Life Sciences, Journal Year: 2019, Volume and Issue: 239, P. 117043 - 117043
Published: Nov. 10, 2019
Language: Английский
Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 239 - 239
Published: Jan. 26, 2022
The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk many diseases related metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, cancer. Citrus, genus Citrus L., is one most important fruit crops, rich in carotenoids, flavonoids, terpenes, limonoids, other bioactive compounds nutritional nutraceutical value. Moreover, polymethoxylated flavones (PMFs), a unique class abundantly occur citrus fruits. In addition, essential oil, limonoids an economically product due its potent antioxidant, antimicrobial, flavoring properties. Mechanistic, observational, intervention studies have demonstrated health benefits bioactives minimizing syndrome. This review provides comprehensive view composition fruits their associated benefits.
Language: Английский
Citations
312
Journal of Functional Foods, Journal Year: 2022, Volume and Issue: 95, P. 105163 - 105163
Published: June 29, 2022
This review summarizes the potential use of citrus peels in food industry. The present work is an overview different compounds extracted from various species peel and functional properties compounds, along with their applications as valuable ingredients food-based products. Citrus a natural source diverse bioactive including polyphenols, pectins, proteins, pigments, dietary fibers, essential oils. These exhibit many biological activities, antioxidant, antimicrobial, anticancer, anti-inflammatory, antidiabetic activities. Thus, can be considered promising foods. It also utilized food-coloring, flavoring, thickening agent. waste generated processing industry form exhibits economic benefits by reentering line additive while providing sustainable innovative solutions to utilization.
Language: Английский
Citations
110
Current Developments in Nutrition, Journal Year: 2020, Volume and Issue: 4(5), P. nzaa025 - nzaa025
Published: March 10, 2020
Citrus fruit and in particular flavonoid compounds from citrus peel have been identified as agents with utility the treatment of cancer. This review provides a background overview regarding found within putative anticancer potential well associated vitro vivo studies. Historical studies number cellular processes that can be modulated by flavonoids including cell proliferation, cycle regulation, apoptosis, metastasis, angiogenesis. More recently, molecular started to elucidate underlying signaling pathways are responsible for flavonoids' mechanism action. These growing data support further research into chemopreventative extracts, purified particular. critical highlights new field synthesizes other polyphenolic generalized schema.
Language: Английский
Citations
102
Molecules, Journal Year: 2020, Volume and Issue: 25(22), P. 5431 - 5431
Published: Nov. 20, 2020
Peptic ulcers are characterized by erosions on the mucosa of gastrointestinal tract that may reach muscle layer. Their etiology is multifactorial and occurs when balance between offensive protective factors disturbed. represent a global health problem, affecting millions people worldwide showing high rates recurrence. Helicobacter pylori infection use non-steroidal anti-inflammatory drugs (NSAIDs) one most important predisposing for development peptic ulcers. Therefore, new approaches to complementary treatments needed prevent their Natural products such as medicinal plants isolated compounds have been widely used in experimental models Flavonoids among molecules greatest interest biological assays due antioxidant properties. The present study literature review flavonoids reported show ulcer activity models. Studies published from January 2010 2020 were selected reference databases. This refers collection with antiulcer vivo vitro
Language: Английский
Citations
85
Journal of Agricultural and Food Chemistry, Journal Year: 2021, Volume and Issue: 69(39), P. 11676 - 11686
Published: Sept. 24, 2021
Anthocyanins (ACs) are able to protect neurons against β-amyloid-induced neurotoxicity. In this study, we evaluated blood–brain barrier (BBB) permeability of these compounds using a model kit clarify the mechanism AC on brain. Black currant or strawberry extract was orally administrated male Wistar rats. The urine and extirpated brain were collected before after administration analyzed quantitatively by liquid chromatography–tandem mass spectrometry. After AC, several phenolic acids detected in samples. Further, some metabolites found tissue. BBB permeabilities much lower than positive control. Epigallocatechin, daidzein, genistein, equol, nobiletin presented high permeability, whereas apigenin, luteolin, quercetin, kaempferol showed medium epicatechin, rutin, fisetin, resveratrol, curcumin permeation neglected. These results suggested that ACs difficult cross into not directly associated with prevention
Language: Английский
