Coronavirus infections and immune responses

Journal of Medical Virology, Journal Year: 2020, Volume and Issue: 92(4), P. 424 - 432

Published: Jan. 25, 2020

Coronaviruses (CoVs) are by far the largest group of known positive-sense RNA viruses having an extensive range natural hosts. In past few decades, newly evolved have posed a global threat to public health. The immune response is essential control and eliminate CoV infections, however, maladjusted responses may result in immunopathology impaired pulmonary gas exchange. Gaining deeper understanding interaction between innate systems hosts shed light on development persistence inflammation lungs hopefully can reduce risk lung caused CoVs. this review, we provide update infections relevant diseases, particularly host defense against CoV-induced tissue, as well role system pathogenesis clinical treatment.

Language: Английский

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COVID-19: A promising cure for the global panic

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 725, P. 138277 - 138277

Published: April 4, 2020

Language: Английский

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Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(20), P. 10922 - 10922

Published: Oct. 10, 2021

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation causing progressive joint damage that can lead to lifelong disability. The pathogenesis of RA involves a complex network various cytokines and cells trigger synovial cell proliferation cause both cartilage bone. Involvement the tumor necrosis factor (TNF)-α interleukin (IL)-6 central RA, but recent research has revealed other such as IL-7, IL-17, IL-21, IL-23, granulocyte macrophage colony-stimulating (GM-CSF), IL-1β, IL-18, IL-33, IL-2 also play role. Clarification pathology led development therapeutic agents biological disease-modifying anti-rheumatic drugs (DMARDs) Janus kinase (JAK) inhibitors, further details immunological background are emerging. This review covers existing knowledge regarding roles cytokines, related immune system in manipulation which may offer potential for even safer more effective treatments future.

Language: Английский

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Periodontal Inflammation and Systemic Diseases: An Overview

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 27, 2021

Periodontitis is a common inflammatory disease of infectious origins that often evolves into chronic condition. Aside from its importance as stomatologic ailment, periodontitis has gained relevance since it been shown can develop systemic condition characterized by unresolved hyper-inflammation, disruption the innate and adaptive immune system, dysbiosis oral, gut other location's microbiota system-wide alterations may cause, coexist or aggravate health issues associated to elevated morbi-mortality. The relationships between infectious, immune, inflammatory, features many related diseases are far being fully understood indeed still debated. However, date, large body evidence on different biological, clinical, policy-enabling sources information, available. aim present work summarize these information contextualize them under inflammation framework set basis an integral vision, useful for basic, therapeutic goals.

Language: Английский

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Periodontal Disease: The Good, The Bad, and The Unknown

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Dec. 7, 2021

Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues periodontal complex, mediated an interplay between dysbiotic microbial communities aberrant immune responses within gingival tissues. Putative pathogens are enriched as resident oral microbiota becomes inflammatory evoke tissue destruction, thus inducing unremitting positive feedback loop proteolysis, inflammation, enrichment for pathogens. Keystone sustained inflammation critical to progression. However, recent studies have revealed importance previously unidentified microbes involved in progression, including various viruses, phages bacterial species. Moreover, newly identified immunological genetic mechanisms, well environmental host factors, diet lifestyle, been discerned years further contributory factors periodontitis. These collectively expanded established narrative In line with this, new ideologies related maintaining health treating existing explored, such application probiotics, limit attenuate The role systemic pathologies, autoimmune disorders diabetes, pathogenesis has noted. Recent additionally reciprocated potentiating states at distal sites, Alzheimer’s disease, bowel diseases, cancer, highlighting cavity health. Here we review long-standing knowledge progression while integrating novel research concepts that broadened our understanding disease. Further, delve into innovative hypotheses may evolve address significant gaps foundational

Language: Английский

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Advancing the use of genome-wide association studies for drug repurposing

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 22(10), P. 658 - 671

Published: July 23, 2021

Language: Английский

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Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(18), P. 4541 - 4541

Published: Sept. 13, 2019

The association between rheumatoid arthritis (RA) and periodontal disease (PD) has been the focus of numerous investigations driven by their common pathological features. RA is an autoimmune characterized chronic inflammation, production anti-citrullinated proteins antibodies (ACPA) leading to synovial joint inflammation destruction. PD a inflammatory condition associated with dysbiotic microbial biofilm affecting supporting tissues around teeth destruction mineralized non-mineralized connective tissues. Chronic both similar in predominant adaptive immune phenotype, imbalance pro- anti-inflammatory cytokines role smoking genetic background as risk factors. Structural damage that occurs consequence ultimate cause loss function disability observed progression PD. Interestingly, pathogen Porphyromonas gingivalis implicated generation ACPA patients, suggesting direct biological intersection RA. However, more studies are warranted confirm this link, elucidate potential mechanisms involved, ascertain temporal associations This review mainly focused on recent clinical translational research intends discuss provide overview relationship PD, exploring similarities immune-pathological aspects possible linking development diseases. In addition, current available treatments targeting were revised.

Language: Английский

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Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats

Life Sciences, Journal Year: 2021, Volume and Issue: 269, P. 119008 - 119008

Published: Jan. 10, 2021

Ulcerative colitis (UC) is a chronic inflammatory bowel disease related to intestinal dysbiosis. Luteolin has been reported reduce inflammation. However, it remains unclear whether luteolin ameliorates UC and regulates gut microbiota. In this study, we investigated the effects of on colonic structure inflammation dextran sulfate sodium (DSS)-induced rats using hematoxylin-eosin staining, immunohistochemistry enzyme-linked immunosorbent assay evaluated microbiota 16S rDNA sequencing. We found that treatment significantly reduced damage, inhibited in rats, evidenced by decreased levels NF-κB, IL-17 IL-23 increased level PPAR-γ. addition, sequencing analysis revealed could alter diversity composition rats. Lactobacillus, Bacteroides, Roseburia Butyricicoccus were dominant genera group. DSS-induced ratios Lactobacillus Prevotella_9. Furthermore, KEGG was mainly DNA repair recombination proteins, ribosome, purine metabolism, peptidases, pyrimidine metabolism. conclusion, our results alleviate had potential serve as promising biomarkers for uncovering mechanism which improved UC.

Language: Английский

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Role of the IL23/IL17 Pathway in Crohn’s Disease

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: March 30, 2021

Crohn’s disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and represents one main entities inflammatory bowel (IBD). CD affects genetically susceptible patients that are influenced by environmental factors intestinal microbiome, which results in excessive activation mucosal immune system aberrant cytokine responses. Various studies have implicated pro-inflammatory cytokines IL17 IL23 pathogenesis CD. member IL12 family able to enhance affect expansion pathogenic T helper type 17 (Th17) cells through various mechanisms, including maintenance Th17 signature genes, upregulation effector genes or suppression repressive factors. Moreover, signaling induce cascade molecules like TNF, IFNγ, IL22, lymphotoxin, IL1β lipopolysaccharide (LPS). Here, IL17A TNF known mediate synergistically drive expression genes. Recent advances understanding immunopathogenetic mechanisms underlying led development new biological therapies selectively intervene inhibit processes caused mediators IL23. Recently published data demonstrate treatment with selective inhibitors lead markedly high response rates cohort failed previous anti-TNF therapy. Macrophages considered as source intestine supposed play key role molecular crosstalk cell subsets innate lymphoid gut. The following review focuses on pathways specific IL23/IL17 pathway.

Language: Английский

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Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114985 - 114985

Published: June 11, 2023

The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.

Language: Английский

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