Post-COVID-19 fatigue: A systematic review

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 11, 2022

Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2. This systematic review was performed to describe symptoms, etiology, possible risk factors related post-COVID-19 fatigue and therapeutic approaches used for treatment fatigue. For literature search databases PubMed, Web Science, Cochrane Library, PsycInfo were used. All articles that met inclusion criteria analyzed demographics, clinical data treatment. Included studies which focused on an adult population (18-65 years old); elderly patients chronic somatic diseases can also cause excluded. We identified 2,851, screened 2,193 finally included 20 moderate high methodological quality, encompassing 5,629 participants. Potential old age, female sex, severe status acute phase infection, a number comorbidities, prediagnosis depression/anxiety. Lastly, autoimmune etiology suspected. Several have been tested mostly small uncontrolled so far: Chinese herbal formulation improved breathlessness Moreover, molecular hydrogen (H

Language: Английский

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Molecular Hydrogen Therapy—A Review on Clinical Studies and Outcomes

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7785 - 7785

Published: Nov. 26, 2023

With its antioxidant properties, hydrogen gas (H2) has been evaluated in vitro, animal studies and human for a broad range of therapeutic indications. A simple search “hydrogen gas” various medical databases resulted more than 2000 publications related to as potential new drug substance. parallel clinical trial registers also generated many hits, reflecting the diversity ongoing trials involving therapy. This review aims assess discuss current findings about therapy 81 identified 64 scientific on studies. Positive indications have found major disease areas including cardiovascular diseases, cancer, respiratory central nervous system disorders, infections more. The available administration methods, which can pose challenges due hydrogens’ explosive hazards low solubility, well possible future innovative technologies mitigate these challenges, reviewed. Finally, an elaboration is included with aim addressing following questions: will be substance practice? If so, what might form indications?

Language: Английский

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Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study

Medical Gas Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental clinical studies have shown that has anti-inflammatory, anti-apoptotic, strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes inhalation on respiratory gas analysis parameters using randomized, double-blind, placebo-controlled, crossover design. The conducted at Faculty Physical Culture, Palacký University Olomouc from September 2022 March 2023. Twenty, physically active female participants aged 22.1 ± 1.6 years who inhaled either or ambient air through nasal cannula (300 mL/min) for while resting were included in this study. Metabolic response measured indirect calorimetry. Breath-by-breath data averaged over four 15-minute intervals. Compared with placebo (ambient air), significantly decreased exchange ratio ventilation across all Furthermore, change negatively correlated body fat percentage 30 onwards. In conclusion, increased oxidation, as evidenced by ratio, particularly individuals higher percentages.

Language: Английский

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Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted porphyrin

Aging Pathobiology and Therapeutics, Journal Year: 2023, Volume and Issue: 5(1), P. 25 - 32

Published: March 28, 2023

Oxidative stress is one of the major causes most age-dependent neurodegenerative disorders. Neurons accumulate oxidative damage over time due to post-mitotic cells. Thus, modulation essential overcome these Molecular hydrogen (H2) has great potential for treating various diseases and improving quality life by exerting multiple functions including anti-oxidation, anti-inflammation, energy metabolism promotion. Among functions, H2 activates a transcription factor, nuclear factor erythroid 2-related 2 (Nrf2) enhance transcribe broad range anti-stress enzymes, antioxidant enzymes. There was an elusive contradiction between Nrf2 because activated in response stress, whereas reducing potential. The target molecule recently been identified as oxidized form Fe-porphyrin conjugated with -OH group (PrP-Fe(III)-OH). As initial step, hydroxyl radical (•OH) oxidizes heme (PrP-Fe(II)) PrP-Fe(III)-OH. Then, reacts PrP-Fe(III)-OH produce PrP-Fe(III)-H H2O. In turn, Fe(III) H act electrophile oxidize Kelch-like ECH-associated protein 1 (Keap1), resulting activating Nrf2. when original highly damaging electrophilicity •OH buffered its porphyrin, provided can indirectly activate reduce stress. Even without lowering dosage, effect alleviated potent considered be hormesis-like. This “Therapeutic Brief” propose that Keywords: Hematin, radical, molecular hydrogen, Nrf2, porphyrin

Language: Английский

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The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7884 - 7884

Published: July 18, 2024

Ischemia/reperfusion injury (IRI) represents a significant contributor to morbidity and mortality associated with various clinical conditions, including acute coronary syndrome, stroke, organ transplantation. During ischemia, profound hypoxic insult develops, resulting in cellular dysfunction tissue damage. Paradoxically, reperfusion can exacerbate this through the generation of reactive oxygen species induction inflammatory cascades. The extensive sequelae IRI necessitate development therapeutic strategies mitigate its deleterious effects. This has become cornerstone ongoing research efforts both basic translational science. review examines use molecular hydrogen for different organs explores underlying mechanisms action. Molecular is selective antioxidant anti-inflammatory, cytoprotective, signal-modulatory properties. It been shown be effective at mitigating models, heart failure, cerebral transplantation, surgical interventions. Hydrogen reduces via mechanisms, like suppression oxidative stress inflammation, enhancement ATP production, decreasing calcium overload, regulating cell death, etc. Further still needed integrate into practice.

