Homeostasis and Dysbiosis of the Intestinal Microbiota: Comparing Hallmarks of a Healthy State with Changes in Inflammatory Bowel Disease DOI Creative Commons
Jasminka Talapko,

Aleksandar Včev,

Tomislav Meštrović

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(12), P. 2405 - 2405

Published: Dec. 5, 2022

The gut microbiota, which represent a community of different microorganisms in the human intestinal tract, are crucial to preserving health by participating various physiological functions and acting as metabolic organ. In conditions, microbiota-host partnership exerts homeostatic stability; however, changes microbiota composition (dysbiosis) an important factor pathogenesis inflammatory bowel disease its two main entities: ulcerative colitis Crohn's disease. incidence prevalence these conditions have increased rapidly last decade, becoming significant problem for healthcare system true challenge finding novel therapeutic solutions. issue is that, despite numerous studies, etiopathogenesis not completely clear. Based on current knowledge, chronic inflammation occurs due altered environmental factors, well complex interplay between genetic predisposition host inappropriate innate acquired immune response. It note that development biological immunomodulatory therapy has led progress treating Certain lifestyle approaches-including fecal transplantation nutritional supplementation with probiotics, prebiotics, synbiotics-have offered solutions dysbiosis management paved way towards restoring healthy microbiome, only minimal long-term unfavorable effects.

Language: Английский

Inflammatory Bowel Diseases and Gut Microbiota DOI Open Access

Yuri Haneishi,

Yuma Furuya,

Mayu Hasegawa

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3817 - 3817

Published: Feb. 14, 2023

Inflammatory bowel disease (IBD) is an inflammatory of the gastrointestinal tract, incidence which has rapidly increased worldwide, especially in developing and Western countries. Recent research suggested that genetic factors, environment, microbiota, immune responses are involved pathogenesis; however, underlying causes IBD unclear. Recently, gut microbiota dysbiosis, a decrease abundance diversity specific genera, been as trigger for IBD-initiating events. Improving identifying bacterial species essential understanding pathogenesis treatment autoimmune diseases. Here, we review different aspects role played by provide theoretical basis modulating through probiotics, fecal transplantation, microbial metabolites.

Language: Английский

Citations

110
Vitamin D in Prevention of Autoimmune Diseases DOI Creative Commons
Valeria Dipasquale,

Giovanna Lo Presti,

Gregorio P. Milani

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2022, Volume and Issue: 27(10)

Published: Oct. 24, 2022

Vitamin D is essential for the regulation of immune system. In recent years, role vitamin in control several autoimmune conditions such as inflammatory bowel disease (IBD), celiac disease, type 1 diabetes mellitus (T1DM), and others has been investigated. The aim this review was to define level knowledge on D's these disorders, well preventive therapeutic supplementation. Relevant studies published over last 20 years were identified via a PubMed/Medline (http://www.ncbi.nlm.nih.gov/pubmed/) search using keywords: D, prevention. deficiency or impaired function enzymes necessary its activity shown affect onset severity diseases examined. supplementation appears useful support therapy IBD. Its hepatitis, T1DM, thyroiditis unclear. conclusion, further are needed whether cause result most common autoimmune, extra-skeletal diseases, should be provided all newborns during their first year life. Afterwards, regimen tailored presence risk factors and/or specific disease.

Language: Английский

Citations

97
Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease DOI Open Access

Yoonhwa Shin,

Sunhee Han,

Juhui Kwon

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4466 - 4466

Published: Oct. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Language: Английский

Citations

71
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation DOI
Rongrong Wu, Rui Xiong,

Yan Li

et al.

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103062 - 103062

Published: May 27, 2023

Language: Английский

Citations

69
Multi-omic approaches for host-microbiome data integration DOI Creative Commons
Ashwin Chetty, Ran Blekhman

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 2, 2024

The gut microbiome interacts with the host through complex networks that affect physiology and health outcomes. It is becoming clear these interactions can be measured across many different omics layers, including genome, transcriptome, epigenome, metabolome, proteome, among others. Multi-omic studies of provide insight into mechanisms underlying host-microbe interactions. As more layers are considered, increasingly sophisticated statistical methods required to integrate them. In this review, we an overview approaches currently used characterize multi-omic between data. While a large number have generated deeper understanding host-microbiome interactions, there still need for standardization approaches. Furthermore, would also benefit from collection curation large, publicly available multi-omics datasets.

