Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: June 12, 2024
Abstract
Photoresponsive
drug
delivery
systems
(PDDSs)
have
emerged
as
a
promising
toolbox
for
delivery,
offering
precise
control
over
the
site,
duration,
and
dosage
of
light‐triggered
medication.
It
allows
controlled
release,
photo‐triggered
targeting,
diagnosis,
treatment,
improving
precision
efficacy
therapies
various
diseases.
Despite
progress
in
designing
different
PDDSs,
clinical
translation
has
been
limited
due
to
obstacles.
Herein,
this
review
article
focuses
on
three
critical
challenges
PDDSs:
1)
accumulation
at
diseased
lesions,
2)
light
irradiation,
3)
penetration
tissues.
Also,
summarizes
discusses
current
advancements
strategies
address
these
challenges.
Overall,
it
emphasizes
need
clarify
from
bench
bedside
develop
enhance
therapeutic
outcomes,
increase
compatibility
patient
compliance,
unlock
possibilities
therapies.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(16), P. 2826 - 2826
Published: Aug. 17, 2022
Cancer
theranostics
is
the
combination
of
diagnosis
and
therapeutic
approaches
for
cancer,
which
essential
in
personalized
cancer
treatment.
The
aims
application
nanoparticles
detection
therapy
are
to
reduce
delays
treatment
hence
improve
patient
care.
Recently,
it
has
been
found
that
functionalization
can
efficiency,
performance,
specificity
sensitivity
structure,
increase
stability
body
acidic
environment.
Moreover,
functionalized
have
possess
a
remarkable
theranostic
ability
revolutionized
Each
modality,
such
as
MRI-guided
gene
therapy,
thermal
magnetic
hyperthermia
treatment,
chemotherapy,
immunotherapy,
photothermal
photodynamic
its
strengths
weaknesses,
combining
modalities
allows
better
platform
improved
control.
This
why
investigated
thoroughly
recent
years
enabled
by
nanoparticles.
In
this
topical
review,
we
look
at
advances
using
Through
understanding
updating
development
nanoparticle-based
theranostics,
find
out
future
challenges
perspectives
novel
type
Nanotheranostics,
Journal Year:
2023,
Volume and Issue:
7(4), P. 424 - 449
Published: Jan. 1, 2023
Medical
imaging
is
an
important
factor
for
diagnosis.It
can
be
used
to
diagnose
patients,
differentiate
disease
stages,
and
monitor
treatment
regimens.Although
different
technologies
are
available,
MRI
sensitive
over
other
modalities
as
it
capable
of
deep
tissue
penetration
allowing
image
the
anatomical,
structural,
molecular
level
diseased
organs.Thus,
screening
tool
staging.One
components
contrast
agents
which
increase
sensitivity
technology.While
types
iron-oxide
based
nanoparticles
(IONPS)
widely
these
easy
formulate,
functionalize,
biocompatible
cost
effective.In
addition
its
use
agents,
have
been
drug
carriers
diseases
ranging
from
cancer,
cardiovascular
diseases,
neurological
disorders,
autoimmune
infectious
diseases.For
last
two
decades,
there
has
advancement
in
nanotheranostics,
where
IONPs
formulated
carry
one
system
so
that
image-guided
therapy
real-life
response
tissue.This
technology
stratify
patients
into
responders
non-responders
reduce
adverse
toxicity
lead
a
tailored
treatment.However,
success
nanotheranostics
depends
on
several
factor,
including
identification
associated
biomarkers
targeted
during
formulation.While
many
challenges
exist
clinical
translation
still
potential
implemented
personalized
strategy.In
this
review
article,
we
discussed
relation
their
application
diagnosis
medicine.
Materials Today Chemistry,
Journal Year:
2023,
Volume and Issue:
29, P. 101400 - 101400
Published: Feb. 15, 2023
The
theranostic
term
is
a
revolutionary
topic
in
cancer
treatment,
combining
therapeutic
and
diagnostic.
Theranostic
provides
an
opportunity
for
diagnosis
response
assessment
during
treatment.
Therefore,
single
approach
can
determine
effective
line
of
real-time
monitoring
strategy
aimed
to
be
reached
by
co-delivery
imaging
pharmaceutical
agents.
nanoscale
carriers
are
promising
platforms
applications.
Although,
it
worth
bearing
mind
that
providing
therapy
the
same
structure
troublesome.
Imaging
modalities
designed
improve
signal-to-noise
ratio
with
rapid
clearance.
At
time,
agents
require
accumulate
high
concentrations
at
disease
site.
Moreover,
importance
biocompatibility
nanocarriers
necessitates
careful
design
nanostructures.
Here,
we
present
overview
characteristics
nanoparticles
as
polymeric
biological
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: July 6, 2022
Theranostic
nanoplatforms
integrating
diagnostic
and
therapeutic
functions
have
received
considerable
attention
in
the
past
decade.
