Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

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The interrelationships between sleep regularity, obstructive sleep apnea, and hypertension in a middle-aged community population

SLEEP, Journal Year: 2024, Volume and Issue: 47(3)

Published: Jan. 5, 2024

Abstract Study Objectives Little is known about the interrelationships between sleep regularity, obstructive apnea (OSA) and important health markers. This study examined whether irregular associated with OSA hypertension, if this modifies association hypertension. Methods Six hundred two adults (age mean(SD) = 56.96(5.51) years, female 60%) from Raine who were not evening or night shift workers assessed for (in-laboratory polysomnography; apnea–hypopnea index ≥ 15 events/hour), hypertension (doctor diagnosed, systolic blood pressure ≥140 mmHg and/or diastolic ≥90 mmHg) (wrist actigraphy ≥5 days). A regularity (SRI) was determined actigraphy. Participants categorized by tertiles as severely irregular, mildly regular sleepers. Logistic regression models SRI, Covariates included age, sex, body mass index, duration, insomnia, depression, activity, alcohol, smoking, antihypertensive medication. Results Compared to sleepers, participants (OR 1.97, 95% confidence intervals [CI] 1.20 3.27) 2.06, CI: 1.25 3.42) had greater odds of OSA. those no sleep, combined highest 2.34 1.07 5.12; p interaction 0.02) while regular/mildly at increased risk (p 0.20). Conclusions Sleep irregularity may be an modifiable target among

Language: Английский

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Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(9), P. 2038 - 2053.e5

Published: Aug. 5, 2024

Language: Английский

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Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 512 - 512

Published: March 14, 2024

Hypoxia-inducible factor-1 (HIF-1) is a heterodimer transcription factor composed of an alpha and beta subunit. HIF-1α master regulator cellular response to hypoxia by activating the genes that facilitate metabolic adaptation hypoxia. Since chondrocytes in mature articular cartilage reside hypoxic environment, plays important role chondrogenesis physiological lifecycle cartilage. Accumulating evidence suggests interactions between HIF pathways circadian clock. The clock emerging both developing chondrocytes. However, how rhythm established during early steps formation through what signaling it promotes healthy chondrocyte phenotype still not entirely known. This narrative review aims deliver concise analysis existing understanding dynamic interplay molecular chondrocytes, states health disease, while also incorporating creative interpretations. We explore diverse hypotheses regarding intricate among these propose relevant therapeutic strategies for disorders such as osteoarthritis.

Language: Английский

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The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9080 - 9080

Published: Aug. 13, 2022

Obstructive sleep apnea (OSA) is a relatively common disease in the general population. Besides its interaction with many comorbidities, it can also interact potentially painful conditions and modulate course. The association between OSA pain modulation has recently been topic of concern for scientists. mechanism underlying OSA-related connection linked different pathophysiological changes various mechanisms. Furthermore, may cause both chronic acute aggravation as well influencing antinociceptive mechanism. Characteristic such nocturnal hypoxemia, fragmentation, systemic inflammation are considered to have curtailing impact on perception. Hypoxemia proven significant increased expression proinflammatory cytokines hyperalgesic priming nociceptors. Moreover, hypoxia markers by themselves hypothesized intracellular signal transduction neurons an nociceptive sensitization. Pain management patients create problems arousing from alterations neuropeptide systems overexpression opioid receptors conditions, leading intensification side effects, e.g., respiratory depression sensitivity analgesic effects. In this paper, we summarize current knowledge regarding treatment focus molecular mechanisms modulation.

Language: Английский

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Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences

Metabolites, Journal Year: 2022, Volume and Issue: 13(1), P. 60 - 60

Published: Dec. 30, 2022

Obstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent episodes of and hypopnea during sleep. It associated with various cardiovascular metabolic complications, including type 2 diabetes mellitus (T2DM) obesity. Many pathways can be responsible for T2DM development in OSA patients, e.g., those related to HIF-1 SIRT1 expression. Moreover, epigenetic mechanisms, such as miRNA181a or miRNA199, are postulated play pivotal role this link. has been proven that increases the occurrence circadian clock disruption, which also risk factor disease development. Circadian disruption impairs metabolism glucose, lipids, secretion bile acids. Therefore, OSA-induced may potential, complex, underlying pathway involved developing exacerbating diseases among patients. The current paper summarizes available information pertaining relationship between context potential mechanisms leading disorders.

