Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 16, 2025

The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by carbohydrate intake of less than 50 g/day and daily caloric fewer 800 kcal, which induces ketosis facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, blood pressure, making it promising option for managing type 2 diabetes (T2D) reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides low-density lipoprotein cholesterol (LDL-c), alongside increases high-density (HDL-c). However, the effects VLEKT on metabolism remain controversial. review emphasizes urgent need further research to validate long-term safety efficacy VLEKT. It also highlights critical role personalized plans, supervised healthcare professionals, optimize health outcomes address individual patient needs.

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Children with Obesity: An Obesity Medicine Association (OMA) and Expert Joint Perspective 2025

Obesity Pillars, Journal Year: 2025, Volume and Issue: 14, P. 100164 - 100164

Published: Feb. 1, 2025

This Obesity Medicine Association (OMA) Expert Joint Perspective examines steatotic liver disease (SLD), which is composed of metabolic dysfunction-associated (MASLD), and steatohepatitis (MASH) in children with obesity. The prevalence obesity increasing, rates have tripled since 1963 from 5 % to now 19 US affected 2018. MASLD, the most common seen children, can be a precursor development Type 2 Diabetes (T2DM) primary reason for transplant listing young adults. We must vigilant prevention treatment MASLD childhood prevent further progression. joint clinical perspective based upon scientific evidence, peer expertise. medical literature was reviewed via PubMed search appropriate articles were included this review. work formulated collaboration eight hepatologists/gastroenterologists expertise two physicians OMA. authors who are experts field, determined sentinel questions often asked by clinicians regarding They created consensus guideline on screening, diagnosis, associated children. comorbidity increasing problem that needs addressed urgently. It well known chronic continue these diseases as adults, leads reduced life expectancy, quality life, healthcare financial burden. paper recommend healthy weight reduction not only through lifestyle modification but pharmacotherapy bariatric surgery. Therefore, guidance reviews available therapies achieve reverse progressive fibrosis, disease.

Language: Английский

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Impact of Ketogenic and Mediterranean Diets on Gut Microbiota Profile and Clinical Outcomes in Drug-Naïve Patients with Diabesity: A 12-Month Pilot Study

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 22 - 22

Published: Jan. 6, 2025

Background/Objectives: Managing type 2 diabetes mellitus (T2DM) and obesity requires a multidimensional, patient-centered approach including nutritional interventions (NIs) physical activity. Changes in the gut microbiota (GM) have been linked to metabolic alterations typical of T2DM obesity, they are strongly influenced by diet. However, few studies evaluated effects on GM very-low-calorie ketogenic diet (VLCKD) patients with T2DM, especially mid-term long-term. This longitudinal study is aimed at evaluating long-term impact VLCKD Mediterranean (MD) anthropometric, metabolic, lifestyle parameters 11 (diabesity). extends previously published results short-term (three months) these NIs same patients. Methods: At baseline, were randomly assigned either (KETO group) or (MEDI group). After two months, KETO group gradually shifted (VLCKD-MD), according current guidelines. From fourth month until end both groups followed similar MD. Previous showed that had more beneficial than MD several variables for 3 months NI. In this study, analyses extended six (T6) twelve (T12) NI comparing data prospectively against baseline (T0). The analysis was performed through next-generation sequencing. Results: Improvements anthropometric pronounced T6, particularly body mass index (−5.8 vs. −1.7 kg/m2; p = 0.006) waist circumference (−15.9 −5.2 cm; 0.011). significant improvement HbA1c (6.7% 5.5% 0.02) triglyceride (158 95 mg/dL 0.04) values compared T0 observed only group, which maintained achieved T3. VLCKD-MD phenotype. A substantial positive modulatory effect up sixth due progressive increase bacterial markers human health. month, most health decreased, though still increased baseline. Among them, Verrucomicrobiota phylum identified as main biomarker together its members Verrucomicrobiae, Akkermansiaceae, Verrucomicrobiales, Akkermansia T6 Conclusions: Both dietary approaches ameliorated status, but VLCKD, support MD, has shown greater improvements parameters, well profile,

Language: Английский

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Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 965 - 965

Published: March 10, 2025

With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.

