Fetal exposure to a mixture of endocrine‐disrupting chemicals and biomarkers of male fecundity: A population‐based cohort study DOI Creative Commons
Sidsel Dan Hull, Karin Sørig ­Hougaard,

Gunnar Toft

et al.

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but few studies considering chemical mixtures. We assessed the association between fetal a mixture of EDCs and biomarkers fecundity in young adulthood. The study population comprised 841 adult males enrolled Programming Semen Quality cohort, established as offspring sub-cohort within Danish National Birth Cohort. Maternal blood samples were analyzed for concentrations per- polyfluoroalkyl substances (PFAS), phthalate metabolites, triclosan. used quantile g-computation estimate change semen characteristics, testicular volume, reproductive hormone levels 95% confidence intervals (CI) per one-quartile increase all three mixtures; an overall mixture, PFAS non-persistent mixture. was 4.0 million/mL lower sperm concentration (95% CI: -9.1, 1.1), 16.1 million total count -33.8, 1.6), 0.5 mL smaller volume -1.2, 0.3), 5% higher proportion non-progressive immotile spermatozoa 0.99, 1.11), 7% FSH 1.16), limited precision. Effect sizes greatest magnitude count. observed somewhat similar associations no Results suggest that may be adversely several findings are also compatible null associations. These associations, if true, appeared driven by PFAS, misclassification due single measurement metabolites triclosan have attenuated results.

Language: Английский

Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis DOI Creative Commons
Samradhi Singh, Poonam Sharma,

Namrata Pal

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1457 - 1457

Published: July 19, 2022

Over the last few years, microbiome has emerged as a high-priority research area to discover missing links between brain health and gut dysbiosis. Emerging evidence suggests that commensal is an important regulator of gut–brain axis plays critical role in physiology. Engaging microbiome-generated metabolites such short-chain fatty acids, immune system, enteric nervous endocrine system (including HPA axis), tryptophan metabolism or vagus nerve crucial communication microbes brain. Humans are exposed wide range pollutants everyday life impact our intestinal microbiota manipulate bidirectional brain, resulting predisposition psychiatric neurological disorders. However, interaction xenobiotics, neurotoxicity yet be completely investigated. Although into precise processes microbiota–gut–brain growing rapidly, comprehending implications environmental contaminants remains challenging. In these milieus, we herein discuss how various phthalates, heavy metals, Bisphenol A particulate matter may alter intricate thereby impacting overall mental health.

Language: Английский

Citations

74
Microplastics Derived from Food Packaging Waste—Their Origin and Health Risks DOI Open Access
Kornelia Kadac-Czapska, Eliza Knez, Magdalena Gierszewska

et al.

Materials, Journal Year: 2023, Volume and Issue: 16(2), P. 674 - 674

Published: Jan. 10, 2023

Plastics are commonly used for packaging in the food industry. The most popular thermoplastic materials that have found such applications polyethylene (PE), polypropylene (PP), poly(ethylene terephthalate) (PET), and polystyrene (PS). Unfortunately, plastic is disposable. As a consequence, significant amounts of waste generated, entering environment, undergoing degradation processes. They can occur under influence mechanical forces, temperature, light, chemical, biological factors. These factors present synergistic or antagonistic effects. result their action, microplastics formed, which undergo further fragmentation decomposition into small-molecule compounds. During process, various additives at plastics' processing stage also be released. Both negatively affect human animal health. Determination negative consequences on environment health not possible without knowing course processes products. In this article, we sources microplastics, causes places formation, transport particles, plastics often production storage, affecting said its

Language: Английский

Citations

65
Phthalate toxicity mechanisms: An update DOI
Chendruru Geya Sree, Buddolla Viswanath,

Buddolla Anantha Lakshmi

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2022, Volume and Issue: 263, P. 109498 - 109498

Published: Oct. 28, 2022

Language: Английский

Citations

57
Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn? DOI Open Access
Barbara Predieri, Lorenzo Iughetti, Sergio Bernasconi

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11899 - 11899

Published: Oct. 7, 2022

Thousands of natural or manufactured chemicals were defined as endocrine-disrupting (EDCs) because they can interfere with hormone activity and the endocrine system. We summarize discuss what we know still need to learn about EDCs' pathogenic mechanisms action, well effects most common EDCs on system health in childhood. The MEDLINE database (PubMed) was searched 13 May 2022, filtering for EDCs, diseases, children. are a group compounds high heterogeneity, but usually disrupt by mimicking interfering hormones body's hormonal balance through other mechanisms. Individual studied detail, while humans' "cocktail effect" is unclear. In utero, early postnatal life, and/or pubertal development highly susceptible periods exposure. Human epidemiological studies suggest that affect prenatal growth, thyroid function, glucose metabolism, obesity, puberty, fertility several Further needed clarify which mainly act epigenetic processes. A better understanding human crucial developing future regulatory strategies prevent exposure ensure children today, generations, environment.