Language: Английский

Citations

21
Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine DOI Creative Commons
Muneer Yaqub,

Aashika Jain,

Chinedu Eucharia Joseph

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 7 - 7

Published: Jan. 15, 2025

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.

Language: Английский

Citations

4
Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update DOI Open Access
Sara Jarmakiewicz-Czaja, Magdalena Zielińska, Aneta Sokal

et al.

Genes, Journal Year: 2022, Volume and Issue: 13(12), P. 2388 - 2388

Published: Dec. 16, 2022

Inflammatory bowel disease (IBD) is a chronic with periods of exacerbation and remission the disease. The etiology IBD not fully understood. Many studies point to presence genetic, immunological, environmental, microbiological factors interactions between them in occurrence IBD. review looks at genetic context both predisposition pharmacogenetics.

Language: Английский

Citations

59
Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis DOI Creative Commons
Sumel Ashique, Neeraj Mishra, Ashish Garg

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 20, 2023

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because an improperly managed immunological reactivity intestinal microbiota found in GIT. The immune response common commensal microbes plays essential role inflammation related UC synbiotics, and it important element optimal therapy UC. Therefore, i.e., mixture prebiotics probiotics, help control diseased state. Synbiotics alleviate colon by lowering reactive oxygen species (ROS) improving level antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). Prebiotic supplementation not practice at moment, despite numerous research findings proving that benefits both probiotics encourage their continued existence positioning GIT, with positive effects on human health managing response. However, fact there have been fewer studies treatment different coupled selected prebiotics, outcomes these very favorable. This evidence-based study explores possible ROS, SOD, synbiotics proposed review also focuses alteration gut microbiota, defense tract, management Thus, current article emphasizes oxidative stress signaling GI stress-based pathomechanisms patients, therapies inhibiting stress’ effects.

Language: Английский

Citations

31
Bacteroides acidifaciens and its derived extracellular vesicles improve DSS-induced colitis DOI Creative Commons
Cihua Zheng,

Yuchun Zhong,

Jian Xie

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 30, 2023

"Probiotic therapy" to regulate gut microbiota and intervene in intestinal diseases such as inflammatory bowel disease (IBD) has become a research hotspot. Bacteroides acidifaciens, new generation of probiotics, shown beneficial effects on various diseases.In this study, we utilized mouse colitis model induced by dextran sodium sulfate (DSS) investigate how B. acidifaciens positively affects IBD. We evaluated the ofB. fecal transplantation, bacterial extracellular vesicles (EVs) DSS-induced mice. monitored phenotype colitis, detected serum factors using ELISA, mucosal barrier function Western blotting tissue staining, 16S rRNA sequencing, analyzed differences EVs protein composition derived from proteomics explore positive impact colitis.We confirmed that protective effect including alleviating phenotype, reducing response, improving function, accompanied an increase relative abundance Ruminococcus callidus but decrease fragilis. Further transplantation or filtrate eosinophil-regulated metabolites colitis. Finally, validated contain rich functional proteins can contribute relief colitis.Therefore, its alleviate damage colon tissue, promoting repair, restoring diversity, balance The results study provide theoretical basis for preclinical application probiotics.

Language: Английский

Citations

26
Relevance of gut microbiota to Alzheimer's Disease (AD): Potential effects of probiotic in management of AD DOI Creative Commons

Mahadev Dhami,

Khadga Raj,

Shamsher Singh

et al.

Aging and Health Research, Journal Year: 2023, Volume and Issue: 3(1), P. 100128 - 100128

Published: Feb. 17, 2023

The gut microbiota consists of a group microorganisms required to support the gastrointestinal system. microbiota-gut-brain axis is dynamic bidirectional communication pathway that links cognitive and emotional perception with peripheral intestinal functions. change in architecture increases permeability intestine, activates immune system, changes blood-brain barrier (BBB) permeability, proinflammatory mediators, eventually causes neurodegeneration. increased bowel upset altered BBB cause dysbiosis leads release amyloids lipopolysaccharides. This further modulate NF-κB signaling immense cytokines storm loss neurons. A growing body experimental clinical reports indicates role microbiota-host interaction use germ-free animals pathogenic infections probiotics affect pathogenesis Alzheimer's disease (AD) associated an ongoing developmental research area. therapeutic indication modulating would be strategy AD. purpose article explore how gut-brain linked impairment maintain microbial flora prevent AD-like symptoms.

Language: Английский

Citations

24