Language: Английский

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Circadian clock disruptions link oxidative stress and systemic inflammation to metabolic syndrome in obstructive sleep apnea patients

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 29, 2022

Objectives: Obstructive sleep apnea (OSA) is an independent risk factor for metabolic syndrome (MetS). Recent studies have indicated that circadian clock genes were dysregulated in OSA. In addition, it clear the impairment of clocks drives progression MetS. Therefore, we hypothesized rhythm disruption links OSA with Methods: A total 118 participants, who underwent polysomnography (PSG) and diagnosed as healthy snorers (control, n = 29) or (n 89) patients based on apnea-hypopnea index (AHI), enrolled present study. General information, anthropometric data, blood biochemical indicators, gene expressions, levels oxidative inflammatory indicators collected, determined, compared all participants. Results: We found Brain muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) Differentiated embryo chondrocyte (Dec1) upregulated, while Period (Per1) was reduced patients. these changing trends closely associated hypoxia indicator AHI a significant impact presence MetS components, such hyperglycemia (Dec1 Per1, p < 0.05 0.001, respectively), hypertension (Bmal1 Dec1, 0.001 0.01, hyperlipidemia (Dec1, 0.01), obesity 0.05). Notably, expressions Dec1 correlated IR predicted Finally, also observed expression interrelated both biomarkers (IL-6) Conclusion: This study concluded disruptions, especially link inflammatory-related manner. Circadian can be used specific biomarker (p 0.001) therapeutic target combined Mets

Language: Английский

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Is obstructive sleep apnea a circadian rhythm disorder?

Journal of Sleep Research, Journal Year: 2023, Volume and Issue: 32(4)

Published: March 15, 2023

Summary Obstructive sleep apnea is the most common sleep‐related breathing disorder worldwide and remains underdiagnosed. Its multiple associated comorbidities contribute to a decreased quality of life work performance as well an increased risk death. Standard treatment seems have limited effects on cardiovascular metabolic aspects disease, emphasising need for early diagnosis additional therapeutic approaches. Recent evidence suggests that dysregulation circadian rhythms, processes with endogenous rhythmicity are adjusted environment through various cues, involved in pathogenesis comorbidities. In patients obstructive apnea, altered gene expression patterns been demonstrated. respiratory events may promote disturbance intermittent hypoxia, subsequent inflammation disruption neural hormonal homeostasis. this review, current knowledge rhythm regulation, disorders summarised. Studies connect abnormalities critically evaluated. Furthermore, pathogenetic mechanisms underlie association, notably hypoxia signalling, presented. A bidirectional relationship between proposed. Approaching prove beneficial development new, personalised diagnostic, prognostic tools. However, further studies needed before clinical approach includes targeting system.

Language: Английский

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Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 7, 2024

Abstract Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and presence severity depressive symptoms in OSA patients. The included 184 individuals, who underwent polysomnography (PSG) had their peripheral blood collected evening before morning after PSG. Patients were divided into two groups: (apnea-hypopnea index (AHI) > 5) control group (AHI < 5). RNA was extracted from leukocytes. Expression levels selected genes ( BMAL1 , CLOCK PER1 CRY1 NPAS2 NR1D1 ) assessed qRT-PCR. Questionnaire data (including Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Chronotype (CQ), Montgomery–Åsberg Depression Rating (MADRS)). expression all examined patients upregulated compared (except ). No differences observed between groups at either time point. Additionally, there a positive correlation (assessed MADRS) Finally, multivariable linear regression, ISI score B = 0.750, p 0.001), AM CQ 0.416, 0.007), 4.310, 0.042) found be predictive factors for greater depression Dysregulated linked symptom severity, suggesting disruption may underlie OSA.

Language: Английский

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Associations between sleep-related symptoms, obesity, cardiometabolic conditions, brain structural alterations and cognition in the UK biobank

Sleep Medicine, Journal Year: 2023, Volume and Issue: 103, P. 41 - 50

Published: Jan. 31, 2023

Language: Английский

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