Recent Progress in Development of Carbon-Nanotube-Based Photo-Thermoelectric Sensors and Their Applications in Ubiquitous Non-Destructive Inspections DOI Creative Commons
Kou Li,

Yuya Kinoshita,

Daiki Sakai

et al.

Micromachines, Journal Year: 2022, Volume and Issue: 14(1), P. 61 - 61

Published: Dec. 26, 2022

The photo-thermoelectric (PTE) effect in electronic materials effectively combines photo-absorption-induced local heating and associated thermoelectric conversion for uncooled broadband photo-detection. In particular, this work comprehensively summarizes the operating mechanism of carbon nanotube (CNT)-film-based PTE sensors ubiquitous non-destructive inspections realized by exploiting material properties CNT films. Formation heterogeneous junctions across CNT-film-based sensors, namely photo-detection interfaces, triggers Seebeck with heating. Typical interfaces include a channel–electrode boundary junction between P-type CNTs N-type (PN junctions). While original film channel exhibits positive coefficient values, selections counterpart freely govern intensity polarity response signals. Based on these mechanisms, demonstrate variety physical chemical inspections. device aggregates broad multi-spectral optical information regarding targets reconstructs their inner composite or layered structures. Arbitrary deformations are attributed to macroscopic flexibility films further monitor from omni-directional viewing angles without blind spots. Detection blackbody radiation using also visualizes behaviors changes.

Language: Английский

Tumor-derived exosomal non-coding RNAs as diagnostic biomarkers in cancer DOI

Nasim Ebrahimi,

Ferdos Faghihkhorasani,

Siavash Seifollahy Fakhr

et al.

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(11)

Published: Oct. 29, 2022

Language: Английский

Citations

25
Identification of a chromatin regulator signature and potential candidate drugs for bladder cancer DOI Creative Commons
Ke Zhu, Xiaoqiang Liu, Wen Deng

et al.

Hereditas, Journal Year: 2022, Volume and Issue: 159(1)

Published: Feb. 7, 2022

Bladder cancer (BLCA) is a malignant tumor with dismay outcome. Increasing evidence has confirmed that chromatin regulators (CRs) are involved in progression. Therefore, we aimed to explore the function and prognostic value of CRs BLCA patients.Chromatin were acquired from previous top research. The mRNA expression clinical information downloaded TCGA GEO datasets. Cox regression analysis least absolute shrinkage selection operator (LASSO) performed select gene construct risk model for predicting outcome BLCA. Kaplan-Meier was used assess prognosis between high- low-risk groups. We also investigated drug sensitivity difference CMAP dataset screen small molecule drugs treatment.We successfully constructed validated an 11 CRs-based patients Moreover, found independent factor. Functional suggested mainly enriched cancer-related signaling pathways. CR-based correlated immune cells infiltration checkpoint. Patients high-risk group more sensitive several drugs, such as mitomycin C, gemcitabine, cisplatin. Eight could be beneficial treatment patients.In conclusion, our study provided novel insights into identified reliable biomarker survival

Language: Английский

Citations

23
Advanced Bladder Cancer: Changing the Treatment Landscape DOI Open Access
Vladimir Bilim,

Hiroo Kuroki,

Yuko Shirono

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(10), P. 1745 - 1745

Published: Oct. 20, 2022

Bladder cancer is the 10th most common type in world. There were more than 573,000 new cases of bladder 2020. It 13th cause death with an estimated 212,000 deaths worldwide. Low-grade non-muscle-invasive (NMIBC) usually successfully managed transurethral resection (TUR) and overall survival for NMIBC reaches 90% according to some reports. However, long-term muscle-invasive (MIBC) metastatic remains low. Treatment options have undergone a rapid change recent years. Immune checkpoint inhibitors (ICI), targeted therapies, antibody-drug conjugates are available now. As genetically heterogeneous, optimization patient selection identify those likely benefit from specific therapy urgent issue treatment patients cancer.

Language: Английский

Citations

23
Testing the accuracy of a four serum microRNA panel for the detection of primary bladder cancer: a discovery and validation study DOI
Chong Lu,

Shengjie Lin,

Zhenyu Wen

et al.

Biomarkers, Journal Year: 2024, Volume and Issue: 29(5), P. 276 - 284

Published: May 20, 2024

Bladder cancer (BC) is one of the ten most common cancers worldwide with late detection and early age diagnosis. There abundant evidence that timely intervention can lead to a better prognosis BC. Substantial has indicated microRNAs (miRNAs) are specific different tumour types remarkably stable, indicating serum miRNAs may serve as potential diagnostic markers. This study aimed identify suitable create panel be used diagnose primary

Language: Английский

Citations

5
MicroRNAs: Their Role in Metastasis, Angiogenesis, and the Potential for Biomarker Utility in Bladder Carcinomas DOI Open Access
Raneem Y. Hammouz, Damian Kołat, Żaneta Kałuzińska‐Kołat

et al.

Cancers, Journal Year: 2021, Volume and Issue: 13(4), P. 891 - 891

Published: Feb. 20, 2021

Angiogenesis is the process of generating new capillaries from pre-existing blood vessels with a vital role in tumor growth and metastasis. MicroRNAs (miRNAs) are noncoding RNAs that exert post-transcriptional control protein regulation. They participate development progression several cancers including bladder cancer (BLCA). In tissue, changes microRNA expression exhibit tissue specificity high levels stability detectability. miRNAs less vulnerable to degradation, making them novel targets for therapeutic approaches. A suitable means targeting aberrant activated signal transduction pathways carcinogenesis BLCA possibly through altering key regulate them, exerting strong effect on transduction. Precaution must be taken, as complexity miRNA regulation might result downstream suppressors or oncogenes, enhancing further. Since exosomes contain both mRNA miRNA, they could therefore more effective recipient cell if deliver specific modify production gene expression. this review, we discuss molecules have been shown play significant development. We also roles various angiogenesis Advances management metastatic limited; mimics targeted at (anti-miRs) well serve modalities diagnostic biomarkers.

