Wound Repair and Regeneration,
Journal Year:
2024,
Volume and Issue:
33(1)
Published: Nov. 28, 2024
Diabetes
mellitus
remains
a
global
challenge
to
public
health
as
it
results
in
non-healing
chronic
ulcers
of
the
lower
limb.
These
wounds
are
challenging
heal,
and
despite
different
treatments
available
improve
healing,
there
is
still
high
rate
failure
relapse,
often
necessitating
amputation.
Chronic
diabetic
do
not
follow
an
orderly
progression
through
wound
healing
process
associated
with
persistent
inflammatory
state
characterised
by
accumulation
pro-inflammatory
macrophages,
cytokines
proteases.
Photobiomodulation
has
been
successfully
utilised
involves
illuminating
at
specific
wavelengths
using
predominantly
light-emitting
diodes
or
lasers.
induces
diminishing
inflammation
oxidative
stress,
among
others.
Research
into
application
photobiomodulation
for
current
ongoing
drawn
attention
many
researchers
healthcare
sector.
This
review
focuses
on
pathway
influence
this
wavelengths.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(1), P. 583 - 583
Published: Jan. 2, 2024
Wound
healing
is
a
complex
process
involving
coordinated
series
of
events
aimed
at
restoring
tissue
integrity
and
function.
Regulatory
B
cells
(Bregs)
are
subset
lymphocytes
that
play
an
essential
role
in
fine-tuning
immune
responses
maintaining
homeostasis.
Recent
studies
have
suggested
Bregs
important
players
cutaneous
immunity.
This
review
summarizes
the
current
understanding
skin
immunity
health
pathology,
such
as
diabetes,
psoriasis,
systemic
sclerosis,
lupus
erythematosus,
hypersensitivity,
pemphigus,
dermatomyositis.
We
discuss
mechanisms
by
which
maintain
homeostasis
wound
microenvironment
through
promotion
angiogenesis,
suppression
effector
cells,
induction
regulatory
cells.
also
mention
potential
clinical
applications
promoting
healing,
use
adoptive
Breg
transfer.
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: April 18, 2024
Abstract
Chronic,
non-healing
wounds
represent
a
significant
challenge
for
healthcare
systems
worldwide,
often
requiring
human
and
financial
resources.
Chronic
arise
from
the
complex
interplay
of
underlying
comorbidities,
such
as
diabetes
or
vascular
diseases,
lifestyle
factors,
genetic
risk
profiles
which
may
predispose
extremities
to
local
ischemia.
Injuries
are
further
exacerbated
by
bacterial
colonization
formation
biofilms.
Infection,
consequently,
perpetuates
chronic
inflammatory
microenvironment,
preventing
progression
completion
normal
wound
healing.
The
current
standard
care
(SOC)
involves
surgical
debridement
along
with
localized
irrigation,
requires
inpatient
under
general
anesthesia.
This
could
be
followed
by,
if
necessary,
defect
coverage
via
reconstructive
ladder
utilizing
skin
graft,
local,
free
flap
techniques
once
conditions
stabilized
adequate
blood
supply
is
restored.
To
promote
physiological
healing,
variety
approaches
have
been
subjected
translational
research.
Beyond
conventional
healing
drugs
devices
that
currently
supplement
treatments,
cellular
immunotherapies
emerged
promising
therapeutics
can
behave
tailored
therapies
cell-
molecule-specific
properties.
However,
in
contrast
clinical
omnipresence
disorders,
there
remains
shortage
studies
condensing
body
evidence
on
wounds.
review
provides
comprehensive
exploration
therapies,
experimental
approaches,
studies,
offering
insights
into
their
efficacy
limitations.
Ultimately,
we
hope
this
line
research
serve
an
evidence-based
foundation
guide
optimize
patient
long-term.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(2)
Published: Jan. 1, 2025
ABSTRACT
Currently,
an
effective
treatment
for
spinal
cord
injury
(SCI)
is
not
available.
Due
to
the
irreversible
primary
associated
with
SCI,
prevention
and
of
secondary
are
very
important.
In
stage,
pyroptosis
exacerbates
deterioration
injury,
inhibiting
beneficial
recovery
from
SCI.
The
aim
this
study
was
clarify
role
resveratrol
(RES)
antipyroptotic
mechanisms
RES
miR‐124‐3p
in
SCI
lay
a
theoretical
foundation
clinical
provide
new
therapeutic
approaches.
Using
cell
staining
related
molecular
protein
detection
techniques
assess
DAPK1,
effects
on
were
investigated,
injured
repair
rats
evaluated
using
tissue
functional
experiments.
vitro,
DAPK1
interacts
NLRP3,
exerting
pyroptotic
effect
through
NLRP3/Caspase‐1/GSDMD
pathway
knockdown
inhibits
pyroptosis.
miR‐124‐3P
negatively
regulates
level
reduced
increased
expression
reduces
expression,
affecting
vivo,
GSDMD‐N
levels
promotes
recovery,
thus
Therefore,
we
concluded
that
increases
miR‐124‐3p,
which
targets
pathway,
alleviates
BMC Cardiovascular Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 14, 2025
Creatinine-to-albumin
ratio
(CAR)
has
been
recognized
as
a
predictive
indicator
in
the
postoperative
setting.