Among
them,
hollow
manganese
(Mn)-based
are
superior
since
they
combine
advantages
of
structures
intrinsic
theranostic
features
Mn
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 19, 2024
Abstract
Humanity
is
suffering
from
cancer
which
has
become
a
root
cause
of
untimely
deaths
individuals
around
the
globe
in
recent
past.
Nanotheranostics
integrates
therapeutics
and
diagnostics
to
monitor
treatment
response
enhance
drug
efficacy
safety.
We
hereby
propose
discuss
all
imaging
diagnostic
tools,
mechanism
targeting
tumor
cells,
current
nanotheranostic
platforms
available
for
cancer.
This
review
discusses
various
agents
novel
molecular
tools
like
MRI,
CT,
PET,
SPEC,
PAT
used
diagnostics.
Emphasis
given
gold
nanoparticles,
silica,
liposomes,
dendrimers,
metal-based
agents.
also
highlight
limitations
different
field
research
treatment.
Due
complexity
this
area,
multifunctional
hybrid
nanoparticles
functionalized
with
targeted
moieties
or
anti-cancer
drugs
show
best
feature
theranostics
that
enables
them
work
on
carrying
delivering
active
materials
desired
area
requirement
early
detection
diagnosis.
Non-invasive
techniques
have
specificity
receptor
binding
internalization
processes
nanosystems
within
cells.
may
provide
appropriate
medicine
at
dose
patient
time.
Graphical
abstract
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1339 - 1339
Published: Jan. 25, 2022
Humans
are
exposed
to
a
complex
mix
of
man-made
electric
and
magnetic
fields
(MFs)
at
many
different
frequencies,
home
work.
Epidemiological
studies
indicate
that
there
is
positive
relationship
between
residential/domestic
occupational
exposure
extremely
low
frequency
electromagnetic
some
types
cancer,
although
other
no
relationship.
In
this
review,
after
an
introduction
on
the
MF
definition
description
natural/anthropogenic
sources,
epidemiology
MFs
cancer
reviewed,
with
reference
leukemia,
brain,
breast
cancer.
The
in
vivo
vitro
effects
reviewed
considering
both
human
animal
cells,
particular
involvement
reactive
oxygen
species
(ROS).
application
diagnostic
therapy
(theranostic)
also
by
describing
use
resonance
imaging
(MRI)
applications
for
detection
several
cancers.
Finally,
nanoparticles
described
terms
treatment
nanomedical
precise
delivery
anticancer
drugs,
nanosurgery
magnetomechanic
methods,
selective
killing
cells
hyperthermia.
supplementary
tables
provide
quantitative
data
methodologies
epidemiological
cell
biology
studies.
Although
scientists
do
not
generally
agree
cause-effect
might
be
direct
cause
but
may
contribute
produce
ROS
generate
oxidative
stress,
which
could
trigger
or
enhance
expression
oncogenes.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(21), P. 2887 - 2887
Published: Oct. 31, 2023
Timely
diagnosis
and
appropriate
antitumoral
treatments
remain
of
utmost
importance,
since
cancer
remains
a
leading
cause
death
worldwide.
Within
this
context,
nanotechnology
offers
specific
benefits
in
terms
therapy
by
reducing
its
adverse
effects
guiding
drugs
to
selectively
target
cells.
In
comprehensive
review,
we
have
summarized
the
most
relevant
novel
outcomes
range
2010-2023,
covering
design
application
nanosystems
for
therapy.
We
established
general
requirements
nanoparticles
be
used
drug
delivery
strategies
their
uptake
tumor
microenvironment
vasculature,
including
reticuloendothelial
system
surface
functionalization
with
protein
corona.
After
brief
review
classes
nanovectors,
covered
different
therapies.
First,
advances
encapsulation
(such
as
paclitaxel
fisetin)
into
nanoliposomes
nanoemulsions
are
described,
well
relevance
current
clinical
trials.
Then,
polymeric
presented,
namely
ones
comprising
poly
lactic-co-glycolic
acid,
polyethylene
glycol
(and
PEG
dilemma)
dendrimers.
The
quantum
dots
bioimaging
is
also
covered,
systems
zinc
sulfide
indium
phosphide.
Afterwards,
reviewed
gold
(spheres
anisotropic)
plasmon-induced
photothermal
iron
oxide
nanoparticles,
such
magnetite
maghemite,
has
been
analyzed
fields,
magnetic
resonance
imaging,
immunotherapy,
hyperthermia,
delivery.
Lastly,
recent
using
carbon
nanomaterials,
graphene
oxide,
nanotubes,
fullerenes,
dots.
Finally,
compared
passive
active
targeting
theranostics.
This
aims
(nano)mark
on
ongoing
journey
towards
realizing
remarkable
potential
realm
therapeutics.
