Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(8), P. 906 - 906
Published: July 25, 2024
Schizophrenia
is
a
frequently
debilitating
and
complex
mental
disorder
affecting
approximately
1%
of
the
global
population,
characterized
by
symptoms
such
as
hallucinations,
delusions,
disorganized
thoughts
behaviors,
cognitive
dysfunction,
negative
symptoms.
Traditional
treatment
has
centered
on
postsynaptic
dopamine
antagonists,
commonly
known
antipsychotic
drugs,
which
aim
to
alleviate
improve
functioning
quality
life.
Despite
availability
these
medications,
significant
challenges
remain
in
schizophrenia
therapeutics,
including
incomplete
symptom
relief,
resistance,
medication
side
effects.
This
opinion
article
explores
advancements
treatment,
emphasizing
molecular
mechanisms,
novel
drug
targets,
innovative
delivery
methods.
One
promising
approach
strategies
that
target
neural
networks
circuits
rather
than
single
neurotransmitters,
acknowledging
complexity
brain
region
interconnections
involved
schizophrenia.
Another
development
biased
agonists,
selectively
activate
specific
signaling
pathways
downstream
receptors,
offering
potential
for
more
precise
pharmacological
interventions
with
fewer
The
concept
polypharmacy,
where
targets
multiple
pathways,
exemplified
KarXT,
combining
xanomeline
trospium
address
both
psychosis
dysfunction.
represents
comprehensive
strategy
potentially
improving
outcomes
patients.
In
conclusion,
advancing
understanding
exploring
therapeutic
hold
promise
addressing
unmet
needs
aiming
effective
tailored
interventions.
Future
research
should
focus
approaches
achieve
better
clinical
functional
level
life
individuals
Cellular and Molecular Life Sciences,
Journal Year:
2022,
Volume and Issue:
79(2)
Published: Jan. 19, 2022
Abstract
The
gut
and
brain
link
via
various
metabolic
signalling
pathways,
each
with
the
potential
to
influence
mental,
cognitive
health.
Over
past
decade,
involvement
of
microbiota
in
gut–brain
communication
has
become
focus
increased
scientific
interest,
establishing
microbiota–gut–brain
axis
as
a
field
research.
There
is
growing
number
association
studies
exploring
microbiota’s
possible
role
memory,
learning,
anxiety,
stress,
neurodevelopmental
neurodegenerative
disorders.
Consequently,
attention
now
turning
how
can
target
nutritional
therapeutic
strategies
for
improved
health
well-being.
However,
while
such
that
function
are
currently
under
development
varying
levels
success,
still
very
little
yet
known
about
triggers
mechanisms
underlying
apparent
on
or
most
evidence
comes
from
pre-clinical
rather
than
well
controlled
clinical
trials/investigations.
Filling
knowledge
gaps
requires
standardised
methodology
human
studies,
including
strong
guidance
specific
areas
axis,
need
more
extensive
biological
sample
analyses,
identification
relevant
biomarkers.
Other
urgent
requirements
new
advanced
models
vitro
vivo
mechanisms,
greater
omics
technologies
supporting
bioinformatics
resources
(training,
tools)
efficiently
translate
study
findings,
targets
populations.
key
building
validated
base
rely
increasing
sharing
multi-disciplinary
collaborations,
along
continued
public–private
funding
support.
This
will
allow
research
move
its
next
phase
so
we
identify
realistic
opportunities
modulate
better
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: April 14, 2022
The
gut
microbiome
has
a
tremendous
influence
on
human
physiology,
including
the
nervous
system.
During
fetal
development,
initial
colonization
of
coincides
with
development
system
in
timely,
coordinated
manner.
Emerging
studies
suggest
an
active
involvement
and
its
metabolic
by-products
regulating
early
brain
development.
However,
any
disruption
during
this
developmental
process
can
negatively
impact
functionality,
leading
to
range
neurodevelopment
neuropsychiatric
disorders
(NPD).
In
review,
we
summarize
recent
evidence
as
how
association
major
neurodevelopmental
psychiatric
such
autism
spectrum
disorders,
attention-deficit
hyperactivity
disorder,
schizophrenia.
Further,
discuss
alterations
also
play
role
inducing
drug
resistance
affected
individuals.
We
propose
model
that
establishes
direct
link
dysbiosis
exacerbated
inflammatory
state,
functional
deficits
associated
NPD.
Based
existing
research,
framework
whereby
diet
intervention
boost
mental
wellness
subjects
call
for
further
research
better
understanding
mechanisms
govern
gut-brain
axis
may
lead
novel
approaches
study
pathophysiology
treatment
disorders.
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
14(10), P. 1717 - 1763
Published: May 8, 2023
Gut
microbiota
includes
a
vast
collection
of
microorganisms
residing
within
the
gastrointestinal
tract.
It
is
broadly
recognized
that
gut
and
brain
are
in
constant
bidirectional
communication,
which
its
metabolic
production
major
component,
form
so-called
microbiome–brain
axis.
