Background:
Supplementation
of
olive
oil
and
flaxseed
their
impacts
on
hypertension
inflammation
have
been
reported
for
healthy
hypertensive
adults.
However,
a
comprehensive
systematic
literature
review
meta-analysis
the
preventive
benefit
plant
supplementation
in
adults
at
risk
inducing
is
lacking.
Food and Agricultural Immunology,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 16, 2025
The
Very
Low-Energy
Ketogenic
Therapy
(VLEKT)
is
a
structured,
multi-phase
dietary
regimen
characterized
by
carbohydrate
intake
of
less
than
50
g/day
and
daily
caloric
fewer
800
kcal,
which
induces
ketosis
facilitates
significant
weight
loss.
Evidence
suggests
that
this
nutritional
therapy
can
improve
glycemic
control,
lipid
profiles,
blood
pressure,
making
it
promising
option
for
managing
type
2
diabetes
(T2D)
reducing
cardiovascular
risk.
These
benefits
are
achieved
through
reductions
in
triglycerides
low-density
lipoprotein
cholesterol
(LDL-c),
alongside
increases
high-density
(HDL-c).
However,
the
effects
VLEKT
on
metabolism
remain
controversial.
review
emphasizes
urgent
need
further
research
to
validate
long-term
safety
efficacy
VLEKT.
It
also
highlights
critical
role
personalized
plans,
supervised
healthcare
professionals,
optimize
health
outcomes
address
individual
patient
needs.
Obesity Pillars,
Journal Year:
2025,
Volume and Issue:
14, P. 100164 - 100164
Published: Feb. 1, 2025
This
Obesity
Medicine
Association
(OMA)
Expert
Joint
Perspective
examines
steatotic
liver
disease
(SLD),
which
is
composed
of
metabolic
dysfunction-associated
(MASLD),
and
steatohepatitis
(MASH)
in
children
with
obesity.
The
prevalence
obesity
increasing,
rates
have
tripled
since
1963
from
5
%
to
now
19
US
affected
2018.
MASLD,
the
most
common
seen
children,
can
be
a
precursor
development
Type
2
Diabetes
(T2DM)
primary
reason
for
transplant
listing
young
adults.
We
must
vigilant
prevention
treatment
MASLD
childhood
prevent
further
progression.
joint
clinical
perspective
based
upon
scientific
evidence,
peer
expertise.
medical
literature
was
reviewed
via
PubMed
search
appropriate
articles
were
included
this
review.
work
formulated
collaboration
eight
hepatologists/gastroenterologists
expertise
two
physicians
OMA.
authors
who
are
experts
field,
determined
sentinel
questions
often
asked
by
clinicians
regarding
They
created
consensus
guideline
on
screening,
diagnosis,
associated
children.
comorbidity
increasing
problem
that
needs
addressed
urgently.
It
well
known
chronic
continue
these
diseases
as
adults,
leads
reduced
life
expectancy,
quality
life,
healthcare
financial
burden.
paper
recommend
healthy
weight
reduction
not
only
through
lifestyle
modification
but
pharmacotherapy
bariatric
surgery.
Therefore,
guidance
reviews
available
therapies
achieve
reverse
progressive
fibrosis,
disease.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 965 - 965
Published: March 10, 2025
With
the
prevalence
of
obesity
and
overweight
increasing
at
an
alarming
rate,
more
researchers
are
focused
on
identifying
effective
weight
loss
strategies.
The
ketogenic
diet
(KD),
used
as
a
treatment
in
epilepsy
management
for
over
100
years,
is
additionally
gaining
popularity
method.
Although
its
efficacy
well
documented,
areas
where
it
may
be
beneficial
to
other
dietary
approaches
need
carefully
examined.
objective
this
paper
identify
potential
benefits
KD
alternative
strategies
based
comprehensive
literature
review.
It
has
been
shown
that
bioenergetically
efficient
than
strategies,
inter
alia
owing
effect
curtailing
hunger,
improving
satiety
decreasing
appetite
(influence
hunger
hormones
sensation
hunger),
inducing
faster
initial
(associated
with
lower
glycogen
levels
reduced
water
retention),
controlling
glycaemia
insulinemia
(directly
attributable
low-carbohydrate
nature
indirectly
described).
These
effects
accompanied
by
improved
insulin
sensitivity,
inflammation
(through
ketone
bodies
avoidance
pro-inflammatory
sugars),
pharmacological
control
(the
diet’s
mechanisms
similar
those
medication
but
without
side
effects),
positive
impacts
psychological
factors
food
addiction.
Based
authors’
review
latest
research,
reasonable
conclude
that,
due
these
many
additional
health
benefits,
advantageous
diet-based
This
important
hypothesis
deserves
further
exploration,
which
could
achieved
including
outcome
measures
future
clinical
trials,
especially
when
comparing
different
diets
equal
caloric
value.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 938 - 938
Published: March 24, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
multifaceted
and
heterogeneous
disorder,
linked
with
notable
reproductive,
metabolic,
psychological
outcomes.
During
adolescence,
key
components
of
PCOS
treatment
involve
weight
loss
achieved
through
lifestyle
dietary
interventions,
subsequently
pursued
by
pharmacological
or
surgical
therapies.
