Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(10), P. 937 - 937
Published: Sept. 29, 2020
The
astronomical
increase
of
the
world’s
aged
population
is
associated
with
increased
prevalence
neurodegenerative
diseases,
heightened
disability,
and
extremely
high
costs
care.
Alzheimer’s
Disease
(AD)
a
widespread,
age-related,
multifactorial
disease
that
has
enormous
social
financial
drawbacks
worldwide.
unsatisfactory
outcomes
available
AD
pharmacotherapy
necessitate
search
for
alternative
natural
resources
can
target
various
underlying
mechanisms
pathology
reduce
occurrence
and/or
progression.
Royal
jelly
(RJ)
main
food
bee
queens;
it
contributes
to
their
fertility,
long
lifespan,
memory
performance.
It
represents
potent
nutraceutical
pharmacological
properties,
been
used
in
number
preclinical
studies
age-related
cognitive
deterioration.
To
understand
through
which
RJ
affects
performance
both
aging
AD,
we
reviewed
literature,
elaborating
on
metabolic,
molecular,
cellular
mediate
its
anti-AD
effects.
Preclinical
findings
revealed
acts
as
multidomain
enhancer
restore
models.
promotes
brain
cell
survival
function
by
targeting
multiple
adversities
neuronal
microenvironment
such
inflammation,
oxidative
stress,
mitochondrial
alterations,
impaired
proteostasis,
amyloid-β
toxicity,
Ca
excitotoxicity,
bioenergetic
challenges.
Human
trials
using
are
limited
quantity
quality.
Here,
limitations
RJ-based
treatment
strategies
discussed,
directions
future
examining
effect
cognitively
subjects
noted.
International Journal of Environmental Research and Public Health,
Journal Year:
2020,
Volume and Issue:
17(14), P. 5028 - 5028
Published: July 13, 2020
Menopause
is
an
inevitable
developmental
event
that
women
encounter
at
age
of
42–54
years.
The
drop
estrogen
levels
accompanies
cessation
menstruation
associated
with
multiple
vasomotor,
physical,
neuropsychological,
and
sexual
symptoms,
which
may
hamper
quality
life.
This
study
aimed
to
examine
the
severity
psychological
symptoms
their
correlates
among
peri-
postmenopausal
Emirati
(N
=
60,
mean
54.88
±
6
years).
Participants
were
interviewed
using
Menopause-Specific
Quality
Life
(MENQOL)
attitudes
toward
menopause
scale
(ATMS).
In
four
path
analysis
models,
vasomotor
weight
gain,
fatigue
had
significant
direct
effects
on
anxiety,
depression
(only
gain
fatigue),
distress.
Fatigue
significantly
mediated
symptoms),
distress,
memory
problems.
These
models
explained
47.6%,
44.5%,
56.6%,
29.1%
variances
in
depression,
problems,
respectively.
more
severe
menopausal
expressed
negative
though
regression
revealed
only
could
contribute
ATMS
scores.
conclusion,
distress
widespread
women,
it
fatigue,
change
body
composition
(obesity).
Psychological
along
express
a
key
link
menopause.
Therefore,
interventional
strategies
target
promote
coping
midlife
transition
improve
mental
health
women.
Foods,
Journal Year:
2020,
Volume and Issue:
9(10), P. 1362 - 1362
Published: Sept. 25, 2020
The
global
pandemic
of
sarcopenia,
skeletal
muscle
loss
and
weakness,
which
prevails
in
up
to
50%
older
adults
is
increasing
worldwide
due
the
expansion
aging
populations.
It
now
striking
young
midlife
as
well
because
sedentary
lifestyle
increased
intake
unhealthy
food
(e.g.,
western
diet).
lockdown
measures
economic
turndown
associated
with
current
outbreak
Coronavirus
Disease
2019
(COVID-19)
are
likely
increase
prevalence
sarcopenia
by
promoting
sedentarism
patterns
eating.
Sarcopenia
has
multiple
detrimental
effects
including
falls,
hospitalization,
disability,
institutionalization.
Although
a
few
pharmacological
agents
bimagrumab,
sarconeos,
exercise
mimetics)
being
explored
different
stages
trials,
not
single
drug
been
approved
for
treatment.
Hence,
research
focused
on
testing
effect
nutraceuticals,
such
bee
products,
safe
treatments
prevent
and/or
treat
sarcopenia.
Royal
jelly,
propolis,
pollen
common
products
that
rich
highly
potent
antioxidants
flavonoids,
phenols,
amino
acids.
These
order,
stimulate
larval
development
into
queen
bees,
promote
defenses
hive
against
microbial
environmental
threats,
royal
jelly
production
nurse
bees.
