Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 218, P. 930 - 968

Published: July 24, 2022

Language: Английский

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Additive manufacturing of sustainable biomaterials for biomedical applications

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100812 - 100812

Published: April 27, 2023

Biopolymers are promising environmentally benign materials applicable in multifarious applications. They especially favorable implantable biomedical devices thanks to their excellent unique properties, including bioactivity, renewability, bioresorbability, biocompatibility, biodegradability and hydrophilicity. Additive manufacturing (AM) is a flexible intricate technology, which widely used fabricate biopolymer-based customized products structures for advanced healthcare systems. Three-dimensional (3D) printing of these sustainable applied functional clinical settings wound dressing, drug delivery systems, medical implants tissue engineering. The present review highlights recent advancements different types biopolymers, such as proteins polysaccharides, employed develop by using extrusion, vat polymerization, laser inkjet 3D techniques addition normal bioprinting four-dimensional (4D) techniques. This also incorporates the influence nanoparticles on biological mechanical performances 3D-printed scaffolds. work addresses current challenges well future developments friendly polymeric manufactured through AM Ideally, there need more focused research adequate blending biodegradable biopolymers achieving useful results targeted areas. We envision that composites have potential revolutionize sector near future.

Language: Английский

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Development of Scaffolds from Bio-Based Natural Materials for Tissue Regeneration Applications: A Review

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 100 - 100

Published: Jan. 23, 2023

Tissue damage and organ failure are major problems that many people face worldwide. Most of them benefit from treatment related to modern technology’s tissue regeneration process. engineering is one the booming fields widely used replace damaged tissue. Scaffold a base material in which cells growth factors embedded construct substitute Various materials have been develop scaffolds. Bio-based natural biocompatible, safe, do not release toxic compounds during biodegradation. Therefore, it highly recommendable fabricate scaffolds using such materials. To date, there no singular fulfill all features scaffold. Hence, combining two or more encouraged obtain desired characteristics. design reliable scaffold by different materials, need choose good fabrication technique. In this review article, bio-based fine techniques currently developing for applications, along with number articles published on each material, briefly discussed. It envisaged gain explicit knowledge applications.

Language: Английский

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Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives

Materials & Design, Journal Year: 2023, Volume and Issue: 231, P. 112064 - 112064

Published: June 7, 2023

Ceramic bone implants have potential properties ideal for long-term implantation applications. On comparison with other materials, ceramic biomaterials advantages such as biocompatibility, low cost, osteoconductivity, osteoinductivity, corrosion resistance, and can be made into various shapes desired surface properties. Among transplantation surgeries, is the second largest in globe after blood transfusion which an indication rising hope on treatment options bone. 3D printing one of most advanced fabrication techniques to create customized using materials ceramics their composites. Developing scaffolds that precisely recapitulate mechanical biological functions remains a major challenge. However, extensive research resulted successful complex bony designs >50% porosity cortical This review critically analyses use fabricate scaffolds. Further, natural synthetic producing are discussed along clinical Finally, list companies offer printed future translation outlined.

Language: Английский

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Chitosan, Gelatin, and Collagen Hydrogels for Bone Regeneration

Polymers, Journal Year: 2023, Volume and Issue: 15(13), P. 2762 - 2762

Published: June 21, 2023

Hydrogels are versatile biomaterials characterized by three-dimensional, cross-linked, highly hydrated polymeric networks. These polymers exhibit a great variety of biochemical and biophysical properties, which allow for the diffusion diverse molecules, such as drugs, active ingredients, growth factors, nanoparticles. Meanwhile, these can control chemical molecular interactions at cellular level. The network be molded into different structures, imitating structural characteristics surrounding tissues bone defects. Interestingly, application hydrogels in tissue engineering (BTE) has been gathering significant attention due to beneficial improvement results that have achieved. Moreover, essential clinical osteoblastic fate-controlling advances achieved with use synthetic production hydrogels. However, current trends look towards fabricating from biological precursors, biopolymers, high biocompatibility, degradability, mechanical regulated. Therefore, this review analyzes concept chitosan, collagen, gelatin excellent candidates BTE scaffolds. changes opportunities brought on biopolymers regeneration discussed, considering integration, synergy, biocompatibility features.

Language: Английский

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

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Hydrogel-integrated graphene superstructures for tissue engineering: From periodontal to neural regeneration

Carbon, Journal Year: 2024, Volume and Issue: 223, P. 118970 - 118970

Published: Feb. 26, 2024

Hydrogel-integrated graphene superstructures (GSSs) represent a promising platform for applications in tissue engineering and regenerative medicine. Graphene, two-dimensional carbon-based material, possesses remarkable mechanical, thermal, electrical characteristics, making it strong candidate application biomedicine. Researchers have pursued the integration of with hydrogels, known their biocompatibility ability to provide conducive environment cellular growth, craft sophisticated scaffolds tailored needs. The hydrogels enables construction 3D frameworks that closely mimic natural extracellular matrix (ECM) found biological tissues. Hydrogels furnish biocompatible, well-hydrated environment, while component bolsters scaffold's mechanical integrity conductivity. This amalgamation enhances adhesion, differentiation, proliferation, thereby facilitating regeneration. A notable advantage hydrogel-integrated GSSs lies capacity support growth differentiation variety cell types such as PC12, MG-63, U-87, MC3T3-E1 lines. Overall, exhibit great potential advancing biomimetic combination unique properties development advanced scaffold systems Further research this domain will play crucial role medicine treatment various diseases injuries.

Language: Английский

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Poly(methyl methacrylate) in Orthopedics: Strategies, Challenges, and Prospects in Bone Tissue Engineering

Polymers, Journal Year: 2024, Volume and Issue: 16(3), P. 367 - 367

Published: Jan. 29, 2024

Poly(methyl methacrylate) (PMMA) is widely used in orthopedic applications, including bone cement total joint replacement surgery, fillers, and substitutes due to its affordability, biocompatibility, processability. However, the regeneration efficiency of PMMA limited because lack bioactivity, poor osseointegration, non-degradability. The use also has disadvantages such as methyl methacrylate (MMA) release high exothermic temperature during polymerization PMMA, which can cause thermal necrosis. To address these problems, various strategies have been adopted, surface modification techniques incorporation bioactive agents biopolymers into PMMA. In this review, physicochemical properties synthesis methods are discussed, with a special focus on utilization composites tissue engineering. Additionally, challenges involved incorporating regenerative medicine discussed suitable research findings intention providing insightful advice support successful clinical applications.

Language: Английский

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Innovative designs of 3D scaffolds for bone tissue regeneration: Understanding principles and addressing challenges

European Polymer Journal, Journal Year: 2024, Volume and Issue: 215, P. 113251 - 113251

Published: June 19, 2024

Meeting the escalating demands in biomedical applications has spurred creation of diverse scaffolds, where selection materials and manufacturing techniques stands as a linchpin fostering bone tissue formation. These scaffolds provide fundamental structural framework that supports cell growth differentiation. It is vital for repair, addressing various biological requisites such biocompatibility, biodegradability, mechanical properties becomes imperative. This comprehensive review discusses recent advancements 3D tailored specifically engineering applications. Stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, bioprinting (including laser-based, inkjet extrusion bioprinting) are meticulously explored. Focusing on their respective applications, limitations, well advantages disadvantages within context regeneration. Furthermore, article underscores pivotal role material potential solution to address challenges associated with grafts. emphasizes need nuanced understanding significant considerations regardless type when designing or evaluating suitability integration into expansive realm engineering.

Language: Английский

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An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3836 - 3836

Published: March 29, 2024

Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.

Language: Английский

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