Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e29128 - e29128

Published: April 1, 2024

Pesticides are chemical constituents used to prevent or control pests, including insects, rodents, fungi, weeds, and other unwanted organisms. Despite their advantages in crop production disease management, the use of pesticides poses significant hazards environment public health. Pesticide elements have now perpetually entered our atmosphere subsequently contaminated water, food, soil, leading health threats ranging from acute chronic toxicities. can cause toxicity if a high dose is inhaled, ingested, comes into contact with skin eyes, while prolonged recurrent exposure leads toxicity. produce different types toxicity, for instance, neurotoxicity, mutagenicity, carcinogenicity, teratogenicity, endocrine disruption. The pesticide formulation may depend on specific active ingredient presence synergistic inert compounds that enhance modify its Safety concerns need hour contemporary pesticide-induced hazards. effectiveness implementation current legislature providing ample protection human key concerns. This review explored comprehensive summary regarding updated impacts advanced safety legislation. Implementing regulations, proper training, education help mitigate negative promote safer more sustainable agricultural practices.

Language: Английский

---

Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review

Environmental Research, Journal Year: 2023, Volume and Issue: 227, P. 115724 - 115724

Published: March 21, 2023

Language: Английский

---

Cu0-doped graphitic carbon quantum dots for rapid electrochemical sensing of glyphosate herbicide in environmental samples

Microchemical Journal, Journal Year: 2024, Volume and Issue: 200, P. 110294 - 110294

Published: March 6, 2024

Language: Английский

---

Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories

Chemosphere, Journal Year: 2023, Volume and Issue: 324, P. 138251 - 138251

Published: March 4, 2023

Language: Английский

---

Neurotoxicity of glyphosate: Focus on molecular mechanisms probably associated with alterations in cognition and behavior

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 106, P. 104381 - 104381

Published: Feb. 2, 2024

Language: Английский

---

Dinitroaniline herbicides: a comprehensive review of toxicity and side effects on animal non-target organisms

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(51), P. 76687 - 76711

Published: Sept. 29, 2022

Abstract The widespread use of herbicides has increased concern about the hazards and risks to animals living in terrestrial aquatic ecosystems. A comprehensive understanding their effective action at different levels biological organization is critical for establishing guidelines protect ecosystems human health. Dinitroanilines are broad-spectrum pre-emergence currently used weed control conventional agriculture. They considered extremely safe agrochemicals because they act specifically on tubulin proteins inhibit shoot root growth plants. However, there a lack toxicity information regarding potential risk exposure non-target organisms. aim present review focus side effects most commonly active ingredients, e.g. pendimethalin, oryzalin, trifluralin benfluralin, animal cells invertebrates vertebrates. Acute varies from slightly high species (i.e. nematodes, earthworms, snails, insects, crustaceans, fish mammals) depending species-specific ability tested organisms adsorb discharge toxicants. Cytotoxicity, genotoxicity activation oxidative stress pathways as well alterations physiological, metabolic, morphological, developmental behavioural traits, reviewed here, indicate that sublethal concentrations ingredients poses clear hazard humans. Further research required evaluate molecular mechanisms these cell functions multiple levels, communities, including commercial formulations.

Language: Английский

---

Association between glyphosate exposure and cognitive function, depression, and neurological diseases in a representative sample of US adults: NHANES 2013–2014 analysis

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116860 - 116860

Published: Aug. 9, 2023

Language: Английский

---

The inadequacy of current pesticide regulations for protecting brain health: the case of glyphosate and Parkinson's disease

The Lancet Planetary Health, Journal Year: 2023, Volume and Issue: 7(12), P. e948 - e949