Disturbances
homeostasis
caused
by
imbalance
their
functional
composition
activities,
known
as
dysbiosis,
cause
dysregulation
these
pathways
trigger
changes
blood–brain
barrier
permeability,
thereby
causing
pathological
malfunctions,
including
neurological
disorders.
In
turn,
can
affect
structure
function
through
autonomic
nervous
system
regulating
motility,
intestinal
transit
secretion,
permeability.
Here,
we
examine
data
from
CAS
Content
Collection,
largest
published
scientific
information,
analyze
publication
landscape
recent
research.
We
review
advances
knowledge
related
to
human
microbiome,
complexity
functionality,
communication
with
central
system,
effect
axis
on
mental
health.
discuss
correlations
between
various
diseases,
specifically
also
explore
metabolites
regard
impact
associated
diseases.
Finally,
assess
clinical
applications
gut-microbiota-related
substances
development
pipelines.
hope
this
serve
useful
resource
understanding
current
emerging
field
an
effort
further
solving
remaining
challenges
fulfilling
potential.
Frontiers in Pediatrics,
Journal Year:
2022,
Volume and Issue:
10
Published: March 7, 2022
The
volume
and
breadth
of
research
on
the
role
microbiome
in
neurodevelopmental
neuropsychiatric
disorders
has
expanded
greatly
over
last
decade,
opening
doors
to
new
models
mechanisms
gut-brain
axis
therapeutic
interventions
reduce
burden
these
outcomes.
Studies
have
highlighted
window
birth
3
years
as
an
especially
sensitive
when
may
be
most
effective.
Harnessing
powerful
during
this
critical
developmental
clarifies
important
investigations
into
microbe-human
connection
developing
brain,
affording
opportunities
prevent
rather
than
treat
illness.
In
review,
we
present
overview
intestinal
age
3;
its
prospective
relationship
with
neurodevelopment,
particular
emphasis
immunological
mechanisms.
Next,
neurobehavioral
outcomes
(such
autism,
anxiety,
attention-deficit
hyperactivity
disorder)
well
cognitive
development
are
described.
sections,
highlight
importance
pairing
mechanistic
studies
murine
large
scale
epidemiological
that
aim
clarify
typical
health
promoting
early
life
across
varied
populations
comparison
dysbiosis.
is
focus
human
because
it
so
readily
alterable
simple
interventions,
briefly
outline
what
known
about
targeted
More
novel
examinations
environmental
chemicals
adversely
impact
potential
a
mediator
or
modifier
discussed.
Finally,
look
future
emphasize
need
for
additional
identify
alterations
their
gut
how
might
correct
optimize
European Spine Journal,
Journal Year:
2022,
Volume and Issue:
31(4), P. 917 - 925
Published: March 14, 2022
Abstract
Purpose
Low
back
pain
(LBP),
a
widely
prevalent
and
costly
disease
around
the
world,
is
mainly
caused
by
intervertebral
disc
(IVD)
degeneration
(IDD).
Although
numerous
factors
may
trigger
this
degenerative
process,
microbiome
dysbiosis
has
recently
been
implicated
as
one
of
likely
causes.
However,
exact
relationship
between
IDD
not
well
understood.
This
review
summarizes
potential
mechanisms
discusses
dysbiosis’s
possible
influence
on
LBP.
Methods
Prospective
literature
review.
Results
Alterations
in
composition
host
responses
to
microbiota
causing
pathological
bone
development
involution,
led
concept
gut-bone
marrow
axis
axis.
Moreover,
gut-disc
was
also
proposed
explain
microbiome’s
role
According
existing
evidence,
could
be
an
important
factor
for
inducing
aggravating
through
changing
or
regulating
outside
inside
microenvironment
IVD.
Three
which
gut
can
induce
IVD
cause
LBP
are:
(1)
translocation
bacteria
across
epithelial
barrier
into
IVD,
(2)
regulation
mucosal
systemic
immune
system,
(3)
nutrient
absorption
metabolites
formation
at
epithelium
its
diffusion
Furthermore,
investigate
whether
initiated
pathogenic
establish
correlation
presence
certain
microbial
groups
with
question,
diversity
analysis
based
on16S
rRNA
data
used
characterise
stool/blood
from
patients.
Conclusion
Future
studies
microbiome,
fungi
viruses
necessary
revolutionize
our
thinking
about
their
diseases.
we
believe
that
inflammation
inhibition
interruption
amplification
cascade
reaction
targeting
worthwhile
treatment
Level
Evidence
I
Diagnostic:
individual
cross-sectional
consistently
applied
reference
standard
blinding.
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2023,
Volume and Issue:
128, P. 110861 - 110861
Published: Sept. 9, 2023
There
is
a
lot
of
evidence
establishing
that
nervous
system
development
related
to
the
composition
and
functions
gut
microbiome.
In
addition,
central
(CNS)
controls
imbalance
intestinal
microbiota,
constituting
bidirectional
communication
system.
At
present,
various
gut-brain
crosstalk
routes
have
been
described,
including
immune,
endocrine
neural
circuits
via
vagal
pathway.
