Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1886 - 1886

Published: Sept. 6, 2022

Solid lipid nanoparticles (SLNs) are an alternate carrier system to liposomes, polymeric nanoparticles, and inorganic carriers. SLNs have attracted increasing attention in recent years for delivering drugs, nucleic acids, proteins, peptides, nutraceuticals, cosmetics. These nanocarriers industrial due their ease of preparation, physicochemical stability, scalability. characteristics make attractive manufacture on a large scale. Currently, several products with clinical trials, there is high possibility that SLN carriers will quickly increase presence the market. A large-scale manufacturing unit required commercial applications prepare enough formulations studies. Furthermore, continuous processing becoming more popular pharmaceutical sector reduce product batch-to-batch differences. This review paper discusses some conventional methods rationale production. It further covers progress scale-up synthesis SLNs, including high-pressure homogenization (HPH), hot melt extrusion coupled HPH, microchannels, nanoprecipitation using static mixers, microemulsion-based methods. technologies enable commercialization SLNs. ongoing studies indicate these eventually reach

Language: Английский

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Plant and Microbial Approaches as Green Methods for the Synthesis of Nanomaterials: Synthesis, Applications, and Future Perspectives

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 463 - 463

Published: Jan. 3, 2023

The unique biological and physicochemical characteristics of biogenic (green-synthesized) nanomaterials (NMs) have attracted significant interest in different fields, with applications the agrochemical, food, medication delivery, cosmetics, cellular imaging, biomedical industries. To synthesize nanomaterials, green synthesis techniques use microorganisms, plant extracts, or proteins as bio-capping bio-reducing agents their role bio-nanofactories for material at nanoscale size. Green chemistry is environmentally benign, biocompatible, nontoxic, economically effective. By taking into account findings from recent investigations, we shed light on most developments using types microbes plants. Additionally, cover green-synthesized food textile industries, water treatment, applications. Furthermore, discuss future perspectives to advance production

Language: Английский

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Biofabrication of nanoparticles: sources, synthesis, and biomedical applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: May 2, 2023

Graphical Abstract Sources for biogenic synthesis: The synthesis sources include but are not limited to bacteria, fungi, algae, yeasts, marine and plant sources.

Language: Английский

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An overview of green synthesized silver nanoparticles towards bioactive antibacterial, antimicrobial and antifungal applications

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 323, P. 103053 - 103053

Published: Nov. 26, 2023

Language: Английский

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Polymeric Micelles for Breast Cancer Therapy: Recent Updates, Clinical Translation and Regulatory Considerations

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1860 - 1860

Published: Sept. 3, 2022

With the growing burden of cancer, parallel advancements in anticancer nanotechnological solutions have been witnessed. Among different types cancers, breast cancer accounts for approximately 25% and leads to 15% deaths. Nanomedicine its allied fields material science revolutionized medicine 21st century. Novel treatments paved way improved drug delivery systems that better efficacy reduced adverse effects. A variety nanoformulations using lipids, polymers, inorganic, peptide-based nanomedicines with various functionalities are being synthesized. Thus, elaborate knowledge these intelligent highly promising is prime importance. Polymeric micelles (PMs) generally easy prepare good solubilization properties; hence, they appear be an attractive alternative over other nanosystems. Although overall perspective PM has presented recent reviews, a brief discussion provided on PMs cancer. This review provides state-of-the-art together most advances this field. Furthermore, special emphasis placed regulatory guidelines, clinical translation potential, future aspects use treatment. The developments micelle formulations look promising, guidelines now more clearly defined; we anticipate early near future.

Language: Английский

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Advances in preparation and application of antibacterial hydrogels

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 26, 2023

Bacterial infections, especially those caused by drug-resistant bacteria, have seriously threatened human life and health. There is urgent to develop new antibacterial agents reduce the problem of antibiotics. Biomedical materials with good antimicrobial properties been widely used in applications. Among them, hydrogels become focus research field biomedical due their unique three-dimensional network structure, high hydrophilicity, biocompatibility. In this review, latest progresses about recent years were summarized, mainly including preparation methods According different mechanisms, several representative introduced, such as antibiotics loaded hydrogels, antibiotic-free metal-based peptide polymers, stimuli-responsive smart light-mediated hydrogels. addition, we also discussed applications challenges biomedicine, which are expected provide directions ideas for application clinical therapy.

