Journal of Laboratory Medicine,
Journal Year:
2023,
Volume and Issue:
47(1), P. 1 - 11
Published: Feb. 1, 2023
Abstract
The
increase
in
the
formation
of
reactive
oxygen
and
nitrogen
species
endogenous
or
exogenous
origin
causes
oxidative
stress
due
to
pro-oxidant
antioxidant
imbalance
that
cellular
damage
metabolism.
This
can
inflammation
cells,
apoptosis
necrosis,
DNA
base
damage,
protein
cross-links,
lipid
membrane
peroxidation,
mitochondrial
dysfunction.
Antioxidants
be
described
as
a
system
protects
biomolecules
organism
against
harmful
effects
free
radicals,
reduces
repairs
done
by
(ROS)
target
molecule,
this
is
called
defense.
It
known
mechanisms
caused
ROS
resulting
from
are
positively
related
pathology
many
diseases
such
cancer,
metabolic
syndrome,
atherosclerosis,
malaria,
Alzheimer’s
disease,
rheumatoid
arthritis,
neurodegenerative
preeclampsia.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 7898 - 7898
Published: April 26, 2023
Metabolic
syndrome
is
a
cluster
of
conditions
associated
with
the
risk
diabetes
mellitus
type
2
and
cardiovascular
diseases
(CVDs).
closely
related
to
obesity.
Increased
adiposity
promotes
inflammation
oxidative
stress,
which
are
precursors
various
complications
involving
metabolic
components,
namely
insulin
resistance,
hypertension,
hyperlipidemia.
An
increasing
number
studies
confirm
importance
stress
chronic
in
etiology
syndrome.
However,
few
have
reviewed
mechanisms
underlying
role
contributing
In
this
review,
we
highlight
by
reactive
oxygen
species
(ROS)
increase
mitochondrial
dysfunction,
protein
damage,
lipid
peroxidation,
impair
antioxidant
function
Biomarkers
can
be
used
disease
diagnosis
evaluation
severity.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
162, P. 114606 - 114606
Published: March 28, 2023
Cells
are
continually
exposed
to
reactive
oxygen
species
(ROS)
generated
during
cellular
metabolism.
Apoptosis,
necrosis,
and
autophagy
biological
processes
involving
a
feedback
cycle
that
causes
ROS
molecules
induce
oxidative
stress.
To
adapt
exposure,
living
cells
develop
various
defense
mechanisms
neutralize
use
as
signaling
molecule.
The
redox
networks
combine
pathways
regulate
cell
metabolism,
energy,
survival,
death.
Superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPX)
essential
antioxidant
enzymes
required
for
scavenging
in
compartments
response
stressful
situations.
Among
the
non-enzymatic
defenses,
vitamin
C,
(GSH),
polyphenols,
carotenoids,
E,
etc.,
also
essential.
This
review
article
describes
how
produced
byproducts
of
oxidation/reduction
(redox)
antioxidants
system
is
directly
or
indirectly
engaged
ROS.
In
addition,
we
used
computational
methods
determine
comparative
profile
binding
energies
several
with
enzymes.
analysis
demonstrates
high
affinity
their
structures.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 5979 - 5979
Published: Aug. 9, 2023
Malondialdehyde
(MDA)
is
a
compound
that
derived
from
the
peroxidation
of
polyunsaturated
fatty
acids.
It
has
been
used
as
biomarker
to
measure
oxidative
stress
in
various
biological
samples
patients
who
are
affected
by
wide
range
diseases.
The
aim
our
work
provide
an
updated
overview
role
MDA
marker
allergy-related
We
considered
studies
involving
both
paediatric
and
adult
rhinitis,
asthma,
urticaria
atopic
dermatitis.
measurement
was
performed
on
different
types
samples.
reported
data
highlight
serum
inflammatory
airway
According
literature
review,
status
asthmatic
patients,
assessed
via
determination,
appears
worsen
presence
other
allergic
diseases
relation
disease
severity.
This
suggests
can
be
suitable
for
monitoring
status.
However,
there
several
limitations
due
lack
phenotyping
description
clinical
period
examined.
In
cutaneous
diseases,
controversial
because
smallness
heterogeneity
patients.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(2), P. 408 - 408
Published: Feb. 17, 2022
Free
radicals
are
formed
as
a
part
of
normal
metabolic
activities
but
neutralized
by
the
endogenous
antioxidants
present
in
cells/tissue,
thus
maintaining
redox
balance.
This
balance
is
disrupted
certain
neuropathophysiological
conditions,
causing
oxidative
stress,
which
implicated
several
progressive
neurodegenerative
diseases.
Following
neuronal
injury,
secondary
injury
progression
also
caused
excessive
production
free
radicals.
