Sleep Medicine Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102080 - 102080
Published: March 1, 2025
Infertility
affects
millions
of
couples
globally,
with
male
factors
contributing
up
to
50
%
cases.
Despite
the
existing
Assisted
Reproduction
Technologies
(ART),
decreased
sperm
quality
and
infertility
persist.
Evidence
suggests
that
sleep
is
crucial
for
normal
reproductive
function,
noticeable
increase
in
rates
aligns
growing
prevalence
deprivation,
suggesting
a
connection
between
both
conditions.
This
literature
review
explores
possible
links
disturbances,
special
emphasis
on
insomnia,
most
prevalent
disorder,
health.
It
delves
into
latest
findings
regarding
such
as
quality,
hormone
levels,
overall
function
from
studies
mammals,
rodents
humans.
Through
concise
synthesis
these
findings,
we
unveil
potential
mechanisms
provide
insights
clinicians
researchers
field
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6302 - 6302
Published: March 27, 2023
Sex
hormones
are
key
determinants
of
gender-related
differences
and
regulate
growth
development
during
puberty.
They
also
exert
a
broad
range
modulation
immune
cell
functions,
dichotomy
exists
in
the
response
between
sexes.
Both
clinical
animal
models
have
demonstrated
that
androgens,
estrogens,
progestogens
mediate
many
gender-specific
responses,
from
susceptibility
to
infectious
diseases
prevalence
autoimmune
disorders.
Androgens
mainly
promote
immunosuppressive
or
immunomodulatory
effects,
whereas
estrogens
enhance
humoral
immunity
both
men
women.
This
study
summarizes
available
evidence
regarding
physiological
effects
sex
on
human
function
underlying
biological
mechanisms,
focusing
gender
triggered
by
different
amounts
androgens
males
females.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
23(1), P. 218 - 218
Published: Dec. 25, 2021
Obesity
and
its
complications
have
become
a
prominent
global
public
health
problem
that
severely
threatens
human
health.
Melatonin,
originally
known
as
an
effective
antioxidant,
is
endogenous
hormone
found
throughout
the
body
serves
various
physiological
functions.
In
recent
decades,
increasing
attention
has
been
paid
to
unique
function
in
regulating
energy
metabolism,
especially
glucose
lipid
metabolism.
Accumulating
evidence
established
relationship
between
melatonin
obesity;
nevertheless,
not
all
preclinical
clinical
indicates
anti-obesity
effect
of
melatonin,
which
makes
it
remain
conclude
fight
against
obesity.
this
review,
we
summarized
current
knowledge
obesity-related
symptoms,
with
emphasis
on
underlying
mechanisms.
The
role
profile,
adipose
tissue,
oxidative
stress,
inflammation,
well
interactions
circadian
rhythm,
gut
microbiota,
sleep
disorder,
α7nAChR,
opioidergic
system,
exosomes,
make
promising
agent
open
new
avenues
intervention
Journal of Endocrinological Investigation,
Journal Year:
2022,
Volume and Issue:
45(6), P. 1151 - 1160
Published: Feb. 3, 2022
Abstract
Human
body
is
colonized
by
trillions
of
microbes,
influenced
several
factors,
both
endogenous,
as
hormones
and
circadian
regulation,
exogenous
as,
life-style
habits
nutrition.
The
alteration
such
factors
can
lead
to
microbial
dysbiosis,
a
phenomenon
which,
in
turn,
represents
risk
factor
many
different
pathologies
including
cancer,
diabetes,
autoimmune
cardiovascular
disease,
infertility.
Female
microbiota
dysbiosis
(vaginal,
endometrial,
placental)
male
(seminal
fluid)
influence
the
fertility,
determining
detrimental
impact
on
various
conditions,
pre-term
birth,
neonatal
illnesses,
macroscopic
sperm
parameters
impairments.
Furthermore,
unprotected
sexual
intercourse
creates
bacterial
exchange
between
partners,
and,
addition,
each
partner
composition
partner’s
reproductive
tracts.
