Biofabrication,
Journal Year:
2022,
Volume and Issue:
14(3), P. 034104 - 034104
Published: March 30, 2022
Microvasculature
is
essential
for
the
exchange
of
gas
and
nutrient
most
tissues
in
our
body.
Some
tissue
structures
such
as
meniscus
presents
spatially
confined
blood
vessels
adjacent
to
non-vascularized
regions.
In
biofabrication,
mimicking
spatial
distribution
vascular
components
paramount,
capillary
ingrowth
into
can
lead
matrix
alterations
subsequent
pathology.
Multi-material
three-dimensional
(3D)
bioprinting
strategies
have
potential
resolve
anisotropic
features,
although
building
complex
constructs
comprising
stable
vascularized
regions
remains
a
major
challenge
date.
this
study,
we
developed
endothelial
cell-laden
pro-
anti-angiogenic
bioinks,
supplemented
with
bioactive
matrix-derived
microfibers
(MFs)
that
were
created
from
type
I
collagen
sponges
(col-1)
cartilage
decellularized
extracellular
(CdECM),
respectively.
Human
umbilical
vein
cell
(HUVEC)-driven
networks
started
form
2
d
after
bioprinting.
Supplementing
cartilage-derived
MFs
endothelial-cell
laden
bioinks
reduced
total
length
neo-microvessels
by
29%,
number
microvessel
junctions
37%
14
d,
compared
pro-angiogenic
col-1
MFs.
As
proof
concept,
bioprinted
an
anatomical
shape
biomimetic
outer
inner
region,
using
gellan
gum
microgel
suspension
bath.
These
3D
meniscus-like
cultured
up
zone
HUVEC-,
mural
cell-,
MF-laden
bioink,
progenitor
(MPC)-
CdECM
revealing
successful
confinement
nascent
network
only
zone.
Further,
co-facilitate
both
formation
MPC-derived
formation,
formulated
culture
medium
conditions
temporal
switch.
Overall,
study
provides
new
strategy
could
be
applied
develop
zonal
meniscal
constructs.
Moreover,
use
ECM-derived
promote
or
inhibit
opens
possibilities
biofabrication
microvascular
distribution.
many
applications
includingin
vitromodels
vascular-to-avascular
interfaces,
cancer
progression,
testing
therapies.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
15(4)
Published: April 26, 2023
Carbon
dots
(CDs)
correspond
to
carbon-based
materials
(CBM)
with
sizes
usually
below
10
nm.
These
nanomaterials
exhibit
attractive
properties
such
us
low
toxicity,
good
stability,
and
high
conductivity,
which
have
promoted
their
thorough
study
over
the
past
two
decades.
The
current
review
describes
four
types
of
CDs:
carbon
quantum
(CQDs),
graphene
(GQDs),
nanodots
(CNDs),
carbonized
polymers
(CPDs),
together
state
art
main
routes
for
preparation,
either
by
"top-down"
or
"bottom-up"
approaches.
Moreover,
among
various
usages
CDs
within
biomedicine,
we
focused
on
application
as
a
novel
class
broad-spectrum
antibacterial
agents,
concretely,
owing
photoactivation
capability
that
triggers
an
enhanced
property.
Our
work
presents
recent
advances
in
this
field
addressing
CDs,
composites
hybrids,
applied
photosensitizers
(PS),
photothermal
agents
(PA)
strategies
photodynamic
therapy
(PDT),
(PTT),
synchronic
PDT/PTT.
Furthermore,
discuss
prospects
possible
future
development
large-scale
preparation
potential
these
be
employed
applications
combat
other
pathogens
harmful
human
health.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Infectious
Disease.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(4), P. 5732 - 5743
Published: Jan. 23, 2023
Carbon-based
nanostructures
are
attracting
a
lot
of
attention
because
their
very
low
toxicity,
excellent
visible
light-triggered
optical
and
photothermal
properties,
intriguing
applications.
Currently,
the
development
multifunctional
carbon-based
for
synergistic
chemo-photothermal
approach
is
challenging
topic
advancement
cancer
treatment.
Here,
we
report
an
unprecedented
example
photoresponsive
polymer
dots
(CPDs-PNM)
obtained
by
one-pot
thermal
process
from
poly(N-isopropylacrylamide)
(PNIPAM)
without
using
organic
solvent
additional
reagents.
The
CPDs-PNM
were
characterized
spectroscopic
techniques,
transmission
electron
microscopy,
atomic
force
microscopy.
exhibited
high
conversion
efficiency,
lower
critical
solution
temperature
(LCST)
behavior,
good
cytarabine
(arabinosyl
cytosine,
AraC)
loading
capacity
(62.3%).
formation
CPDs-PNM/AraC
adduct
photothermal-controlled
drug
release,
triggered
green
light
excitation,
demonstrated
drug-polymer
interaction
release
mechanism
well
supported
modeling
simulation
calculations.
cellular
uptake
empty
AraC-loaded
was
imaged
confocal
laser
scanning
In
vitro
experiments
evidenced
that
did
not
affect
viability
neuroblastoma
cells,
while
under
irradiation
significantly
higher
toxicity
than
AraC
alone
combined
effect.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(4), P. 1323 - 1338
Published: March 15, 2023
Cancer
diagnosis
and
treatment
are
the
most
critical
challenges
in
modern
medicine.
Conventional
cancer
treatments
no
longer
meet
needs
of
health
field
due
to
high
rate
mutations
epigenetic
factors
that
have
caused
drug
resistance
tumor
cells.
