Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(5), P. 1000 - 1000
Published: April 26, 2022
Accumulating
data
suggest
that
chronic
neuroinflammation-mediated
neurodegeneration
is
a
significant
contributing
factor
for
progressive
neuronal
and
glial
cell
death
in
age-related
neurodegenerative
pathology.
Furthermore,
it
could
be
encountered
as
long-term
consequences
some
viral
infections,
including
post-COVID-19
Parkinsonism-related
sequelae.
The
current
systematic
review
focused
on
recent
question
aroused
during
the
pandemic’s
successive
waves:
are
there
post-SARS-CoV-2
immune-mediated
reactions
responsible
promoting
neurodegeneration?
Does
host’s
dysregulated
immune
counter-offensive
contribute
to
pathogenesis
of
diseases,
emerging
Parkinson’s
disease,
complex
interrelation
between
genetic
epigenetic
risk
factors?
A
synthetic
literature
was
accomplished
based
”Preferred
Reporting
Items
Systematic
Principles
Reviews
Meta-Analyses”
(PRISMA)
methodology,
registration
specific
online
platform:
International
prospective
register
reviews—PROSPERO,
no.
312183.
Initially,
1894
articles
were
detected.
After
fulfilling
five
steps
selection
104
papers
selected
this
review.
Documentation
enhanced
with
supplementary
47
bibliographic
resources
identified
within
non-standardized
search
connected
subject.
As
final
step
PRISMA
method,
we
have
fulfilled
Population-Intervention-Comparison-Outcome-Time
(PICOT)/Population-Intervention-Comparison-Outcome-Study
type
(PICOS)—based
metanalysis
clinical
trials
our
search,
targeting
outcomes
rehabilitative
kinesitherapeutic
interventions
compared
approaches
lacking
such
kind
treatment.
Accordingly,
10
related
article.
multi/interdisciplinary
conventional
therapy
disease
non-conventional
multitarget
approach
an
integrative
treatment
briefly
analyzed.
This
article
synthesizes
findings
pathogenic
interference
mechanisms
involved
aging,
neuroinflammation,
neurodegeneration,
focusing
acute
repercussions
COVID-19.
Time
will
tell
whether
COVID-19
neuroinflammatory
events
trigger
effects
worsening
and/or
explosion
new
cases
PD.
extent
interrelated
neuropathogenic
phenomenon
remains
obscure,
so
further
observations
longitudinal
cohort
studies
needed.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(9)
Published: Dec. 14, 2023
Abstract
Osteoarthritis
(OA)
is
a
chronic
joint
disease
characterized
by
synovitis
and
cartilage
destruction.
The
severity
of
OA
highly
associated
with
the
imbalance
between
M1
M2
synovial
macrophages.
In
this
study,
novel
strategy
designed
to
modulate
macrophage
polarization
reducing
intracellular
reactive
oxygen
species
(ROS)
levels
regulating
mitochondrial
function.
A
ROS‐responsive
polymer
synthesized
self‐assemble
astaxanthin
autophagy
activator
rapamycin
form
nanoparticles
(NP@Poly
RHAPM
).
vitro
experiments
show
that
NP@Poly
significantly
reduced
ROS
levels.
Furthermore,
restored
membrane
potential,
increased
glutathione
(GSH)
levels,
promoted
autophagy,
hence
successfully
repolarizing
macrophages
into
phenotype.
This
repolarization
enhanced
chondrocyte
proliferation
vitality
while
inhibiting
apoptosis.
vivo
utilizing
an
anterior
cruciate
ligament
transection
(ACLT)‐induced
mouse
model
revealed
anti‐inflammatory
cartilage‐protective
effects
,
effectively
mitigating
progression.
Consequently,
findings
suggest
intra‐articular
delivery
nanocarrier
systems
holds
significant
promise
as
potential
effective
therapeutic
for
treatment.
Cell Biology International,
Journal Year:
2022,
Volume and Issue:
46(9), P. 1320 - 1344
Published: July 13, 2022
Abstract
Immune‐mediated
diseases
(IMDs)
are
chronic
conditions
that
have
an
immune‐mediated
etiology.
Clinically,
these
appear
to
be
unrelated,
but
pathogenic
pathways
been
shown
connect
them.
While
inflammation
is
a
common
occurrence
in
the
body,
it
may
either
stimulate
favorable
immune
response
protect
against
harmful
signals
or
cause
illness
by
damaging
cells
and
tissues.
Nanomedicine
has
tremendous
promise
for
regulating
treating
IMIDs.
Various
nanoparticles
coated
with
nanotherapeutics
recently
fabricated
effective
targeted
delivery
inflammatory
RNA
interference
(RNAi)
offers
genetic
approach,
particularly
if
traditional
treatments
ineffective
IMDs.
In
cells,
several
signaling
can
suppressed
using
RNAi,
which
blocks
expression
of
particular
messenger
RNAs.