Language: Английский

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Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed assess the effect of molecular administration on muscle performance, damage, perception soreness up 24 h recovery after two strenuous training sessions performed same day in elite fin swimmers. Methods: Eight females (mean ± SD; age 21.5 5.0 years, maximal oxygen consumption 45.0 2.5 mL.kg −1 .min ) four males (age 18.9 1.3 52.2 1.7 12 × 50 m sprints morning session a 400 competitive performance afternoon session. Participants consumed hydrogen-rich water (HRW) or placebo 3 days before (1,260 mL/day) 2,520 mL experimental day. Muscle (countermovement jump), damage (creatine kinase), (100 mm visual analogue scale) were measured during at Results: HRW compared reduced blood activity creatine kinase (156 63 vs. 190 64 U.L , p = 0.043), (34 42 mm, 0.045), improved countermovement jump height (30.7 5.5 cm 29.8 5.8 cm, 0.014) Conclusion: Four supplementation is promising hydration strategy for promoting Clinical Trial Registration: clinicaltrials.gov identifier NCT05799911

Language: Английский

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Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 434 - 434

Published: March 13, 2023

(1) Background: Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) therapeutic medical with multiple functions such as anti-oxidant, anti-inflammation, anti-cell death, the stimulation of energy metabolism. To develop disease-modifying treatment for AD through multifactorial mechanisms, an open label pilot study on H2 was conducted. (2) Methods: Eight patients inhaled 3% one hour twice daily 6 months then followed 1 year without inhaling gas. The were clinically assessed using Disease Assessment Scale-cognitive subscale (ADAS-cog). objectively assess neuron integrity, diffusion tensor imaging (DTI) advanced magnetic resonance (MRI) applied to bundles passing hippocampus. (3) Results: mean individual ADAS-cog change showed significant improvement after (−4.1) vs. untreated (+2.6). As by DTI, significantly improved integrity neurons hippocampus initial stage. DTI assessments maintained during follow-up (significantly) or (non-significantly). (4) Conclusions: This suggests that not only relieves temporary symptoms, but also has effects, despite its limitations.

Language: Английский

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Hydrogen therapy: recent advances and emerging materials

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4136 - 4154

Published: Jan. 1, 2024

Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO

Language: Английский

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Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 2, 2023

Background Fatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk injuries. Studies indicate that molecular hydrogen (H 2 ), with antioxidant anti-inflammatory properties, may be a promising strategy alleviate fatigue improve capacity. However, such effects have not been comprehensively characterized. Objective To systematically assess in taking H on capacity healthy adults. Methods The search was conducted August 2022 five databases. randomized controlled or crossover designs investigated rating perceived exertion (RPE), maximal uptake (VO 2max peak 2peak endurance performance were selected. data (mean ± standard deviation sample size) extracted from included studies converted into standardized mean difference (SMD). Random-effects meta-analyses performed. Subgroup analysis used analyze potential sources heterogeneity due intervention period, training status, type exercise. Results Seventeen publications (19 studies) consisting 402 participants included. pooled effect sizes RPE (SMD = −0.38, 95%CI −0.65 −0.11, p 0.006, I 33.6%, 0.149) blood lactate −0.42, 95% CI −0.72 −0.12, 35.6%, 0.114) small yet significant low heterogeneity. VO 0.09, −0.10 0.29, 0.333, 0%, 0.998) 0.01, −0.23 0.25, 0.946, > 0.999) trivial without revealed impacted significantly status (i.e., untrained trained), period implementation, types continuous intermittent exercises). Conclusions This meta-analysis provides moderate evidence supplementation alleviates but does enhance Systematic review registration www.crd.york.ac.uk/PROSPERO/ , identifier: CRD42022351559.

Language: Английский

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Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 234 - 234

Published: Jan. 19, 2025

Background: Hydrogen gas (H2) has been shown to be effective in the treatment of various clinical conditions, from acute illnesses chronic illnesses. However, its indications and corresponding appropriate hydrogen delivery methods have yet determined. This is due fact that pharmacokinetics pharmacodynamics each method not experimentally proven. Here, we verified after infusion hydrogen-saturated saline. Methods: Hydrogen-saturated saline was prepared checked for sterility component specifications. administered intravenously (125 mL/h) through left internal jugular vein pigs, blood concentration measured over time. Results: It confirmed can safely mixed under pressure into intravenous solutions (pharmaceutical products) without contamination foreign substances by using a needle-less vial access cannula. No change PH or composition solution observed filling. The concentrations samples collected 3 cm heart tip line were 6.4 (30 min), 4.7 (60 4.9 (90 5.3 (120 min) ppb w/w, respectively. right atrium 0.7 0.5 ppb, carotid artery 0.1 (pre), 0.2 0.3 0.0 Conclusions: We could pressurized filled (pharmaceutical) objects needle-free When saturated dripped intravenously, almost all expelled during passage lungs supplied arterial side.

Language: Английский

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