Constitution of Long COVID illness, patienthood and recovery: a critical synthesis of qualitative studies DOI Creative Commons
Mia Harrison, Tim Rhodes, Kari Lancaster

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(3), P. e083340 - e083340

Published: March 1, 2024

Objectives To investigate the lived experiences of Long COVID. Design Critical interpretive synthesis qualitative research. Data sources PubMed and Web Science databases were searched on 14 September 2023. Eligibility criteria Original peer-reviewed studies describing COVID eligible for inclusion. extraction We used established methods to search, screen manually code included studies. interpretation analyse data develop synthetic constructs. Results 68 articles identified in first phase sampling, with 16 879 participants final synthesis. The analysis these was organised into three thematic constructions COVID: (1) illness, (2) patient (3) recovery. diversely characterised across study approaches, designs findings but underpinned by shared diagnostic logics, which shaped identification measurement symptoms. boundaries between different constitutions accounts illness experience often imprecise. Slippages definitions had implications relation diagnosis, help-seeking care, expectations Conclusions is a site multiple diverse interpretation. Accounts emphasise patienthood recovery as situated emergent. ongoing context-based negotiation defining feature condition. Approaches researching, diagnosing developing health interventions must be adaptive varieties experience.

Language: Английский

Clinical and Laboratory Characteristics of Fatigue-Dominant Long-COVID Subjects: A Cross-Sectional Study DOI
Jin‐Seok Lee, Yujin Choi,

Jin‐Yong Joung

et al.

The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Language: Английский

Citations

10
Anxiety and depression symptoms among patients with long COVID: a retrospective cohort study DOI
M. Sauer, Patrick B. Barlow, Alejandro P. Comellas

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 17, 2024

Language: Английский

Citations

9
Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial DOI Creative Commons
Dhammika Leshan Wannigama, Cameron Hurst, Phatthranit Phattharapornjaroen

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 70, P. 102517 - 102517

Published: March 14, 2024

Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials studied combinations these agents. The aim this trial was to assess effectiveness affordable, widely available, repurposed used combination for which may be particularly relevant low-resource countries.

Language: Английский

Citations

9
Experiencias de las personas con sintomatología neuropsicológica de covid persistente en Cataluña: un estudio fenomenológico DOI
Eduard Moreno‐Gabriel, Jofre Bielsa-Pascual, Maria Verdaguer

et al.

Atención Primaria, Journal Year: 2025, Volume and Issue: 57(6), P. 103214 - 103214

Published: Jan. 23, 2025

Language: Английский

Citations

1
An exploration of the experiences and self-generated strategies used when navigating everyday life with Long Covid DOI Creative Commons
Fiona J Leggat, Celayne Heaton‐Shrestha, Jessica N. Fish

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 13, 2024

Abstract Background Around one in ten people who contract Covid-19 report ongoing symptoms or ‘Long Covid’. Without any known interventions to cure the condition, forms of self-management are routinely prescribed by healthcare professionals and described with condition. However, there is limited research exploring what strategies used navigate everyday life Long Covid, experiences that initiate development these strategies. Our study aimed explore range influence self-generated Covid within context their own Methods Forming part Personalised Self-managemenT support co-design EvaluatioN (LISTEN) project, we conducted a qualitative using narrative interviews adults were not hospitalised Covid-19. Participants aged over 18 years, self-identified recruited from England Wales. Data analysed patient contributors reflexive thematic analysis. Results Eighteen participants (mean age = 44 SD 13 years) took held between December 2021 February 2022. Themes constructed which depicted 1) landscape behind experience 2) participants’ Covid. The comprised combination physical, emotional, social factors, forming three sub-themes: centrality physical symptoms, navigating ‘experts’ ‘true colour’ personal communities, rollercoaster psychological ambiguity ). third theme, manage was unique presentations solutions life. This five seeking reassurance knowledge, developing greater self-awareness through monitoring, trial error ‘safe’ ideas, building pleasure comfort, prioritising ‘me’ . Conclusions Among this sample highlighted unpredictable nature condition but also use creative wide ranging results offer supporting them, an overview collective evidence relating individuals' can enable ways live ‘better’ regain some sense identity whilst facing impact debilitating, episodic Trial registration LISTEN ISRCTN36407216.