Highly
reactive
radicals,
mainly
oxygen
species
(ROS)
and
nitrogen
(RNS),
damage
cell
membrane,
proteins,
DNA,
triggers
self-propagating
inflammatory
cascade
degenerative
events.
Dysfunctional
mitochondria
under
stress
conditions
considered
key
mediator
neurodegeneration.
Exogenous
delivery
holds
promise
to
alleviate
regain
In
this
regard,
natural
synthetic
have
been
evaluated.
Despite
promising
results
preclinical
studies,
clinical
translation
therapy
treat
diseases
remains
elusive.
The
issues
could
be
their
low
bioavailability,
instability,
limited
transport
target
tissue,
and/or
poor
antioxidant
capacity,
requiring
repeated
high
dosing,
cannot
administered
humans
because
dose-limiting
toxicity.
Our
laboratory
investigating
nanoparticle-mediated
enzymes
address
some
above
issues.
Apart
from
being
endogenous,
main
advantage
catalytic
mechanism
action;
hence,
they
significantly
more
effective
at
lower
doses
detoxifying
deleterious
effects
than
nonenzymatic
antioxidants.
review
provides
comprehensive
analysis
potential
therapy,
challenges
translation,
role
nanoparticles/drug
systems
play
addressing
these
challenges.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 18, 2023
Increased
production
and
buildup
of
reactive
oxygen
species
(ROS)
can
lead
to
various
health
issues,
including
metabolic
problems,
cancers,
neurological
conditions.
Our
bodies
counteract
ROS
with
biological
antioxidants
such
as
SOD,
CAT,
GPx,
which
help
prevent
cellular
damage.
However,
if
there
is
an
imbalance
between
these
antioxidants,
it
result
in
oxidative
stress.
This
cause
genetic
epigenetic
changes
at
the
molecular
level.
review
delves
into
how
plays
a
role
disorders
caused
by
We
also
look
animal
models
used
for
researching
pathways.
study
offers
insights
mechanism,
pathology,
changes,
assist
drug
development
disease
understanding.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3921 - 3921
Published: May 6, 2023
The
current
state
of
heavy
metal
(HM)
environmental
pollution
problems
was
considered
in
the
review:
effects
HMs
on
vital
activity
plants
and
functioning
their
antioxidant
system,
including
phenolic
antioxidants.
latter
performs
an
important
function
distribution
binding
metals,
as
well
HM
detoxification
plant
organism.
Much
attention
focused
cadmium
(Cd)
ions
one
most
toxic
elements
for
plants.
data
accumulation
HMs,
Cd
soil,
entry
into
plants,
effect
various
physiological
biochemical
processes
(photosynthesis,
respiration,
transpiration,
water
regime)
were
analyzed.
Some
aspects
Cd,
inactivation
tissues,
cell
compartments,
are
considered,
metabolic
pathways
at
stage
stress
reaction
cells
under
action
pollutants.
system
low
molecular
weight
bioantioxidants,
role
ligand
inactivators
summarized.
issues
polyphenol
biosynthesis
regulation
considered.
Understanding
antioxidants
nature
metal-induced
is
assessing
effect/aftereffect
objects-the
producers
these
secondary
metabolites
widely
used
health
saving
world's
population.
This
review
reflects
latest
achievements
field
studying
influence
organism
enriches
our
knowledge
about
multifunctional
polyphenols,
common
metabolites,
formation
resistance
adaptation.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(6), P. 1141 - 1141
Published: May 23, 2023
As
the
world’s
population
grows,
so
does
need
for
more
and
animal
feed.
In
2006,
EU
banned
use
of
antibiotics
other
chemicals
in
order
to
reduce
chemical
residues
food
consumed
by
humans.
It
is
well
known
that
oxidative
stress
inflammatory
processes
must
be
combated
achieve
higher
productivity.
The
adverse
effects
pharmaceuticals
synthetic
compounds
on
health
product
quality
safety
have
increased
interest
phytocompounds.
With
plant
polyphenols
nutrition,
they
are
gaining
attention
as
a
supplement
Livestock
feeding
based
sustainable,
environmentally
friendly
approach
(clean,
safe,
green
agriculture)
would
also
win–win
farmers
society.
There
an
increasing
producing
healthier
products
origin
with
ratio
polyunsaturated
fatty
acids
(PUFAs)
saturated
modulating
nutrition.
Secondary
metabolites
(polyphenols)
essential
physiology
involved
various
functions
such
growth,
pigmentation,
resistance
pathogenic
organisms.
Polyphenols
exogenous
antioxidants
act
one
first
lines
cell
defense.
Therefore,
discoveries
intracellular
antioxidant
activity
contributed
significantly
improvement
activity,
prevent
damage
eliminate
excessively
produced
free
radicals.
To
welfare,
medicines,
increase
origin,
addition
research
breeding
can
practised
part
free-choice
