Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: March 22, 2024

In the field of eye health, profound impact exercise and physical activity on various ocular diseases has become a focal point attention. This review summarizes elucidates positive effects activities common diseases, including dry disease (DED), cataracts, myopia, glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD). It also catalogues offers recommendations based varying impacts that different types intensities may have specific conditions. Beyond correlations, this compiles potential mechanisms through which beneficially affect health. From mitigating oxidative stress inflammatory responses, reducing intraocular pressure, enhancing mitochondrial function, to promoting blood circulation release protective factors, complex biological triggered by reveal their substantial in preventing even assisting treatment diseases. aims not only foster awareness appreciation for how can improve health but serve as catalyst further exploration into key targets Such inquiries are crucial advancing innovative strategies thereby holding significant implications development new therapeutic approaches.

Language: Английский

---

Myopia Is an Ischemic Eye Condition: A Review from the Perspective of Choroidal Blood Flow

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2777 - 2777

Published: May 9, 2024

Myopia is a common refractive error that affects large proportion of the population. Recent studies have revealed alterations in choroidal thickness (ChT) and blood flow (ChBF) play important roles progression myopia. Reduced ChBF could affect scleral cellular matrix remodeling, which leads to axial elongation further myopia progression. As ChT be used as potential biomarkers for myopia, several recent treatments targeted ChBF. Our review provides comprehensive overview literature on relationship between We also highlight importance an biomarker This summary has significant implications development novel strategies preventing treating

Language: Английский

---

Practicing Meta-Analytics with Rectification

Publications, Journal Year: 2025, Volume and Issue: 13(1), P. 2 - 2

Published: Jan. 2, 2025

This article demonstrates the necessity of assessing homogeneity in meta-analyses using Higgins method. The researchers realize importance meta-analytic work. However, a significant issue with method has been identified. In this article, we explain nature problem and propose solutions to address it. Our narrative is point out problem, analyze it, present it well. A prerequisite check consistency findings comparable studies that should be homogeneous, not heterogeneous. I2 score, version Cochran Q value, commonly used assess heterogeneity. score an improvement value. there statistically. supposed follow Chi-squared distribution, but does do so because distribution becomes invalid once less than degrees freedom. was recently rectified alternative (S2 score). Using method, examined 14 published articles representing 133 datasets observed many declared homogeneous by were, fact, urges research community cautious making inferences

Language: Английский

---

Prevalence and associated factors of myopia among adolescents aged 12–15 in Shandong Province, China: a cross-sectional study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 27, 2024

Myopia is a growing concern worldwide, especially among adolescents. This study aimed to investigate the prevalence and associated factors of myopia in adolescents aged 12-15 Shandong Province, China. cross-sectional adhered Strengthening Reporting Observational Studies Epidemiology guidelines involved stratified random cluster sampling 128,678 students from 186 middle schools across 17 cities Province. Data collection was conducted March April 2024. We excluded with organic eye diseases, abnormal binocular vision functions, or history injuries surgeries. assessed using standard logarithmic visual acuity chart autorefractor without inducing ciliary muscle paralysis. A comprehensive questionnaire survey gather demographic characteristics daily life behaviors. With chi-squared test for univariable analysis multivariable logistic regression identifying significant factors. included 126,375 participants, gender distribution 51.02% male 48.98% female. The overall 71.34%. Higher observed girls (72.26%) compared boys (70.45%), increased age, peaking at 73.12% 15-year-olds. Urban residents had higher (71.86%) than rural (70.39%). Factors such as frequency usage while lying down leaning forward, frequent use eyes walking riding car, prolonged screen time, extended homework duration were odds developing myopia. Conversely, outdoor exercise, maintaining proper posture during reading writing, greater distance screen, longer sleep lower odds. Additionally, female gender, older urban residence, parental risk. high Province influenced by combination demographic, behavioral, environmental highlighted importance lifestyle modifications, increasing activities habits, limiting exposure sessions, extending duration, mitigate risk These findings underscored need targeted public health interventions educational campaigns address this issue.

Language: Английский

---

Analysis of Secondhand Smoke Exposure and Myopia Among Children Aged 6 to 8 Years in Hong Kong

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(5), P. e2313006 - e2313006

Published: May 11, 2023

Importance Secondhand smoke (SHS) exposure potentially threatens ocular health; however, its association with myopia is unknown. Objective To examine the between SHS and childhood myopia. Design, Setting, Participants Cross-sectional data from population-based Hong Kong Children Eye Study were used. Data collected March 5, 2015, to September 12, 2021, at The Chinese University of Center. included children aged 6 8 years. was evaluated using a validated questionnaire. All participants underwent comprehensive ophthalmic physical examinations. Exposure exposure. Main Outcomes Measures Generalized estimating equations constructed spherical equivalent axial length; logistic regression models, rate; linear onset. Results A total 12 630 (mean [SD] age, 7.37 [0.88] years; 53.2% boys) in analysis. Among participants, 4092 (32.4%) had After adjusting for sex, parental myopia, body mass index, near-work time, outdoor family income, associated greater myopic refraction (β = −0.09 [95% CI, −0.14 −0.03]) longer length 0.05 0.02-0.08]). more likely develop moderate (odds ratio [OR], 1.30 1.06-1.59]) high (OR, 2.64 1.48-4.69]). equivalence magnified younger children. For each year child’s SHS, 0.07-D decrease 0.07 0.01-0.13]) 0.05-mm increase −0.05 −0.08 −0.01]). an earlier mean (SD) age onset (72.8 [0.9] vs 74.6 [0.6] months; P .01). Every units 10 cigarettes per day −0.07 −0.11 −0.02]), 0.04 0.01-0.06]), likelihood developing 1.23 1.05-1.44]) 1.75 1.20-2.56]), −1.30 −2.32 −0.27]). Conclusions Relevance findings this cross-sectional study suggest that refraction, length, larger quantity child, advanced development progression which associated.

