Nanomaterials,
Journal Year:
2020,
Volume and Issue:
10(1), P. 119 - 119
Published: Jan. 8, 2020
This
paper
provides
a
comprehensive
overview
of
nanofibrous
structures
for
tissue
engineering
purposes
and
the
role
non-thermal
plasma
technology
(NTP)
within
this
field.
Special
attention
is
first
given
to
nanofiber
fabrication
strategies,
including
thermally-induced
phase
separation,
molecular
self-assembly,
electrospinning,
highlighting
their
strengths,
weaknesses,
potentials.
The
review
then
continues
discuss
biodegradable
polyesters
typically
employed
fabrication,
while
primary
focus
lies
on
applicability
limitations.
From
thereon,
reader
introduced
concept
NTP
its
application
in
plasma-assisted
surface
modification
scaffolds.
final
part
discusses
available
literature
NTP-modified
nanofibers
looking
at
impact
activation
polymerization
treatments
wettability,
chemistry,
cell
adhesion/proliferation
protein
grafting.
As
such,
complete
introduction
into
nanofibers,
aiming
address
current
unexplored
potentials
left
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(32)
Published: June 12, 2021
Abstract
During
natural
tissue
regeneration,
microenvironment
and
stem
cell
niche
including
cell–cell
interaction,
soluble
factors,
extracellular
matrix
(ECM)
provide
a
train
of
biochemical
biophysical
cues
for
modulation
behaviors
functions.
Design
functional
biomaterials
to
mimic
the
tissue/cell
have
great
potentials
regeneration
applications.
Recently,
electroactive
drawn
increasing
attentions
not
only
as
scaffolds
adhesion
structural
support,
but
also
modulators
regulate
cell/tissue
function,
especially
electrically
excitable
cells
tissues.
More
importantly,
electrostimulation
can
further
modulate
myriad
biological
processes,
from
cycle,
migration,
proliferation
differentiation
neural
conduction,
muscle
contraction,
embryogenesis,
regeneration.
In
this
review,
endogenous
bioelectricity
piezoelectricity
are
introduced.
Then,
design
rationale
is
discussed
imitating
dynamic
microenvironment,
well
their
mediated
applying
pathways.
Recent
advances
in
systematically
overviewed
fate
mainly
nerve
bone
engineering,
cardiac
engineering.
Finally,
significance
simulating
native
emphasized
open
challenges
future
perspectives
concluded.
Nanomaterials,
Journal Year:
2020,
Volume and Issue:
11(1), P. 21 - 21
Published: Dec. 24, 2020
Many
types
of
polymer
nanofibers
have
been
introduced
as
artificial
extracellular
matrices.
Their
controllable
properties,
such
wettability,
surface
charge,
transparency,
elasticity,
porosity
and
to
volume
proportion,
attracted
much
attention.
Moreover,
functionalizing
polymers
with
other
bioactive
components
could
enable
the
engineering
microenvironments
host
cells
for
regenerative
medical
applications.
In
current
brief
review,
we
focus
on
most
recently
cited
electrospun
nanofibrous
polymeric
scaffolds
divide
them
into
five
main
categories:
natural
polymer-natural
composite,
polymer-synthetic
synthetic
crosslinked
reinforced
inorganic
materials.
Then,
their
physiochemical,
biological
mechanical
features
discussed
capability
efficiency
function
matrix
support
cellular
function.
Nanomaterials,
Journal Year:
2019,
Volume and Issue:
9(7), P. 952 - 952
Published: June 30, 2019
Polyvinylidene
fluoride
(PVDF)
and
polyvinylidene
fluoride-trifluoroethylene
(P(VDF-TrFE)
with
excellent
piezoelectricity
good
biocompatibility
are
attractive
materials
for
making
functional
scaffolds
bone
neural
tissue
engineering
applications.
Electrospun
PVDF
P(VDF-TrFE)
can
produce
electrical
charges
during
mechanical
deformation,
which
provide
necessary
stimulation
repairing
defects
damaged
nerve
cells.
As
such,
these
fibrous
mats
promote
the
adhesion,
proliferation
differentiation
of
cells
on
their
surfaces.
Furthermore,
aligned
enhance
neurite
growth
along
fiber
orientation
direction.
