Drug Design Development and Therapy,
Journal Year:
2020,
Volume and Issue:
Volume 14, P. 5495 - 5503
Published: Dec. 1, 2020
Abstract:
Cancers
have
always
been
an
intractable
problem
because
of
recurrence
and
drug
resistance.
In
the
past
few
decades,
nanoparticles
explored
intensely
to
diagnose,
prevent
treat
malignancy
due
their
good
penetrability
better
targeting.
However,
most
nanocarriers
poor
biodegradation
can
be
discharged
out
body
quickly
or
cleared
by
immune
cells
while
failing
obtain
effective
concentration
at
specific
sites.
The
emergence
biological
membrane
encapsulation
technology
relieves
fast
clearance
antitumor
drugs
reduces
toxicity
in
vivo.
This
review
will
discuss
advantages
disadvantages
several
blood
cell
membrane-coated
further
introduce
exosome-carried
evidence
promising
prospect
biomimetic
nanoparticle
delivery
systems.
Keywords:
tumor,
systems,
cells,
membranes
Molecules,
Journal Year:
2020,
Volume and Issue:
25(1), P. 204 - 204
Published: Jan. 3, 2020
Development
of
nanotechnology
has
become
prominent
in
many
fields,
such
as
medicine,
electronics,
production
materials,
and
modern
drugs.
Nanomaterials
nanoparticles
have
gained
recognition
owing
to
the
unique
biochemical
physical
properties.
Considering
cellular
application,
it
is
speculated
that
can
transfer
through
cell
membranes
following
different
routes
exclusively
their
size
(up
100
nm)
surface
functionalities.
Nanoparticles
capacity
enter
cells
by
themselves
but
also
carry
other
molecules
lipid
bilayer.
This
quality
been
utilized
delivery
substances
like
small
chemical
drugs
or
nucleic
acids.
Different
including
lipids,
silica,
metal
exploited
conjugation
with
However,
noble
create
an
alternative,
out
which
gold
(AuNP)
are
most
common.
The
hybrids
DNA
RNA
be
employed
for
functional
assemblies
variety
applications
diagnostics
nano-electronics
means
biomarkers,
specific
imaging
probes,
gene
expression
regulatory
function.
In
this
review,
we
focus
on
conjugates
acids
view
potential
application
biomedicine.
review
covers
current
advances
RNA-AuNP
applications.
We
emphasize
crucial
role
explore
biological
systems.
Finally,
mechanisms
guiding
process
intake,
essential
therapeutics,
will
discussed.
Theranostics,
Journal Year:
2020,
Volume and Issue:
11(2), P. 579 - 601
Published: Oct. 28, 2020
Current
cancer
therapies,
including
chemotherapy
and
radiotherapy,
are
imprecise,
non-specific,
often
administered
at
high
dosages
-
resulting
in
side
effects
that
severely
impact
the
patient's
overall
well-being.
A
variety
of
multifunctional,
cancer-targeted
nanotheranostic
systems
integrate
therapy,
imaging,
tumor
targeting
functionalities
a
single
platform
have
been
developed
to
overcome
shortcomings
traditional
drugs.
Among
imaging
modalities
used,
magnetic
resonance
(MRI)
provides
resolution
structures
deep
within
body
and,
combination
with
other
modalities,
complementary
diagnostic
information
for
more
accurate
identification
characteristics
precise
guidance
anti-cancer
therapy.
This
review
article
presents
comprehensive
assessment
combine
MRI-based
(T1
MRI,
T2
multimodal
imaging)
therapy
(chemo-,
thermal-,
gene-
therapy),
connecting
range
topics
hybrid
treatment
options
(e.g.
combined
chemo-gene
unique
T1-T2
triple
quadruple
imaging),
novel
strategies
dual
magnetic-active
nanoparticles
carrying
multiple
ligands),
microenvironment-responsive
drug
release
redox
pH-responsive
nanomaterials).
With
special
focus
on
tested
vivo,
this
is
an
essential
summary
most
advanced
developments
rapidly
evolving
field.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
11
Published: Jan. 19, 2022
In
recent
years,
the
morbidity
and
mortality
of
gastrointestinal
cancer
have
remained
high
in
China.
Due
to
deep
location
organs,
such
as
gastric
cancer,
early
symptoms
are
not
obvious.
It
is
generally
discovered
at
an
advanced
stage
with
distant
metastasis
lymph
node
infiltration,
making
it
difficult
cure.
Therefore,
there
a
significant
need
for
novel
technologies
that
can
effectively
diagnose
treat
ultimately
reducing
its
mortality.
Gold
nanoparticles
(GNPs),
type
nanocarrier
unique
optical
properties
remarkable
biocompatibility,
potential
influence
fate
by
delivering
drugs,
nucleic
acids
cells
tissues.