Citations
85
Journal of Agricultural and Food Chemistry, Journal Year: 2019, Volume and Issue: 67(18), P. 5122 - 5134
Published: April 17, 2019
Neuroinflammation has been intensively demonstrated to be related various neurodegenerative diseases including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer's (AD). A natural polymethoxylated flavone, nobiletin (NOB) reported alleviate oxidative stress, insulin resistance, obesity. In this study, we evaluated the protection effects of NOB on neuroinflammation memory deficit. Three-month mice were administrated with by oral gavage every day for 6 weeks (100 mg/kg/day); subsequently injected intraperitoneally lipopolysaccharide (LPS) 7 days. Results behavioral tests revealed that dramatically ameliorated LPS-triggered deficit regarding synaptic dysfunctions neuronal loss. Also, suppressed microglial activation proinflammatory cytokine secretion, such as COX-2, IL-1β, TNF-α, iNOS. Similarly, upon LPS stimulation, pretreatment diminished secretion cytokines in BV-2 microglia cells exposure via modulating MAPKs, PI3K/AKT, NF-κB signaling pathways. addition, alleviated LPS-amplified redox imbalance, disturbance mitochondrial membrane potential (MMP), dampening expression protein respiration. The present study provides compelling evidence decreased LPS-stimulated impairment through maintaining cellular balance blocking transcriptional pathway, illustrating nutritional compound may serve a approach neuroinflammation-related diseases.
Language: Английский
Citations
79
Marine Drugs, Journal Year: 2021, Volume and Issue: 19(4), P. 201 - 201
Published: April 3, 2021
Neurological disorders are diseases of the central and peripheral nervous system that affect millions people, numbers rising gradually. In pathogenesis neurodegenerative diseases, roles many signaling pathways were elucidated; however, exact pathophysiology neurological possible effective therapeutics have not yet been precisely identified. This necessitates developing multi-target treatments, which would simultaneously modulate neuroinflammation, apoptosis, oxidative stress. The present review aims to explore potential therapeutic use astaxanthin (ASX) in neuroinflammatory diseases. ASX, a member xanthophyll group, was found be promising anti-inflammatory agent for disorders, including cerebral ischemia, Parkinson’s disease, Alzheimer’s autism, neuropathic pain. An drug delivery ASX should developed further tested by appropriate clinical trials.
Language: Английский
Citations
67
Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(19)
Published: Sept. 30, 2021
Neurodegenerative diseases encompass a large group of conditions that are clinically and pathologically diverse yet linked by shared pathology misfolded proteins. The accumulation insoluble aggregates is accompanied progressive loss vulnerable neurons. For some patients, the symptoms motor focused (ataxias), while others experience cognitive psychiatric (dementias). Among neurodegenerative disruption sleep/wake cycle occurs early in trajectory disease may be risk factor for development. In many cases, timing sleep other rhythmic physiological markers immediately raises possibility neurodegeneration-driven circadian system. aim this Review to summarize evidence supporting hypothesis core symptom within diseases, including Alzheimer's disease, Huntington's Parkinson's discuss latest progress field. discusses processes disrupt structure function system describes circadian-based interventions as well timed drug treatments improve wide range associated with disorders. It also identifies key gaps our knowledge.
Language: Английский
Citations
64
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13630 - 13630
Published: Nov. 7, 2022
Alzheimer’s disease (AD) is a frequent and disabling neurodegenerative disorder, in which astrocytes participate several pathophysiological processes including neuroinflammation, excitotoxicity, oxidative stress lipid metabolism (along with critical role apolipoprotein E function). Current evidence shows that have both neuroprotective neurotoxic effects depending on the stage microenvironmental factors. Furthermore, appear to be affected by presence of amyloid-beta (Aβ), alterations calcium levels, gliotransmission proinflammatory activity via RAGE-NF-κB pathway. In addition, play an important tau clearance Aβ through glymphatic system. this review, we will discuss novel pharmacological non-pharmacological treatments focused as therapeutic targets for AD. These interventions include anti-inflammatory/antioxidant systems, glutamate activity, metabolism, neurovascular coupling system, dysregulation, release peptides affects glial neuronal function. According AD stage, these therapies may benefit either preventing or delaying progression disease.
Language: Английский
Citations
64
Life Sciences, Journal Year: 2022, Volume and Issue: 306, P. 120855 - 120855
Published: Aug. 1, 2022
Language: Английский
Citations
45