Wound Healing: From Passive to Smart Dressings

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(16)

Published: June 26, 2021

Abstract The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on healthcare systems. Although, application traditional wound dressings contributes to an effective healing outcome, yet, complexity process remains major health challenge. Recent advances materials fabrication technologies have led that provide proper conditions for healing. 3D‐printed dressings, biomolecule‐loaded as well smart flexible bandages are among recent alternatives been developed accelerate Additionally, new generation contains variety microelectronic sensors real‐time monitoring environment is able apply required actions support progress. Moreover, manufacturing enable development next dressing substrates, known electronic skin, whole physiochemical markers single platform. current study reviews importance emerging strategy care management highlights different types promoting process.

Language: Английский

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Electrospun Medicated Nanofibers for Wound Healing: Review

Membranes, Journal Year: 2021, Volume and Issue: 11(10), P. 770 - 770

Published: Oct. 9, 2021

With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet needs of existing market due their limited antibacterial properties other defects. Electrospinning technology has attracted more researchers’ attention as a simple versatile manufacturing method. The electrospun nanofiber membrane unique structure biological function similar extracellular matrix (ECM), is considered an advanced dressing. They significant potential in encapsulating delivering active substances that promote healing. This article first discusses common types dressing, then summarizes development fiber preparation technology. Finally, polymers biologically used electrospinning are summarized, portable equipment also discussed. Additionally, future research put forward.

Language: Английский

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Electrospun nanofibers: Exploring process parameters, polymer selection, and recent applications in pharmaceuticals and drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 90, P. 105156 - 105156

Published: Nov. 10, 2023

Electrospinning is acknowledged as a versatile technique for producing polymer nanofibers. Various methods, such template synthesis, self-assembly, phase separation, and drawing, have been employed to create However, due its simplicity, adaptability, the inherently high surface area-to-volume ratio in electrospun fibers, electrospinning has emerged most suitable method nanofiber fabrication. This review delves into mechanisms of techniques establishes how overcomes challenges presented by other nanofabrication methods. The explores principles electrospinning, processing parameters, their effects on resulting fibers. It also discusses properties selection polymers used highlighting various types commonly pharmaceutical applications. Additionally, covers different configurations, discussing impact drug release profiles, along with respective advantages disadvantages. recent applications enhancing outcomes are examined, addressing crucial aspects field, improving dissolution rates, masking undesirable tastes, enabling delivery through systems. In summary, this article provides comprehensive understanding pivotal role advancing approaches.

Language: Английский

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Production and Application of Biomaterials Based on Polyvinyl alcohol (PVA) as Wound Dressing

Chemistry - An Asian Journal, Journal Year: 2022, Volume and Issue: 17(21)

Published: Sept. 6, 2022

The development of ideal wound dressing with excellent properties, such as exudate absorption capacity, drug release control ability, and increased healing, is currently a major requirement for healing. Polyvinyl alcohol (PVA) biodegradable semi-crystalline synthetic polymer that has been used in the field biotechnology tissue regeneration, dressing, delivery systems. In recent years, PVA-based materials have received considerable attention due to their properties biodegradability, biocompatibility, non-toxicity low cost. PVA can be material create necessary moist environment, improve physical increase healing rates. addition, also mixed other organic inorganic This review article addresses role biomaterials based on ingredients dressing. It focuses its use dressings carriers active substances.

Language: Английский

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Multifunctional and Smart Wound Dressings—A Review on Recent Research Advancements in Skin Regenerative Medicine

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(8), P. 1574 - 1574

Published: July 28, 2022

The healing of wounds is a dynamic function that necessitates coordination among multiple cell types and an optimal extracellular milieu. Much the research focused on finding new techniques to improve manage dermal injuries, chronic burn sepsis, which are frequent medical concerns. A strategy involves developing multifunctional dressings aid innate combat numerous issues trouble incompletely healed such as extreme inflammation, ischemic damage, scarring, wound infection. Natural origin-based compounds offer distinct characteristics, excellent biocompatibility, cost-effectiveness, low toxicity. Researchers have developed biopolymer-based with drugs, biomacromolecules, cells cytocompatible, hemostatic, initiate skin rejuvenation rapid healing, possess anti-inflammatory antimicrobial activity. main goal would be mimic characteristics fetal tissue regeneration in adult phase, including complete hair glandular restoration without delay or scarring. Emerging treatments based biomaterials, nanoparticles, biomimetic proteases keys improving care will vital addition therapeutic toolkit for slow-healing wounds. This study focuses recent discoveries several undergone extensive pre-clinical development now undergoing fundamental research.