As
safe
reliable
visualization
agent,
GNPs
track
drugs
accurately
indicate
boundaries
opening
up
new
possibilities
treatment.
addition,
been
used
photodynamic
therapy
deliver
photosensitizers,
well
combination
photothermal
therapy.
be
effective
nanomaterial
treatment
diagnosis
cancer.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: June 7, 2021
Immunotherapy
of
malignant
tumor
is
a
verified
and
crucial
anti-tumor
strategy
to
help
patients
with
cancer
for
prolonging
prognostic
survival.
It
novel
anticancer
tactics
that
activates
the
immune
system
discern
damage
cells,
thereby
prevent
them
from
proliferating.
However,
immunotherapy
still
faces
many
challenges
in
view
clinical
efficacy
safety
issues.
Various
nanomaterials,
especially
gold
nanoparticles
(AuNPs),
have
been
developed
not
only
treatment
but
also
delivering
antitumor
drugs
or
combining
other
strategies.
Recently,
some
studies
focused
on
AuNPs
enhancing
immunotherapy.
In
this
review,
we
summarized
how
applicated
as
agents,
drug
carriers
combinations
immunotherapies
treatment.
can
act
regulators
deliver
cancer.
Therefore,
are
candidates
efficiency
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: Feb. 7, 2022
Though
single
tumor
immunotherapy
and
radiotherapy
have
significantly
improved
the
survival
rate
of
patients,
there
are
certain
limitations
in
overcoming
metastasis,
recurrence,
reducing
side
effects.
Therefore,
it
is
urgent
to
explore
new
treatment
methods.
The
combination
shows
promise
improving
therapeutic
efficacy
recurrence
by
enhancing
ability
immune
system
recognize
eradicate
cells,
overcome
tolerance
mechanisms.
Nanomaterials,
as
drug-delivery-system
materials
21st
century,
can
maintain
activity
drugs,
improve
drug
targeting,
reduce
effects
immunotherapy.
Additionally,
nanomaterials,
radiosensitizers,
shown
great
potential
due
their
unique
properties,
such
light,
heat,
electromagnetic
Here,
we
review
mechanisms
synergy
with
multiple
types
immunotherapies,
including
checkpoint
inhibitors
(ICIs),
vaccines,
adoptive
cell
therapy,
cytokine
therapy.
Finally,
propose
for
nanomaterials
Journal of Functional Biomaterials,
Journal Year:
2022,
Volume and Issue:
13(4), P. 196 - 196
Published: Oct. 20, 2022
The
advent
of
nanotechnology
has
brought
about
revolutionary
innovations
in
biological
research
techniques
and
medical
practice.
In
recent
years,
various
“smart”
nanocarriers
have
been
introduced
to
deliver
therapeutic
agents
specifically
the
tumor
tissue
a
controlled
manner,
thereby
minimizing
their
side
effects
reducing
both
dosage
frequency.
A
large
number
nanoparticles
demonstrated
initial
success
preclinical
evaluation
but
modest
benefits
clinical
setting,
partly
due
insufficient
delivery
site
penetration
tissue.
Therefore,
precise
understanding
relationships
betweenthe
physicochemical
properties
interaction
with
surrounding
microenvironment
body
is
extremely
important
for
achieving
higher
concentrations
better
functionality
tissues.
This
knowledge
would
help
effectively
combine
multiple
advantageous
functions
one
nanoparticle.
main
focus
discussion
this
review,
therefore,
will
relate
while
interacting
within
tuning
potential
increased
performance.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 21, 2023
Abstract
Immune
checkpoint
(ICP)
molecules
expressed
on
tumor
cells
can
suppress
immune
responses
against
tumors.
ICP
therapy
promotes
anti-tumor
by
targeting
inhibitory
and
stimulatory
pathways
of
like
T
dendritic
(DC).
The
investigation
into
the
combination
therapies
through
novel
inhibitors
(ICIs)
has
been
limited
due
to
immune-related
adverse
events
(irAEs),
low
response
rate,
lack
optimal
strategy
for
combinatorial
cancer
immunotherapy
(IMT).
Nanoparticles
(NPs)
have
emerged
as
powerful
tools
promote
multidisciplinary
cooperation.
feasibility
efficacy
targeted
delivery
ICIs
using
NPs
overcome
primary
barrier,
improve
therapeutic
efficacy,
provide
a
rationale
more
clinical
investigations.
Likewise,
conjugate
or
encapsulate
ICIs,
including
antibodies,
RNAs,
small
molecule
inhibitors.
Therefore,
combining
drug
system
(DDS)
with
could
profitable
immunotherapeutic
treatment.
This
article
reviews
significant
controlled
DDS
current
data
from
pre-clinical
trials
mono-
IMT
limitations.
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