Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

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Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2140 - 2140

Published: June 22, 2022

Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to World Health Organization (WHO), neurological main causes mortality worldwide. include Alzheimer’s disease, Parkinson′s Huntington′s Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion Brain tumor, Spinal cord injury, and Stroke. These diseases considered incurable because no specific therapies available cross blood-brain barrier (BBB) reach brain in a significant amount for pharmacological effect brain. There is need development strategies that can improve efficacy drugs circumvent BBB. One promising approaches use different types nano-scale materials. nano-based have ability increase therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, drug loading capacity. Different shapes nanomaterials been widely used treatment disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. nanoparticles unique characteristics, sensitivity, selectivity, BBB when nano-sized particles, imaging studies NDs. In this review, we briefly summarized recent literature on various their mechanism action disorders.

Language: Английский

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Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(4), P. 712 - 712

Published: Feb. 12, 2022

Nanotechnology has opened up a world of possibilities for the treatment brain disorders. Nanosystems can be designed to encapsulate, carry, and deliver variety therapeutic agents, including drugs nucleic acids. Nanoparticles may also formulated contain photosensitizers or, on their own, serve as photothermal conversion agents phototherapy. Furthermore, nano-delivery enhance efficacy contrast improved imaging diagnostics. However, effective is seriously hampered by formidable blood-brain barrier (BBB). Advances in understanding natural transport routes across BBB have led receptor-mediated transcytosis being exploited possible means nanoparticle uptake. In this regard, oligopeptide Angiopep-2, which high capacity, been utilized targeting ligand. Various organic inorganic nanostructures functionalized with Angiopep-2 direct diagnostic brain. Not only these shown great promise diagnosis cancer but they investigated injury, stroke, epilepsy, Parkinson's disease, Alzheimer's disease. This review focuses studies conducted from 2010 2021 Angiopep-2-modified nanoparticles aimed at

Language: Английский

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Lipid Nanoparticles: Promising Treatment Approach for Parkinson’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9361 - 9361

Published: Aug. 19, 2022

Parkinson’s disease (PD), a neurodegenerative disorder, is life-altering, debilitating exhibiting severe physical, psychological, and financial burden on patients. Globally, approximately 7–10 million people are afflicted with this disease, the number of cases estimated to increase 12.9 by 2040. PD progressive movement disorder nonmotor symptoms, including insomnia, depression, anxiety, anosmia. While current therapeutics available patients, treatment remains palliative, necessitating alternative approaches. A major hurdle in treating protective nature blood–brain barrier (BBB) its ability limit access foreign molecules, therapeutics. Drugs utilized presently nonspecific administered at dosages that result numerous adverse side effects. Nanomedicine has emerged as potential strategy for many diseases. From array nanomaterials available, lipid nanoparticles (LNPs) possess various advantages, enhanced permeability brain via passive diffusion specific transporters. Their bioavailability, nontoxic nature, be conjugated drugs, targeting moieties catapult LNPs promising therapeutic nanocarriers PD. PD-related studies limited, their evident formulations vaccines. This review aimed examining roles properties make them efficient nanodelivery vehicles PD, advances made date.

Language: Английский

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Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress

Smart Materials in Medicine, Journal Year: 2022, Volume and Issue: 3, P. 274 - 288

Published: Jan. 1, 2022

We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting of endoplasmic reticulum stress as a potential emerging therapeutic strategy against neuronal degeneration. The multicompartment organization the liquid crystalline (LCNPs), fabricated by self-assembly, was characterized cryogenic transmission electron microscopy (cryo-TEM) small-angle X-ray scattering (SAXS). Monoolein-based LCNPs co-encapsulated natural plant-derived antioxidant curcumin, fish oil rich in ω-3 polyunsaturated fatty acids (PUFA), neurotrophin brain-derived neurotrophic factor (BDNF), which is vital need neurogenesis. neuroprotective properties were vitro investigated cellular model tunicamycin-induced (ER) using differentiated human neuroblastoma SH-SY5Y cells deprieved from serum. intracellular accumulation aggregates misfolded proteins, typical ER process, analyzed fluorescence co-localization imaging staining. performed bioassays established that BDNF-loaded enhanced cell survival. diminution upon internalization quantified via changes Thioflavin T fluorescence, sensitive marker protein aggregation. with multi-drug loading appear to be promising candidates face challenges nanomedicine development exploiting ER-stress mechanisms.