Language: Английский

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Bioinspired and Green Synthesis of Silver Nanoparticles for Medical Applications: A Green Perspective

Applied Biochemistry and Biotechnology, Journal Year: 2023, Volume and Issue: 196(6), P. 3636 - 3669

Published: Sept. 5, 2023

Silver nanoparticles (AgNPs) possess unmatched chemical, biological, and physical properties that make them unique compounds as antimicrobial, antifungal, antiviral, anticancer agents. With the increasing drug resistance, AgNPs serve promising entities for targeted therapy against several bacterial, fungal, viral components. In addition, also successful agents cancers, including breast, prostate, lung cancers. Several works in recent years have been done towards development of by using plant extracts like flowers, leaves, bark, root, stem, whole parts. The green method AgNP synthesis thus has advantages over chemical methods, especially low cost synthesis, no toxic byproducts, eco-friendly production pathways, can be easily regenerated, bio-reducing potential derived nanoparticles. Furthermore, are biocompatible do not harm normally functioning human or host cells. This review provides an exhaustive overview synthesized used After a brief introduction, we discussed studies on from different extracts, leaf parts, seeds, stems, plants. following section, highlighted therapeutic actions various bacteria, fungi, viruses, We then general mechanism action AgNPs. methods were article. Finally, concluded providing future perspectives this field nanotechnology.

Language: Английский

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The Role of Silver Nanoparticles in Electrochemical Sensors for Aquatic Environmental Analysis

Sensors, Journal Year: 2023, Volume and Issue: 23(7), P. 3692 - 3692

Published: April 2, 2023

With rapidly increasing environmental pollution, there is an urgent need for the development of fast, low-cost, and effective sensing devices detection various organic inorganic substances. Silver nanoparticles (AgNPs) are well known their superior optoelectronic physicochemical properties, have, therefore, attracted a great deal interest in sensor arena. The introduction AgNPs onto surface two-dimensional (2D) structures, incorporation into conductive polymers, or within three-dimensional (3D) nanohybrid architectures common strategy to fabricate novel platforms with improved chemical physical properties analyte sensing. In first section this review, main wet reduction approaches successful synthesis functional electrochemical applications discussed. Then, brief on principles voltammetric amperometric sensors given. current utilization silver silver-based composite nanomaterials fabrication as pollutants water matrices summarized. Finally, challenges future directions nanosilver-based outlined.

Language: Английский

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Biofabrication of Fe3O4 Nanoparticles from Spirogyra hyalina and Ajuga bracteosa and Their Antibacterial Applications

Molecules, Journal Year: 2023, Volume and Issue: 28(8), P. 3403 - 3403

Published: April 12, 2023

Iron oxide nanoparticles (NPs) have attracted substantial interest due to their superparamagnetic features, biocompatibility, and nontoxicity. The latest progress in the biological production of Fe3O4 NPs by green methods has improved quality applications significantly. In this study, fabrication iron from Spirogyra hyalina Ajuga bracteosa was conducted via an easy, environmentally friendly, cost-effective process. fabricated were characterized using various analytical study unique properties. UV-Vis absorption peaks observed algal plant-based at 289 nm 306 nm, respectively. Fourier transform infrared (FTIR) spectroscopy analyzed diverse bioactive phytochemicals present plant extracts that functioned as stabilizing capping agents NPs. X-ray diffraction revealed crystalline nature both biofabricated small size. Scanning electron microscopy (SEM) algae are spherical rod-shaped, averaging 52 75 Energy dispersive showed green-synthesized require a high mass percentage oxygen ensure synthesis. exhibited stronger antioxidant properties than algal-based efficient antibacterial potential against E. coli, while displayed higher zone inhibition S. aureus. Moreover, superior scavenging compared This might be greater number plants surround during fabrication. Hence, over improves applications.

Language: Английский

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Metal-based nanoparticles in antibacterial application in biomedical field: Current development and potential mechanisms

Biomedical Microdevices, Journal Year: 2024, Volume and Issue: 26(1)

Published: Jan. 23, 2024

Abstract The rise in drug resistance pathogenic bacteria greatly endangers public health the post-antibiotic era, and drug-resistant currently pose a great challenge not only to community but also clinical procedures, including surgery, stent implantation, organ transplantation, other medical procedures involving any open wound compromised human immunity. Biofilm-associated failure, as well rapid last-resort antibiotics, necessitates search for novel treatments against bacterial infection. In recent years, flourishing development of nanotechnology has provided new insights exploiting promising alternative therapeutics bacteria. Metallic agents have been applied antibacterial usage several centuries, functional modification metal-based biomaterials using now attracted interest field, their intrinsic nature ready on-demand functionalization enhanced interaction with bacteria, rendering them good potential further translation. However, possible toxicity MNPs host cells tissue still hinders its application, current knowledge on cellular pathways is enough. This review will focus advances developing metallic nanoparticles (MNPs), silver, gold, copper, nanoparticles, applications, mechanisms hosts.

Language: Английский

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