These
beneficial
effects
derive
from
formation
electroactive,
polar
β-phase
having
piezoelectric
properties.
Polar
be
induced
in
fibers
as
a
result
polymer
jet
stretching
poling
electrospinning.
Moreover,
incorporation
TrFE
monomer
into
stabilize
without
or
poling.
The
main
drawbacks
electrospinning
process
PVDF-based
small
pore
sizes
use
highly
toxic
organic
solvents.
prevent
infiltration
neuronal
scaffolds,
leading
to
single
cell
layer
scaffold
Accordingly,
modified
methods
such
melt-electrospinning
near-field
have
been
explored
by
researchers
tackle
this
issue.
This
article
reviews
recent
development
strategies,
achievements
major
challenges
electrospun
Polymers,
Journal Year:
2020,
Volume and Issue:
12(4), P. 844 - 844
Published: April 6, 2020
Polymer
scaffolds
constitute
a
very
interesting
strategy
for
tissue
engineering.
Even
though
they
are
generally
non-toxic,
in
some
cases,
may
not
provide
suitable
support
cell
adhesion,
proliferation,
and
differentiation,
which
decelerates
regeneration.
To
improve
biological
properties,
frequently
enriched
with
bioactive
molecules,
inter
alia
extracellular
matrix
proteins,
adhesive
peptides,
growth
factors,
hormones,
cytokines.
Although
there
many
papers
describing
synthesis
properties
of
polymer
proteins
or
few
reviews
comprehensively
summarize
these
molecules.
Thus,
this
review
presents
the
current
knowledge
about
most
important
peptides
used
modification
This
paper
also
describes
influence
addition
on
physicochemical,
mechanical,
scaffolds.
Moreover,
article
sums
up
major
applications
biodegradable
natural
synthetic
modified
have
been
developed
within
past
five
years.
Polymers,
Journal Year:
2021,
Volume and Issue:
13(6), P. 924 - 924
Published: March 17, 2021
The
development
of
advanced
composite
biomaterials
combining
the
versatility
and
biodegradability
polymers
unique
characteristics
metal
oxide
nanoparticles
unveils
new
horizons
in
emerging
biomedical
applications,
including
tissue
regeneration,
drug
delivery
gene
therapy,
theranostics
medical
imaging.
Nanocrystalline
cerium(IV)
oxide,
or
nanoceria,
stands
out
from
a
crowd
other
oxides
as
being
truly
material,
showing
great
potential
biomedicine
due
to
its
low
systemic
toxicity
numerous
beneficial
effects
on
living
systems.
combination
nanoceria
with
generations
polymers,
such
PolyHEMA
(poly(2-hydroxyethyl
methacrylate)-based
hydrogels,
electrospun
nanofibrous
polycaprolactone
natural-based
chitosan
cellulose,
helps
expand
prospective
area
applications
by
facilitating
their
bioavailability
averting
negative
effects.
This
review
describes
recent
advances
polymeric
material
practices,
highlights
up-to-the-minute
cerium
nanoparticle
well
polymer-nanoceria
composites,
aims
address
question:
how
can
enhance
modern
materials?
Journal of Controlled Release,
Journal Year:
2021,
Volume and Issue:
333, P. 448 - 486
Published: March 31, 2021
Tendon
injuries
are
a
global
health
problem
that
affects
millions
of
people
annually.
The
properties
tendons
make
their
natural
rehabilitation
very
complex
and
long-lasting
process.
Thanks
to
the
development
fields
biomaterials,
bioengineering
cell
biology,
new
discipline
has
emerged,
tissue
engineering.
Within
this
discipline,
diverse
approaches
have
been
proposed.
obtained
results
turn
out
be
promising,
as
increasingly
more
tendon-like
structures
obtained.
In
review,
nature
tendon
conventional
treatments
applied
so
far
underlined.
Then,
comparison
between
different
engineering
proposed
date
is
made,
focusing
on
each
elements
necessary
obtain
allow
adequate
regeneration
tendon:
growth
factors,
cells,
scaffolds
techniques
for
scaffold
development.
analysis
all
these
aspects
allows
understanding,
in
way,
effect
element
used
and,
thus,
clarify
possible
future
by
making
combinations
materials,
designs,
cells
bioactive
molecules
achieve
personalized
functional
tendon.
