Materials,
Journal Year:
2022,
Volume and Issue:
15(3), P. 775 - 775
Published: Jan. 20, 2022
The
use
of
silver
nanoparticles
(Ag
NPs)
in
the
biomedical
field
deserves
a
mindful
analysis
possible
inflammatory
response
which
could
limit
their
clinic.
Despite
anti-cancer
properties
Ag
NPs
having
been
widely
demonstrated,
there
are
still
few
studies
concerning
involvement
activation
specific
pathways.
outcome
depends
on
synthetic
route
used
production,
toxic
reagents
employed.
In
this
work,
we
compared
two
types
NPs,
obtained
by
different
chemical
routes:
conventional
synthesis
using
sodium
citrate
and
green
protocol
based
leaf
extracts
as
source
reduction
capping
agents.
A
careful
physicochemical
characterization
was
carried
out
showing
spherical
stable
with
an
average
size
between
20
nm
35
for
respectively.
Then,
evaluated
ability
to
induce
inflammation
Human
Leukemic
Monocytes
(THP-1)
differentiated
into
M0
macrophages
1
µM
2
concentrations
(corresponded
0.1
µg/mL
0.2
respectively)
two-time
points
(24
h
48
h).
Our
results
showed
clear
difference
Nuclear
Factor
κB
(NF-κb)
activation,
Interleukins
6-8
(IL-6,
IL-8)
secretion,
Tumor
Necrosis
Factor-α
(TNF-α)
Cyclooxygenase-2
(COX-2)
expression
exerted
kinds
NPs.
Green
were
definitely
tolerated
induced
all
factors
mentioned
above.
Subsequently,
exposure
breast
cancer
cell
line
(MCF-7)
that
they
exhibited
antitumor
activity
like
ones,
but
surprisingly,
MCF-10A
(not
tumoral
cells)
did
not
cause
significant
decrease
viability.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(5), P. 2485 - 2485
Published: March 2, 2021
Silver
nanoparticles
(AgNPs)
have
been
successfully
applied
in
several
areas
due
to
their
significant
antimicrobial
activity
against
microorganisms.
In
dentistry,
AgNP
can
be
disinfection,
prophylaxis,
and
prevention
of
infections
the
oral
cavity.
this
work,
use
silver
dentistry
associated
technological
innovations
was
analyzed.
The
scientific
literature
searched
using
PubMed
Scopus
databases
with
descriptors
related
resulting
90
open-access
articles.
search
for
patents
restricted
A61K
code
(International
Patent
Classification),
same
descriptors,
206
patents.
results
found
were
ordered
by
dental
specialties
demonstrated
incorporation
AgNPs
different
dentistry.
context,
reaffirmed
growth
technology
dominance
USA
pharmaceutical
industry
over
product
development.
It
could
concluded
that
nanotechnology
is
a
promising
area
applications.
Materials,
Journal Year:
2021,
Volume and Issue:
14(1), P. 221 - 221
Published: Jan. 5, 2021
Denture
stomatitis
is
a
common
manifestation
of
oral
candidiasis
affecting
some
65%
denture
wearers.
This
condition
initiated
by
the
adherence
Candida
albicans
to
base
acrylic
resin.
The
present
study
aimed
test
in
vitro
effect
traditional
and
novel
fabrication
methods
on
adhesion
samples.
based
discs
were
fabricated
using:
(i)
computerized
milling,
(ii)
3D
printing,
(iii)
heat
curing,
(iv)
cold
curing.
Discs
tested
for
surface
roughness
(Ra),
hydrophobicity
(contact
angle),
mucin
adsorption
(Bradford
assay),
adhesion.
printing
significantly
increased
microbial
cell
as
compared
with
milling
decreased
it.
These
results
associated
levels
rather
than
roughness.
Results
suggest
that
may
increase
risk
developing
stomatitis,
whereas
decrease
it
curing
fabrication.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(18), P. 10288 - 10288
Published: Sept. 7, 2022
Polymethyl
methacrylate
(PMMA),
a
well-known
polymer
of
the
family,
is
extensively
used
in
biomedicine,
particularly
odontological
applications
including
artificial
teeth,
dentures
and
denture
bases,
obturators,
provisional
or
permanent
crowns,
so
forth.
The
exceptional
PMMA
properties,
aesthetics,
inexpensiveness,
simple
manipulation,
low
density,
adjustable
mechanical
make
it
perfect
candidate
field
dentistry.
However,
presents
some
deficiencies,
weakness
regarding
hydrolytic
degradation,
poor
fracture
toughness,
lack
antibacterial
activity.
To
further
enhance
its
properties
solve
these
drawbacks,
different
approaches
can
be
performed,
incorporation
nanofillers.