Language: Английский

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Phytochemical-Based Synthesis of Silver Nanoparticle: Mechanism and Potential Applications

BioNanoScience, Journal Year: 2023, Volume and Issue: 13(3), P. 1359 - 1380

Published: May 23, 2023

Language: Английский

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Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 13, 2023

Neurons and their connecting axons gradually degenerate in neurodegenerative diseases (NDs), leading to dysfunctionality of the neuronal cells eventually death. Drug delivery for treatment effected nervous system is notoriously complicated because presence natural barriers, i.e., blood-brain barrier blood cerebrospinal fluid barrier. Palliative care currently standard many diseases. Therefore, programs that target disease's origin rather than its symptoms are recommended. Nanotechnology-based drug platforms offer an innovative way circumvent these obstacles deliver medications directly central system, thereby enabling several common neurological problems, Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis. Interestingly, combination nanomedicine gene therapy enables targeting selective mutant genes responsible progression NDs, which may provide a much-needed boost struggle against Herein, we discussed various obstacles, followed by detailed insight into recently developed techniques restore function via differentiation neural stem cells. Moreover, comprehensive background on role controlling neurogenesis explained. Additionally, numerous phytoconstituents with neuroprotective properties molecular targets identification management NDs also deliberated. Furthermore, ongoing clinical trials marketed products provided this manuscript.

Language: Английский

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Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: April 29, 2024

Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio-chemical features, such high surface-to-volume ratio and unique optical, electric, magnetic properties. The CNPs, based on nature, can either increase the reactive oxygen species (ROS) level for tumor antibacterial therapy or eliminate ROS cytoprotection, anti-inflammation, anti-aging. In addition, catalytic of nanozymes specifically trigger a specific reaction accompanied by optical feature change, presenting feasibility biosensor bioimaging applications. Undoubtedly, CNPs play pivotal role in pushing evolution technologies medical clinical fields, advanced strategies nanomaterials rely input chemical experts develop. Herein, systematic comprehensive review challenges recent development biomedical applications is presented from viewpoint nanomaterial with additional functions. Furthermore, biosafety issue applying biodegradable non-biodegradable future perspectives are critically discussed guide promising direction developing span-new more intelligent overcoming current limitations.

Language: Английский

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Digital Barcodes for High-Throughput Screening

Chem & Bio Engineering, Journal Year: 2024, Volume and Issue: 1(1), P. 2 - 12

Published: Jan. 26, 2024

High-throughput screening is an indispensable technology in drug discovery, cancer therapy, and disease diagnosis, it could greatly reduce time cost, reagent consumption, labor expense. Here, four high-throughput methods with high sensitivity accessibility are discussed detail. Fluorescence, DNA, heavy metal, nonmetal isotope barcodes, which generally label antibodies, proteins, saccharides to identify cells, detected by flow cytometry, second-generation DNA sequencing, mass second-ion spectrometry, respectively. Encoding binary information labeling individual cells performing the characterization of together, identifying result belonging via barcodes main steps for screening. Applications digital both vitro vivo tests described detail, their advantages disadvantages also summarized. has provided a powerful platform widely accessible multidisciplinary studies sped up progress therapy.

Language: Английский

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Nanotechnology-Driven Therapeutic Innovations in Neurodegenerative Disorders: A Focus on Alzheimer’s and Parkinson’s Disease

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(2), P. 352 - 379

Published: April 30, 2024

Neurodegenerative disorders entail a progressive loss of neurons in cerebral and peripheral tissues, coupled with the aggregation proteins exhibiting altered physicochemical properties. Crucial to these conditions is gradual degradation central nervous system, manifesting as impairments mobility, aberrant behaviors, cognitive deficits. Mechanisms such proteotoxic stress, neuroinflammation, oxidative programmed cell death contribute ongoing dysfunction demise neurons. Presently, neurodegenerative diseases lack definitive cures, available therapies primarily offer palliative relief. The integration nanotechnology into medical practices has significantly augmented both treatment efficacy diagnostic capabilities. Nanoparticles, capable traversing blood–brain barrier, hold considerable potential for diagnosing treating brain pathologies. By combining gene therapy nanotechnology, therapeutic effectiveness against can be substantially enhanced. Recent advancements nano-biomaterial-based methodologies have fortified existing approaches neural stem (NSC) differentiation therapies. NSC-targeting technologies promising, potentially safe method diseases. This review endeavors summarize current insights perspectives on nanotechnology-driven innovations disorders, particular emphasis Alzheimer’s Parkinson’s disease.

Language: Английский

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