However,
its
relationship
with
outcomes
patients
receiving
cardiac
surgery
remains
elusive.
This
study
aimed
to
discuss
link
between
CAR
and
28-day
mortality
admitted
intensive
care
unit
(ICU)
following
surgery,
hoping
provide
some
insights
for
targeted
interventions
improvement
of
patient
outcomes.
MIMIC-IV
database
was
searched
obtain
data
ICU
surgery.
Retrieved
were
split
into
three
groups
based
on
levels.
The
each
group
evaluated
compared
using
Kaplan—Meier
analysis.
Subgroup
analysis,
multivariate
Cox
regression
restricted
cubic
spline
(RCS)
analysis
used
further
examine
Receiver
operating
characteristic
(ROC)
curves
assess
ability
CAR.
Mediation
conducted
investigate
potential
mechanism
by
which
affects
mortality.
A
total
5,670
included
divided
groups.
Patients
high
values
(CAR
≥
0.31)
had
significantly
increased
rate
(11.4%),
those
low
levels
<
0.23,
1.83%).
In
addition,
lowest
survival
than
other
two
(p
0.0001).
ROC
curve
showed
that
exhibited
moderate
power
(AUC
=
0.748).
Moreover,
identified
strong
risk
factor
mortality,
significant
dose–response
association
presented.
Further
subgroup
revealed
pronounced
risks
females
without
chronic
conditions
such
kidney
disease
(CKD)
type
2
diabetes
mellitus
(T2DM).
indicated
affected
through
biomarkers
like
chloride
(39.8%),
glucose
(11.8%),
potassium
(24.4%),
sodium
(28.3%).
served
it
complex
subgroup-specific
Additionally,
multiple
key
biomarkers,
providing
interventions.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 366 - 366
Published: March 13, 2025
Chronic
wounds
pose
a
significant
healthcare
challenge,
impacting
millions
of
patients
worldwide
and
burdening
systems
substantially.
These
often
occur
as
comorbidities
are
prone
to
infections.
Such
infections
hinder
the
healing
process,
complicating
clinical
management
proving
recalcitrant
therapy.
The
environment
within
wound
itself
poses
challenges
such
lack
oxygen,
restricted
blood
flow,
oxidative
stress,
ongoing
inflammation,
bacterial
presence.
Traditional
systemic
treatment
for
chronic
peripheral
may
not
be
effective
due
inadequate
supply,
resulting
in
unintended
side
effects.
Furthermore,
topical
applications
impervious
persistent
biofilm
A
growing
concern
is
therapeutic
modalities
treating
wounds.
Additionally,
chemically
harsh
microenvironment
can
reduce
effectiveness
treatments,
highlighting
need
drug
delivery
that
deliver
therapies
precisely
where
needed
with
optimal
dosages.
Compared
cell-based
therapies,
exosome-based
offer
distinct
advantages
cell-free
approach
treatment.
Exosomes
endosomal
origin
enable
cell-to-cell
communications,
they
possess
benefits,
including
biocompatibility
decreased
immunogenicity,
making
them
ideal
vehicles
efficient
targeting
minimizing
off-target
damage.
However,
exosomes
rapidly
cleared
from
body,
it
difficult
maintain
concentrations
at
sites.
hydrogel-based
development
biocompatible
scaffolds
beneficial
sustained
release
prolong
presence
these
Engineered
have
been
shown
stability
promoting
compared
their
unmodified
counterparts.
Significant
progress
has
made
this
field,
but
further
research
essential
unlock
potential.
This
review
seeks
explore
benefits
opportunities
wounds,
ensuring
efficacy
precise
despite
obstacles
posed
by
environment.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 6425 - 6448
Published: Nov. 1, 2023
Abstract:
Chronic
wounds
are
recalcitrant
complications
of
a
variety
diseases,
with
pathologic
features
including
bacterial
infection,
persistent
inflammation,
and
proliferation
reactive
oxygen
species
(ROS)
levels
in
the
wound
microenvironment.
Currently,
use
antimicrobial
drugs,
debridement,
hyperbaric
therapy,
other
methods
clinical
for
chronic
treatment
is
prone
to
problems
such
as
resistance,
expansion,
even
exacerbation.
In
recent
years,
researchers
have
proposed
many
novel
materials
targeting
disease
characteristics,
among
which
metal–phenolic
networks
(MPNs)
supramolecular
network
structures
that
utilize
multivalent
metal
ions
natural
polyphenols
complexed
through
ligand
bonds.
They
flexible
versatile
combination
structural
forms
formations
(nanoparticles,
coatings,
hydrogels,
etc.)
can
be
constructed.
Functionally,
MPNs
combine
chemocatalytic
bactericidal
properties
well
anti-inflammatory
antioxidant
polyphenol
compounds.
Together
excellent
rapid
synthesis
negligible
cytotoxicity,
attracted
researchers'
great
attention
biomedical
fields
anti-tumor,
anti-bacterial,
anti-inflammatory.
This
paper
will
focus
on
composition
MPNs,
mechanisms
wounds,
application
therapies.
Keywords:
networks,
antimicrobial,
antioxidant,
scavenging,
revascularization
