Method to analyze phthalate esters from soft toys dissolving into water mimicking infant playing DOI Creative Commons
Min Jang, Minkyung Lee,

Hyemin Yang

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 330, P. 138695 - 138695

Published: April 18, 2023

Along with bisphenol-A (BPA), conventional phthalate esters (PAEs) have been reported as environmental hormones, despite their functional usefulness plasticizers. Nevertheless, they are frequently found in various products, including children's utensils and toys made of poly (vinyl chloride). This is tremendously important because PAEs harmful to infants. In addition, gel/slime-type alcohol) currently popular for developing infant' tactile senses. this study, we developed a method qualitatively quantitatively detect mimicking, infants playing them bathtub. As result, 1,2-cyclohexanedicarboxylic acid diisononyl ester (DINCH), one the PAE alternatives, transferred into water from was detected most commonly (108-719 μg g-1; 0.01-0.07 wt%) among PAEs. The DINCH levels were below universally accepted (0.1 wt%). However, amount could still be toxic, accordance toxicity tests using fleas. Furthermore, unpleasant odors emitted when containing toxic volatile organic compounds unpacked. first study develop analyze determine that alternatives cannot unconditionally regarded safe chemicals. Therefore, revised standards regulating must reconsidered.

Language: Английский

Microplastics Derived from Food Packaging Waste—Their Origin and Health Risks DOI Open Access
Kornelia Kadac-Czapska, Eliza Knez, Magdalena Gierszewska

et al.

Materials, Journal Year: 2023, Volume and Issue: 16(2), P. 674 - 674

Published: Jan. 10, 2023

Plastics are commonly used for packaging in the food industry. The most popular thermoplastic materials that have found such applications polyethylene (PE), polypropylene (PP), poly(ethylene terephthalate) (PET), and polystyrene (PS). Unfortunately, plastic is disposable. As a consequence, significant amounts of waste generated, entering environment, undergoing degradation processes. They can occur under influence mechanical forces, temperature, light, chemical, biological factors. These factors present synergistic or antagonistic effects. result their action, microplastics formed, which undergo further fragmentation decomposition into small-molecule compounds. During process, various additives at plastics' processing stage also be released. Both negatively affect human animal health. Determination negative consequences on environment health not possible without knowing course processes products. In this article, we sources microplastics, causes places formation, transport particles, plastics often production storage, affecting said its

Language: Английский

Citations

65
Risks Associated with the Presence of Polyvinyl Chloride in the Environment and Methods for Its Disposal and Utilization DOI Open Access
Marcin H. Kudzin, Dominika Piwowarska, Natalia Festinger

et al.

Materials, Journal Year: 2023, Volume and Issue: 17(1), P. 173 - 173

Published: Dec. 28, 2023

Plastics have recently become an indispensable part of everyone's daily life due to their versatility, durability, light weight, and low production costs. The increasing use plastics poses great environmental problems incomplete utilization, a very long period biodegradation, negative impact on living organisms. Decomposing lead the formation microplastics, which accumulate in environment organisms, becoming food chain. contamination soils water with poly(vinyl chloride) (PVC) seriously threatens ecosystems around world. Their durability weight make microplastic particles easily transported through or air, ending up soil. Thus, problem pollution affects entire ecosystem. Since microplastics are commonly found both drinking bottled water, humans also exposed harmful effects. Because existing risks associated PVC ecosystem, intensive research is underway develop methods clean remove it from environment. plastic, especially microplastic, results reduction soil resources used for agricultural utility purposes. This review provides overview PVC's its disposal options.

Language: Английский

Citations

30
Associations of phthalates with prostate cancer among the US population DOI
Tao Guo, Xiangyu Meng, Xuekui Liu

et al.

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 116, P. 108337 - 108337

Published: Jan. 13, 2023

Language: Английский

Citations

23
Possible mechanisms involved in the protective effect of lutein against cyclosporine-induced testicular damage in rats DOI Creative Commons

Obukohwo Mega Oyovwi,

Benneth Ben‐Azu,

Edesiri P. Tesi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e24989 - e24989

Published: Jan. 22, 2024

Oxidative stress and aberrant inflammatory response have important implications in cyclosporin-induced reproductive functions. Previous studies shown that agents with antioxidant anti-inflammatory activities might be beneficial reversing impairment. Lutein is a naturally occurring compound properties. However, the effect of lutein against impairment remains complete. Hence, we investigated protective lutein, specifically focusing on role nuclear factor erythroid 2 related factor-2 (Nrf2)/heme-oxygenase-1 (HO-1)/connexin-43 (Cx-43) upregulation system cyclosporine-induced Six male Wistar rats were allotted into 5 groups given daily gavage cyclosporine (40 mg/kg) and/or (30 for four (4) weeks or combination, respectively. The testicular scaffolds: superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), add to sulfhydryl (T-SH), non-protein (NP-SH), reductase (GR), glutathione-S -transferase (GST), peroxidase (GSH-Px), thiobarbituric acid reactive substances (TBARS), myeloperoxidase (MPO), proinflammatory cytokines, apoptotic protein, nucleic acids, sialic acid, proton pump ATPase, responsive BTB-related protein total levels testes assayed thereafter. Cyclosporin significantly increased NOX-1, TNF-α, IL-1β, MPO, caspase-3 -9 levels, which reversed by lutein. decreases Nrf2, HO-1, BCL-2, cytochrome C, corresponding increase CAT, SOD, GSH, T-SH, NP-SH, GST, GR, GSH-Px, Cx-43 compared cyclosporin groups. also abates alterations Na + -K -ATPase activities. Our findings showed lutein's associated mechanisms linked its antioxidant, anti-apoptotic, properties, notably through up-regulation Nrf2/HO-1/Cx-43 signaling down-regulation NOX-1 signaling.