Nutritional
interventions
represent
the
first-line
therapeutic
approach
in
adolescents
affected
PCOS,
but
different
kinds
protocols
exist,
so
it
necessary
to
clarify
effectiveness
benefits
most
well-known
nutritional
approaches.
We
provided
comprehensive
review
current
literature
concerning
definition,
pathophysiology,
options,
highlighting
strategies,
particularly
those
related
high-fat
diets.
The
proposed
literature,
such
as
ketogenic
diet
(KD),
appear
provide
patients
terms
control
metabolic
parameters.
Among
types
KD
studies,
very
low-calorie
diets
(VLCKD),
can
be
considered
an
effective
intervention
for
short-term
PCOS.
It
rapidly
leads
alongside
improvements
body
composition
profile.
Even
though
extremely
advantageous,
long-term
adherence
limiting
factor.
Indeed,
this
regimen
could
become
unsustainable
due
important
restrictions
required
ketosis
development.
Thus,
combination
more
nutrient-rich
regimens,
Mediterranean
diet,
amplify
positive
effects
individuals
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(1), P. 22 - 22
Published: Jan. 6, 2025
Background/Objectives:
Managing
type
2
diabetes
mellitus
(T2DM)
and
obesity
requires
a
multidimensional,
patient-centered
approach
including
nutritional
interventions
(NIs)
physical
activity.
Changes
in
the
gut
microbiota
(GM)
have
been
linked
to
metabolic
alterations
typical
of
T2DM
obesity,
they
are
strongly
influenced
by
diet.
However,
few
studies
evaluated
effects
on
GM
very-low-calorie
ketogenic
diet
(VLCKD)
patients
with
T2DM,
especially
mid-term
long-term.
This
longitudinal
study
is
aimed
at
evaluating
long-term
impact
VLCKD
Mediterranean
(MD)
anthropometric,
metabolic,
lifestyle
parameters
11
(diabesity).
extends
previously
published
results
short-term
(three
months)
these
NIs
same
patients.
Methods:
At
baseline,
were
randomly
assigned
either
(KETO
group)
or
(MEDI
group).
After
two
months,
KETO
group
gradually
shifted
(VLCKD-MD),
according
current
guidelines.
From
fourth
month
until
end
both
groups
followed
similar
MD.
Previous
showed
that
had
more
beneficial
than
MD
several
variables
for
3
months
NI.
In
this
study,
analyses
extended
six
(T6)
twelve
(T12)
NI
comparing
data
prospectively
against
baseline
(T0).
The
analysis
was
performed
through
next-generation
sequencing.
Results:
Improvements
anthropometric
pronounced
T6,
particularly
body
mass
index
(−5.8
vs.
−1.7
kg/m2;
p
=
0.006)
waist
circumference
(−15.9
−5.2
cm;
0.011).
significant
improvement
HbA1c
(6.7%
5.5%
0.02)
triglyceride
(158
95
mg/dL
0.04)
values
compared
T0
observed
only
group,
which
maintained
achieved
T3.
VLCKD-MD
phenotype.
A
substantial
positive
modulatory
effect
up
sixth
due
progressive
increase
bacterial
markers
human
health.
month,
most
health
decreased,
though
still
increased
baseline.
Among
them,
Verrucomicrobiota
phylum
identified
as
main
biomarker
together
its
members
Verrucomicrobiae,
Akkermansiaceae,
Verrucomicrobiales,
Akkermansia
T6
Conclusions:
Both
dietary
approaches
ameliorated
status,
but
VLCKD,
support
MD,
has
shown
greater
improvements
parameters,
well
profile,
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(2), P. 85 - 85
Published: Feb. 1, 2025
The
‘Body
Mass
Index’
(BMI)
is
an
anachronistic
and
outdated
ratio
that
used
as
internationally
accepted
diagnostic
criterion
for
obesity,
to
prioritise,
stratify,
outcome-assess
its
management
options.
On
individual
level,
the
BMI
has
potential
mislead,
including
inaccuracies
in
cardiovascular
risk
assessment.
Furthermore,
places
excessive
emphasis
on
a
reduction
overall
body
weight
(rather
than
optimised
composition)
contributes
towards
misunderstanding
of
quiddity
obesity
dispassionate
societal
perspective
response
global
problem.
objective
this
review
provide
overview
transitions
away
from
novel
vista:
viewing
skeletal
muscle
(SM).
We
resurrect
SM
tissue
hidden
plain
sight
key
role
plays
influencing
metabolic
health
efficiency.
discuss
complex
interlinks
between
adipose
(AT)
through
myokines
adipokines,
argue
rather
two
separate
tissues,
AT
should
be
considered
single
entity:
‘Adipo–Muscle
Axis’.
vicious
circle
sarcopenic
which
aging-
obesity-related
decline
mass
worsened
status
insulin
resistance,
turn
further
compounds
function.
approaches
can
mitigate
against
context
negative
energy
balance,
optimisation
dietary
protein
intake
resistance
physical
exercises,
molecules
development
target
SM,
will
play
important
future
obesity.