This
comprehensive
overview
effects
sexes
how
partners
might
other
will
allow
for
better
personalization
infertility
management.
Reproductive Biology and Endocrinology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Jan. 18, 2022
Abstract
Sleep
is
vital
to
human
bodily
function.
Growing
evidence
indicates
that
sleep
deprivation,
disruption,
dysrhythmia,
and
disorders
are
associated
with
impaired
reproductive
function
poor
clinical
outcomes
in
women.
These
associations
largely
mediated
by
molecular-genetic
hormonal
pathways,
which
crucial
for
the
complex
time
sensitive
processes
of
hormone
synthesis/secretion,
folliculogenesis,
ovulation,
fertilization,
implantation,
menstruation.
Pathologic
patterns
closely
linked
menstrual
irregularity,
polycystic
ovarian
syndrome,
premature
insufficiency,
sub/infertility,
early
pregnancy
loss.
Measures
success
assisted
technology
also
lower
among
women
who
engage
shift
work,
or
experience
disruption
short
duration.
Extremes
duration,
quality,
disordered
breathing,
work
several
harmful
conditions
pregnancy,
including
gestational
diabetes
hypertensive
disorders.
While
accumulating
implicates
pathologic
outcomes,
additional
research
needed
determine
causality
propose
therapeutic
interventions.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 17, 2023
It
is
estimated
that
more
and
couples
suffer
from
fertility
pregnancy
maintenance
disorders.
associated
with
impaired
androgen
secretion,
which
influenced
by
many
factors,
ranging
genetic
to
environmental.
also
important
remember
disorders
can
result
abnormal
anatomy
of
the
reproductive
male
female
organ
(congenital
uterine
anomalies
–
septate,
unicornuate,
bicornuate
uterus;
acquired
defects
uterus
structure
fibroids,
polyps,
hypertrophy),
disturbed
hormonal
cycle
obstruction
fallopian
tubes
resulting
presence
adhesions
due
inflammation,
endometriosis,
surgery,
rhythm
menstrual
bleeding,
concentration
hormones.
There
are
relationships
between
endocrine
organs,
leading
a
chain
reaction
when
one
them
fails
function
properly.
Conditions
in
immune
system
involved,
including
infections
autoimmune
diseases,
affect
fertility.
The
form
treatment
depends
on
infertility
duration
patient’s
age.
includes
ovulation
stimulation
clomiphene
citrate
or
gonadotropins,
metformin
use,
weight
loss
interventions.
Since
so
different
factors
fertility,
it
correctly
diagnose
what
causing
problem
modify
regimen
if
necessary.
This
review
describes
disturbances
hormone
secretion
individual
organs
context
pregnancy.
Endocrine,
Journal Year:
2024,
Volume and Issue:
85(2), P. 461 - 472
Published: Feb. 14, 2024
Abstract
It
is
well
known
that
both
type
1
and
2
diabetes
mellitus
(DM)
are
related
to
increased
risk
for
cardiovascular
(CV)
chronic
kidney
disease
(CKD).
However,
besides
these
prominently
presented
complications,
DM
has
also
been
associated
with
reproductive
dysfunctions.
seems
disorders
met
in
up
40%
of
women
consist
delayed
menarche,
all
types
menstrual
disorders,
such
as
amenorrhea,
oligomenorrhea,
irregularity,
menorrhagia,
infertility,
characteristics
polycystic
ovary
syndrome
(PCOS)
early
(or
rarely
late)
menopause.
In
(T1DM),
insulin
treatment,
although
it
reduced
the
rates
insulinopenic-induced
hypogonadotropic
hypogonadism,
an
entity
commonly
many
past
decades,
when
used
excess
can
promote
hyperandrogenism.
Regarding
(T2DM),
resistance
(IR)
hyperinsulinemia
have
mainly
implicated
pathogenesis
dysfunctions,
act
gonadotropin
on
theca
cells
lead
hyperandrogenism
inhibition
proper
ovulation.
