European Journal of Nutrition, Journal Year: 2024, Volume and Issue: 63(4), P. 1163 - 1175
Published: Feb. 15, 2024
Language: Английский
Degenerative Neurological and Neuromuscular Disease, Journal Year: 2024, Volume and Issue: Volume 14, P. 47 - 74
Published: May 1, 2024
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there currently no cure for AD, several pharmacotherapeutic targets management strategies have been explored. Additionally, traditional medicinal plants gained attention their potential role in AD management. Pharmacotherapeutic include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, cholinergic dysfunction. Traditional plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), Panax ginseng, demonstrated the ability to modulate these through bioactive compounds. biloba , instance, contains flavonoids terpenoids that exhibit neuroprotective effects reducing Aβ deposition enhancing cerebral blood flow. serrata natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving function. enriched with curcumin, exhibits anti-inflammatory antioxidant effects, potentially mitigating neuroinflammation stress. ginseng's ginsenosides shown anti-amyloidogenic properties. The investigation complementary approach offers advantages, including lower risk adverse multi-target interactions. Furthermore, cultural knowledge utilization provide rich information development new therapies. However, further research necessary elucidate precise mechanisms action, standardize preparations, assess safety efficacy remedies. Integrating medicinal-plant-based therapies modern pharmacotherapies may hold key more comprehensive effective treatment. This review aims explore its Keywords: disease, acetylcholinesterase, amyloid beta, protein, medicine, Ayurvedic herbs, acetylcholinesterase inhibitors, disorders, cognition
Language: Английский
Citations
56
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102091 - 102091
Published: Oct. 12, 2023
Language: Английский
Citations
40
World Journal of Diabetes, Journal Year: 2023, Volume and Issue: 14(2), P. 92 - 109
Published: Feb. 14, 2023
Several epidemiological studies have clearly identified diabetes mellitus (DM) as a major risk factor for cognitive dysfunction, and it is going to be public health issue in the coming years because of alarming rise prevalence across world. Brain neural tissues predominantly depend on glucose energy substrate hence, any alterations carbohydrate meta-bolism can directly impact cerebral functional output including cognition, executive capacity, memory. DM affects neuronal function mental capacity several ways, some which include hypoperfusion brain from cerebrovascular disease, diabetes-related transporters causing abnormalities uptake metabolism, local hyper- hypometabolism areas insulin resistance, recurrent hypoglycemic episodes inherent pharmacotherapy resulting damage. Cognitive decline further worsen care disease largely self-managed by patients. Therefore, crucial understand pathobiology dysfunction relation its management optimal long-term plan A thorough appraisal normal metabolic characteristics brain, how metabolism diagnostic algorithm patients with dementia, prognosis when they this dangerous combination illnesses imperative context. This evidence-based narrative back-up latest clinical trial reviews elaborates current understanding empower physicians manage their day-to-day practice.
Language: Английский
Citations
39
Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Aims Obesity is a global public health challenge, and the traditional WHO‐proposed diagnostic criteria based on body mass index (BMI) often fail to fully assess related risks. The European Association for Study of (EASO) has proposed new that combine BMI, waist‐to‐height ratio (WtHR) complications more accurately evaluate obesity‐related Materials Methods This study utilized data from National Health Nutrition Examination Survey database, covering years 1999–2018. validated EASO diagnosing obesity, defined as BMI ≥25 kg/m 2 , WtHR ≥0.5 presence 12 complications. associations between obesity mortality were assessed using Kaplan–Meier survival curves Cox proportional hazards regression analyses. Mediation analysis was conducted explore potential mechanisms by which impacts patient prognosis. Results A total 39 066 participants included, with mean age 43.6 years; 51.3% male. Over median follow‐up period 141 months, 3708 deaths recorded. prevalence 63.04% according criteria. rate ≥30 only 35.55%. achieved C‐index 0.5549, surpasses predictive accuracy criterion, 0.5265. indicated when criterion diagnose it associated all‐cause cardiovascular disease (CVD)‐related mortality, but did not predict cancer‐related mortality. diagnosed significantly an increased risk (hazard [HR] 95% confidence interval [CI]: 1.13 [1.02, 1.24]), CVD (HR CI: 1.48 [1.20, 1.83]) cancer 1.26 [1.03, 1.54]). When simplified any top five (diabetes mellitus, hypertension, CVD, metabolic syndrome ageing) criteria, had highest (0.612), remained independent prognostic factor poor overall CI mortality: 1.41 [1.26, 1.58], HR 2.08 [1.61, 2.68] 1.32 [1.06, 1.65]). Conclusions confirms value EASO, suggesting these offer accurate assessment
Language: Английский
Citations
1
Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14044 - 14044
Published: Sept. 13, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative that affects most people worldwide. AD complex central nervous system disorder. Several drugs have been designed to cure AD, but with low success rates. Because the blood–brain and blood–cerebrospinal fluid barriers are two protect system, their presence has severely restricted efficacy of many treatments studied for diagnosis and/or therapy. The use nanoparticles treatment focus an established rapidly developing field nanomedicine. Recent developments in nanomedicine made it possible effectively transport brain. However, numerous obstacles remain successful nanomedicines clinical settings treatment. Furthermore, given rapid advancement therapeutics, better outcomes patients can be anticipated. This article provides overview recent using different types management AD.