Finally,
we
Adipo–Muscle
Ratio
(AMR)
would
more
clinically
meaningful
descriptor
definition
help
shift
our
focus
regarding
effective
merely
inducing
loss
optimising
AMR
with
proper
attention
maintenance
augmentation
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 1082 - 1082
Published: April 7, 2024
Background:
Cardiovascular
and
metabolic
diseases
include
a
large
group
of
pathologies
constitute
one
the
most
serious
chronic
health
problems
facing
21st
century,
with
high
rates
morbidity
mortality
worldwide.
Unhealthy
diets
influence
development
these
pathologies.
The
Mediterranean
diet
can
be
an
important
part
in
treatment
diseases.
objective
this
study
was
to
assess
effect
program
that
aims
increase
adherence
on
improvement
different
cardiometabolic
risk
parameters.
Methods:
A
prospective
intervention
carried
out
7034
Spanish
workers.
Prior
intervention,
22
scales
were
evaluated.
Participants
informed
both
orally
writing
characteristics
benefits
given
website
Ministry
Health,
Consumption
Social
Welfare
Spain,
which
provides
advice
nutrition.
Adherence
reinforced
by
sending
monthly
SMS
their
mobile
phones.
After
six
months
follow-up,
re-evaluated
changes.
Means
standard
deviations
calculated
using
Student’s
t
test
analyse
quantitative
variables.
Prevalence
Chi-square
when
variables
qualitative.
Results:
All
studied
decreased
after
implementing
improve
enhance
diet.
number
losses
sample
very
low,
standing
at
4.31%.
Conclusions:
is
effective
reducing
all
cardiovascular
mean
values
prevalence
analysed
led
lower
implementation
We
observed
significant
positive
difference
age
sexes.
have
obtained
insulin
resistance
index,
especially
SPISE-IR
data
we
not
found
previous
publications.
Easy
access
Internet
new
information
communication
technologies
facilitate
reduce
losses.
Endocrine Metabolic & Immune Disorders - Drug Targets,
Journal Year:
2024,
Volume and Issue:
24(15), P. 1794 - 1812
Published: Feb. 12, 2024
The
Mediterranean
diet,
listed
as
the
intangible
cultural
heritage
of
humanity
by
UNESCO,
is
known
healthy
and
consumed
worldwide.
Japanese
diet
also
considered
healthy.
This
narrative
review
compares
with
its
counterpart.
Research
has
reported
that
people
in
regions,
such
Italy
Greece,
have
one-third
mortality
ratio
from
cardiovascular
diseases
compared
to
United
States
Northern
Europe
because
difference
eating
habits.
Therefore,
diets
are
A
typical
Western
containing
high
amounts
fat,
sugar,
calories
responsible
for
several
like
metabolic
syndrome
obesity,
which
induced
chronic
inflammation.
In
contrast,
contain
them
only
less.
similarity
between
substantial
intake
vegetables,
beans,
fish.
On
other
hand,
consumes
large
olive
oil,
especially
polyphenol-rich
extra
virgin
oil
dairy
products,
but
meat
consumption
relatively
small.
does
not
use
contains
abundant
fermented
foods,
seaweed.
Japan
longevity,
think
a
well-balanced
daily
good
preventing
curing
illness.
this
regard,
finding
non-disease
conditions,
so-called
"ME-BYO,"
before
manifestation
becoming
more
common.
review,
we
discuss
habit,
"The
Mediterranean-styled
diet,"
prevents
ME-BYO
condition
reduces
risk
various
diseases.
hybrid
diets,
suppressing
nutritional
intervention
beneficial
longevity.
Hence,
might
be
helpful
longevity
around
world.
Microbiome Research Reports,
Journal Year:
2024,
Volume and Issue:
3(2)
Published: May 17, 2024
The
global
prevalence
of
obesity
currently
exceeds
1
billion
people
and
is
accompanied
by
an
increase
in
the
aging
population.
Obesity
share
many
hallmarks
are
leading
risk
factors
for
cardiometabolic
disease
premature
death.
Current
anti-obesity
pro-longevity
pharmacotherapies
limited
side
effects,
warranting
development
novel
therapies.
gut
microbiota
plays
a
major
role
human
health
disease,
with
dysbiotic
composition
evident
obese
aged
individuals.
bidirectional
communication
system
between
central
nervous
system,
known
as
gut-brain
axis,
may
link
to
unhealthy
aging.
Modulating
microbiome-targeted
therapies,
such
biotics,
strategy
treat
and/or
manage
promote
longevity.
Biotics
represent
material
derived
from
living
or
once-living
organisms,
which
have
therapeutic
effects.
Pre-,
pro-,
syn-
post-biotics
beneficially
modulate
microbial
function
improve
process.
However,
investigation
biotics
next-generation
therapeutics
has
only
just
begun.
Further
research
needed
identify
understand
their
mechanisms
action.
Investigating
axis
lead
strategies
obese,
comorbid
(e.g.,
sarcopenic
obese)
patient
populations.
This
review
discusses
interrelationship
aging,
particular
emphasis
on
microbiome,
presents
agents
obesity,
related
states.