Thanks
their
versatile
activities
anti-aging,
anti-inflammatory,
anticarcinogenic,
antimicrobial,
etc.),
these
have
used
chronic
conditions
predispose
wasting
hypertension,
diabetes
mellitus,
cardiovascular
disorder,
cancer,
name
few.
They
were
also
some
evolving
studies
laboratory
animals
and,
limited
degree,
humans.
However,
collective
understanding
mechanism
action
well-developed.
Therefore,
this
review
examines
literature
possible
pollen,
propolis
aged
experimental
models,
cell
cultures,
Collectively,
data
from
reviewed
denote
varying
levels
positive
mass,
strength,
function.
underlying
mechanisms
include
amelioration
inflammation
oxidative
damages,
promotion
metabolic
regulation,
enhancement
satellite
stem
responsiveness,
improvement
muscular
blood
supply,
inhibition
catabolic
genes,
peripheral
neuronal
regeneration.
This
offers
suggestions
other
be
provides
guidance
future
trials
investigating
among
people
Journal of Functional Foods,
Journal Year:
2021,
Volume and Issue:
82, P. 104514 - 104514
Published: May 11, 2021
Royal
jelly
(RJ)
is
a
kind
of
bee
product
widely
used
in
cosmetics,
medicine
and
other
fields.
Not
only
can
RJ
regulate
the
physiological
function
population,
but
also
play
specific
biological
role
many
diseases.
This
paper
overviews
main
active
ingredients
functional
food
RJ,
including
major
royal
protein,
fatty
acids,
phenols,
flavonoids,
etc,
summarizes
maintenance
human
health,
such
as
regulation
immunity,
lifespan,
memory,
digestive
system,
blood
glucose,
obesity,
antibacterial
anti-cancer
effect,
among
which
memory
be
treatment
Alzheimer's
disease.
These
findings
will
benefit
for
comprehensive
understanding
use
hence
making
it
more
effective
maintaining
health.
Journal of Materials Research and Technology,
Journal Year:
2021,
Volume and Issue:
13, P. 2078 - 2114
Published: June 11, 2021
Tissue
regeneration
is
a
vital
phenomenon
in
the
skeletal
system
of
human
beings
during
their
life
span.
The
structure
bony
architecture
and
teeth
are
highly
dependent
to
this
ongoing
procedure
maintain
functional
form.
Regarding
fundamental
function
our
system,
all
involved
components
at
constant
risk
for
injuries
deformations
throughout
life.
Therefore,
modern
medicine,
promotion
bone
tooth
has
become
critical
counter
measure
correct
these
acquired
defects.
There
numerous
ways
address
related
erosive
pathologies
but
utilization
natural
compounds
gained
immense
popularity
recent
years.
These
materials
provide
broad
spectrum
therapeutic
agents
with
variety
biological
characteristics.
In
review,
comprehensive
exploration
been
implemented
extract
categorize
relevant
scientific
evidence
on
issue,
based
source
candidates
potential
clinical
indications.
Database
searching
presented
considerable
data
pool
more
than
300
references
field.
According
results,
proposed
items
can
be
categorized
two
major
groups
including
scaffolding
osteogenesis
(or
dentinogenesis)
induction.
applicability
number
them
properly
demonstrated
trials
rest,
examinations
required
reach
conclusive
decision.
Phytomedicine Plus,
Journal Year:
2022,
Volume and Issue:
2(2), P. 100239 - 100239
Published: Feb. 12, 2022
Humanity
has
benefited
from
bee
products
over
the
centuries
for
treating
and
preventing
various
illnesses,
apitherapy
been
employed
in
several
countries
as
a
complementary
medicine.
This
review
aimed
to
discuss
scientific
research
clinical
trials
using
their
relationship
with
apitherapy.
Scientific
researches
based
on
studies
carried
out
vitro
different
cell
cultures,
vivo
studying
mice
or
other
experimental
animals
are
discussed.
Clinical
also
documented.
The
most
common
applications
of
presented,
well
cases
allergy
allergies.
Standardization
use
Apitherapy
is
practiced
some
parts
world,
bringing
benefits
healthy
individuals
patients,
no
clear
consensus
its
application
according
world
regions
prevalent
product
treated
disease.
Different
recommendations
regarding
found
people
ingest
amounts
once
times
day.
Although
we
have
advanced
lot
about
knowledge
products,
it
imperative
exploit
potential
standardize
use,
communicating
results
alternative
events
reinforce
exchange
information
between
beekeepers,
researchers,
apitherapists,
nutritionists,
physicians,
sellers
consumers
products.
