Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 495, P. 117212 - 117212
Published: Dec. 22, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 11, 2024
Vascular calcification (VC) is considered a common pathological process in various vascular diseases. Accumulating studies have confirmed that VC involved the inflammatory response heart disease, and SPP1+ macrophages play an important role this process. In VC, focused on physiological functions of macrophages, such as pro-inflammatory or anti-inflammatory cytokines pro-fibrotic vesicles. Additionally, activated lymphocytes highly express SPP1 atherosclerotic plaques, which promote formation fatty streaks plaque development, also plaques results failure, but crosstalk between SPP1-mediated immune cells has not been adequately addressed. review, we summarize regulatory effect T cells, dendritic different organs' could be potential therapeutic target for VC.
Language: Английский
Citations
12
Circulation Research, Journal Year: 2024, Volume and Issue: 135(11), P. 1067 - 1083
Published: Oct. 18, 2024
Mitochondrial dysfunction, characterized by impaired lipid metabolism and heightened reactive oxygen species generation, results in peroxidation ferroptosis. Ferroptosis is an inflammatory mode of cell death that promotes complement activation macrophage recruitment. In pulmonary arterial hypertension (PAH), endothelial cells exhibit cellular phenotypes promote Moreover, there ectopic deposition accumulation the vasculature. However, effects ferroptosis inhibition on these pathogenic mechanisms landscape vasculature are incompletely defined.
Language: Английский
Citations
9
AJP Lung Cellular and Molecular Physiology, Journal Year: 2022, Volume and Issue: 322(5), P. L737 - L760
Published: March 23, 2022
Concentric pulmonary vascular wall thickening due partially to increased artery (PA) smooth muscle cell (PASMC) proliferation contributes elevating resistance (PVR) in patients with hypertension (PH). Although vasoconstriction may be an early contributor increasing PVR, the transition of contractile PASMCs proliferative play important role development and progression remodeling PH. A rise cytosolic Ca 2+ concentration ([Ca ] cyt ) is a trigger for PASMC contraction proliferation. Here, we report that upregulation Piezo1, mechanosensitive cation channel, involved contractile-to-proliferative phenotypic potential remodeling. By comparing freshly isolated PA (contractile PASMCs) primary cultured (from same rat) growth medium (proliferative PASMCs), found Notch2/3, CaSR protein levels were significantly higher than PASMCs. Upregulated Piezo1 was associated increase expression PCNA, marker proliferation, whereas downregulation (with siRNA) or inhibition GsMTx4) attenuated Furthermore, remodeled from rats experimental PH upregulated compared control rats. These data indicate adaptation membrane channels receptors. critical Upregulation likely required provide sufficient assure nuclear/cell division contributing
Language: Английский
Citations
31
Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(3), P. 1827 - 1897
Published: Nov. 24, 2022
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system that allows the lungs to receive entire cardiac output. Pulmonary arterial pressure function of output vascular resistance, resistance inversely proportional fourth power intraluminal radius artery. Therefore, very small decrease lumen diameter results in significant increase pressure. hypertension fatal progressive disease with poor prognosis. Regardless initial pathogenic triggers, sustained vasoconstriction, concentric remodeling, occlusive intimal lesions, situ thrombosis, wall stiffening are major direct causes for elevated patients other forms precapillary hypertension. In this review, we aim discuss basic principles physiological mechanisms involved regulation lung hemodynamics function, changes vasculature contribute increased pressure, development progression We focus on reviewing roles membrane receptors, ion channels, intracellular Ca
Language: Английский
Citations
30
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: June 28, 2023
Pulmonary hypertension (PH) is a progressive, pulmonary vascular disease with high morbidity and mortality. Unfortunately, the pathogenesis of PH complex remains unclear. Existing studies have suggested that inflammatory factors are key in PH. Interleukin-6 (IL-6) multifunctional cytokine plays crucial role regulation immune system. Current reveal IL-6 elevated serum patients it negatively correlated lung function those patients. Since one most important mediators inflammation PH, signaling mechanisms targeting may become therapeutic targets for this disease. In review, we detailed potential accelerating process specific pathways. We also summarized current drugs these pathways to treat hope study will provide more theoretical basis targeted treatment future.
Language: Английский
Citations
22
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: Sept. 1, 2022
Cardiovascular disease is a group of diseases with high mortality in clinic, including hypertension, coronary heart disease, cardiomyopathy, valve failure, to name few. In the development cardiovascular diseases, pathological cardiac remodeling most common change, which often becomes domino accelerate deterioration disease. Therefore, inhibiting may delay occurrence and provide patients greater long-term benefits. Resveratrol non-flavonoid polyphenol compound. It mainly exists grapes, berries, peanuts red wine, has protective effects, such as anti-oxidation, inflammatory reaction, antithrombotic, dilating blood vessels, apoptosis delaying atherosclerosis. At present, research resveratrol made rich progress. This review aims summarize possible mechanism against remodeling, order some help for in-depth exploration drug targets.
Language: Английский
Citations
23
Respiratory Research, Journal Year: 2022, Volume and Issue: 23(1)
Published: Nov. 15, 2022
Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on vessels is unknown. Here we analyzed the contribution of PH patients with IPF and potential mechanism implicated. arteries, lung tissue serum control subjects (n = 20), 20) were used study expression localization IL-11Rα. Two models bleomycin-induced Tie2-GFP transgenic mice evaluate endothelial cells artery remodeling. The effect soluble IL-11Rα human smooth muscle cell transformations proliferation analyzed. over-expressed arteries vs without PH. Recombinant (rm)IL-11 induced mice, activating vivo EnMT as contributor remodeling fibrosis. Transient transfection siRNA-IL-11 reduced bleomycin model. Human (h)rIL-11 hrIL-11Rα mesenchymal transition (EnMT) myofibroblast-like transformation, senescence vitro. are overexpressed patients, contributes
Language: Английский
Citations
22
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156062 - 156062
Published: Sept. 17, 2024
Language: Английский
Citations
4
Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: May 2, 2025
With a high frequency and poor prognosis, combined pre-and post-capillary pulmonary hypertension (Cpc-PH) is significant subtype of linked to left-sided heart disease (PH-LHD). The complicated pathophysiology Cpc-PH primarily characterized by elevated venous pressure leading an increase in retrocapillary pressure, which followed artery marked rise vascular resistance (PVR). There currently no well-defined treatment plan for Cpc-PH, there are numerous obstacles overcome. In patients with the effectiveness targeted medications limited debatable. Recent research has revealed that prevalence progression may be influenced genetic factors, metabolic syndrome, oxidative stress, fibrosis. To help doctors better manage treat this review provides detailed description disease’s epidemiology, pathogenesis, diagnostic techniques, current status, potential therapeutic targets.
Language: Английский
Citations
0