Language: Английский

Citations

47
Prepubertal phthalate exposure can cause histopathological alterations, DNA methylation and histone acetylation changes in rat brain DOI
Serkan Naci Koç, Ekin Erdoğmuş, Özlem Bozdemir

et al.

Toxicology and Industrial Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Di-2-(ethylhexyl)phthalate (DEHP) is a phthalate derivative used extensively in wide range of materials, such as medical devices, toys, cosmetics, and personal care products. Many mechanisms, including epigenetics, may be involved the effects phthalates on brain development. In this study, Sprague-Dawley male rats were obtained 21-23 days after their birth (post-weaning) exposed to DEHP during prepubertal period with low-dose (DEHP-L, 30 mg/kg/day) high-dose (DEHP-H, 60 mg/kg/day, 37 days) until end adolescence (PND 60). The study groups sacrificed adulthood, histopathological changes, epigenetic oxidative stress parameters evaluated tissues. Histopathological findings indicating presence deterioration tissue morphology obtained, more prominently DEHP-H group. Examining hippocampus under light microscope, pyramidal neuron loss was detected only CA1 DEHP-L group, while rats, losses CA1, CA2, CA3 regions. No significant change observed lipid peroxidation levels compared control. Significant increases total glutathione (GSH) both dose considered an adaptive response DEHP-induced stress. decrease DNA methylation brain, although not statistically significant, increase histone modification showed that exposure cause changes these also take place one mechanisms underlying damage brain. results suggest early development have effect

Language: Английский

Citations

1
Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio) DOI
Wenlong Huang,

Jiefeng Xiao,

Xiaoling Shi

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2022, Volume and Issue: 93, P. 103885 - 103885

Published: May 17, 2022

Language: Английский

Citations

33
Environmental Toxicants and the Developing Brain DOI Creative Commons
Amanda Wylie, Sarah J. Short

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 93(10), P. 921 - 933

Published: Jan. 18, 2023

Language: Английский

Citations

22
Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review DOI Open Access
R. Großklaus,

Klaus‐Peter Liesenkötter,

Klaus Doubek

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2249 - 2249

Published: May 9, 2023

This scoping review critically discusses the publications of last 30 years on impact mild to moderate iodine deficiency and additional endocrine disrupters during pregnancy embryonal/fetal brain development. An asymptomatic and/or isolated maternal hypothyroxinemia might affect development brain. There is sufficient evidence underlining importance an adequate supply for all women childbearing age in order prevent negative mental social consequences their children. threat thyroid hormone system ubiquitous exposure disrupters, which exacerbate effects pregnant neurocognitive offspring. Ensuring intake therefore essential not only healthy fetal neonatal general, but it also extenuate disruptors. Individual supplementation living areas with mandatory as long worldwide universal salt iodization does guarantee supply. urgent need detailed strategies identify reduce according “precautional principle”.

Language: Английский

Citations

21
Development of a Phthalate Environmental Reproductive Health Literacy (PERHL) Scale DOI Creative Commons
Kathryn S. Tomsho,

Marlee R. Quinn,

Gary Adamkiewicz

et al.

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(4)

Published: April 1, 2024

Substantial evidence exists linking phthalate exposure to adverse reproductive health outcomes. Current US federal regulations of consumer product chemicals place the onus on individuals mitigate their phthalates, with assumptions sufficient environmental literacy (EHL). Few validated scales for people age exist evaluate phthalate-specific EHL.

Language: Английский

Citations

7
New insights on the effects of endocrine-disrupting chemicals on children DOI Creative Commons
Barbara Predieri, Crésio Alves, Lorenzo Iughetti

et al.

Jornal de Pediatria, Journal Year: 2021, Volume and Issue: 98, P. S73 - S85

Published: Dec. 15, 2021

Endocrine disrupting chemicals (EDCs) are present in many areas and materials of the common life, exposure to these can occur from products personal care, air food. This review aims summarize more recent epidemiological findings for impact EDCs on endocrine system health children, including effects growth, metabolism, sexual development, reproduction. The MEDLINE database (PubMed) was searched August 24th, 2021, filtering EDCs, disruptors, humans. Intrauterine have transgenerational effects, thus laying foundation disease later life. dose-response relationship may not always be predictable as even low-level exposures that everyday life significant a susceptible individual. Although individual compounds been studied detail, combination yet understand real-life situation where human beings exposed “cocktail effect” EDCs. Epidemiological studies humans suggest EDCs’ prenatal thyroid function, glucose obesity, puberty, fertility mainly through epigenetic mechanisms. cause adverse animals, their now known irrefutable. Because people typically multiple assessing public is difficult. Legislation ban protect especially pregnant women young children required needs revised adjusted new developments regular basis.

Language: Английский

Citations

36