Using
this
molecular
undesirable
effects
anti‐inflammatory
medications
reduced.
Still,
there
many
problems
short‐interfering
RNAs
(siRNAs)
treat
IMDs,
including
poor
localization
siRNAs
target
tissues,
unstable
gene
expression,
quick
removal
from
blood.
Nanotherapeutics
widely
used
designing
siRNA‐based
carriers
because
restricted
therapy
options
review,
we
discussed
recent
trends
fabrication
siRNA
nanodelivery
systems,
lipid‐based
nanocarriers,
liposomes,
cationic
lipids,
stable
nucleic
acid‐lipid
particles,
polymeric‐based
polyethylenimine
(PEI)‐based
nanosystems,
chitosan‐based
nanoformulations,
inorganic
material‐based
hybrid‐based
systems.
We
also
introduced
novel
nanocarriers
control
IMIDs,
such
as
pulmonary
inflammation,
psoriasis,
bowel
disease,
ulcerative
colitis,
rheumatoid
arthritis,
etc.
This
study
will
pave
way
new
avenues
research
into
diagnosis
treatment
Saudi Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
29(4), P. 2836 - 2855
Published: Jan. 6, 2022
Gold
nanoparticles
with
tiny
sizes
and
biostability
are
particularly
essential
employed
in
a
variety
of
biomedical
applications.
Using
reducing
agent
stabilising
to
make
gold
has
been
reported
number
studies.
particle
size
25.31
nm
were
synthesized
this
study
utilising
Hylocereus
polyrhizus
(Red
Pitaya)
extract,
which
functions
as
agent.
The
extract
Red
Pitaya
is
said
be
powerful
antioxidant
anti-cancer
Because
its
substantial
blood
biocompatibility
physiological
stability,
green
production
H.
fruit
an
alternative
chemical
synthesis
useful
for
biological
medical
formation
distribution
confirmed
by
HPLC,
UV-Vis
spectrophotometer,
X-ray
diffraction
(XRD),
Dynamic
light
scattering
(DLS),
Zeta
potential,
Transmission
electron
microscopy
(TEM),
Fourier
transformed
infrared
spectroscopy
(FTIR),
Energy
dispersive
(EDX)
photoelectron
(XPS).
well-analysed
NPs
used
various
assays,
including
anti-diabetic,
anti-inflammatory,
anti-Alzheimer,
(DPPH),
cytotoxic
investigations.
also
showed
dose-dependent
activity
against
HCT-116,
HepG2
MCF-7
cell
lines,
IC50
100
µg/mL
HCT-116
cells,
155
HepG2,
cells
the
value
was
165
respectively.
Finally,
outstanding
Au-NPs
led
conclusion
that
they
promising
choice
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 805 - 805
Published: April 4, 2024
Pain
is
the
major
symptom
of
osteoarthritis
(OA)
and
an
important
factor
in
strategies
to
manage
this
disease.
However,
current
standard
care
does
not
provide
satisfactory
pain
relief
for
many
patients.
The
pathophysiology
OA
complex,
its
presentation
as
a
clinical
syndrome
associated
with
pathologies
multiple
joint
tissues.
Treatment
options
are
generally
classified
pharmacologic,
nonpharmacologic,
surgical,
complementary
and/or
alternative,
typically
used
combination
achieve
optimal
results.
goals
treatment
alleviation
symptoms
improvement
functional
status.
Several
studies
exploring
various
directions
management,
including
tissue
regeneration
techniques,
personalized
medicine,
targeted
drug
therapies.
aim
present
narrative
review
extensively
describe
all
treatments
available
practice,
further
describing
most
innovative
Advancements
understanding
molecular
genetic
aspects
may
lead
more
effective
tailored
approaches
future.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 102 - 102
Published: Jan. 14, 2025
The
deposition
of
monosodium
urate
(MSU)
crystals
within
joint
spaces
produces
a
painful
inflammatory
condition
known
as
gout,
specific
form
arthritis.
calls
for
combined
curative
and
preventive
management
model.
A
new
development
in
the
approach
to
gout
is
that
NLRP3-targeted
biologic
agents,
such
monoclonal
therapies,
provide
more
accurate
treatment
by
blocking
pro-inflammatory
cytokines.
Nanoparticle
drug
delivery
enhances
biological
availability
targets,
which
may
increase
therapeutic
efficacy
decrease
general
toxicity.
again
cannot
be
ignored,
mainly
keeping
up
certain
modifications
diet
weight,
along
with
pharmacological
therapies
reduce
uric
acid
(UA)
levels
frequency
acute
attacks.
advancement
genetic
profiling
patients
biomarker
discoveries
drives
trend
towards
building
individualized
medicine
care,
quickly
gaining
ground
most
effective
method
delivering
treatments
individual
patients,
moving
away
from
one-size-fits-all
treatments.
following
paper
aims
an
updated
account
focus
on
recent
developments,
order
enhance
these
approaches,
quality
life
standard
treatment.