In
this
regard,
types
metallic
nanoparticles,
metal
oxide
nanofillers,
carbon-based
nanomaterials
have
been
recently
integrated
into
matrices
with
aim
to
reduce
water
absorption
improve
their
performance,
namely
thermal
flexural
properties.
review,
recent
studies
development
PMMA-based
nanocomposites
for
odontology
are
summarized
future
perspectives
highlighted.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 864 - 864
Published: Feb. 22, 2022
This
review
aims
to
describe
and
critically
analyze
studies
published
over
the
past
four
years
on
application
of
polymeric
dental
nanomaterials
as
antimicrobial
materials
in
various
fields
dentistry.
Nanoparticles
are
promising
additives
restoration
materials.
According
data,
composites
based
silver
nanoparticles,
zinc(II),
titanium(IV),
magnesium(II),
copper(II)
oxide
chitosan
calcium
phosphate
or
fluoride
nanodiamonds
can
be
used
therapy
endodontics.
Composites
with
nanoparticles
hydroxyapatite
bioactive
glass
proved
low
efficiency
for
these
fields.
The
applicable
orthodontics
include
nanodiamonds,
titanium(IV)
zinc(II)
glass,
yttrium(III)
nanoparticles.
periodontics,
silver,
chitosan,
employed
implantology
prosthetics.
also
utilized
maxillofacial
surgery
manufacture
prostheses.
halloysite
nanotubes
field
denture
calcium(II)
therapeutic
dentistry
tooth
restoration.
Sustainability,
Journal Year:
2022,
Volume and Issue:
14(19), P. 12942 - 12942
Published: Oct. 10, 2022
The
development
of
novel
antifungal
agents
and,
in
particular,
the
widespread
use
these
medications
over
course
past
two
decades,
has
had
a
significant
impact
on
treatment
fungal
infectious
diseases.
This
resulted
complete
transformation
However,
antibiotic
resistance
masked
significance
such
breakthroughs.
Antifungal
infection
with
nanoparticles
been
shown
to
be
effective.
As
result
their
unique
characteristics,
substances,
contrast
antibiotics
purest
form,
are
able
exhibit
an
increased
anti-proliferative
capacity
while
requiring
lower
concentration
than
traditional
drugs
do
order
achieve
same
effect.
Decreased
drug
effectiveness,
minimal
tissue
penetration
throughout
tissue,
restricted
penetration,
decreased
bioavailability,
poor
pharmacokinetics,
and
low
water
solubility
some
major
factors
contributing
employment
medicines
delivery
systems.
Because
this,
one
primary
goals
incorporating
into
varying
sorts
is
reduce
negative
effects
drugs’
inherent
qualities.
article
provides
overview
many
types
nanoparticles,
as
metal,
metal
oxide,
non-metal
oxide
carbon-based
nanostructured
lipid
carriers,
polymeric
solid
nanofibers,
peptides,
composites,
ZnO
quantum
dots,
that
can
used
systems,
well
benefits
nanomaterials
have
purified
medications.
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(4), P. 3029 - 3029
Published: Feb. 9, 2023
One
of
the
most
common
oral
diseases
affecting
people
wearing
dentures
is
chronic
atrophic
candidiasis
or
denture
stomatitis
(DS).
The
aim
paper
to
provide
an
update
on
pathogenesis,
presentation,
and
management
DS
in
general
dental
practice
settings.
A
comprehensive
review
literature
published
last
ten
years
was
undertaken
using
multiple
databases,
including
PubMed
via
MEDLINE,
EMBASE,
Scopus.
eligible
articles
were
analyzed
identify
evidence-based
strategies
for
DS.
Despite
its
multifactorial
nature,
leading
cause
development
Candida
albicans
biofilm,
which
facilitated
by
poor
hygiene,
long-term
wear,
ill-fitting
dentures,
porosity
acrylic
resin
dentures.
affects
between
17
75%
population
with
a
slight
predominance
elderly
females.
mucosal
surfaces
posterior
tongue
are
sites
DS,
affected
areas
exhibit
erythema,
swelling
palatal
mucosa
edema.
Oral
hygiene
protocols,
adjusting
re-fabricating
poorly
adapting
smoking
cessation,
avoiding
nocturnal
administration
topical
systemic
antifungals
mainstay
management.
Alternate
treatments
such
as
microwave
disinfection,
phytomedicine,
photodynamic
therapy,
incorporation
nanoparticles
into
resins
being
evaluated
treatment
but
require
further
evidence
before
routine
use
clinical
practice.
In
summary,
inflammatory
lesion
experienced
wearers.
Most
patients
can
be
managed
Effective
practitioners
may
supported
thorough
understanding
recognition
awareness
contemporary
strategies.