Language: Английский

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High Fat Diet and Polycystic Ovary Syndrome (PCOS) in Adolescence: An Overview of Nutritional Strategies

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 938 - 938

Published: March 24, 2024

Polycystic ovary syndrome (PCOS) is a multifaceted and heterogeneous disorder, linked with notable reproductive, metabolic, psychological outcomes. During adolescence, key components of PCOS treatment involve weight loss achieved through lifestyle dietary interventions, subsequently pursued by pharmacological or surgical therapies. Nutritional interventions represent the first-line therapeutic approach in adolescents affected PCOS, but different kinds protocols exist, so it necessary to clarify effectiveness benefits most well-known nutritional approaches. We provided comprehensive review current literature concerning definition, pathophysiology, options, highlighting strategies, particularly those related high-fat diets. The proposed literature, such as ketogenic diet (KD), appear provide patients terms control metabolic parameters. Among types KD studies, very low-calorie diets (VLCKD), can be considered an effective intervention for short-term PCOS. It rapidly leads alongside improvements body composition profile. Even though extremely advantageous, long-term adherence limiting factor. Indeed, this regimen could become unsustainable due important restrictions required ketosis development. Thus, combination more nutrient-rich regimens, Mediterranean diet, amplify positive effects individuals

Language: Английский

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The Recommendation of the Mediterranean-styled Japanese Diet for Healthy Longevity

Endocrine Metabolic & Immune Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 24(15), P. 1794 - 1812

Published: Feb. 12, 2024

The Mediterranean diet, listed as the intangible cultural heritage of humanity by UNESCO, is known healthy and consumed worldwide. Japanese diet also considered healthy. This narrative review compares with its counterpart. Research has reported that people in regions, such Italy Greece, have one-third mortality ratio from cardiovascular diseases compared to United States Northern Europe because difference eating habits. Therefore, diets are A typical Western containing high amounts fat, sugar, calories responsible for several like metabolic syndrome obesity, which induced chronic inflammation. In contrast, contain them only less. similarity between substantial intake vegetables, beans, fish. On other hand, consumes large olive oil, especially polyphenol-rich extra virgin oil dairy products, but meat consumption relatively small. does not use contains abundant fermented foods, seaweed. Japan longevity, think a well-balanced daily good preventing curing illness. this regard, finding non-disease conditions, so-called "ME-BYO," before manifestation becoming more common. review, we discuss habit, "The Mediterranean-styled diet," prevents ME-BYO condition reduces risk various diseases. hybrid diets, suppressing nutritional intervention beneficial longevity. Hence, might be helpful longevity around world.

Language: Английский

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The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1082 - 1082

Published: April 7, 2024

Background: Cardiovascular and metabolic diseases include a large group of pathologies constitute one the most serious chronic health problems facing 21st century, with high rates morbidity mortality worldwide. Unhealthy diets influence development these pathologies. The Mediterranean diet can be an important part in treatment diseases. objective this study was to assess effect program that aims increase adherence on improvement different cardiometabolic risk parameters. Methods: A prospective intervention carried out 7034 Spanish workers. Prior intervention, 22 scales were evaluated. Participants informed both orally writing characteristics benefits given website Ministry Health, Consumption Social Welfare Spain, which provides advice nutrition. Adherence reinforced by sending monthly SMS their mobile phones. After six months follow-up, re-evaluated changes. Means standard deviations calculated using Student’s t test analyse quantitative variables. Prevalence Chi-square when variables qualitative. Results: All studied decreased after implementing improve enhance diet. number losses sample very low, standing at 4.31%. Conclusions: is effective reducing all cardiovascular mean values prevalence analysed led lower implementation We observed significant positive difference age sexes. have obtained insulin resistance index, especially SPISE-IR data we not found previous publications. Easy access Internet new information communication technologies facilitate reduce losses.

