Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1136 - 1136

Published: March 30, 2021

Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and general the deficiency this micronutrient induce changes biochemical pathways that can increase risk illness and, particular, chronic degenerative diseases. The assessment status is consequently great importance, however, its evaluation difficult. measurement serum concentration most commonly used readily available method for assessing status, even if levels have no reliable correlation with total body or concentrations specific tissues. Therefore, review offers overview recent insights into from multiple perspectives. Starting a point view, it aims at highlighting due to insufficient uptake (frequently content modern western diet), suggesting strategies reach recommended dietary reference values, focusing on importance detecting pathological various districts, order counteract social impact diseases linked deficiency.

Language: Английский

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The crucial role and mechanism of insulin resistance in metabolic disease

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 28, 2023

Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, nonalcoholic fatty liver disease, provides basis for common understanding these chronic diseases. In this study, we provide systematic review causes, mechanisms, treatments IR. The pathogenesis IR depends on genetics, obesity, age, drug effects. Mechanistically, any factor leading to abnormalities insulin signaling pathway leads host, including receptor abnormalities, disturbances internal environment (regarding inflammation, hypoxia, lipotoxicity, immunity), metabolic function organelles, other abnormalities. available therapeutic strategies are mainly exercise dietary habit improvement, chemotherapy based biguanides glucagon-like peptide-1, traditional Chinese medicine (e.g., herbs acupuncture) can also be helpful. Based current there still some vacancies follow up consider, is need define more precise biomarkers different lifestyle interventions, explore natural or synthetic drugs targeting treatment. This could enable treatment patients with multiple combined diseases, aim treating disease holistically reduce healthcare expenditures improve quality life extent.

Language: Английский

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Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 320 - 320

Published: Jan. 22, 2021

Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It frequent obese patients, subjects with type-2 diabetes and metabolic syndrome, both adulthood childhood. This narrative review aims to offer insights into pathophysiological mechanisms linking Mg2+ obesity risk of developing syndrome type 2 diabetes. Literature highlights critical issues about treatment deficiency, such as lack a clear definition nutritional status, use different salts dosage duration supplementation. Despite agreement, an appropriate dietary pattern, including right intake Mg2+, improves by reducing blood pressure, hyperglycemia, hypertriglyceridemia. occurs through modulation gene expression proteomic profile well positive influence on composition intestinal microbiota metabolism vitamins B1 D.

Language: Английский

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Review of the beneficial and anti-nutritional qualities of phytic acid, and procedures for removing it from food products

Food Research International, Journal Year: 2021, Volume and Issue: 143, P. 110284 - 110284

Published: March 10, 2021

Language: Английский

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Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice

Chemosphere, Journal Year: 2021, Volume and Issue: 288, P. 132607 - 132607

Published: Oct. 20, 2021

Language: Английский

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The Role of Magnesium in the Pathogenesis of Metabolic Disorders

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1714 - 1714

Published: April 20, 2022

Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It involved in many fundamental processes, and Mg deficiency often correlated with negative health outcomes. On the one hand, most western civilizations consume less than recommended daily allowance of Mg. other a growing body evidence has indicated that chronic hypomagnesemia may be implicated pathogenesis various metabolic disorders such as overweight obesity, insulin resistance (IR) type 2 diabetes mellitus (T2DM), hypertension (HTN), changes lipid metabolism, low-grade inflammation. High intake diet and/or supplementation seems to prevent complications. The protective action include limiting adipose tissue accumulation, improving glucose enhancing endothelium-dependent vasodilation, normalizing profile, attenuating inflammatory processes. Thus, it currently plays important role developing associated although more randomized controlled trials (RCTs) evaluating strategies are needed. This work represents review synthesis recent data on disorders.

Language: Английский

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Overview of the vital roles of macro minerals in the human body

Journal of Trace Elements and Minerals, Journal Year: 2023, Volume and Issue: 4, P. 100076 - 100076

Published: June 1, 2023

Macro minerals, also known as macro elements, are minerals that required in large amounts the human body. part of biological structure body, play an important role metabolic processes, and participate almost all processes occur can be toxic if consumed quantities for extended period. There is some evidence to suggest calcium intake may associated with a lower risk obesity. However, relationship between obesity not well understood, more research needed fully understand link. Calcium has been studied its potential development certain types cancer, specifically colorectal breast prostate cancer. higher A deficiency macroelement refers lack one or essential by humans. Macroelement deficiencies lead various health problems, such anemia, osteoporosis, muscle weakness, corrected. The macroelements blood cause many chronic diseases. Hormonal changes resulting from have consequences weight gain, obesity, increased cancer future. It maintain balanced diet ensure adequate elements.

Language: Английский

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Energy metabolism in health and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 18, 2025

Language: Английский

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‘Magnesium’-the master cation-as a drug—possibilities and evidences

BioMetals, Journal Year: 2021, Volume and Issue: 34(5), P. 955 - 986

Published: July 2, 2021

Language: Английский

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Role of Magnesium in Type 2 Diabetes Mellitus

Biological Trace Element Research, Journal Year: 2019, Volume and Issue: 196(1), P. 74 - 85

Published: Nov. 11, 2019

Language: Английский

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