Activation of cannabinoid receptor 2 alleviates glucocorticoid-induced osteonecrosis of femoral head with osteogenesis and maintenance of blood supply DOI Creative Commons
Houyi Sun,

Weicheng Zhang,

Ning Yang

et al.

Cell Death and Disease, Journal Year: 2021, Volume and Issue: 12(11)

Published: Oct. 30, 2021

Abstract In glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH), downregulated osteogenic ability and damaged blood supply are two key pathogenic mechanisms. Studies suggested that cannabinoid receptor 2 (CB2) is expressed in bone tissue it plays a positive role osteogenesis. However, whether CB2 could enhance formation GC-induced ONFH remains unknown. this study, we focused on effect possible mechanisms vitro vivo. By using rat model, rat-bone mesenchymal stem cells (BMSCs) human umbilical vein endothelial (HUVECs) to address interaction vivo, evaluate angiogenic variation Micro-CT, histological staining, angiography, calcein labeling, Alizarin red staining (ARS), alkaline phosphatase (ALP), tartrate-resistant acid (TRAP) TUNEL migration assay, scratch tube were applied study. Our results showed selective activation alleviates ONFH. The strengthened activity BMSCs under influence GCs by promotion GSK-3β/β-catenin signaling pathway. Furthermore, promoted HUVECs tube-forming capacities. findings indicated may serve as rational new treatment strategy against osteogenesis maintenance supply.

Language: Английский

Disorders of cancer metabolism: The therapeutic potential of cannabinoids DOI Open Access
Dingya Sun, Xin Li, Shengdan Nie

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 113993 - 113993

Published: Nov. 12, 2022

Abnormal energy metabolism, as one of the important hallmarks cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, glutamine-dependent anaplerosis. Considering that metabolic reprogramming provides various nutrients for tumor survival development, it has been considered a potential target cancer therapy. Cannabinoids have shown to exhibit variety anticancer activities unclear mechanisms. This paper first reviews recent progress related signaling pathways (reactive oxygen species (ROS), AMP-activated protein kinase (AMPK), mitogen-activated kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor-1alpha (HIF-1α), p53) mediating metabolism (including glucose amino acid metabolism). Then we comprehensively explore latest discoveries possible mechanisms effects cannabinoids through regulation above-mentioned pathways, provide new targets insights prevention treatment.

Language: Английский

Citations

74
The Endocannabinoid System: A Target for Cancer Treatment DOI Open Access
Chiara Laezza, Cristina Pagano, Giovanna Navarra

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 747 - 747

Published: Jan. 23, 2020

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer by modulating several pathways involved cell growth, differentiation, migration, and angiogenesis. However, efficacy of cannabinoids is limited to treatment chemotherapy-induced symptoms or cancer pain, but their use drugs chemotherapeutic protocols requires further investigation. this paper, we reviewed role modulation signaling mechanisms implicated tumor progression.

Language: Английский

Citations

123
Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer DOI Open Access
Brigitta Kis,

Feng Chen Ifrim,

Valentina Buda

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(23), P. 5905 - 5905

Published: Nov. 25, 2019

Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal psychoactive properties. It the main source of phytocannabinoids, over 100 compounds detected so far. In recent years, lot attention has been given to phytochemicals present in L., namely, cannabidiol (CBD) Δ9-tetrahydrocannabinol (THC). Compared THC, CBD non-psychoactive effects, an advantage clinical applications anti-tumor benefits. The review designed provide update regarding multi-target effects different types cancer. focus on latest vitro vivo studies that data anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, immunomodulatory properties together their mechanisms action. evidence anticancer also outlined. Moreover, aspects pharmacological toxicological profiles are given.

Language: Английский

Citations

117
Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol DOI
Patrícia Alves, Cristina Amaral, Natércia Teixeira

et al.

Pharmacological Research, Journal Year: 2020, Volume and Issue: 157, P. 104822 - 104822

Published: April 23, 2020

Language: Английский

Citations

106
Terpenoids and Phytocannabinoids Co-Produced in Cannabis Sativa Strains Show Specific Interaction for Cell Cytotoxic Activity DOI Creative Commons

Dvora Namdar,

Hillary Voet, A. C. Vinayaka

et al.