If
not,
will
always
be
working
separately,
without
complementing
our
expertise.
Science Advances,
Journal Year:
2022,
Volume and Issue:
8(37)
Published: Sept. 16, 2022
Development
is
tightly
connected
to
aging,
but
whether
pharmacologically
targeting
development
can
extend
life
remains
unknown.
Here,
we
subjected
genetically
diverse
UMHET3
mice
rapamycin
for
the
first
45
days
of
life.
The
grew
slower
and
remained
smaller
than
controls
their
entire
lives.
Their
reproductive
age
was
delayed
without
affecting
offspring
numbers.
treatment
sufficient
median
span
by
10%,
with
strongest
effect
in
males,
helped
preserve
health
as
measured
frailty
index
scores,
gait
speed,
glucose
insulin
tolerance
tests.
Mechanistically,
liver
transcriptome
epigenome
treated
were
younger
at
completion
treatment.
Analogous
mice,
exposure
during
robustly
extended
Daphnia
magna
reduced
its
body
size.
Overall,
results
demonstrate
that
short-term
a
novel
longevity
intervention
acts
slowing
down
suggesting
aging
may
be
targeted
already
early
International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(5), P. 2772 - 2772
Published: March 9, 2021
Malnutrition
is
common
among
severe
patients
with
coronavirus
disease
2019
(COVID-19),
mainly
elderly
adults
and
comorbidities.
It
also
associated
atypical
presentation
of
the
disease.
Despite
possible
contribution
malnutrition
to
acquisition
severity
COVID-19,
it
not
clear
which
nutritional
screening
measures
may
best
diagnose
in
these
at
early
stages.
This
crucial
importance
given
urgency
rapid
progression
vulnerable
groups.
Accordingly,
this
review
examines
available
literature
for
different
approaches
implemented
COVID-19
patients,
a
special
focus
on
adults.
After
search,
we
selected
scrutinized
14
studies
assessing
patients.
The
Nutrition
Risk
Screening
2002
(NRS-2002)
has
demonstrated
superior
sensitivity
other
traditional
measures.
controlling
status
(CONUT)
score,
comprises
serum
albumin
level,
cholesterol
lymphocytes
count,
as
well
combined
CONUT-lactate
dehydrogenase-C-reactive
protein
score
expressed
predictive
capacity
even
that
NRS-2002
(0.81%
0.92%
vs.
0.79%)
midlife
elder
Therefore,
simple
based
routinely
conducted
laboratory
investigations
such
CONUT
be
timely,
cheap,
valuable
alternatives
identifying
high
risk.
Mini
Nutritional
Assessment
(MNA)
was
only
measure
used
detect
residual
risk
remitting
patients—MNA
scores
correlated
hypoalbuminemia,
hypercytokinemia,
weight
loss.
Older
males
inflammation,
gastrointestinal
symptoms,
pre-existing
comorbidities
(diabetes,
obesity,
or
hypertension)
are
more
prone
subsequently
poor
prognosis
both
during
acute
phase
convalescence.
Thus,
they
need
frequent
monitoring
support
while
detecting
treating
general
public
might
necessary
increase
resilience
against
COVID-19.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Aug. 18, 2022
Abstract
In
recent
years
silver
nanoparticles
(Ag
NPs)
gained
increased
and
widespread
applications
in
various
fields
of
industry,
technology,
medicine.
This
study
describes
the
green
synthesis
applying
a
low-molecular-weight
fraction
(LMF)
Royal
Jelly,
nanoparticle
characterization,
particularly
their
antibacterial
activity.
The
optical
properties
NPs,
characterized
by
UV–Vis
absorption
spectroscopy,
showed
peak
at
~
430
nm.
hydrodynamic
radius
concentration
were
determined
complementary
dynamic
light
scattering
(DLS)
tracking
analysis
(NTA).
particle
morphology
was
investigated
using
transmission
electron
microscopy
(TEM),
crystallinity
confirmed
X-ray
diffraction
(XRD).
activities
evaluated
utilizing
Gram-negative
Gram-positive
bacteria
colony
counting
assays.
growth
inhibition
curve
method
applied
to
obtain
information
about
corresponding
minimum
inhibitory
concentrations
(MIC)
bactericidal
(MBC)
required.
Obtained
results
that
(i)
sizes
Ag
NPs
are
increasing
within
increase
ion
precursor
concentration,
(ii)
DLS,
agreement
with
NTA,
most
particles
have
dimensions
range
50–100
nm;
(iii)
E.
coli
more
susceptible
all
NP
samples
compared
B.
subtilis
.