Language: Английский

Citations

11
Inhalation of Microplastics—A Toxicological Complexity DOI Creative Commons
Myriam Borgatta, Florian Breider

Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 358 - 358

Published: May 11, 2024

Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat human health. Inhalation toxicological studies crucial for assessing the effects MPs and exposure-reduction measures. This communication paper addresses important health concerns related MPs, taking into consideration three levels complexity, i.e., themselves, additives present plastics, exogenous substances adsorbed onto them. approach aims obtain comprehensive profile deposited lungs, encompassing local systemic effects. The physicochemical characteristics may play pivotal role toxicity. Although evidence suggests toxic animal cell models, no established causal link with pulmonary or diseases humans has established. transfer associated chemicals from lungs bloodstream and/or circulation remains be confirmed humans. Understanding toxicity requires multidisciplinary investigation using One Health approach.

Language: Английский

Citations

11
Uptake, translocation, and biotransformation of phthalate acid esters in crop plants: A comprehensive review DOI
Nai-Xian Feng, Bogui Pan,

Hong-Jia Huang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137580 - 137580

Published: Feb. 11, 2025

Language: Английский

Citations

1
Relationship between phthalates exposures and metabolic dysfunction-associated fatty liver disease in United States adults DOI Creative Commons

Junhao Sun,

Siqi Yang,

Yue Zhang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0301097 - e0301097

Published: April 19, 2024

As a new definition for the evidence of hepatic steatosis and metabolic dysfunctions, relationship between phthalates (PAEs) dysfunction-associated fatty liver disease (MAFLD) remains virtually unexplored. This study included 3,137 adults from National Health Nutrition Examination Survey spanning 2007-2018. The diagnosis MAFLD depended on US Fatty Liver Index (US FLI) dysregulation. Eleven metabolites PAEs were in study. Poisson regression, restricted cubic spline (RCS), weighted quantile sum (WQS) regression used to assess associations phthalate MAFLD. After adjusting potential confounders, analysis showed that mono-2-ethyl-5-carboxypentyl (MECPP), mono-n-butyl phthalate, mono-(3-carboxypropyl) mono-ethyl (MEP), mono-(2-ethyl-5-hydroxyhexyl) (MEHHP) mono-(2-ethyl-5-oxohexyl) generally significant positively associated with (P<0.05). Furthermore, WQS index constructed eleven was significantly related (OR:1.43; 95%CI: 1.20, 1.70), MEHHP (33.30%), MEP (20.84%), MECPP (15.43%), mono-isobutyl (11.78%) contributing most. suggests exposure phthalates, individually or combination, may be an increased risk

Language: Английский

Citations

6
Metabolomics and Lipidomics with Mass Spectrometry Imaging Reveal Mechanistic Insights into Dibutyl Phthalate-Promoted Proliferation of Breast Cancer Cell Spheroids DOI Creative Commons
Qingyuan Dai,

Peisi Xie,

Hongli Tan

et al.

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(3), P. 208 - 215

Published: March 1, 2024

Dibutyl phthalate (DBP), extensively used as a plasticizer, has endocrine-disrupting properties that may increase the risk of breast cancer at low concentrations. However, previous studies on effects DBP mainly focused activation typical intracellular receptors, and downstream mechanisms metabolic level have not been well elucidated. Therefore, our study applied metabolomics, lipidomics, mass spectrometry imaging (MSI) techniques to investigate responses MCF-7 cell spheroid (CCS) exposure. The omics results showed exposure resulted in increased glucose glutamine uptake catabolism CCS which supported production nucleotides, glycerophospholipids, amino acids, providing sufficient energy building blocks for synthesis DNA/RNA cytomembrane necessary proliferation. These were further corroborated by MSI data, showing enhanced abundances ATP, GMP, UDP, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines treated with DBP. Interestingly, most these biomolecules predominantly distributed proliferative region. Our result indicated supply biosynthetic substrates peripheral area facilitated proliferation CCS, shedding new light DBP-promoted development.

Language: Английский

Citations

5
Leachates from plastics and bioplastics reduce lifespan, decrease locomotion, and induce neurotoxicity in Caenorhabditis elegans DOI
Michael Sigfrid S. Reyes, Paul Mark B. Medina

Environmental Pollution, Journal Year: 2024, Volume and Issue: 357, P. 124428 - 124428

Published: June 22, 2024

Language: Английский

Citations

5
Sustainable Rubber Nanocomposites for Hydrogen Sealings: Impact of Carbon Nano-Onions and Bio-Based Plasticizer DOI
Sohail Yasin, Jianfeng Shi, Sheng Ye

et al.

Polymer Degradation and Stability, Journal Year: 2024, Volume and Issue: unknown, P. 111051 - 111051

Published: Oct. 1, 2024

Language: Английский

Citations

5