This
review
aims
detail
dysfunctions
provide
scientific
data
enlighten
underlying
pathogenetic
mechanisms.
Endocrinology,
Journal Year:
2021,
Volume and Issue:
162(8)
Published: June 14, 2021
Abstract
Declining
female
fertility
has
become
a
global
health
concern.
It
results
partially
from
an
abnormal
circadian
clock
caused
by
unhealthy
diet
and
sleep
habits
in
modern
life.
The
system
is
hierarchical
network
consisting
of
central
peripheral
clocks.
not
only
controls
the
sleep–wake
feeding–fasting
cycles
but
also
coordinates
maintains
required
reproductive
activities
body.
Physiologically,
processes
are
governed
hypothalamic–pituitary–gonadal
(HPG)
axis
time-dependent
manner.
HPG
releases
hormones,
generates
characteristics,
achieves
fertility.
Conversely,
daily
rhythm
aberrant
genes
or
environmental
stimuli
contributes
to
disorders
system,
such
as
polycystic
ovarian
syndrome
premature
insufficiency.
Therefore,
breaking
“time
code”
crucial.
In
this
paper,
we
review
interplay
between
clocks
present
its
regulatory
principles,
moving
normal
physiology
regulation
disease
etiology.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 7, 2024
Background
Obesity
and
psychological
factors
were
identified
as
risk
for
female
infertility.
The
study
investigated
the
correlation
between
WWI,
depression,
secondary
infertility,
focusing
on
potential
mediating
role
of
depression.
Methods
According
to
data
from
NHANES,
this
cross-sectional
used
multiple
regression
analysis,
subgroup
smooth
curve
fitting
explore
relationship
diagnostic
ability
WWI
was
evaluated
compared
other
obesity
indicators
using
ROC
curve.
effect
test
adopted
distribution
product.
Results
This
involved
2778
participants,
including
381
(13.7%)
women
with
showed
that
higher
(OR
=
1.31;
95%
CI,
1.11-1.56)
depression
scores
1.03;
1.01-1.06)
associated
There
a
positive
infertility
(nonlinear
p
0.8272)
association
still
consistent
in
subgroups
(all
P
interaction>
0.05).
Compared
indicators,
(AUC
0.588)
also
shows
good
predictive
performance
Mediation
analysis
mediated
3.94%
confidence
interval
Z
*
b
excluding
0.
Conclusion
exhibited
relatively
predicting
than
may
be
mediator
Focusing
due
beneficially
reduced
women.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(11), P. 4872 - 4883
Published: March 5, 2024
G
protein-coupled
receptors
(GPCRs)
are
central
mediators
of
cell
signaling
and
physiological
function.
Despite
their
biological
significance,
GPCRs
have
not
been
widely
studied
in
the
field
toxicology.
Herein,
we
investigated
these
as
novel
targets
plastic
chemicals
using
a
high-throughput
drug
screening
assay
with
126
human
non-olfactory
GPCRs.
In
first-pass
screen,
tested
activity
triphenol
phosphate,
bisphenol
A,
diethyl
phthalate,
well
three
real-world
mixtures
extracted
from
food
packaging
covering
all
major
polymer
types.
We
found
11
GPCR-chemical
interactions,
which
chemical
exhibited
most
robust
at
adenosine
receptor
1
(ADORA1)
melatonin
(MTNR1A).
further
confirm
that
polyvinyl
chloride
polyurethane
products
contain
ADORA1
or
MTNRA1
agonists
confirmatory
secondary
screen
pharmacological
knockdown
experiments.
Finally,
an
analysis
associated
gene
ontology
terms
suggests
MTNR1A
activation
may
be
linked
to
downstream
effects
on
circadian
metabolic
processes.
This
work
highlights
disruption
caused
by
is
broader
than
previously
believed
demonstrates
relevance
nongenomic
pathways,
have,
thus
far,
remained
unexplored.
