Microplastics and human health: Integrating pharmacokinetics

Critical Reviews in Environmental Science and Technology, Journal Year: 2023, Volume and Issue: 53(16), P. 1489 - 1511

Published: April 8, 2023

Microplastics are widespread contaminants leading to environmental exposure. While studies on the prevalence in human tissues have multiplied, little is known about their pharmacokinetics. Mechanisms of absorption, distribution, metabolism, and excretion (ADME) must be addressed before effects health (i.e. pharmacodynamics) can understood. Therefore, objective this review was provide an integrated assessment fate microplastics body by gathering information from multiple fields research (e.g. implants microspheres). Absorption mainly occurs through transcytosis enterocytes, while larger particles may internalized gaps persorption) or uptake phagocytes. Only <5 µm reach alveolar region, large found lungs usually result entrapment circulating narrow pulmonary capillary network. Overall, absorption rates expected low. then distributed circulatory system, accumulating respiratory digestive liver, spleen, brain. Metabolism lead biodegradation microplastics, enzymes reactive oxygen species macrophages, exposure physiologic fluids, microbiologic activity gut lumen. Finally, most will removed liver spleen excreted feces. work provides initial attempt at constructing a pharmacokinetics model for further required. Ideally, future works should conducted using histopathology techniques obtain precise location radiolabelled allow tracking time.

Language: Английский

---

Understanding microplastic pollution of marine ecosystem: a review

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 31(29), P. 41402 - 41445

Published: July 14, 2023

Language: Английский

---

Microplastics in Terrestrial Domestic Animals and Human Health: Implications for Food Security and Food Safety and Their Role as Sentinels

Animals, Journal Year: 2023, Volume and Issue: 13(4), P. 661 - 661

Published: Feb. 14, 2023

Terrestrial domestic animals are exposed to microplastics, therefore, contaminating the food chain, in case of livestock, or acting as sentinels for human exposure, companion animals. The aim this review was address importance terrestrial on exposure microplastics. Animal products may already show some microplastics contamination, which occur during their lifetime, possibly also compromising productivity, and processing, originating from equipment packaging. Moreover, release animal feces (or manure) leads contamination agricultural fields, with possible impacts internalization plants. Therefore, pose a threat security, safety, by being foreign material found products. Conversely, urban environments, (cats dogs) be relevant exposure. While oral vary pets compared humans, due indiscriminate ingestion chewing licking behaviors, airborne is likely good indicator future studies should both chain environmental

Language: Английский

---

Nanomaterials and biochar mediated remediation of emerging contaminants

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 916, P. 170064 - 170064

Published: Jan. 20, 2024

Language: Английский

---

The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(6), P. 101581 - 101581

Published: May 22, 2024

Non-communicable diseases (NCD) constitute one of the highest burdens disease globally and are associated with inflammatory responses in target organs. There is increasing evidence significant human exposure to micro- nanoplastics (MnPs). This review environmental MnP health impacts indicates that particles, directly indirectly through their leachates, may exacerbate inflammation. Meanwhile, persistent inflammation NCDs gastrointestinal respiratory systems potentially increases uptake, thus influencing access distal Consequently, a future increase augments risk severity NCDs. critical need for an integrated one-health approach research assessing drivers bidirectional links Assessing these risks requires interdisciplinary efforts identify link organismal uptake studies impacted mechanisms outcomes.

Language: Английский

---

Microplastics in maternal amniotic fluid and their associations with gestational age

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 920, P. 171044 - 171044

Published: Feb. 19, 2024

Language: Английский

---

Benefits and challenges of food processing in the context of food systems, value chains and sustainable development goals

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 153, P. 104703 - 104703

Published: Sept. 7, 2024

Language: Английский

---

Is there tea complemented with the appealing flavor of microplastics? A pioneering study on plastic pollution in commercially available tea bags in Bangladesh

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 837, P. 155833 - 155833

Published: May 10, 2022

Language: Английский

---

Human health risk assessment of potentially toxic elements and microplastics accumulation in products from the Danube River Basin fish market

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 104, P. 104307 - 104307

Published: Nov. 1, 2023

The present study aimed to quantify the concentration levels of potentially toxic elements (PTEs) such as aluminum, arsenic, cadmium, chromium, copper, nickel, lead, zinc, and mercury, well microplastics occurrence in various tissues fish seafood species, commercialized Lower Danube River Basin. A health risk assessment analysis was performed based on PTEs muscle tissue. Estimated daily intake (EDI), target hazard quotient (THQ), index (HI), cancer (TR) were calculated. It observed that species within category registered highest PTEs. For instance, tissue bivalve Mytilus galloprovincialis (from Black Sea), value case Zn (37.693 mg/kg), presence polystyrene polymer identified. values associated with EDI, THQ, HI, TR PTE exposure significantly lower than 1.

Language: Английский

---

Review of emerging contaminants in green stormwater infrastructure: Antibiotic resistance genes, microplastics, tire wear particles, PFAS, and temperature

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167195 - 167195

Published: Sept. 28, 2023

Language: Английский

---