Language: Английский

---

Safety and efficacy of 0.01% and 0.1% low-dose atropine eye drop regimens for reduction of myopia progression in Danish children: a randomized clinical trial examining one-year effect and safety

BMC Ophthalmology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 30, 2023

Abstract Background To investigate the efficacy and safety of 0.1% 0.01% low-dose atropine eye drops in reducing myopia progression Danish children. Methods Investigator-initiated, placebo-controlled, double-masked, randomized clinical trial. Ninety-seven six- to twelve-year old myopic participants were loading dose for six months followed by (loading group, Number (N) = 33), twelve (0.01% N 32) or vehicle (placebo, 32). Primary outcomes axial length spherical equivalent refraction. Secondary included adverse events reactions, choroidal thickness ocular biometry. Outcomes measured at baseline three-month intervals. Data was analyzed with linear-mixed model analysis according intention-to-treat. Results Mean elongation 0.10 mm less (95% confidence interval (CI): 0.17; 0.02, adjusted-p 0.06) 0.07 CI: 0.15; 0.00, 0.16) group compared placebo. refraction 0.24 D 0.05; 0.42) 0.19 0.00; 0.38) groups months, placebo (adjusted-p 0.06 0.14, respectively). A total 108 reported during initial six-month period, primarily 14 following switching, all deemed mild except two serious events, unrelated intervention. Conclusions Low-dose are safe over otherwise healthy There may be a modest but clinically relevant reduction children after treatment, effect statistically non-significant multiple comparisons adjustment. After dose-switching approached potentially indicating an early “rebound-effect”. Trial registration this study registered European Clinical Trials Database (EudraCT, number: 2018-001286-16) 05/11/2018 first posted www.clinicaltrials.gov (NCT03911271) 11/04/2019, prior initiation.

Language: Английский

---

The impact of lifestyle factors on myopia development: Insights and recommendations

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100010 - 100010

Published: April 1, 2024

This study evaluates the influence of various lifestyle factors, such as screen time, physical inactivity, dietary habits, and psychological stress, on development progression myopia in comparison to genetic predisposition. It underscores critical role adopting healthier lifestyles minimize risk myopia, especially genetically susceptible individuals. integrates a systematic review existing literature with empirical data assess relationship between habits providing nuanced understanding its multifaceted etiology. Comprehensive analysis from multiple institutional clinical studies. The includes research individuals across spectrum, examining factors addition influences. Analysis focused behaviors, including digital device use, activity, patterns, sleep quality relation myopia. Correlation prevalence choices susceptibility. results highlight strong association behaviors predispositions exacerbating effects detrimental habits. In particular, proactive modifications, increasing outdoor appear be effective preventing supports an integrative approach management, emphasizing modifications conjunction awareness. calls for comprehensive public health strategies address increase advocating balanced interplay maintaining health, engaging activities, promoting mental wellness counteract multifactorial risks associated development.

Language: Английский

---

Lifestyle Factors in Myopic Spanish Children

Children, Journal Year: 2024, Volume and Issue: 11(2), P. 139 - 139

Published: Jan. 23, 2024

Background: Childhood myopia represents a global concern with increasing prevalence in recent decades. Lifestyle factors significantly impact myopia. Aim: To evaluate lifestyle myopic children from metropolitan area Europe. Methods: This was descriptive study including subjects aged 4–18 years. Patient demographic and clinical data were collected, cycloplegic refraction spherical equivalent (SER) axial length (AL). In addition, questionnaire on conducted between September 2022 April 2023. Results: A total of 321 included, 10.72 ± 3.05 years, whom 51.4% boys, SER −2.25 1.9 D AL 24.54 0.98 mm. The mean age onset 7.69 59.8% had family history Those who <2 h/day screen time (on weekdays) presented −2 1.91 D, compared to those >2 h/day, SER: −2.50 ±1.88 (p = 0.009). Children spent doing near work after school less (SER: −1.75 1.83 vs. −2.75 1.82, respectively, p 0.03). However, no significant association observed outdoors nor academic performance > 0.05). Conclusions: Screen near-work appear be related

Language: Английский

---

Synergistic effect of defocus incorporated multiple segment glasses and repeated low level red light therapy against myopia progression

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Defocus incorporated multiple segment (DIMS) lenses and repeated low-level red-light (RLRL) are used to retard myopia progression. However, it is currently unknown if there a synergistic effect of the two interventions. In current study, 190 school-aged children with (380 eyes) were studied for change in axial length (AL) over nearly one year follow-up. Of 380 eyes, 170 eyes wore DIMS lenses, 80 had RLRL therapy, 130 both interventions (DIMS_RLRL) control. AL changes calculated at each follow-up visit by subtracting baseline measurements normalized yearly mm. as primary outcome analyzed generalized linear mixed model compare sizes control among three while adjusting age, sex, length, length. Participants mean age 9.84 ± 2.63 years old, 24.49 1.20 mm, SER -2.90 2.08 diopters, time 301 91 days. By end adjusted combination therapy was - 0.13 -0.04 mm alone, 0.16 alone (p < 0.0001). Combination has significantly greater size controlling progression than either = 0.0009) or

Language: Английский

---

Color vision-associated environmental and biological factors in the development of myopia

Experimental Eye Research, Journal Year: 2025, Volume and Issue: 254, P. 110324 - 110324

Published: March 7, 2025

Language: Английский

---