Molecules, Journal Year: 2019, Volume and Issue: 24(17), P. 3031 - 3031

Published: Aug. 21, 2019

Mixtures of different Cannabis sativa phytocannabinoids are more active biologically than single phytocannabinoids. However, cannabis terpenoids as potential instigators phytocannabinoid activity have not yet been explored in detail. Terpenoid groups were statistically co-related to certain strains rich Δ9-tetrahydrocannabinolic acid (THCA) or cannabidiolic (CBDA), and their ability enhance the decarboxylase (i.e., THC CBD) was determined. Analytical HPLC GC/MS used identify quantify secondary metabolites 17 C. sativa, correlations between cannabinoids each strain Column separation separate collect compounds, cell viability assay assess biological activity. We found that “high THC” CBD” strains, produced alongside sets terpenoids. Only enhanced cytotoxic on MDA-MB-231 HCT-116 lines. This be most effective natural ratios extracts inflorescence. The correlation a particular THCA CBDA set terpenoids, partial specificity interaction may influenced cultivation implications for therapeutic treatments.

Language: Английский

Citations

84
Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy DOI Open Access
Dimakatso Mokoena, Blassan P. George, Heidi Abrahamse

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4771 - 4771

Published: Sept. 26, 2019

Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over past decades, it acceptable to admit these are expensive, invasive, associated with many side effects and, therefore, reduced quality life. One most possible solutions this could be gold nanoparticle (AuNP) conjugated photodynamic therapy (PDT) in combination cannabidiol (CBD), Cannabis derivative from sativa. Since has always been recreation and psychoactive qualities, positive or its derivatives on treatment have misunderstood hence misinterpreted. On other hand, AuNP-PDT favoured form for cancer, due augmented specificity minimal risk compared treatments. However, consideration several physical, biologic, pharmacologic immunological factors, which may hinder effectiveness if not taken into consideration. In review, role mediated PDT combined CBD breast cells will deliberated.

Language: Английский

Citations

79
Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities DOI
Samridhi Lal,

Anusmita Shekher,

Puneet Kumar

et al.

Pharmacological Research, Journal Year: 2020, Volume and Issue: 163, P. 105302 - 105302

Published: Nov. 24, 2020

Language: Английский

Citations

75
Molecular Mechanism of Cannabinoids in Cancer Progression DOI Open Access
Cristina Pagano, Giovanna Navarra, Laura Coppola

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(7), P. 3680 - 3680

Published: April 1, 2021

Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems organs. They exert anticancer action by modulating signaling pathways involved cancer progression; furthermore, induced their use depend on type tumor components endocannabinoid system. This review will explore mechanism cannabinoids proliferation, neovascularisation, migration, invasion, metastasis, angiogenesis.

Language: Английский

Citations

72
Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview DOI
Pradeep Kumar, Dipendra Kumar Mahato, Madhu Kamle

et al.

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(11), P. 6010 - 6029

Published: July 8, 2021

Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis‐based medicines have been legalized under certain conditions because of their immense prospects in applications. With comprehensive insight into the challenges associated with pharmacological use global trade C. , this mini‐review focuses on importance its legal status worldwide; compounds therapeutic potential along underlying public health concerns future perspective are herein discussed. The existence major including Δ 9 ‐tetrahydrocannabinol (Δ ‐THC), cannabidiol, cannabinol, cannabichromene contributes to effects cannabis plant. These also involved treatment various types cancer, epilepsy, Parkinson's disease displaying several mechanisms action. significant potential. However, aspects need an in‐depth understanding drug mechanism interaction other drugs. Only after addressing these concerns, legalization could be utilized full as medicine.

Language: Английский

Citations

72
Cannabidiol (CBD) in Cancer Management DOI Open Access
Kylie O’Brien

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 885 - 885

Published: Feb. 10, 2022

The plant Cannabis sativa has been in use medicinally for several thousand years. It over 540 metabolites thought to be responsible its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating Preclinical clinical research indicates that a wide range effects, many them relevant management cancer. In this article, we explore some potential mechanisms action cancer, evidence efficacy integrative cancer including side effects associated with treatment, demonstrating integration orthodox care.

Language: Английский

Citations

53