Published: Nov. 7, 2023

Parkinson's disease is undergoing the fastest rise in prevalence among neurological diseases worldwide.1Dorsey ER Sherer T Okun MS Bloem BR The emerging evidence of Parkinson pandemic.J Parkinsons Dis. 2018; 8: S3-S8Crossref PubMed Scopus (608) Google Scholar This growth caused part by exposure to environmental toxicants, with a particular concern revolving around pesticides. Many pesticides cause nigrostriatal cell death and produce parkinsonian signs exposed animals. Moreover, farmers have an increased risk developing disease.1Dorsey There intense debate Europe glyphosate, vote November, 2023, on renewing its marketing authorisation. Glyphosate controversial herbicide because concerns public health risks, including cancer. individuals are international SPRINT study finding glyphosate residues faeces 70% participants (farmers, their neighbours, urban residents).2Mol H, Dias J, Scheepers P, et al. Pesticides biomonitoring: feces as new matrix comparison urine data. International Society for Exposure Science Annual meeting; Aug 27–31, 2023.Google We urgently appeal governments policy makers throughout European Union against extending authorisation another 10 years. Our opinion based two considerations, illustrated here using example, although similar apply other neurodegenerative (eg, Alzheimer's, motor neuron disease) intellectual disabilities children. Current regulatory actions inadequate. It impossible estimate safety relation current actions—defined Food Safety Authority (EFSA)—have serious shortcomings. First, procedures test neurotoxicity too crude. Experimental animals pesticides, assessed primarily evaluating occurrence clinically discernible symptoms However, case system, arise only after extensive damage has been inflicted, loss 60–70% nerve cells. If, 40% those cells died, animal seems healthy, but tested pesticide anything safe. Therefore, absence these experiments does not exclude relevant damage. Targeted post-mortem counts brain regions necessary, actions. shortcoming had long recognised researchers, was also acknowledged recent working conference organised EFSA:3EFSAWorkshop EFSA NAMs project neurotoxicants.https://www.pan-europe.info/sites/pan-europe.info/files/public/resources/other/Agreed%20minutes%207-8%20September%202022.pdfDate accessed: November 4, 2023Google "Overall, there broad consensus that currently existing procedures, actions, likely give us inadequate insight into actual neurotoxic specific substantia nigra, consequently, offer assessment human exposure." Second, doses were probably low representative everyday exposure. present concentrations typically reach humans dietary can travel distances through air high house dust homes residents living nearby farmland,4Navarro I de la Torre A Sanz P al.Occurrence indoor farmworker households across Argentina.Sci Total Environ. 2023; 905167797Crossref (0) thus creating via skin inhalation. These entry routes such should be considered explicitly when assessing glyphosate's neurotoxicity. Third, neurodegeneration affecting gut microbiome, shown studies where produced changes intestinal bacteria.5Kulcsarova K Bang B Berg D Schaeffer E microbiome-gut-brain axis: Convergent pathways pathogenesis Disease.J : 1-28Google Such microbial could act first event triggers cascade processes, spreading from neurons vagal brain. Evaluation microbiome downstream processes therefore become improved Fourth, isolated presently being assessed. reality so-called cocktails which contain multiple pesticides.2Mol Recent work showed co-exposures different results greater dopaminergic than any single pesticide.6Paul KC Krolewski RC Lucumi Moreno al.A iPSC screen identifies classifies Parkinson-relevant pesticides.Nat Commun. 142803Google identified cocktail included mechanisms action, compounds raised previously isolation. findings indicate little said about used glyphosate. Finally, much research far conducted industry itself, they omit at least some evaluation dossier. For omitted linked young rats utero.7Mie Rudén C What you don't know still hurt you—underreporting EU regulation.Environ Health. 2022; 21: 79Crossref (3) Independent evaluation. Taken together, data gap it comes diseases. this important knowledge addressed reassessment might disease, indicated four (summarised here8Eriguchi M Iida Ikeda S al.Parkinsonism Relating Intoxication Glyphosate.Intern Med. 2019; 58: 1935-1938Crossref (19) Scholar) one epidemiological study.9Caballero Amiri Denney JT Monsivais Hystad Amram O Estimated Residential Agricultural Chemicals Premature Mortality Disease Washington State.Int J Environ Res Public 152885Crossref (22) In experiment, co-exposure plus MPTP, potent neurotoxin kills neurons, associated MPTP alone.10Pu Y Chang L Qu al.Glyphosate exacerbates mouse repeated administration MPTP.Neurosci Lett. 2020; 730135032Crossref (8) Furthermore, higher levels urinary neurofilament light protein, indicator neural diseases.11Yang AM Chu PL Wang Lin CY Association between serum chain sample US adults: NHANES 2013-2014.J Expo Sci Epidemiol. (published online Sept 6.)https://doi.org/10.1038/s41370-023-00594-2Crossref latter effects seen general population—that is, people professionally. vitro suggest oxidative stress, neuroinflammation mitochondrial dysfunction, all context disease.12Costas-Ferreira Durán R Faro LRF Toxic Effects Nervous System: Systematic Review.Int Mol Sci. 234605Crossref (25) Overall, inconclusive, sufficient biologically plausible link death, hence disease. Together shortcomings rapid concern. following advice makers: first, years, consider admission briefer period time, maximally 5 urge authorities release funding development specifically targeting evaluated according framework independent scientific institutions, immediately include same Only demonstrate criteria may continue used. parallel, alternatives use must pursued vigorously. measures will help protect our population risks. RadboudUMC Centre Expertise & Movement Disorders supported centre excellence grant Foundation. sources did involvement preparation manuscript. BRB co-Editor Chief Journal Disease. He editorial board Practical Neurology Digital Biomarkers, received honoraria advisory Abbvie, Biogen, Chimique Belge (UCB); fees speaking conferences AbbVie, Zambon, Roche, General Electric Healthcare, Bial; support Netherlands Organization Scientific Research, Michael Fox Foundation, UCB, Not Impossible, Hersenstichting Nederland, Verily Life Sciences, Horizon 2020, Vereniging (all paid institute). TAB shareholder F Hoffmann-La Roche Ltd. Dutch alliance AbbVie (paid

Language: Английский

---

Glyphosate and neurotoxicity — a call for scientific renewal

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(3), P. 131 - 132

Published: Jan. 2, 2024

Language: Английский

---

Synergistic Insights into Pesticide Persistence and Microbial Dynamics for Bioremediation

Environmental Research, Journal Year: 2024, Volume and Issue: 257, P. 119290 - 119290

Published: May 31, 2024

Language: Английский

---