Hence,
search
for
unique
methods
is
quickly
expanding.
The
development
nanotechnology
medicine
a
system
integrate
achieve
an
effective
approach
overcome
known
limitations
conventional
led
emergence
theranostic
nanoparticles
nanosystems
based
on
these
nanoparticles.
An
influential
group
carbon-based
These
received
significant
attention
their
properties,
such
as
electrical
conductivity,
strength,
excellent
surface
chemistry,
wide
range
structural
diversity
(graphene,
nanodiamond,
carbon
quantum
dots,
fullerenes,
nanotubes,
nanohorns).
were
widely
used
various
fields,
tissue
engineering,
delivery,
imaging,
biosensors.
In
this
review,
we
discuss
detail
recent
features
advances
advanced
diverse
strategies
treat
diseases
with
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100827 - 100827
Published: Oct. 2, 2023
Biofilms
are
aggregates
of
organized
microbial
growth
that
function
as
barriers
and
create
a
stable
internal
environment
for
cell
survival.
The
bacteria
in
the
biofilms
exhibit
characteristics
quite
different
from
planktonic
bacteria,
such
strong
resistance
to
antibiotics
other
bactericides,
getting
out
host
immunity,
developing
harsh
environments,
which
all
contribute
persistent
intractable
treatment.
Hence,
there
is
an
urgent
need
develop
novel
materials
strategies
combat
biofilms.
However,
most
reviews
on
anti-biofilms
published
recent
years
based
specific
fields
or
materials.
Microorganisms
ubiquitous,
except
context
medical
health
issues;
however,
exert
detrimental
effects
advancement
progress
various
fields.
Therefore,
this
review
aims
provide
comprehensive
summary
effective
methodologies
applicable
across
industries.
Firstly,
process
formation
was
introduced
enhance
our
comprehension
"enemy".
Secondly,
intervene
important
links
were
discussed,
taking
timely
action
during
early
weak
stages
Thirdly,
treatment
mature
summarized
deal
with
break
through
defense
line.
Finally,
several
substances
antibacterial
properties
presented.
concludes
standpoint
author
about
potential
developments
strategies.
This
may
help
researchers
quickly
understand
research
challenges
field
design
more
efficient
methods
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: May 2, 2024
Graphene
quantum
dots
(GQDs)
are
a
newly
developed
class
of
material,
known
as
zero-dimensional
nanomaterials,
with
characteristics
derived
from
both
carbon
(CDs)
and
graphene.
GQDs
exhibit
several
ideal
properties,
including
the
potential
to
absorb
incident
energy,
high
water
solubility,
tunable
photoluminescence,
good
stability,
drug-loading
capacity,
notable
biocompatibility,
which
make
them
powerful
tools
for
various
applications
in
field
biomedicine.
Additionally,
can
be
incorporated
additional
materials
develop
nanocomposites
exceptional
qualities
enriched
functionalities.
Inspired
by
intriguing
scientific
discoveries
substantial
contributions
biomedicine,
we
present
broad
overview
recent
advancements
GQDs-based
biomedical
applications.
The
review
first
outlines
latest
synthesis
classification
nanocomposite
enables
their
use
advanced
composite
Furthermore,
systematic
study
drug
delivery,
biosensing,
photothermal,
photodynamic
combination
therapies
emphasized.
Finally,
possibilities,
challenges,
paths
highlighted
encourage
research,
will
lead
new
therapeutics
global
healthcare
improvements.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
9(3), P. 334 - 364
Published: Jan. 1, 2024
Integrating
the
advances
of
emerging
hyperthermia
techniques
with
3D
tumor
models
and
non-invasive
temperature
control
systems
can
contribute
to
identifying
top-performing
hyperthermic
nanomedicines
in
preclinical
evaluation
stages.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 2, 2024
Abstract
Functional
metal
doping
endows
fluorescent
carbon
dots
with
richer
physical
and
chemical
properties,
greatly
expanding
their
potential
in
the
biomedical
field.
Nonetheless,
fabricating
integrated
functionality
for
diagnostic
therapeutic
modalities
remains
challenging.
Herein,
we
develop
a
simple
strategy
to
prepare
Gd/Ru
bimetallic
doped
(Gd/Ru-CDs)
via
one-step
microwave-assisted
method
Ru(dcbpy)
3
Cl
2
,
citric
acid,
polyethyleneimine,
GdCl
as
precursors.
Multiple
techniques
were
employed
characterize
morphology
properties
of
obtained
dots.
The
Gd/Ru-CDs
are
high
mono-dispersity,
uniform
spherical
nanoparticles
an
average
diameter
4.2
nm.
Moreover,
X-ray
photoelectron
spectroscopy
(XPS),
Fourier
transform
infrared
(FTIR)
confirmed
composition
surface
In
particular,
successful
enables
not
only
show
considerable
magnetic
resonance
imaging
(MRI)
performance
but
also
obtain
better
fluorescence
(FL)
especially
red
emission
area.
More
impressively,
it
has
low
cytotoxicity,
excellent
biocompatibility,
efficient
reactive
oxygen
species
(ROS)
generation
ability,
making
effective
imaging-guided
tumor
treatment
reagent.
vivo
experiments
have
revealed
that
can
achieve
light-induced
suppression
non-invasive
fluorescence/magnetic
bimodal
reagents
monitor
process
mouse
models.
Thus,
this
dot
manufacturing
by
functional
metals
expanded
avenues
development
application
multifunctional
all-in-one
theranostics.
