50
μg/L
until
120
h
post-fertilization
(hpf).
Heart
size
increased
56.7%,
liver
was
reduced
by
17.1%
22.7
24.2
DM,
respectively.
RNA
sequencing
bioinformatic
analyses
predicted
key
biological
processes
affected
exposure
related
inflammatory
responses.
Expression
IL-1
protein
69.0%
24.4
treatment,
aggregation
neutrophils
cardiac
hepatic
histologic
sections
also
observed.
Coexposure
resatorvid,
an
anti-inflammatory
agent,
mitigated
responses
induced
restored
biomass.
Our
data
indicated
complex
proinflammatory
mechanism
DM-induced
cardiotoxicity
hepatotoxicity
which
may
be
important
for
events
adverse
outcomes
associated
risks
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 6945 - 6945
Published: June 25, 2024
Pesticides
serve
as
essential
tools
in
agriculture
and
public
health,
aiding
pest
control
disease
management.
However,
their
widespread
use
has
prompted
concerns
regarding
adverse
effects
on
humans
animals.
This
review
offers
a
comprehensive
examination
of
the
toxicity
profile
pesticides,
focusing
detrimental
impacts
nervous,
hepatic,
cardiac,
pulmonary
systems,
impact
reproductive
functions.
Additionally,
it
discusses
how
pesticides
mimic
hormones,
thereby
inducing
dysfunction
endocrine
system.
disrupt
system,
leading
to
neurological
impairments,
hepatocellular
abnormalities,
cardiac
dysfunction,
respiratory
issues.
Furthermore,
they
also
exert
organs,
disrupting
hormone
levels
causing
dysfunction.
Mechanistically,
interfere
with
neurotransmitter
function,
enzyme
activity,
regulation.
highlights
male
reproduction,
particularly
sperm
capacitation,
process
wherein
ejaculated
undergo
physiological
changes
within
female
tract,
acquiring
ability
fertilize
an
oocyte.
have
been
reported
inhibit
morphological
crucial
for
resulting
poor
capacitation
eventual
infertility.
Understanding
toxic
is
mitigating
human
animal
guiding
future
research
endeavors.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(40), P. 47338 - 47349
Published: Sept. 26, 2023
Acute
liver
injury
(ALI)
is
a
severe
health
condition
with
limited
treatment
options.
Phlorotannin
(PT),
natural
compound
extracted
from
seaweeds,
has
shown
potential
in
improving
function.
However,
its
poor
stability
and
bioavailability
have
applications
vivo.
In
this
study,
we
developed
PT-based
nanoparticles
(NPs)
through
Mannich
reaction
glycine,
which
exhibited
good
biocompatibility
prolonged
circulation
time
Our
results
revealed
that
the
PT
NPs
possess
strong
free
radical
scavenging
ability,
effectively
reducing
reactive
oxygen
species
(ROS)
alleviating
oxidative
stress
proinflammatory
responses
H2O2-induced
damage
model
of
HepG2
cells.
Furthermore,
attenuated
inflammation
tissue
carbon
tetrachloride
(CCl4)-induced
mice
by
regulating
Nrf2/HO-1
signaling
pathway.
summary,
our
suggested
could
serve
as
promising
nano-therapeutic
strategy
for
ALI.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(4), P. 393 - 393
Published: April 10, 2025
Background/Objectives:
Marbofloxacin,
a
second-generation
fluoroquinolone,
is
used
to
control
economically
significant
poultry
diseases
caused
by
pathogenic
bacteria
such
as
Staphylococcus
aureus
and
Escherichia
coli.
Although
synergistic
antimicrobial
activity
between
fluoroquinolones
N-acetyl-L-cysteine
(NAC)
has
been
observed
in
vitro,
data
on
their
pharmacokinetic
interactions
vivo
remain
limited.
This
study
aimed
evaluate
the
effect
of
NAC
oral
pharmacokinetics
marbofloxacin
broiler
chickens
its
antibacterial
against
E.
coli
ATCC
25922
S.
25923,
assessing
potential
benefits
combined
administration.
Methods:
The
was
evaluated
broilers
(5
mg/kg
dose)
after
single
intravenous
(n
=
12)
or
administration
into
crop.
protocol
for
co-administration
(400
via
feed)
follows:
first
day,
received
dose
crop
over
next
four
days
fluoroquinolone
drug
administered
drinking
water.
plasma
levels
drugs
were
determined
using
LC-MS/MS
analyses,
minimum
inhibitory
concentrations
microbroth
dilution
method.
Results:
significantly
reduced
bioavailability
decreased
elimination
rate
constant
following
both
drugs.
At
concentration
20
μg/mL,
led
3.8-fold
reduction
MIC
2-fold
decrease
at
1
μg/mL
6
while
no
change
marbofloxacin’s
25923.
Conclusions:
Oral
fluoroquinolone’s
two-fold
enhancing
25922.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
264, P. 115475 - 115475
Published: Sept. 14, 2023
To
date,
it
is
unclear
whether
deltamethrin
(DLM)
intake
causes
damage
to
colon
tissue.
Hence,
in
this
study,
we
aimed
clarify
the
effect
of
long-term
exposure
low-dose
DLM
on
tissues,
and
its
potential
mechanisms.
Biomedical Chromatography,
Journal Year:
2024,
Volume and Issue:
38(6)
Published: March 3, 2024
N-acetyl-l-cysteine
(NAC)
shows
beneficial
effects
in
cases
of
aflatoxicosis
and
heat
stress
poultry
but
little
is
known
about
its
pharmacokinetics
chickens.
Therefore,
the
study
aimed
to
develop
validate
a
sensitive
LC-MS/MS
analytical
method
for
quantitative
analysis
NAC
chicken
plasma.
A
split
calibration
curve
approach
was
used
determination
Standard
curves
low
(0.05-2.5
μg/ml)
high
(2.5-100
ranges
concentrations
were
prepared.
The
standard
(r