Language: Английский

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Methodological insights into intervention and outcomes in randomised controlled trials of herbal medicine for obesity: a scoping review

Therapeutic Advances in Chronic Disease, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 1, 2025

Background: With rising obesity rates worldwide, clinical trials focused on identifying effective treatments are increasing. While guidelines exist for pharmaceutical drugs targeting obesity, there none herbal medicine anti-obesity. Both industries refer to the same trials. Objectives: This scoping review aimed gather information from anti-obesity randomised controlled (RCTs), analyse methodologies and assess their alignment with international guidelines. Eligibility criteria: included RCTs of participants all ages utilising any comparators focusing various outcome measures. Sources evidence: Only published journal articles were included. Charting methods: Articles extracted MEDLINE, CENTRAL EMBASE using predetermined keywords. Relevant data, such as study characteristics, types interventions controls, treatment durations, measures safety monitoring methods recorded in a table format comparative analysis. Results: We 99 that showed participant sample sizes ranging 8 182, 18 80 years body mass indexes (BMIs) between 25 49.9 kg/m 2 . Herbal used single herbs ( n = 57) mixtures 42), given 14 days 56 weeks. Studies implementing diet modifications include restricted calorie diets 35), food-portion 7) fixed 7). Of 28 studies exercise, most moderate intensity 22). All collected BMI weight primary outcomes. Body fat composition was measured over 50% analyser 57). Waist, hip abdominal circumferences infrequently measured. Radiological tools dual-energy X-ray absorptiometry 16), computed tomography scans 10) ultrasound 2). Safety reported 76). Conclusion: In conclusion, almost adhered trial guidelines, addressing dietary, lifestyle, physical activity cardiovascular risk factors. Nonetheless, more need consider assessment maintenance.

Language: Английский

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Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 85 - 85

Published: Feb. 1, 2025

The ‘Body Mass Index’ (BMI) is an anachronistic and outdated ratio that used as internationally accepted diagnostic criterion for obesity, to prioritise, stratify, outcome-assess its management options. On individual level, the BMI has potential mislead, including inaccuracies in cardiovascular risk assessment. Furthermore, places excessive emphasis on a reduction overall body weight (rather than optimised composition) contributes towards misunderstanding of quiddity obesity dispassionate societal perspective response global problem. objective this review provide overview transitions away from novel vista: viewing skeletal muscle (SM). We resurrect SM tissue hidden plain sight key role plays influencing metabolic health efficiency. discuss complex interlinks between adipose (AT) through myokines adipokines, argue rather two separate tissues, AT should be considered single entity: ‘Adipo–Muscle Axis’. vicious circle sarcopenic which aging- obesity-related decline mass worsened status insulin resistance, turn further compounds function. approaches can mitigate against context negative energy balance, optimisation dietary protein intake resistance physical exercises, molecules development target SM, will play important future obesity. Finally, we Adipo–Muscle Ratio (AMR) would more clinically meaningful descriptor definition help shift our focus regarding effective merely inducing loss optimising AMR with proper attention maintenance augmentation

Language: Английский

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Dietary Patterns and Nutritional Status in Bariatric Surgery Candidates—A Cross-Sectional Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 716 - 716

Published: Feb. 18, 2025

Observing a patient's dietary behaviour before bariatric surgery may help to predict their diet (and indirectly, the rate of weight loss) after procedure. Consequently, aim this study was identify patterns (DPs) in candidates, as well assess relationship between DPs, degree obesity, and body composition. The participants were comprised 117 candidates. Data concerning diet, lifestyle, socioeconomic status collected using KomPAN® questionnaire. following three DPs identified principal component analysis: 'Sandwiches & Sweets', 'Fast Food, Convenience Food Alcohol' 'Prudent'. Baseline nutritional composition electric bioimpedance assessed. Differences found Prudent DP primarily involved high consumption healthy products. Following DP, differentiated obesity most. In turn, Fast Alcohol associated with higher likelihood Degree III very visceral fat level (VFL). Sandwiches Sweets included most VFL. candidates shown follow different diets, could be identified. Patients followed more beneficial which likely due awareness risks morbidity post-surgical complications. Socioeconomic factors attenuate association

Language: Английский

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