Language: Английский

Citations

32
Urinary exosomal microRNA-96-5p and microRNA-183-5p expression as potential biomarkers of bladder cancer DOI
Amal S. El‐Shal, Sally M. Shalaby, Safwat Abouhashem

et al.

Molecular Biology Reports, Journal Year: 2021, Volume and Issue: 48(5), P. 4361 - 4371

Published: May 1, 2021

Language: Английский

Citations

32
The Role of Androgens and Androgen Receptor in Human Bladder Cancer DOI Creative Commons

Elizabeth Martínez-Rojo,

Laura C. Berumen, Guadalupe Garcı́a-Alcocer

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(4), P. 594 - 594

Published: April 18, 2021

Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have higher risk (4:1) developing bladder than women. Cigarette smoking exposure to chemicals such as aromatic amines, aniline dyes been established factors for may contribute sex disparity. Male internal genitalia, including urothelium prostate, are derived from urothelial sinus endoderm; both tissues express androgen receptor (AR). Several investigations shown evidence that AR plays important role in initiation development different types cancer. In this article, we summarize available data help explain progression cancer, well therapies used its treatment.

Language: Английский

Citations

30
An Insight into miR-1290: An Oncogenic miRNA with Diagnostic Potential DOI Open Access
Małgorzata Guz, Witold Jeleniewicz, Marek Cybulski

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1234 - 1234

Published: Jan. 22, 2022

For more than two decades, the view of roles non-coding RNAs (ncRNAs) has been radically changing. These RNA molecules that are transcribed from our genome do not have capacity to encode proteins, but critical regulators gene expression at different levels. Our knowledge is constantly enriched by new reports revealing role these molecular players in development many pathological conditions, including cancer. One ncRNA classes includes short called microRNAs (miRNAs), which involved post-transcriptional control affecting various cellular processes. The aberrant miRNAs with oncogenic and tumor-suppressive function associated cancer initiation, promotion, malignant transformation, progression metastasis. Oncogenic miRNAs, also known as oncomirs, mediate downregulation tumor-suppressor genes their upregulated Nowadays, show promising application diagnosis, prediction, disease monitoring therapy response. review presents a current miR-1290 emphasis on its properties biomarker clinical medicine.

Language: Английский

Citations

22
Urinary exosomal mRNA as a biomarker for the diagnosis of bladder cancer DOI Creative Commons
Xinying Wang, Dianbin Song,

Baoxing Zhu

et al.

Anti-Cancer Drugs, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Objective To study the diagnostic value of mRNA expression in urinary exocrine body bladder cancer. Methods From February 2022 to December 2022, 60 patients diagnosed with cancer by pathology Department Urology, Affiliated Hospital Chengde Medical University were selected as case group. In total, 40 healthy subjects receiving physical examinations control 100 mL morning urine samples collected from both groups based on same standard. Three randomly each Urinary exosomes extracted differential ultracentrifugation. High-throughput sequencing (RNA-seq) was used detect profiles and identify differentially expressed genes. Bioinformatic analysis performed predict major biological functions genes related signaling pathways. RT-PCR validated levels between two groups. ROC curves evaluated for Spearman’s correlation determined correlations occurrence speculated using combined Results Compared normal subjects, there 189 significantly patients, including 33 up-regulated 156 down-regulated. According go kyoto encyclopedia genomes (KEGG) analysis, above may participate development through MAPK pathway, PPAP PI3K Akt pathway Hippo affect protein lipid metabolism, RNase activity, polysaccharide synthesis, signal transduction other processes, cell proliferation, death, movement adhesion, well differentiation transduction. verified that tmeff1, SDPR, ACBD7, SCG2 COL6A2 statistically significant ( P < 0.05). The curve showed area under five 0.6934, 0.7746, 0.7239, 0.6396 0.6610, respectively. sensitivity 42.11%, 64.86%, 47.37%, 73.53% 76.47%, specificity 90%, 81.36%, 96.36%, 61.02% 58.18%, Spearman SDPR acbd7 associated diagnosis three diagnoses suggested 0.7945, 89.09%, 60.53%. Conclusion gene profile has changed significantly, play an important role detection exosome ACBD7 a certain

Language: Английский

Citations

4
Potential molecular biomarkers for the diagnosis and prognosis of bladder cancer DOI Open Access

Junping Fan,

Bo Chen,

Xingqiang Lü

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116312 - 116312

Published: Feb. 27, 2024

Bladder cancer (BC) is a common malignant tumor of urinary system, which can be divided into muscle-invasive BC (MIBC) and nonmuscle-invasive (NMIBC). The number patients has been gradually increasing currently. At present, bladder tumours are diagnosed followed-up using combination cystoscopic examination, cytology histology. However, the detection early grade tumors, much easier to treat effectively than advanced stage disease, still insufficient. It frequently recurs progress when not expeditiously monitored following initial therapy for NMIBC. Treatment strategies totally different diseases. Therefore, it great practical significance study new biomarkers diagnosis prognosis. In this review, we summarize current state biomarker development in prognosis prediction. We retrospectively analyse eight diagnostic prognostic biomarkers, CK, P53, PPARγ, PTEN ncRNA emphasized discussion. Eight molecular subtype systems also identified. Clinical translation diagnosis, prognosis, monitoring treatment will hopefully improve outcomes patients. These potential provide an opportunity diagnose tumors earlier with greater accuracy, help identify those most at risk disease recurrence.

Language: Английский

Citations

4