Language: Английский
Citations
19
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102450 - 102450
Published: Aug. 10, 2024
Language: Английский
Citations
6
Cells, Journal Year: 2022, Volume and Issue: 11(23), P. 3767 - 3767
Published: Nov. 25, 2022
Dementia is reported to be common in those with type 2 diabetes mellitus. Type contributes molecular mechanisms and an underlying pathology dementia. Brain cells becoming resistant insulin leads elevated blood glucose levels, impaired synaptic plasticity, microglial overactivation, mitochondrial dysfunction, neuronal apoptosis, nutrient deprivation, TAU (Tubulin-Associated Unit) phosphorylation, cholinergic dysfunction. If has neuroprotective properties, resistance may interfere properties. Risk factors have a significant impact on the development of diseases, such as diabetes, obesity, stroke, other conditions. Analysis risk importance for association between dementia important because they impede clinical management early diagnosis. We discuss pathological physiological behind mellitus dementia, resistance, signaling, sporadic forms dementia; relationship receptor activation phosphorylation; mRNA expression downregulation related receptors; neural modulation due secretion homeostasis; apoptosis Addressing these will offer outcome-based insights into connection patients cognitive impairment. Furthermore, we explore role brain evidence anti-diabetic drugs prevention diabetes.
Language: Английский
Citations
20
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: March 15, 2023
Background Many clinical studies have shown a correlation between plasma cortisol and neurological disorders. This study explored the causal relationship dementia, epilepsy multiple sclerosis based on Mendelian randomization (MR) method. Methods Data were taken from summary statistics of genome-wide association study, FinnGen consortium United Kingdom Biobank. Dementia, epilepsy, used as outcomes, genetic variants associated with instrumental variables. The main analysis was performed using inverse variance weighted method, results assessed according to odds ratio (OR) 95% confidence interval. Heterogeneity tests, pleiotropy leave-one-out method conducted evaluate stability accuracy results. Results In two-sample MR analysis, showed that Alzheimer’s disease (AD) [odds (95% interval) = 0.99 (0.98-1.00), P 0.025], vascular dementia (VaD) 2.02 (1.00-4.05), 0.049)], Parkinson’s (PDD) 0.24 (0.07-0.82), 0.023] 2.00 (1.03-3.91), 0.042]. There no statistically significant associations Lewy bodies (DLB), frontotemporal (FTD) sclerosis. Conclusion demonstrates increase incidence rates VaD decrease AD PDD. Monitoring concentrations in practice can help prevent diseases, such AD, PDD, epilepsy.
Language: Английский
Citations
12
Obesity Pillars, Journal Year: 2023, Volume and Issue: 7, P. 100076 - 100076
Published: June 13, 2023
A common adiposopathic complication of obesity is type 2 diabetes mellitus. Healthful weight reduction in patients with can improve glucose metabolism and potentially promote remission However, weight-reduction increased adiposity impaired among mellitus compared to without Data for this review were derived from PubMed appliable websites. Among body fat, the mechanisms underlying those are multifactorial, include energy conservation (i.e., improved control reduced glucosuria), hyperinsulinemia (commonly found many mellitus), potential use obesogenic anti-diabetes medications, contributions multiple systems. Other factors age, sex, genetic/epigenetic predisposition, environments. Even though impairs adiposity, clinically meaningful improves sometimes remission. An illustrative approach mitigate due choosing medications that increase insulin sensitivity loss deprioritize exposure gain.
Language: Английский
Citations
12