Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(30), P. 7024 - 7040
Published: Jan. 1, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
affecting
44
million
people
worldwide.
Although
many
issues
(pathogenesis,
genetics,
clinical
features,
and
pathological
aspects)
are
still
unknown,
this
characterized
by
noticeable
hallmarks
such
as
the
formation
of
β-amyloid
plaques,
hyperphosphorylation
tau
proteins,
overproduction
reactive
oxygen
species,
reduction
acetylcholine
levels.
There
no
cure
for
AD
current
treatments
aimed
at
regulating
cholinesterase
levels,
attenuating
symptoms
temporarily
rather
than
preventing
progression.
In
context,
coordination
compounds
regarded
promissing
tool
in
treatment
and/or
diagnosis.
Coordination
(discrete
or
polymeric)
possess
several
features
that
make
them
an
interesting
option
developing
new
drugs
(good
biocompatibility,
porosity,
synergetic
effects
ligand-metal,
fluorescence,
particle
size,
homogeneity,
monodispersity,
etc.).
This
review
discusses
recent
progress
development
novel
discrete
metal
complexes
metal-organic
frameworks
(MOFs)
treatment,
diagnosis
theragnosis
AD.
These
advanced
therapies
organized
according
to
target:
Aβ
peptides,
hyperphosphorylated
synaptic
dysfunction,
mitochondrial
failure
with
subsequent
oxidative
stress.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1259 - 1259
Published: March 21, 2022
Polyacrylic
acid
(PAA)
is
a
non-toxic,
biocompatible,
and
biodegradable
polymer
that
gained
lots
of
interest
in
recent
years.
PAA
nano-derivatives
can
be
obtained
by
chemical
modification
carboxyl
groups
with
superior
properties
comparison
to
unmodified
PAA.
For
example,
nano-particles
produced
from
derivatives
used
deliver
drugs
due
their
stability
biocompatibility.
its
nanoconjugates
could
also
regarded
as
stimuli-responsive
platforms
make
them
ideal
for
drug
delivery
antimicrobial
applications.
These
good
candidate
conventional
novel
carrier
systems.
Here,
we
started
synthesis
approaches,
structure
characteristics,
other
architectures
nanoplatforms.
Then,
different
conjugations
PAA/nanostructures
potential
various
fields
nanomedicine
such
antimicrobial,
anticancer,
imaging,
biosensor,
tissue
engineering
were
discussed.
Finally,
biocompatibility
challenges
nanoplatforms
highlighted.
This
review
will
provide
fundamental
knowledge
current
information
connected
the
applications
biological
broad
audience
researchers,
engineers,
newcomers.
In
this
light,
have
great
research
development
new
nano
vaccines
future.
Small,
Journal Year:
2023,
Volume and Issue:
19(23)
Published: March 12, 2023
Abstract
Neurological
diseases
are
the
foremost
cause
of
disability
and
second
leading
death
worldwide.
Owing
to
special
microenvironment
neural
tissues
biological
characteristics
cells,
a
considerable
number
neurological
disorders
currently
incurable.
In
past
few
years,
development
nanoplatforms
based
on
metal–organic
frameworks
(MOFs)
has
broadened
opportunities
for
offering
sensitive
diagnosis/monitoring
effective
therapy
neurology‐related
diseases.
this
article,
obstacles
neurotherapeutics,
including
delayed
diagnosis
misdiagnosis,
existence
blood
brain
barrier
(BBB),
off‐target
treatment,
irrepressible
inflammatory
storm/oxidative
stress,
irreversible
nerve
cell
summarized.
Correspondingly,
MOFs‐based
diagnostic/monitoring
strategies
such
as
neuroimaging
biosensors
(electrochemistry,
fluorometry,
colorimetry,
electrochemiluminescence,
etc.)
therapeutic
higher
BBB
permeability,
targeting
specific
lesion
sites,
attenuation
neuroinflammation/oxidative
stress
well
regeneration
extensively
highlighted
management
Finally,
challenges
present
research
from
perspective
clinical
translation
discussed,
hoping
facilitate
interdisciplinary
studies
at
intersections
between
neurotheranostics.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(5), P. 953 - 953
Published: March 6, 2023
A
variety
of
nanomaterials
have
been
developed
specifically
for
biomedical
applications,
such
as
drug
delivery
in
cancer
treatment.
