Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(10), P. 2871 - 2887
Published: July 18, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 1820 - 1845
Published: Jan. 9, 2024
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, BBB also prevents passage of various forms therapeutic agents, nanocarriers, their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe effective vehicles in neurotheranostics. In this Review, first we introduce anatomical physiological functions BBB. Second, present endogenous exogenous transport mechanisms by NPs cross We report nanomaterials, carriers, cargos, with detailed uptake permeability characteristics. Third, describe effect regulating size, shape, charge, surface ligands affect permeability, can be exploited enhance promote classify typical functionalized nanomaterials developed for crossing. Fourth, provide comprehensive review recent progress functional polymeric applications multimodal bioimaging, therapeutics, drug delivery. Finally, conclude discussing existing directions, future perspectives employing
Language: Английский
Citations
80
Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(8), P. 578 - 600
Published: June 6, 2022
Language: Английский
Citations
68
Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 293, P. 115257 - 115257
Published: April 5, 2022
Language: Английский
Citations
67
Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 154, P. 424 - 442
Published: Oct. 29, 2022
Language: Английский
Citations
44
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 28, 2023
Neurological disorders are recognized as major causes of death and disability worldwide. Because this, they represent one the largest public health challenges. With awareness massive burden associated with these disorders, came recognition that treatment options were disproportionately scarce and, oftentimes, ineffective. To address problems, modern research is increasingly looking into novel, more effective methods to treat neurological patients; which cell-based therapies. In this review, we present a critical analysis features, challenges, prospects stem cell types can be employed numerous disorders—mesenchymal cells (MSCs). Despite fact several studies have already established safety MSC-based approaches, there still some reservations within field regarding their immunocompatibility, heterogeneity, stemness stability, range adverse effects—one tumor-promoting ability. We additionally examine MSCs’ mechanisms action respect in vitro vivo well detail findings past ongoing clinical trials for Parkinson’s Alzheimer’s disease, ischemic stroke, glioblastoma multiforme, multiple sclerosis. Finally, review discusses therapeutics form biomaterials, use electromagnetic fields enhance proliferation differentiation neuronal cells.
Language: Английский
Citations
25
Microvascular Research, Journal Year: 2023, Volume and Issue: 151, P. 104621 - 104621
Published: Nov. 1, 2023
Language: Английский
Citations
21
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115051 - 115051
Published: Aug. 6, 2023
Language: Английский
Citations
17
Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)
Published: Feb. 4, 2022
Abstract Background Fat grafting is one of the most common soft tissue filling methods in plastic surgery. Bone marrow mesenchymal stem cell (BM-MSC) transplantation an effective method for improving graft retention. However, role BM-MSCs fat not completely clear. Methods Human particles, together with or PBS as a control, were subcutaneously transplanted into backs nude mice. Samples taken on days 14, 30 and 90 post-grafting to calculate retention rate, staining was evaluated. Furthermore, macrophages treated BM-MSC conditioned medium (BM-MSC-CM) identify beneficial component secreted by these cells. Results In this study, we found that improved enhancing angiogenesis grafting. Further analysis revealed could significantly inhibit expression proinflammatory M1 macrophage markers interleukin (IL)-1β, tumor necrosis factor-α (TNF-α) IL-6 early stages promote anti-inflammatory M2 Arg1, IL-10 VEGF. our results showed induced polarization vitro. Conclusions can improve rate angiogenesis, which may be related macrophages. These help elucidate
Language: Английский
Citations
26
Cells, Journal Year: 2022, Volume and Issue: 11(10), P. 1664 - 1664
Published: May 17, 2022
Huntington’s disease (HD) is a neurodegenerative inherited genetic disorder, which leads to the onset of motor, neuropsychiatric and cognitive disturbances. HD characterized by loss gamma-aminobutyric acid (GABA)ergic medium spiny neurons (MSNs). To date, there no treatment for HD. Mesenchymal stem cells (MSCs) provide substantial therapeutic opportunity treatment. Herein, we investigated potential human immature dental pulp (hIDPSC), special type MSC originated from neural crest, Two different doses hIDPSC were intravenously administrated in subacute 3-nitropropionic (3NP)-induced rat model. We demonstrated homing striatum, cortex subventricular zone using specific markers cells. Thirty days after administration, found brain are still express hallmarks undifferentiated MSC. Immunohistochemistry quantities analysis revealed significant increase number BDNF, DARPP32 D2R positive stained striatum groups that received hIDPSC. The differences more expressive animals only one administration Altogether, these data suggest intravenous hIDPSCs can restore expression, promoting neuroprotection neurogenesis.
Language: Английский
Citations
23
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 1037 - 1057
Published: Dec. 23, 2023
Language: Английский
Citations
14