Language: Английский

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Recent progress on electrospun nanofibrous polymer membranes for water and air purification: A review

Chemosphere, Journal Year: 2022, Volume and Issue: 310, P. 136886 - 136886

Published: Oct. 17, 2022

Language: Английский

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Recent Development of Polyhydroxyalkanoates (PHA)-Based Materials for Antibacterial Applications: A Review

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(4), P. 1398 - 1430

Published: March 13, 2023

The diseases caused by microorganisms are innumerable existing on this planet. Nevertheless, increasing antimicrobial resistance has become an urgent global challenge. Thus, in recent decades, bactericidal materials have been considered promising candidates to combat bacterial pathogens. Recently, polyhydroxyalkanoates (PHAs) used as green and biodegradable various alternative applications, especially healthcare for antiviral or purposes. However, it lacks a systematic review of the application emerging material antibacterial applications. Therefore, ultimate goal is provide critical state art development PHA biopolymers terms cutting-edge production technologies well fields. In addition, special attention was given collecting scientific information agents that can potentially be incorporated into biological durable protection. Furthermore, current research gaps declared, future perspectives proposed better understand properties these their possible

Language: Английский

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Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5163 - 5163

Published: July 2, 2023

The present review explores the growing interest in techniques employed for extracting natural products. It emphasizes limitations of conventional extraction methods and introduces superior non-conventional alternatives, particularly ultrasound-assisted extraction. Characterization quantification bioactive constituents through chromatography coupled with spectroscopy are recommended, while importance method development validation biomarker is underscored. At present, electrospun fibers provide a versatile platform incorporating extracts have extensive potential diverse fields due to their unique structural functional characteristics. Thus, also highlights fabrication containing extracts. preparation biologically active under optimal conditions, including selection safe solvents cost-effective equipment, holds promising pharmaceutical, food, cosmetic industries. Integration experimental design into procedures formulation essential efficient production health applications encapsulating product fibers, such as wound healing, antibacterial activity, antioxidant properties, acknowledging need further exploration optimization this field. findings discussed anticipated serve valuable resource processing industry, enabling utilization affordable environmentally friendly, natural, raw materials.

Language: Английский

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Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564

Published: Jan. 1, 2024

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.

Language: Английский

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Immobilization: the promising technique to protect and increase the efficiency of microorganisms to remove contaminants

Journal of Chemical Technology & Biotechnology, Journal Year: 2024, Volume and Issue: 99(8), P. 1707 - 1733

Published: March 8, 2024

Abstract Biodegradation of pollutants is one the most economical methods for their removal and usually accompanied by no production toxic by‐products. In general, this approach favored over others because it offers reduced expenses potential complete mineralization. order to enhance viability longevity bioremediation agents within polluted areas, becomes necessary immobilize cells. Cell immobilization refers procedure confining intact cells specific areas a device or material, without compromising essential biological functions. A wide variety carriers approaches have been used restriction various Immobilization techniques, such as microencapsulation, opened up new possibilities in biotechnology facilitating development artificial organs, cell therapies drug delivery systems. Researchers found promising outcomes applications through microorganisms. This enhances stability, reusability catalytic efficiency, making valuable strategy biocatalysis, other biotechnological processes. Notably, use immobilized microorganisms has led significant improvements pollutants, with some studies achieving 100% efficiency. When comparing degradation between free same time period, results demonstrated that achieved efficiency >21% more than microbial consortia. The primary objective review give an overview key scientific aspects related using cells, particular focus on techniques entrap © 2024 Society Chemical Industry (SCI).

Language: Английский

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