These
materials
involve
both
synthetic
and
natural
nanoparticles
nanofibers
varying
dimensions.
The
efficacy
a
system
(DDS)
depends
on
its
biocompatibility,
intrinsic
high
surface
area,
interconnected
porosity,
chemical
functionality.
Recent
advances
metal-organic
framework
(MOF)
nanostructures
led
to
the
achievement
these
desirable
features.
MOFs
consist
metal
ions
organic
linkers
that
are
assembled
different
geometries
can
be
produced
0,
1,
2,
or
3
defining
features
their
outstanding
variable
functionality,
which
enable
an
endless
range
modalities
loading
drugs
into
hierarchical
structures.
MOFs,
coupled
with
biocompatibility
requisites,
now
regarded
highly
successful
DDSs
treatment
diverse
diseases.
This
review
aims
present
development
applications
based
chemically-functionalized
MOF
context
concise
overview
structure,
synthesis,
mode
action
MOF-DDS
is
provided.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(49), P. 34562 - 34575
Published: Jan. 1, 2023
Metal-organic
frameworks
(MOFs)
and
MXenes
have
demonstrated
immense
potential
for
biomedical
applications,
offering
a
plethora
of
advantages.
MXenes,
in
particular,
exhibit
robust
mechanical
strength,
hydrophilicity,
large
surface
areas,
significant
light
absorption
potential,
tunable
terminations,
among
other
remarkable
characteristics.
Meanwhile,
MOFs
possess
high
porosity
area,
making
them
ideal
protecting
active
biomolecules
serving
as
carriers
drug
delivery,
hence
their
extensive
study
the
field
biomedicine.
However,
akin
to
(nano)materials,
concerns
regarding
environmental
implications
persist.
The
number
studies
investigating
toxicity
biocompatibility
is
growing,
albeit
further
systematic
research
needed
thoroughly
understand
biosafety
issues
biological
effects
prior
clinical
trials.
synthesis
often
involves
use
strong
acids
temperatures,
which,
if
not
properly
managed,
can
adverse
on
environment.
Efforts
should
be
made
minimize
release
harmful
byproducts
ensure
proper
waste
management
during
production
process.
In
addition,
it
crucial
assess
into
environment
applications.
For
applications
MOFs,
several
challenges
exist.
These
include
fabrication
costs,
poor
selectivity,
low
capacity,
quest
stable
water-resistant
well
difficulties
recycling/regeneration
maintaining
chemical/thermal/mechanical
stability.
Thus,
careful
consideration
associated
with
utilization
vital.
addition
manufacturing
processes,
ultimate
fate
must
taken
account.
While
numerous
reviews
been
published
this
perspective
aims
shed
key
issues,
urging
researchers
conduct
field.
aspects
biomedicine
are
discussed,
focusing
main
outlining
future
directions.
Nanoscale Advances,
Journal Year:
2022,
Volume and Issue:
5(1), P. 46 - 80
Published: Nov. 21, 2022
Alzheimer's
disease
(AD)
is
a
common
neurodegenerative
that
brings
about
enormous
economic
pressure
to
families
and
society.
Inhibiting
abnormal
aggregation
of
Aβ
accelerating
the
dissociation
aggregates
treated
as
an
effective
method
prevent
treat
AD.
Recently,
nanomaterials
have
been
applied
in
AD
treatment
due
their
excellent
physicochemical
properties
drug
activity.
As
delivery
platform
or
inhibitor,
various
exhibited
potential
inhibiting
fibrillation,
disaggregating,
clearing
mature
amyloid
plaques
by
enhancing
performance
drugs.
This
review
comprehensively
summarizes
advantages
disadvantages
modulating
treatment.
The
design
functional
discussed,
strategies
for
improved
toward
are
analyzed.
Finally,
challenges
faced
with
different
dimensions
AD-related
aggregate
modulation
expounded,
prospects
proposed.
