International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 250, P. 126153 - 126153
Published: Aug. 7, 2023
Language: Английский
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: June 30, 2022
Colorectal cancer (CRC) is the second most deadly worldwide. CRC management challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs spices used in cooking, practised for generations, have been shown contain protective effect or even be useful as an anti-CRC adjuvant therapy when doses. many bioactive compounds possess beneficial health effects. The chemopreventive properties of these herbs are mainly mediated by BCL-2, K-ras, MMP pathways, caspase activation, extrinsic apoptotic pathway, regulation ER-stress-induced apoptosis. As a safer natural alternative, could good candidates chemotherapeutic agents because their antiproliferative action on colorectal carcinoma cells inhibitory activity angiogenesis. Therefore, this narrative review, six different herbs: ginger ( Zingiber officinale Roscoe), turmeric Curcuma longa L.), garlic Allium sativum fenugreek Trigonella foenum-graecum sesame Sesamum indicum flaxseed Linum usitatissimum L.) daily cuisine were selected study analyzed chemoprotective roles with underlying molecular mechanisms actions. Initially, comprehensively discussed basis development, followed culinary traditional uses, current scientific research, publications cancers. Lead each herb spice, including phytoconstituents, antioxidant activities, anti-inflammatory properties, finally, effects treatment mechanisms. Future possible works suggested where applicable.
Language: Английский
Citations
324
BMC Cancer, Journal Year: 2020, Volume and Issue: 20(1)
Published: Aug. 24, 2020
Abstract Background Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The of curcumin include inhibiting the carcinogenesis, angiogenesis, tumour growth. This study aims determine Clinical different types cancers using systematic review approach. Methods A methodology adopted for undertaking detailed analysis cancer therapy. results presented this paper an outcome extracting findings studies selected from articles published international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed Web Science (ISI). These were thoroughly searched, relevant publications based on plausible keywords, accordance with aims, as follows: prevalence, curcumin, features, cancer. Results are derived several consumption chemotherapy drugs, highlighting increases effectiveness radiotherapy which improving patient’s survival time, increasing expression anti-metastatic proteins along reducing their side effects. Conclusion comprehensive confirms reduces or radiotherapy, resulting patients’ quality life. number reported that, increased patient time decreased tumor markers’ level.
Language: Английский
Citations
312
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9
Published: Jan. 10, 2023
The yellow polyphenolic pigment known as curcumin, originating from the rhizome of turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, well cooking and food coloring. Recently, biological activities curcumin have thoroughly investigated. studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion usage within processing industries its effect health support disease prevention. Curcumin’s bioavailability, bio-efficacy, bio-safety characteristics, side effects quality standards, are also discussed. Finally, curcumin’s multifaceted uses, appeal enhancement, agro-industrial techniques counteracting instability low nanotechnology drug delivery systems increase prospective clinical use tactics all
Language: Английский
Citations
143
Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3834 - 3834
Published: Oct. 27, 2021
Cancer is one of the leading causes death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake toxins have been found contribute development and progression cancer disease states. Early detection proper treatment enhance chances survival healing, but side effects anticancer drugs still produce detrimental responses that counteract benefits in terms hospitalization survival. Recently, several natural bioactive compounds were possess properties, capable killing transformed cancerous cells without being toxic their normal counterparts. This effect occurs when products are conventional treatments, thereby suggesting nutraceutical supplementation may successful therapy. review aims discuss current literature on four extracts mostly characterized by a specific polyphenolic profile. activities reported support treatment: (1) inhibition cell proliferation, (2) antioxidant activity, (3) anti-inflammatory activity. On other hand, owing attenuation therapies, antioxidants improving compliance patients undergoing treatment. Thus, supplementation, along drug treatment, be considered for better cancer. It should noted, however, data from studies plant preparations discussed, it appropriate ensure experiments conducted accordance accepted pharmacological research practices so as not disclose information only partially correct.