Several
empirical
data
associated
microbiota
alterations
(dysbiosis)
with
neuropsychiatric
diseases,
such
as
Alzheimer's
disease,
autism
Parkinson's
other
psychological
disorders,
like
anxiety
depression.
Fecal
transplantation
(FMT)
therapy
has
shown
can
transfer
behavioral
features
recipient
animals,
which
provides
strong
establish
causal-effect
relationship.
Interventions,
based
on
prebiotics,
probiotics
or
synbiotics,
demonstrated
an
important
influence
neurological
disorders
by
synthesis
neuroactive
compounds
interact
regulation
inflammatory
processes.
Further
research
needed
demonstrate
dysbiosis
psychiatric
how
microbiota-based
interventions
may
be
used
potential
therapeutic
tools.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(1), P. 137 - 137
Published: Jan. 10, 2023
Multidrug
resistance
(MDR)
is
a
major
obstacle
in
the
therapy
of
infectious
diseases
and
cancer.
One
mechanisms
MDR
overexpression
efflux
pumps
(EPs)
that
are
responsible
for
extruding
antimicrobial
anticancer
agents.
EPs
have
additional
roles
detoxification
may
aid
development
bacterial
infection
progression
Therefore,
targeting
be
an
attractive
strategy
to
treat
infections
The
discovery
new
drug
require
long
timeline
come
with
high
costs.
A
potential
alternative
reduce
time
costs
repurpose
already
existing
drugs.
Antidepressants
antipsychotic
agents
widely
used
clinical
practice
treatment
psychiatric
disorders
some
somatic
diseases.
antipsychotics
demonstrated
various
beneficial
activities
utilized
This
review
aims
provide
brief
overview
antibacterial
effects
selective
serotonin
reuptake
inhibitors
(SSRIs),
tricyclic
antidepressants
(TCAs)
phenothiazine
antipsychotics,
while
focusing
on
EPs.
However,
it
should
noted
activity
traditionally
non-antibiotic
implications
regarding
dysbiosis
MDR.
Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 23, 2023
The
need
to
find
new
therapeutic
interventions
in
patients
diagnosed
with
psychiatric
disorders
is
supported
by
the
data
suggesting
high
rates
of
relapse,
chronic
evolution,
resistance,
or
lack
adherence
and
disability.
use
pre-,
pro-,
synbiotics
as
add-ons
management
has
been
explored
a
way
augment
efficacy
psychotropics
improve
chances
for
these
reach
response
remission.
This
systematic
literature
review
focused
on
tolerability
psychobiotics
main
categories
it
conducted
through
most
important
electronic
databases
clinical
trial
registers,
using
PRISMA
2020
guidelines.
quality
primary
secondary
reports
was
assessed
criteria
identified
Academy
Nutrition
Diabetics.
Forty-three
sources,
mostly
moderate
quality,
were
reviewed
detail,
regarding
assessed.
Studies
exploring
effects
mood
disorders,
anxiety
schizophrenia
spectrum
substance
eating
attention
deficit
hyperactivity
disorder
(ADHD),
neurocognitive
autism
(ASD)
included.
overall
good,
but
evidence
support
their
specific
mixed.
There
have
favor
probiotics
ADHD,
ASD,
also
association
selenium
disorders.
In
several
domains,
research
still
an
early
phase
development,
e.g.,
(only
three
preclinical
studies
being
found)
(one
identified).
Although
no
well-defined
recommendation
could
yet
be
formulated
product
there
encouraging
further
research,
especially
if
identification
sub-populations
that
may
benefit
from
this
intervention.
Several
limitations
field
should
addressed,
i.e.,
majority
finalized
trials
are
short
duration,
inherent
heterogeneity
diversity
Philae
prevents
generalizability
results
studies.
Current Issues in Molecular Biology,
Journal Year:
2023,
Volume and Issue:
45(5), P. 4080 - 4099
Published: May 6, 2023
The
pathophysiology
of
several
psychiatric
diseases
may
entail
disturbances
in
the
hypothalamic–pituitary–adrenal
(HPA)
axis
and
metabolic
pathways.
Variations
how
these
effects
present
themselves
be
connected
to
individual
variances
clinical
symptoms
treatment
responses,
such
as
observation
that
a
significant
fraction
participants
do
not
respond
current
antipsychotic
drugs.
A
bidirectional
signaling
pathway
between
central
nervous
system
gastrointestinal
tract
is
known
microbiota–gut–brain
axis.
large
small
intestines
contain
more
than
100
trillion
microbial
cells,
contributing
intestinal
ecosystem’s
incredible
complexity.
Interactions
microbiota
epithelium
can
alter
brain
physiology
affect
mood
behavior.
There
has
recently
been
focus
on
relationships
impact
mental
health.
According
evidence,
play
role
neurological
illnesses.
Intestinal
metabolites
origin,
short-chain
fatty
acids,
tryptophan
metabolites,
bacterial
components
might
stimulate
host’s
immune
system,
are
mentioned
this
review.
We
aim
shed
some
growing
gut
inducing/manipulating
disorders,
which
pave
way
for
novel
microbiota-based
therapies.