Language: Английский

Citations

7
Personalized Computerized Training for Cognitive Dysfunction after COVID-19: A Before-and-After Feasibility Pilot Study DOI Open Access
Jon Andoni Duñabeitia,

Francisco Mera,

Óscar Baro

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 3100 - 3100

Published: Feb. 10, 2023

The current pilot study was set to evaluate the feasibility and potential benefit of a personalized computerized cognitive training (CCT) intervention improve function among people living with post-acute sequelae COVID-19 (PASC). Seventy three adults who self-reported dysfunction more than 3 months after diagnosis took part in an 8-week study. Participants' general assessed before they completed as many daily sessions wished during period, using CCT application at home. At end this participants repeated assessment. differences between scores 8 weeks baseline five domains (attention, memory, coordination, perception, reasoning), complemented analyses changes based on participants' age, time, health level time since initial infection. Participants had significant negative levels baseline. Most obtained higher each compared magnitude score increase high across domains. It is concluded that self-administered gamified tasks could be effective way ameliorate persons PASC. ClinicalTrials.gov identifier NCT05571852.

Language: Английский

Citations

13
Role of the microbiota-gut-brain axis in postacute COVID syndrome DOI
Mélanie G. Gareau, Kim E. Barrett

AJP Gastrointestinal and Liver Physiology, Journal Year: 2023, Volume and Issue: 324(4), P. G322 - G328

Published: March 7, 2023

The COVID-19 pandemic has resulted in the infection of hundreds millions individuals over past 3 years, coupled with deaths. Along these more acute impacts infection, a large subset patients developed symptoms that collectively comprise "postacute sequelae COVID-19" (PASC, also known as long COVID), which can persist for months and maybe even years. In this review, we outline current knowledge on role impaired microbiota-gut-brain (MGB) axis signaling development PASC potential mechanisms involved, may lead to better understanding disease progression treatment options future.

Language: Английский

Citations

13
Depression and brain fog as long-COVID mental health consequences: Difficult, complex and partially successful treatment of a 72-year-old patient—A case report DOI Creative Commons
Māris Taube

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: March 24, 2023

SARS-CoV-2 (COVID-19) infection can result in long-term health consequences i.e., long COVID. The clinical manifestations of COVID include depression, anxiety, brain fog with cognitive dysfunction, memory issues, and fatigue. These delayed effects COVID-19 occur up to 30% people who have had an acute case COVID-19. In this report, a 72-year-old, fully vaccinated patient without pre-existing somatic or mental illnesses, other relevant risk factors was diagnosed Nine months following infection, the patient's depressive symptoms improved, but concentration difficulties persisted, remains unable resume work. are possibly linked micro-hemorrhages detected during examinations infection. Patient treatment complex, positive results were attained via antidepressants non-drug therapies e.g., art, music, drama, dance movement therapy, physiotherapy, occupational psychotherapy.

Language: Английский

Citations

12
Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome DOI Creative Commons
Jacob Saucier, Dominique Comeau, Gilles A. Robichaud

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Introduction As the repercussions from COVID-19 pandemic continue to unfold, an ever-expanding body of evidence suggests that infection also elicits pathophysiological manifestations within central nervous system (CNS), known as neurological symptoms post-acute sequelae COVID (NeuroPASC). Although impairments and associated with NeuroPASC have been well described in literature, its etiology remains be fully characterized. Objectives This mini-review explores current literature elucidates various mechanisms underlining NeuroPASC, players, regulators, leading persistent neuroinflammation affected individuals. Specifically, we provide some insights into roles played by microglial astroglial cell reactivity how these subsets potentially contribute impairment response direct or indirect CNS injury. Discussion A better understanding biomarkers this maladaptive neuroimmune will thus diagnostic strategies for reveal new potential therapeutic intervention. Altogether, elucidation pathogenesis improve patient outcomes mitigate socioeconomic burden syndrome.

Language: Английский

Citations

11
Long COVID and gut microbiome: insights into pathogenesis and therapeutics DOI Creative Commons
Raphaela Iris Lau, Qi Su, Siew C. Ng

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

Post-acute coronavirus disease 2019 syndrome (PACS), following severe acute respiratory 2 (SARS-CoV-2) infection or (COVID-19), is typically characterized by long-term debilitating symptoms affecting multiple organs and systems. Unfortunately, there currently a lack of effective treatment strategies. Altered gut microbiome has been proposed as one the plausible mechanisms involved in pathogenesis PACS; extensive studies have emerged to bridge gap between persistent dysbiosis microbiome. Recent clinical trials indicated that modulation using probiotics, prebiotics, fecal microbiota transplantation (FMT) led improvements related PACS, including fatigue, memory loss, difficulty concentration, gastrointestinal upset, disturbances sleep mood. In this review, we highlight latest evidence on key microbial alterations observed well use microbiome-based therapeutics managing PACS symptoms. These novel findings altogether shed light other chronic conditions.

Language: Английский

Citations

0