Language: Английский
Citations
104
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12
Published: Jan. 13, 2022
Cancer chemoprevention approaches are aimed at preventing, delaying, or suppressing tumor incidence using synthetic natural bioactive agents. Mechanistically, chemopreventive agents also aid in mitigating cancer development, either by impeding DNA damage blocking the division of premalignant cells with damage. Several pre-clinical studies have substantiated benefits various dietary components as chemopreventives therapy. The incessant rise number cases globally is an issue major concern. excessive toxicity and chemoresistance associated conventional chemotherapies decrease success rates existent chemotherapeutic regimen, which warrants need for efficient safer alternative therapeutic approach. In this scenario, been proven to be successful protecting high-risk populations from cancer, further validates strategy rational promising. Clinical shown effectiveness approach managing cancers different origins. Phytochemicals, constitute appreciable proportion currently used drugs, tested their efficacy. This review primarily aims highlight efficacy phytochemicals, being investigated chemopreventives. clinical relevance chemoprevention, special emphasis on curcumin, resveratrol, tryptanthrin, kaempferol, gingerol, emodin, quercetin genistein epigallocatechingallate, potential candidates due ability regulate multiple survival pathways without inducing toxicity, forms crux review. majority these phytochemicals polyphenols flavanoids. We analyzed how key molecular targets potentially counteract drivers chemoresistance, causing minimum body. An overview underlying mechanism action regulating players progression suppression discussed A summary trials important that emerge incorporated. elaborate observations, pharmacokinetics, action, some products. To summarize, scope comprises current status, limitations, future directions emphasizing potency effective
Language: Английский
Citations
91
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: April 22, 2022
Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well world's second largest cause mortality. Despite existing preventative, diagnostic, treatment methods, such chemotherapy, number instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, curcumin, have shown significant anti-colorectal characteristics among that can used treat These chemicals are phenolic compounds belong curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro vivo via variety mechanisms, including suppression intrinsic extrinsic apoptotic signaling pathways, stoppage cycle, activation autophagy. also has anti-angiogenesis properties. Thus, this review aimed at emphasizing biological effect mode action curcumin on Furthermore, critical role these substances chemoprevention was emphasized.
Language: Английский
Citations
80
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116034 - 116034
Published: Dec. 22, 2023
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, depression. Most these benefits due to their anti-inflammatory antioxidant properties. Curcumin consumption leads decreased bioavailability, resulting limited absorption, quick metabolism, excretion, hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with a complex. When other enhancing agents, has wide spectrum benefits. This review evaluates therapeutic potential specific emphasis on approach based molecular signaling pathways. study investigated influence progression cancer, inflammation, many health-related mechanisms, cell proliferation, apoptosis, metastasis. significant for prevention treatment various diseases. modulates several biochemical pathways targets involved cancer growth. Despite tissue accumulation administered orally, proven useful. provides in-depth analysis curcumin's applications, pathway-based approach, precision medicine human health.
Language: Английский
Citations
48
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12378 - 12378
Published: Aug. 3, 2023
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention
Language: Английский
Citations
45
Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 441 - 441
Published: March 2, 2024
Oxidative stress refers to the imbalance between production of reactive oxygen species (ROS) and endogenous antioxidant defense system. Its involvement in cell senescence, apoptosis, series diseases has been demonstrated. Advances carcinogenic research have revealed oxidative as a pivotal pathophysiological pathway tumorigenesis be involved lung cancer, glioma, hepatocellular carcinoma, leukemia, so on. This review combs effects on each phase fate determination, three features are discussed. takes part processes ranging from tumor death via pathways like mitochondrial stress, endoplasmic reticulum ferroptosis. It can affect by engaging complex relationships death, cancer. The influence progression is multi-stage interlaced process that includes two aspects promotion inhibition, with mitochondria core regulation. A deeper more comprehensive understanding conducive exploring therapies.
Language: Английский
Citations
21
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 326 - 326
Published: Feb. 24, 2025
Colorectal cancer (CRC) is one of the deadliest neoplasia. Intrinsic or acquired resistance main cause failure therapy regimens that leads to relapse and death in CRC patients. The widely used chemotherapeutic agent 5-fluorouracil (5-FU) remains mainstay for therapeutic combinations. Unfortunately, side effects are frequent events compromise success these therapies; dysregulation enzymes regulate 5-FU metabolism increases expression activity efflux pumps. Additional tumor cell adaptations such as epithelial–mesenchymal transition (EMT), autophagy shaping microenvironment, inflammation contribute chemoresistance. Finding new strategies alternatives enhance conventional chemotherapies has become necessary. Recently, study natural compounds been gaining strength an alternative chemotherapeutics different cancers. Curcumin, trimethylglycine, resveratrol, artemisinin, some helminth-derived molecules, among others, studied context CRC. This review discusses benefits, mechanisms, advances, dark currently evaluated treatment. We also analyzed landscape non-conventional their underlying mechanisms action, which could, short term, provide fundamental knowledge harness anti-tumor allow them be adjuvant therapies.
Language: Английский
Citations
2